A
Air pollution (PM2.5) exposure
Environmental & OccupationalPhysical parameterriskmodifiable
45
evidence score
Also known as: Air pollution (PM2.5), air pollution, particulate matter, pm2.5
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 22.3meta-analyses: 13.8trials: 9genetic: 0MR bonus:
References (167)
4 meta-analyses / systematic reviews- METABurden of cardiovascular disease attributed to air pollution: a systematic review. — Globalization and health 2024 · PMID 38702798
- METAAmbient air pollution and cardiovascular diseases: An umbrella review of systematic reviews and meta‐analyses — Journal of Internal Medicine 2022 · PMID 35138681
- METACoronary heart disease and household air pollution from use of solid fuel: a systematic review. — British medical bulletin 2016 · PMID 27151956
- METAAssociation between fine particulate matter exposure and subclinical atherosclerosis: A meta-analysis. — European journal of preventive cardiology 2015 · PMID 26025448
- Air pollution is associated with increased risk of venous thromboembolism: the Multi-Ethnic Study of Atherosclerosis. — Blood 2025 · PMID 39652776
- Air pollution and coronary atherosclerosis. — Future cardiology 2025 · PMID 39786972
- Climate change and cardiovascular risk. — Current opinion in cardiology 2025 · PMID 39998494
- Long-term air pollution exposure and cardiovascular disease progression in rheumatoid arthritis: A prospective cohort study using multi-state model analysis. — Ecotoxicology and environmental safety 2025 · PMID 40239549
- Air pollution, lifestyle, and cardiovascular disease risk in northwestern China: A cohort study of over 5.8 million participants. — Environment international 2025 · PMID 40253932
- Global Burden and Risk Factors of Stroke in Young Adults, 1990 to 2021: A Systematic Analysis of the Global Burden of Disease Study 2021. — Journal of the American Heart Association 2025 · PMID 40371619
- Stroke Mortality Risk Factors: Global Trends and Regional Variations (1990-2021). — Journal of the American Heart Association 2025 · PMID 40470651
- Air Pollution and Stroke: An Emerging Challenge From Cardio-Cerebrovascular Multimorbidity. — Journal of the American Heart Association 2025 · PMID 40576036
- Long-term air pollution exposure and cardiovascular disease risk across cardiovascular-renal-metabolic stages: a nationwide study. — BMC public health 2025 · PMID 40604548
- Role of Nighttime Light in the Association Between Air Pollution Exposure and Cardiovascular Disease. — Journal of the American Heart Association 2025 · PMID 40767279
- Air pollution, drought, and their synergistic effects on cardiovascular disease risk in China: a nationwide study. — Environmental pollution (Barking, Essex : 1987) 2025 · PMID 40774530
- A comprehensive review/expert statement on environmental risk factors of cardiovascular disease. — Cardiovascular research 2025 · PMID 40795898
- Joint associations of air pollution and frailty on cardiovascular diseases and the modifying role of physical activity: Evidence from the CHARLS. — Environmental pollution (Barking, Essex : 1987) 2025 · PMID 40850460
- Smogged arteries, sneaky killers. — Atherosclerosis 2025 · PMID 41248966
- Air pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study. — Metabolism: clinical and experimental 2025 · PMID 41270966
- The Impact of Climate Change and Extreme Weather Conditions on Cardiovascular Health and Acute Cardiovascular Diseases. — Journal of clinical medicine 2024 · PMID 38337453
- The role of lifestyle in the association between long-term ambient air pollution exposure and cardiovascular disease: a national cohort study in China. — BMC medicine 2024 · PMID 38439026
- Air pollution, APOE genotype and risk of dementia among individuals with cardiovascular diseases: A population-based longitudinal study. — Environmental pollution (Barking, Essex : 1987) 2024 · PMID 38492747
- Public Health Relevance of US EPA Air Quality Index Activity Recommendations. — JAMA network open 2024 · PMID 38587845
- New insight into air pollution-related cardiovascular disease: an adverse outcome pathway framework of PM2.5-associated vascular calcification. — Cardiovascular research 2024 · PMID 38636937
