A
Age
50
evidence score
Also known as: Aging, advanced age, advancing age, age / aging, age 40 to 49 years, age 40-49 years, age 70 years and older, age <60 years, ageing, aging, increasing age, older age
PREVENT status
✓ Used by PREVENT (core input).
Also used by the Pooled Cohort Equations.
Causal support
trial evidence
Score components
lit volume: 24.4meta-analyses: 20trials: 6genetic: 0MR bonus:
References (274)
11 meta-analyses / systematic reviews- METARisk factors for incisional hernia after open abdominal aortic aneurysm repair: a systematic review and meta-analysis. — Hernia : the journal of hernias and abdominal wall surgery 2024 · PMID 39325326
- METARisk factors for stroke-related pneumonia in patients with ischaemic stroke: A systematic evaluation and meta-analysis. — Clinical neurology and neurosurgery 2024 · PMID 39426216
- METAInflammatory and oxidative stress markers in post-traumatic stress disorder: a systematic review and meta-analysis. — Molecular psychiatry 2022 · PMID 35477973
- METAHeat exposure and cardiovascular health outcomes: a systematic review and meta-analysis. — The Lancet. Planetary health 2022 · PMID 35709806
- METAIdentified risk factors for dry eye syndrome: A systematic review and meta-analysis. — PloS one 2022 · PMID 35984830
- METARisk factors for 30-day readmission in patients with ischemic stroke: a systematic review and meta-analysis. — Annals of palliative medicine 2021 · PMID 34763470
- METAChildhood socioeconomic status and inflammation: A systematic review and meta-analysis. — Brain, behavior, and immunity 2019 · PMID 30738842
- METAImpact of sedentary behavior on large artery structure and function in children and adolescents: a systematic review. — European journal of pediatrics 2019 · PMID 31773330
- METARisk factors for intracranial atherosclerosis: A systematic review and meta-analysis. — Atherosclerosis 2018 · PMID 30658194
- METANatriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis. — The lancet. Diabetes & endocrinology 2016 · PMID 27599814
- METADesign of the Coronary ARtery DIsease Genome-Wide Replication And Meta-Analysis (CARDIoGRAM) Study: A Genome-wide association meta-analysis involving more than 22 000 cases and 60 000 controls. — Circulation. Cardiovascular genetics 2010 · PMID 20923989
- Global impact of PMon cardiovascular disease: Causal evidence and health inequities across region from 1990 to 2021. — Journal of environmental management 2025 · PMID 39837142
- GDF15 Analogues Acting as GFRAL Ligands. — ChemMedChem 2025 · PMID 39907315
- Health benefits of leisure-time physical activity by socioeconomic status, lifestyle risk, and mental health: a multicohort study. — The Lancet. Public health 2025 · PMID 39909687
- Predicting major adverse cardiac events in diabetes and chronic kidney disease: a machine learning study from the Silesia Diabetes-Heart Project. — Cardiovascular diabetology 2025 · PMID 39955553
- Chronic alcohol consumption accelerates cardiovascular aging and decreases cardiovascular reserve capacity. — GeroScience 2025 · PMID 40111699
- Exploring the impact of metabolic comorbidities on epicardial adipose tissue in heart failure with preserved ejection fraction. — Cardiovascular diabetology 2025 · PMID 40121452
- Global and tissue-specific transcriptomic dysregulation in human aging: Pathways and predictive biomarkers. — GeroScience 2025 · PMID 40295347
- Perinatal Exposure to Lead or Diethylhexyl Phthalate in Mice: Sex-Specific Effects on Cardiac DNA Methylation and Gene Expression across Time. — Environmental health perspectives 2025 · PMID 40315424
- Epidemiological and Translational Study of Calprotectin and Atherosclerotic Cardiovascular Disease. — JAMA cardiology 2025 · PMID 40332890
- Incidence and Risk of Heart Failure in Patients With Coronary Heart Disease and Stroke: A Population-Based Cohort Study. — The American journal of cardiology 2025 · PMID 40339776
- Proteomic Signatures for Risk Prediction of Atrial Fibrillation. — Circulation 2025 · PMID 40401370
