C
Advanced age
24
evidence score
Also known as: Advanced age (≥70 years), advancing age, age, age 70 or more years old, age related decline in various physiological processes, age, elderly, aging, elderly
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 9meta-analyses: 0trials: 15genetic: 0MR bonus:
References (7)
0 meta-analyses / systematic reviews- Epidemiology of peripheral artery disease. — Circulation research 2015 · PMID 25908725
- Air pollution exposure and cardiovascular disease. — Toxicological research 2014 · PMID 25071915
- Asymptomatic peripheral artery disease and antiplatelet management. — VASA. Zeitschrift fur Gefasskrankheiten 2014 · PMID 25147008
- Epinephrine and the metabolic syndrome. — Current hypertension reports 2012 · PMID 22124970
- Plasminogen activator inhibitor-1 (PAI-1): a key factor linking fibrinolysis and age-related subclinical and clinical conditions. — Cardiovascular therapeutics 2010 · PMID 20626406
- Ageing and vascular ageing. — Postgraduate medical journal 2006 · PMID 16754702
- Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly. — Cardiovascular research 2004 · PMID 15820196
Clinical trials (45)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07420374 | Ambulatory Stroke Unit Treatment for Elderly Patients: A Prospective, Randomized, Controlled, Exploratory Non-Inferiority Trial (ARTIFICE) | RECRUITING | INTERVENTIONAL | Ambulatory Stroke Unit Care, Conventional Stroke Unit Care |
| NCT07359105 | A Registry-based Randomized Controlled Trial of Moderate-intensity Statin Therapy vs. Individualized Low-density Lipoprotein Cholesterol Target-based Therapy for Primary Prevention of Cardiovascular Events in Patients 70 Years of Age or Older With Type 2 Diabetes (iTARGET-Elderly Study) | RECRUITING | INTERVENTIONAL | Moderate-intensity statin monotherapy, Ezetimibe or ezetimibe-statin combination therapy |
| NCT05349955 | Effects and Safety of GUideline Algorithm Based Intervention on CaRdiovascular and Renal Outcomes in Elderly Diabetic Patients With High Cardiovascular Risk in the Community- A Cluster Randomized Controlled Trial (GUARD-Community Study) | RECRUITING | INTERVENTIONAL | Intensive guideline algorithm implementation, Conventional guideline algorithm implementation |
| NCT07628283 | A Prospective, Open-Label, Cluster Randomized Controlled Trial to Evaluate the Efficacy of a Rural Doctor-Led, Telemedicine-Supported Integrated Care Model for Reducing Cardiovascular and Cerebrovascular Events in Elderly Adults at High Risk of Stroke in China | NOT YET RECRUITING | INTERVENTIONAL | Enhanced Usual Stroke Care, Digital Health Platform-Supported Integrated Stroke Management |
| NCT06376266 | Aged and Elderly Individuals | COMPLETED | INTERVENTIONAL | nutritional supplements |
| NCT06029920 | The Effect of Overground Walking on the Increase of Brain-Derived Neurotrophic Factor Levels, IL-6, HS-CRP, Cognitive Function, and Quality of Life in the Elderly | COMPLETED | INTERVENTIONAL | Overground Walking |
| NCT06025071 | Efficacy and Safety of Residual Inflammatory Risk-Guided Low-dose Colchicine Therapy in Elderly Patients With Multivessel Coronary Artery Disease: A Multicenter Randomized Controlled Trial | UNKNOWN | INTERVENTIONAL | colchicine |
| NCT05361421 | Effect of Intensive LDL-cholesterol Targeting for Elderly Patients With Cardiovascular Disease: I-OLD Trial | ACTIVE NOT RECRUITING | INTERVENTIONAL | Intensive targeting group, Conventional therapy group |
| NCT05272033 | The Effect of Transcutaneous Electrical Acupoint Stimulation (TEAS) on Prevention Hypotension Related to Spinal Anesthesia in Elderly Patients | COMPLETED | INTERVENTIONAL | Transcutaneous Electrical Acupoint Stimulation |
| NCT05118165 | Influence of Optimization of Preoperative Nutritional Status on Perioperative Period in Cardiac Surgery in Patients With Frailty | UNKNOWN | INTERVENTIONAL | Dietary supplement with protein |