- Proteomics, Human Environmental Exposure, and Cardiometabolic Risk. — Circulation research 2024 · PMID 38662804
- [Air pollution and cardiovascular disease]. — Giornale italiano di cardiologia (2006) 2024 · PMID 39239818
- Global, regional, and national epidemiology of ischemic stroke from 1990 to 2021. — European journal of neurology 2024 · PMID 39290044
- Combined Effect of Air Pollution and Genetic Risk on Incident Cardiovascular Diseases. — Journal of the American Heart Association 2024 · PMID 39547964
- [Not Available]. — Recenti progressi in medicina 2024 · PMID 39688058
- Carbonaceous cores serve as surrogates for environmental particulate matter inducing vascular endothelial inflammation via inflammasome activation. — Journal of hazardous materials 2024 · PMID 39736255
- Atorvastatin ameliorated PM-induced atherosclerosis in rats. — Archives of environmental & occupational health 2023 · PMID 36660941
- Exposure to Air Pollution during Pre-Hypertension and Subsequent Hypertension, Cardiovascular Disease, and Death: A Trajectory Analysis of the UK Biobank Cohort. — Environmental health perspectives 2023 · PMID 36696106
- A Potential Strategy for Atherosclerosis Prevention in Modernizing China - Hyperhomocysteinemia, MTHFR C677T Polymorphism and Air Pollution (PM2.5) on Atherogenesis in Chinese Adults. — The journal of nutrition, health & aging 2023 · PMID 36806868
- Connections Between Air Pollution, Climate Change, and Cardiovascular Health. — The Canadian journal of cardiology 2023 · PMID 37030516
- Air pollution, cardiovascular disease, and urban greening: an ecological blueprint. — European journal of preventive cardiology 2023 · PMID 37070466
- Ambient air pollution and maternal cardiovascular health in pregnancy. — Heart (British Cardiac Society) 2023 · PMID 37217298
- Air Pollution, Built Environment, and Early Cardiovascular Disease. — Circulation research 2023 · PMID 37289906
- Contaminant Metals as Cardiovascular Risk Factors: A Scientific Statement From the American Heart Association. — Journal of the American Heart Association 2023 · PMID 37306302
- Deprivation and chronic kidney disease-a review of the evidence. — Clinical kidney journal 2023 · PMID 37398697
- Noise Exposure and Cardiovascular Health. — Current problems in cardiology 2023 · PMID 37422031
- Associations between Ambient Air Pollutants and Clonal Hematopoiesis of Indeterminate Potential. — Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2023 · PMID 37466697
- Extreme Temperature Events, Fine Particulate Matter, and Myocardial Infarction Mortality. — Circulation 2023 · PMID 37486993
- Ambient air pollution associated with incident asthma, subsequent cardiovascular disease and death: A trajectory analysis of a national cohort. — Journal of hazardous materials 2023 · PMID 37633014
- Ambient PM2.5 and its components associated with 10-year atherosclerotic cardiovascular disease risk in Chinese adults. — Ecotoxicology and environmental safety 2023 · PMID 37643506
- Particulate Matter Air Pollution is a Significant Risk Factor for Cardiovascular Disease. — Current problems in cardiology 2023 · PMID 37734693
- The impact of air quality on cardiovascular health: A state of the art review. — Current problems in cardiology 2023 · PMID 37913932
- Air pollution and cardiovascular health in South Asia: A comprehensive review. — Current problems in cardiology 2023 · PMID 37977414
- Cigarette smoking and air pollution exposure and their effects on cardiovascular diseases. — Frontiers in public health 2023 · PMID 38045957
- Particulate air pollution and cardiovascular disease mortality in Jiangsu Province, China: a time-series analysis between 2015 and 2021. — Frontiers in public health 2023 · PMID 38174084
- Extracellular vesicles derived from PM2.5-exposed alveolar epithelial cells mediate endothelial adhesion and atherosclerosis in ApoEmice. — FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2022 · PMID 35061300
- Air pollution and cardiovascular disease: the Paul Wood Lecture, British Cardiovascular Society 2021. — Heart (British Cardiac Society) 2022 · PMID 35074847
- Exposure to transportation noise and risk for cardiovascular disease in a nationwide cohort study from Denmark. — Environmental research 2022 · PMID 35304113
- Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention. — Biochemical pharmacology 2022 · PMID 35643340
- PMinduce the defective efferocytosis and promote atherosclerosis via HIF-1α activation in macrophage. — Nanotoxicology 2022 · PMID 35653618
- Climate change and cardiovascular disease: implications for global health. — Nature reviews. Cardiology 2022 · PMID 35672485
- Air Pollution, Political Corruption, and Cardiovascular Disease in the Former Soviet Republics. — Annals of global health 2022 · PMID 35854924
- McIntyre Powder and its potential contributions to cardiovascular disease risk: A literature review through the McIntyre Powder historical lens. — American journal of industrial medicine 2022 · PMID 35863903
- Risk Associations between Vehicular Traffic Noise Exposure and Cardiovascular Diseases: A Residential Retrospective Cohort Study. — International journal of environmental research and public health 2022 · PMID 36011669
- Amygdalin attenuates PM2.5-induced human umbilical vein endothelial cell injury via the TLR4/NF-κB and Bcl-2/Bax signaling pathways. — Acta biochimica et biophysica Sinica 2022 · PMID 36178164
- Pollution and coronary risk: how much does it matter? — European heart journal supplements : journal of the European Society of Cardiology 2022 · PMID 36380773
- Air Pollution: Another Threat to HDL Function. — International journal of molecular sciences 2022 · PMID 36613760
- Air pollution and human health risks: mechanisms and clinical manifestations of cardiovascular and respiratory diseases — Toxin Reviews 2021
- The impact of particulate matter air pollution (PM2.5) on atherosclerosis in modernizing China: a report from the CATHAY study. — International journal of epidemiology 2021 · PMID 33349857
- Taking a Stand Against Air Pollution—The Impact on Cardiovascular Disease — Circulation 2021 · PMID 33506685
- Taking a Stand Against Air Pollution—The Impact on Cardiovascular Disease — Journal of the American College of Cardiology 2021 · PMID 33518378
- Association between ambient air pollution and county-level cardiovascular mortality in the United States by social deprivation index. — American heart journal 2021 · PMID 33592167
- Association of the combined effects of air pollution and changes in physical activity with cardiovascular disease in young adults — European Heart Journal 2021 · PMID 33780974
- Adverse effects of PMon cardiovascular diseases. — Reviews on environmental health 2021 · PMID 33793141
- The changing landscape of atherosclerosis. — Nature 2021 · PMID 33883728
- Miscarriage matters: the epidemiological, physical, psychological, and economic costs of early pregnancy loss. — Lancet (London, England) 2021 · PMID 33915094
- Effect of Short-Term Exposure to Fine Particulate Matter and Temperature on Acute Myocardial Infarction in Korea. — International journal of environmental research and public health 2021 · PMID 33946492
- Air pollution and cardiovascular disease: Can the Australian bushfires and global COVID-19 pandemic of 2020 convince us to change our ways? — BioEssays : news and reviews in molecular, cellular and developmental biology 2021 · PMID 34106476
- PM2.5 induces endothelial dysfunction via activating NLRP3 inflammasome. — Environmental toxicology 2021 · PMID 34173703
- Global, regional, and national burden of stroke and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 — The Lancet Neurology 2021 · PMID 34487721
- Cardiovascular Effects of Particulate Air Pollution. — Annual review of medicine 2021 · PMID 34644154
- Transportation noise exposure and cardiovascular mortality: 15-years of follow-up in a nationwide prospective cohort in Switzerland. — Environment international 2021 · PMID 34775186
- Environmental risk factors of type 2 diabetes-an exposome approach. — Diabetologia 2021 · PMID 34792619
- PM2.5 air pollution and cause-specific cardiovascular disease mortality. — International journal of epidemiology 2020 · PMID 31289812
- Air pollution and cardiovascular disease: car sick. — Cardiovascular research 2020 · PMID 31583404
- Polyaromatic hydrocarbons in pollution: a heart-breaking matter. — The Journal of physiology 2020 · PMID 31840250