- Mid- to Late-Life Traditional Cardiovascular Risk Factor Exposure and Zero Coronary Artery Calcium: The ARIC (Atherosclerosis Risk in Communities) Study. — JACC. Cardiovascular imaging 2025 · PMID 40471761
- Relationship between cerebrovascular risk factors and oxygen metabolic stress in a cognitively impaired population: Dynamic susceptibility contrast-derived oxygen parametric analysis. — Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2025 · PMID 40626458
- Genetic Associations of Clonal Hematopoiesis With Cardioembolic Stroke: Insights From Genome-Wide Mendelian Randomization, Bulk RNA, Single-Cell RNA Sequencing. — CNS neuroscience & therapeutics 2025 · PMID 40702735
- Akkermansia muciniphila: A key player in gut microbiota-based disease modulation. — Microbiological research 2025 · PMID 40845731
- Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women. — Journal of the American College of Cardiology 2025 · PMID 40864016
- How to measure and model cardiovascular aging. — Cardiovascular research 2025 · PMID 40873304
- Menopause and risk of atherosclerotic cardiovascular disease: insights from a women's UK Biobank cohort. — Maturitas 2025 · PMID 40876237
- The aging interactome: From cellular dysregulation to therapeutic frontiers in age-related diseases. — Biochimica et biophysica acta. Molecular basis of disease 2025 · PMID 41014782
- Lung function as a modifiable risk factor for Ischemic Stroke: Evidence from the UK biobank. — Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2025 · PMID 41015216
- Psoriasis and phenotypic age acceleration in relation to all-cause and cardiovascular disease mortality risks in US adults. — European journal of medical research 2025 · PMID 41024224
- [Clonal hematopoiesis]. — [Rinsho ketsueki] The Japanese journal of clinical hematology 2025 · PMID 41034053
- Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease. — Journal of the American Heart Association 2025 · PMID 41368830
- Lipid Metabolism-Signaling Crosstalk in Metabolic Disease and Aging: Mechanisms and Therapeutic Targets. — Nutrients 2025 · PMID 41373990
- Ceramides improve cardiovascular risk prediction beyond low-density lipoprotein cholesterol. — European heart journal open 2024 · PMID 38292914
- Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases — Signal Transduction and Targeted Therapy 2024 · PMID 38360862
- Association between physical frailty, circadian syndrome and cardiovascular disease among middle-aged and older adults: a longitudinal study. — BMC geriatrics 2024 · PMID 38413861
- Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury. — Nature medicine 2024 · PMID 38454125
- Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease. — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 · PMID 38522236
- Longitudinal NT-proBNP: Associations With Echocardiographic Changes and Outcomes in Heart Failure. — Journal of the American Heart Association 2024 · PMID 38639333
- The association of pre-cancer diagnosis cardiovascular risk factors with memory aging after a cancer diagnosis, overall and by race/ethnicity. — Journal of cancer survivorship : research and practice 2024 · PMID 38647590
- Loneliness, social isolation, and cardiovascular disease among nonveteran and Veteran women. — Journal of women & aging 2024 · PMID 38659158
- Combined Effects of Clonal Hematopoiesis and Carotid Stenosis on Cardiovascular Mortality. — Journal of the American College of Cardiology 2024 · PMID 38692825
- Forecasting the 20-Year Incidence of Dementia by Socioeconomic Status, Race/Ethnicity, and Region Based on Mid-Life Risk Factors in a U.S. Nationally Representative Sample. — Journal of Alzheimer's disease : JAD 2024 · PMID 38788068
- Exploring the Relationship of Anxiety and Depressive Symptoms and Impulsiveness with the Quality of Life of Older Patients with Cardiovascular Disease: A Cross-Sectional Study. — International journal of environmental research and public health 2024 · PMID 38791860
- The human gut microbiome and aging — Gut Microbes 2024 · PMID 38831607
- Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss. — Cell 2024 · PMID 38838669
