B
Adiponectin
Novel & Emerging BiomarkersLab test / biomarkerprotectivepartially modifiable
33
evidence score
Also known as: adiponectin plasma levels, reduced adiponectin concentration
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 16.5meta-analyses: 9.1trials: 7.8genetic: 0MR bonus:
References (44)
2 meta-analyses / systematic reviews- METAPhenotype-specific associations of circulating adipokine levels with carotid atherosclerosis: a systematic review and meta-analysis. — International journal of cardiology. Cardiovascular risk and prevention 2025 · PMID 41323746
- METAModerate alcohol consumption and atherosclerosis : Meta-analysis of effects on lipids and inflammation. — Wiener klinische Wochenschrift 2017 · PMID 28762059
- Epicardial fat tissue in metabolically healthy and unhealthy obesity: culprit or bystander? — Minerva endocrinology 2025 · PMID 40635457
- Advances and challenges of targeting epicardial adipose tissue (EAT) and perivascular adipose tissue (PVAT). — Cardiovascular diabetology 2025 · PMID 40760703
- Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity. — Cell metabolism 2024 · PMID 38569471
- Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis? — Anais brasileiros de dermatologia 2023 · PMID 37198010
- Causal Associations Between Circulating Adipokines and Cardiovascular Disease: A Mendelian Randomization Study — The Journal of Clinical Endocrinology & Metabolism 2022 · PMID 35134201
- Adipokines, adiposity, and atherosclerosis. — Cellular and molecular life sciences : CMLS 2022 · PMID 35503385
- Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease — Frontiers in Cardiovascular Medicine 2021 · PMID 34660715
- Dietary Inflammatory Potential and Risk of Cardiovascular Disease Among Men and Women in the U.S. — Journal of the American College of Cardiology 2020 · PMID 33153576
- Adipokine Dysregulation and Insulin Resistance with Atherosclerotic Vascular Disease: Metabolic Syndrome or Independent Sequelae? — Journal of cardiovascular translational research 2019 · PMID 30835048
- Relationship among adiponectin, insulin resistance and atherosclerosis in non-diabetic hypertensive patients and healthy adults. — Clinical and experimental hypertension (New York, N.Y. : 1993) 2018 · PMID 29336612
- Genetic predictors of testosterone and their associations with cardiovascular disease and risk factors: A Mendelian randomization investigation — International Journal of Cardiology 2018 · PMID 29804699
- [Psoriasis,Cardiovascular Disease,and Adipokines]. — Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2018 · PMID 30193612
- Adipokines in Liver Cirrhosis. — International journal of molecular sciences 2017 · PMID 28661458
- Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus — Journal of the American Heart Association 2016 · PMID 27247335
- Relationship of Plasma Adiponectin and Waist-hip Ratio with Coronary Artery Disease. — Medical archives (Sarajevo, Bosnia and Herzegovina) 2016 · PMID 28210011
- Obesity and inflammation: the linking mechanism and the complications — Archives of Medical Science 2016 · PMID 28721154
- Diabetic foot syndrome as a possible cardiovascular marker in diabetic patients. — Journal of diabetes research 2015 · PMID 25883983
- A Comprehensive Review on Metabolic Syndrome — Cardiology Research and Practice 2014 · PMID 24711954
- Nonalcoholic fatty liver disease and cardiovascular disease. — World journal of gastroenterology 2014 · PMID 25024598
- Adipocytokines in relation to cardiovascular disease. — Metabolism: clinical and experimental 2013 · PMID 23866981
- Adiponectin and interleukin-6 in inflammation-associated disease. — Vitamins and hormones 2012 · PMID 23017723
- Effective continuous systemic therapy of severe plaque‐type psoriasis is accompanied by amelioration of biomarkers of cardiovascular risk: results of a prospective longitudinal observational study — Journal of the European Academy of Dermatology and Venereology 2011 · PMID 21241371
- The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis — Journal of the European Academy of Dermatology and Venereology 2011 · PMID 21349112
- Leptin/adiponectin ratio in patients with coronary heart disease: comparing subjects with and without metabolic syndrome. — Annals of clinical biochemistry 2011 · PMID 21502199
- Inflammation in Atherosclerosis: Transition From Theory to Practice — Circulation Journal 2010 · PMID 20065609
- Adipose Tissue, Inflammation and Atherosclerosis — Journal of Atherosclerosis and Thrombosis 2010 · PMID 20124732
- Cystatin C, adipokines and cardiovascular risk in HIV infected patients. — Current HIV research 2010 · PMID 20426756
- Pericardial Adipose Tissue Determined by Dual Source CT Is a Risk Factor for Coronary Atherosclerosis — Arteriosclerosis Thrombosis and Vascular Biology 2009 · PMID 19229071
- Inflammation in atherosclerosis: from vascular biology to biomarker discovery and risk prediction. — Clinical chemistry 2008 · PMID 18160725
- Adipose tissue dysfunction in obesity, diabetes, and vascular diseases — European Heart Journal 2008 · PMID 18775919
- Sleep Duration and Snoring in Relation to Biomarkers of Cardiovascular Disease Risk Among Women With Type 2 Diabetes — Diabetes Care 2007 · PMID 17322482
- Adiponectin and the metabolic syndrome: mechanisms mediating risk for metabolic and cardiovascular disease — Current Opinion in Lipidology 2007 · PMID 17495599
- Adiposity and cardiovascular disorders: disturbance of the regulatory system consisting of humoral and neuronal signals. — Circulation research 2007 · PMID 17615379
- Diabetes mellitus and macrovascular disease: mechanisms and mediators. — The American journal of medicine 2007 · PMID 17826041
- The metabolic syndrome in children and adolescents ? an IDF consensus report — Pediatric Diabetes 2007 · PMID 17850473
- Hemostasis alterations in metabolic syndrome (review). — International journal of molecular medicine 2006 · PMID 17016629
- Adipose Tissue, Inflammation, and Cardiovascular Disease — Circulation Research 2005 · PMID 15890981
- Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men — JAMA 2004 · PMID 15082700
- Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease — New England Journal of Medicine 2004 · PMID 15201411
- Adipokines: inflammation and the pleiotropic role of white adipose tissue — British Journal Of Nutrition 2004 · PMID 15469638
- Increased oxidative stress in obesity and its impact on metabolic syndrome — Journal of Clinical Investigation 2004 · PMID 15599400
- Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index — PLoS Medicine 2004 · PMID 15602591
Clinical trials (5)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07230873 | The Impact of Stationary Combined Exercise on Adiponectin and High-Sensitivity C-Reactive Protein Levels in Overweight Women | COMPLETED | INTERVENTIONAL | Combined Exercise Group, No Structured Exercise |
| NCT07539584 | Adiponectin and Its Role in the Treatment of Patients With Metabolic Disorders | COMPLETED | INTERVENTIONAL | SGLT2 inhibitor, GLP-1 RA |
| NCT03377465 | Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis | COMPLETED | INTERVENTIONAL | ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin |
| NCT01372800 | Serum Adiponectin Concentration, Activity and Isoforms in Chinese Population and Its Correlation to Cardiovascular and Cerebrovascular Diseases | RECRUITING | OBSERVATIONAL | |
| NCT03724825 | Correlation of Serum Adropin to Testosterone and Adiponectin in Obese Men | COMPLETED | OBSERVATIONAL | lipid profile: Total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL) and high density lipoprotein (HDL)), Total testosterone, Adropin |
Genetic associations (0)
None linked.