- Association between cumulative social risk, particulate matter environmental pollutant exposure, and cardiovascular disease risk. — BMC cardiovascular disorders 2020 · PMID 32046641
- Environmental and Health Impacts of Air Pollution: A Review — Frontiers in Public Health 2020 · PMID 32154200
- Cumulative Lifetime Burden of Cardiovascular Disease From Early Exposure to Air Pollution — Journal of the American Heart Association 2020 · PMID 32174249
- Association Between Cardiovascular Disease and Long-term Exposure to Air Pollution With the Risk of Dementia — JAMA Neurology 2020 · PMID 32227140
- Environmental determinants of cardiovascular disease: lessons learned from air pollution. — Nature reviews. Cardiology 2020 · PMID 32382149
- Effects of coal-fired PMon the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoEmice. — BMC pharmacology & toxicology 2020 · PMID 32384920
- Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 — The Lancet Respiratory Medicine 2020 · PMID 32526187
- Associations of outdoor fine particulate air pollution and cardiovascular disease in 157 436 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study — The Lancet Planetary Health 2020 · PMID 32559440
- Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 — The Lancet 2020 · PMID 33069326
- Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 — The Lancet 2020 · PMID 33069327
- The critical role of endothelial function in fine particulate matter-induced atherosclerosis. — Particle and fibre toxicology 2020 · PMID 33276797
- Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association — Deep Blue (University of Michigan) 2019
- Mediterranean Diet and the Association Between Air Pollution and Cardiovascular Disease Mortality Risk — Circulation 2019 · PMID 30700142
- Cardiovascular disease burden from ambient air pollution in Europe reassessed using novel hazard ratio functions — European Heart Journal 2019 · PMID 30860255
- PM2.5 promotes plaque vulnerability at different stages of atherosclerosis and the formation of foam cells via TLR4/MyD88/NFκB pathway. — Ecotoxicology and environmental safety 2019 · PMID 30921699
- Is Endurance Exercise Safe? The Myth of Pheidippides. — Southern medical journal 2019 · PMID 30943538
- Coronary heart disease, hypertension and use of biomass fuel among women: comparative cross-sectional study. — BMJ open 2019 · PMID 31399463
- Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors. — European journal of preventive cardiology 2019 · PMID 31408370
- Ambient Particulate Air Pollution and Daily Mortality in 652 Cities — New England Journal of Medicine 2019 · PMID 31433918
- Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study. — Lancet (London, England) 2019 · PMID 31492503
Clinical trials (7)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06541691 | Coated or Chewable Aspirin in Patients with Established Atherosclerotic Disease and a Hybrid Strategy to Mitigate the Adverse Effects of Air Pollution: the COATED-AIR Randomized Clinical Trial | RECRUITING | INTERVENTIONAL | Enteric-coated aspirin, Plain aspirin, Hybrid strategy |
| NCT04762472 | The Impact of Particulate Matters Air Pollution on Accelerated Atherosclerosis: A Montelukast Interventional Study for Atherosclerosis Prevention in Modernizing China | UNKNOWN | INTERVENTIONAL | Montelukast Oral Tablet, Montelukast Placebo Oral Tablet |
| NCT04908917 | Reducing AIR Pollution Exposure to Lower Blood PRESSURE | UNKNOWN | INTERVENTIONAL | Portable Air Cleaner with a HEPA Filter, Portable Air Cleaner without a HEPA Filter |
| NCT04126434 | Intervention of Air Pollution and Acute Coronary Syndrome | UNKNOWN | INTERVENTIONAL | mask |
| NCT02944682 | Household Air Pollution and Health: A Multi-country LPG Intervention Trial | COMPLETED | INTERVENTIONAL | Liquefied petroleum gas (LPG) cookstove |
| NCT02763917 | AIRWEIGHS: Investigating Obesity as a Susceptibility Factor for Air Pollution in Childhood Asthma | ACTIVE NOT RECRUITING | INTERVENTIONAL | Active Air Purifier, Placebo Air Purifier |
| NCT01864824 | Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial | COMPLETED | INTERVENTIONAL | methyl donor, Placebo |
Genetic associations (0)
None linked.