| NCT04826354 | Effects of High-dose StAtin Versus Low-dose Statin Plus Ezetimibe on Statin-Associated Muscle Symptoms & on Reaching Target LDL-C Levels Among Elderly Patients With Atherosclerotic Cardiovascular Disease | COMPLETED | INTERVENTIONAL | Rosuvastatin and Ezetimibe, Rosuvastatin |
| NCT04796428 | Intraclass Safety and Efficacy Comparison Among SGLT-2 Inhibitors in Elderly Patients With Type 2 Diabetes. A Pragmatic, Phase IV, Multicenter, Open-label, Randomised Controlled Trial. | UNKNOWN | INTERVENTIONAL | Canagliflozin, Dapagliflozin, Empagliflozin |
| NCT06956924 | CT-Based Abdominal Aortic Calcium Score and CAD-RADS 2.0 in Elderly Chest Pain: A Cohort Study | COMPLETED | INTERVENTIONAL | CCTA |
| NCT04183465 | Effectiveness of an Early, Tailored, Physical Activity Intervention in ELderly Patients With Myocardial INfarction: the PIpELINe Randomized Clinical Trial | ACTIVE NOT RECRUITING | INTERVENTIONAL | Health Education, Multi-domain lifestyle intervention |
| NCT04126330 | Effect of Omega-3 and Probiotic Dietary Supplements on Elevated High Sensitivity C-reactive Protein (Hs-CRP) as a Marker of Low-grade Inflammation: Targeting Inflammation and Intestinal Barrier Function in the Elderly and Obese | COMPLETED | INTERVENTIONAL | Probiotic, Omega-3, Vitamin D supplement, Placebo |
| NCT03868007 | Protective Effects of Remote Ischemic Conditioning in Elderly With Acute Ischemic Stroke Complicating Acute Coronary Syndrome: A Single-center Randomised Controlled Trial | COMPLETED | INTERVENTIONAL | RIC, sham-RIC |
| NCT03272737 | Effect of Low Intensity Strength Training Combined With Moderate Blood Flow Restriction on Muscle Vasodilatation and Arterial Stiffness in Elders With Low Gait Velocity. | COMPLETED | INTERVENTIONAL | 1RM Test, Speed gait test, Venous occlusion plethysmography protocol |
| NCT03546270 | The Effects of Swimming Training on Arterial Function, Strength and Cardiorespiratory Capacity in Elderly Women With Stage 2 Hypertension | COMPLETED | INTERVENTIONAL | Swimming |
| NCT02596126 | Secondary Prevention of Cardiovascular Disease in the Elderly Trial | COMPLETED | INTERVENTIONAL | Cardiovascular Polypill, Treatment Prevention for Secondary CV |
| NCT02379806 | Prevention of Symptomatic Venous Thromboembolism by Low Molecular Weight Heparin in Hospitalized Medical Patients Aged 70 Years and Older : a Randomized Placebo-Controlled Study The SYMPTOMS (SYstematic Elderly Medical Patients Thromboprophylaxis : Efficacy on Symptomatic OutcoMeS) Study | COMPLETED | INTERVENTIONAL | Enoxaparin, Placebo |
| NCT02472561 | Verizon mHealth Solution for Elderly Underserved Patients With Peripheral Artery Disease | COMPLETED | INTERVENTIONAL | Fitbit Physical Activity Monitor, mHealth Glucometer, mHealth Blood Pressure |
| NCT02099123 | A Study of STAtins for Reducing Events in the Elderly (STAREE) | ACTIVE NOT RECRUITING | INTERVENTIONAL | Atorvastatin, Placebo (for Atorvastatin) |
| NCT02843906 | Cognitive, Morphological and Neurobiological Progressive Aspects in Bipolar Disorders in the Elderly: Toward to a Neurodegenerescence Detection? | UNKNOWN | INTERVENTIONAL | Lombar Punction, Magnetic Resonance Imaging (MRI), Positron-Emission Tomography (TEP) /(FDG) |
| NCT03592420 | Efficacy of a Multifactorial and Personalized Program for Fall Prevention in Community-dwelling Elderly in Comparison to the Usual Care: a Randomized Controlled Trial | COMPLETED | INTERVENTIONAL | Interdisciplinary multicomponent interventions, Usual care |
| NCT02384980 | Saving Life and Limb: Functional Electrical Stimulation for the Elderly With Peripheral Artery Disease | COMPLETED | INTERVENTIONAL | FES (Gait MyoElectric Stimulator) |