- Individual and Joint Associations of High-Sensitivity Troponin I and High-Sensitivity Troponin T with Cardiac Phenotypes and Outcomes in the General Population: An Analysis From the Dallas Heart Study. — Journal of the American Heart Association 2024 · PMID 38842289
- Intrinsic Capacity, Polygenic Risk Score,Genotype, and Risk of Dementia: A Prospective Cohort Study Based on the UK Biobank. — Neurology 2024 · PMID 38843484
- Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk. — Nature medicine 2024 · PMID 38844795
- Arterial Stiffness and Heart Failure With Preserved Ejection Fraction. — Journal of Korean medical science 2024 · PMID 38887204
- Coffee consumption and cardiometabolic health: a comprehensive review of the evidence. — GeroScience 2024 · PMID 38963648
- [Coronary heart disease: innovative understanding from traditional Chinese medicine and treatment by classic formulas]. — Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2024 · PMID 39041141
- Reproductive factors and risk of cardiovascular outcomes in women with ST-elevation myocardial infarction. — BMC pregnancy and childbirth 2024 · PMID 39138569
- Biological aging mediates the association between periodontitis and cardiovascular disease: results from a national population study and Mendelian randomization analysis. — Clinical epigenetics 2024 · PMID 39182082
- Genetic association between post-traumatic stress disorder and cardiovascular disease: A scoping review. — Journal of psychiatric research 2024 · PMID 39191203
- Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences. — Nature genetics 2024 · PMID 39192095
- Lipids, lipoproteins, and apolipoproteins: Associations with cognition and dementia. — Atherosclerosis 2024 · PMID 39340935
- Reference equations for pulse wave velocity, augmentation index, amplitude of forward and backward wave in a European general adult population. — Scientific reports 2024 · PMID 39367200
- Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study. — Journal of the American Heart Association 2024 · PMID 39494555
- Crosstalk between periodontitis and cardiovascular risk. — Frontiers in immunology 2024 · PMID 39717783
- Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling. — Blood 2023 · PMID 36379023
- Cardiovascular disease and risk assessment in people living with HIV: Current practices and novel perspectives. — Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2023 · PMID 36646212
- The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease — International Journal of Molecular Sciences 2023 · PMID 36768722
- Healthy lifestyle, DNA methylation age acceleration, and incident risk of coronary heart disease. — Clinical epigenetics 2023 · PMID 36978155
- Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing. — Atherosclerosis 2023 · PMID 37059656
- Obesity-induced inflammation exacerbates clonal hematopoiesis. — The Journal of clinical investigation 2023 · PMID 37071471
- Sarcopenia and Cardiovascular Diseases — Circulation 2023 · PMID 37186680
- Ventricular-arterial coupling and cardiovascular risk among young adults: The African-PREDICT study. — American journal of physiology. Heart and circulatory physiology 2023 · PMID 37389948
- Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women. — Circulation research 2023 · PMID 37489536
- Frailty in relation to the risk of carotid atherosclerosis and cardiovascular events in Chinese community-dwelling older adults: A five-year prospective cohort study. — Experimental gerontology 2023 · PMID 37536575
- Association of growth and differentiation factor-15 with coronary artery calcium score and ankle-brachial index in a middle-aged and elderly Caucasian population sample free of manifest cardiovascular disease. — GeroScience 2023 · PMID 37548881
- Maintaining brain health across the lifespan. — Neuroscience and biobehavioral reviews 2023 · PMID 37604360
- Non-HDL-cholesterol in dyslipidemia: Review of the state-of-the-art literature and outlook. — Atherosclerosis 2023 · PMID 37826864
