B
9p21.3 locus variant
Genetic & Family HistoryGenetic / heritablerisknon modifiable
22
evidence score
Also known as: 9p21.3
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 13meta-analyses: 9.1trials: 0genetic: 0MR bonus:
References (19)
2 meta-analyses / systematic reviews- METAAssociation between 9p21.3 genomic markers and coronary artery disease in East Asians: a meta-analysis involving 9,813 cases and 10,710 controls. — Molecular biology reports 2012 · PMID 23086272
- METARepeated replication and a prospective meta-analysis of the association between chromosome 9p21.3 and coronary artery disease. — Circulation 2008 · PMID 18362232
- The 9p21.3 coronary artery disease risk locus drives vascular smooth muscle cells to an osteochondrogenic state. — bioRxiv : the preprint server for biology 2025 · PMID 38853913
- The 9p21.3 Coronary Artery Disease Risk Locus Drives Vascular Smooth Muscle Cells to an Osteochondrogenic State. — Arteriosclerosis, thrombosis, and vascular biology 2025 · PMID 40143812
- Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk. — medRxiv : the preprint server for health sciences 2025 · PMID 40950476
- The mechanisms of Chr.9p21.3 risk locus in coronary artery disease: where are we today? — American journal of physiology. Heart and circulatory physiology 2024 · PMID 39656484
- Influence of Chromosome 9p21.3 rs1333049 Variant on Telomere Length and Their Interactive Impact on the Prognosis of Coronary Artery Disease. — Journal of cardiovascular development and disease 2023 · PMID 37754816
- Bidirectional relationship between type 2 diabetes mellitus and coronary artery disease: Prospective cohort study and genetic analyses. — Chinese medical journal 2023 · PMID 38062574
- Effect of 9p21.3 (lncRNA and CDKN2A/2B) variant on lipid profile. — Frontiers in cardiovascular medicine 2022 · PMID 36158791
- Genetic variants of PON1, GSTM1, GSTT1, and locus 9p21.3, and the risk for premature coronary artery disease in Yucatan, Mexico. — American journal of human biology : the official journal of the Human Biology Council 2021 · PMID 34766662
- A review on coronary artery disease, its risk factors, and therapeutics. — Journal of cellular physiology 2019 · PMID 30790284
- 9p21.3 coronary artery disease risk locus and interferon alpha 21: Association study in an Asian Indian population. — Indian heart journal 2019 · PMID 32248921
- Association Study Between Coronary Artery Disease and rs1333049 Polymorphism at 9p21.3 Locus in Italian Population. — Journal of cardiovascular translational research 2017 · PMID 28639227
- The 9p21.3 risk locus for coronary artery disease: A 10-year search for its mechanism. — Journal of Taibah University Medical Sciences 2017 · PMID 31435240
- Genes and coronary artery disease: where are we? — Journal of the American College of Cardiology 2012 · PMID 23040572
- Emerging genomic applications in coronary artery disease. — JACC. Cardiovascular interventions 2011 · PMID 21596318
- Genomics in coronary artery disease: past, present and future. — The Canadian journal of cardiology 2010 · PMID 20386763
- Cardiovascular Disease Risk Prediction With and Without Knowledge of Genetic Variation at Chromosome 9p21.3 — Annals of Internal Medicine 2009 · PMID 19153409
- Association between the coronary artery disease risk locus on chromosome 9p21.3 and abdominal aortic aneurysm. — Circulation. Cardiovascular genetics 2008 · PMID 20031540
Clinical trials (0)
None linked.
Genetic associations (0)
None linked.