| NCT01594086 | Effects of Green Tea Consumption on Homocysteine Metabolism and Cognitive Dysfunction in Elderly: An Exploratory Clinical Study | COMPLETED | INTERVENTIONAL | green tea powder |
| NCT01508663 | The Beneficial Role of Percutaneous Coronary Intervention Over Optimal Medical Therapy in Elderly Patients (Age > 75 Years Old) With Coronary Artery Disease: a Randomized Controlled Study | UNKNOWN | INTERVENTIONAL | Everolimus Eluting Stent or Zotalolimus Eluting Stent, ARB, CCB, ACE-inhibitor, statin, Nitrate, Antiplate etc. |
| NCT01001052 | Relative Bioavailability of Colcrys™ (Colchicine, USP) 0.6 mg Tablets in Healthy Young and Elderly Volunteers Under Fasted Conditions | COMPLETED | INTERVENTIONAL | Colcrys™ (colchicine) |
| NCT00755664 | Effects of Low-dose B-vitamins Supplementation on Plasma Homocysteine and Framingham Risk Score: Double Blind Randomized Controlled Trial in Healthy Chinese Elderly | COMPLETED | INTERVENTIONAL | Low-dose complex B-vitamins |
| NCT00267839 | Effects of Exercise on Multiple Risk Factors and Health Costs in Community Living Elderly Women. The Senior Fitness and Prevention Study (SEFIP) | TERMINATED | INTERVENTIONAL | physical exercise, wellness |
| NCT00127218 | HDL Increased Plaque Stabilization in the Elderly | COMPLETED | INTERVENTIONAL | any statin, niacin, Placebo |
| NCT01095211 | Effect of B-Vitamins on Cognitive Function in Elderly People | COMPLETED | INTERVENTIONAL | B-vitamin complex |
| NCT00667290 | Exercise for Elderly Peripheral Revascularized Patients | COMPLETED | INTERVENTIONAL | Treadmill exercise |
| NCT06880575 | Seniors Integrated Longitudinal cardioVascular Evaluation of Coronary Heart Disease: a Multicenter, Prospective Registry in China (SILVER-China) | RECRUITING | OBSERVATIONAL | |
| NCT03209414 | Frailty Syndrome in Daily Practice of Interventional Cardiology Ward | RECRUITING | OBSERVATIONAL | |
| NCT07357714 | Longitudinal Study on Urinary Function and Multimorbidity Risks Among Beijing Community-dwelling Elderly UFMR-BCE Longitudinal Study | NOT YET RECRUITING | OBSERVATIONAL | |
| NCT05529147 | The Effects of Medication Induced Blood Pressure Reduction on Cerebral Hemodynamics in Hypertensive Frail Elderly | COMPLETED | OBSERVATIONAL | Antihypertensive Agents |
| NCT03509259 | Discovering Risk Factors for Cardiovascular Diseases in Elderly Asthma | UNKNOWN | OBSERVATIONAL | |
| NCT03860714 | Correlation Between Urine UACR and Postoperative Neurocognitive Disorder in Elderly Patients With Non-cardiac Surgery | UNKNOWN | OBSERVATIONAL | Neuropsychological tests |
| NCT03775343 | Early Postoperative Cognitive Impairment in Elderly Patients Following Ocular Surgery | COMPLETED | OBSERVATIONAL | Neurocognitive Test Battery, Blood sampling |
| NCT06959446 | Association Between Perioperative Homocysteine and Postoperative Complications/All-Cause Mortality in Elderly Patients Undergoing Non-Cardiac Surgery | COMPLETED | OBSERVATIONAL | |
| NCT01370382 | Comparison Between the New Highly Sensitive Troponin T and the Conventional Troponin T Test of the 4th Generation for the Early Identification of Myocardial Necrosis in Elderly Patients With Acute Coronary Syndromes Without ST-segment Elevation | COMPLETED | OBSERVATIONAL | |
| NCT01304641 | Comparison Of Cardiovascular Event Rates In Elderly Patients With Newly Initiated Atorvastatin Or Simvastatin | COMPLETED | OBSERVATIONAL | Atorvastatin Initiators, Simvastatin Initiators |
| NCT00940082 | The Cardiopathic Features and Analysis of Risk Factors in the Elderly Diabetic | UNKNOWN | OBSERVATIONAL | |
| NCT03405675 | Gerontology Research Programme: Biological, Clinical, Psychosocial and Behavioural Predictors of Health Status in Prospectively Followed-up Cohorts of Elderly Persons | UNKNOWN | OBSERVATIONAL | SLAS 1, SLAS 2 |
Genetic associations (0)
None linked.