- Genome-Wide Association Study of Cardiovascular Resilience Identifies Protective Variation in theGene. — Journal of the American Heart Association 2023 · PMID 37929782
- Prediabetes increases the risk of major limb and cardiovascular events. — Cardiovascular diabetology 2023 · PMID 38115080
- Phosphodiesterase inhibitor ameliorates senescent changes of renal interstitial pericytes in aging kidney. — Aging cell 2023 · PMID 38155524
- Update on the Use of Pulse Wave Velocity to Measure Age-Related Vascular Changes. — Current hypertension reports 2023 · PMID 38159167
- Clonal hematopoiesis and vascular disease. — Seminars in immunopathology 2022 · PMID 35122117
- Ceramides and Cardiovascular Risk Factors, Inflammatory Parameters and Left Ventricular Function in AMI Patients. — Biomedicines 2022 · PMID 35203637
- Social Determinants of Cardiovascular Disease — Circulation Research 2022 · PMID 35239404
- Genetics of cancer therapy-associated cardiotoxicity. — Journal of molecular and cellular cardiology 2022 · PMID 35358500
- Fitness and arterial stiffness in healthy aging: Modifiable cardiovascular risk factors contribute to altered default mode network patterns during executive function. — Neuropsychologia 2022 · PMID 35595064
- [Gout]. — Zeitschrift fur Rheumatologie 2022 · PMID 35596003
- Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics — Immunity & Ageing 2022 · PMID 35610705
- Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention. — Biochemical pharmacology 2022 · PMID 35643340
- Shift work and cardiovascular strain on working and non-working days. — Occupational medicine (Oxford, England) 2022 · PMID 35976972
- Clonal hematopoiesis, somatic mosaicism, and age-associated disease. — Physiological reviews 2022 · PMID 36049115
- Clonal hematopoiesis of indeterminate potential and cardiovascular disease. — Translational research : the journal of laboratory and clinical medicine 2022 · PMID 36067904
- Cardiogenic shock among cancer patients. — Frontiers in cardiovascular medicine 2022 · PMID 36072868
- Reference Ranges for NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) and Risk Factors for Higher NT-proBNP Concentrations in a Large General Population Cohort. — Circulation. Heart failure 2022 · PMID 36098049
- Association between periodontitis and heart failure in the general population. — ESC heart failure 2022 · PMID 36101477
- Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease. — Arteriosclerosis, thrombosis, and vascular biology 2022 · PMID 36353993
- Osteoporosis and cardiovascular disease: a review. — Molecular biology reports 2022 · PMID 36449152
- Depression and Anxiety Are Associated With Cardiovascular Health in Young Adults. — Journal of the American Heart Association 2022 · PMID 36533593
- Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in monocyte and macrophage biology and atherosclerotic cardiovascular disease — Current Opinion in Hematology 2021
- Prediabetes and What It Means: The Epidemiological Evidence. — Annual review of public health 2021 · PMID 33355476
- Role of Cachexia and Fragility in the Patient Candidate for Cardiac Surgery. — Nutrients 2021 · PMID 33562449
- Cardiovascular Disease in Chronic Kidney Disease: Pathophysiological Insights and Therapeutic Options. — Circulation 2021 · PMID 33720773
Clinical trials (3)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT01045512 | The Role of the "Inflammatory/ Pathogen Burden" for Cardiac Ageing | TERMINATED | INTERVENTIONAL | fluvastatin |
| NCT00214682 | Beyond Ageing Project: A RCT to Assess the Benefit of Improving Mental Health Literacy as Well as the Effect of Folate and B12, and Physical Activity, in Preventing Major Depression and Cognitive Decline Among Older Australians | COMPLETED | INTERVENTIONAL | Folate (400mcg) and Vitamin B12 (100 mcg), mediated physical activity promotion, Mental health literacy |
| NCT03405675 | Gerontology Research Programme: Biological, Clinical, Psychosocial and Behavioural Predictors of Health Status in Prospectively Followed-up Cohorts of Elderly Persons | UNKNOWN | OBSERVATIONAL | SLAS 1, SLAS 2 |
Genetic associations (0)
None linked.