ASCVD Risk Atlas

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A

APOE genotype

Genetic & Family HistoryGenetic / heritablemixednon modifiable

51

evidence score

Also known as: apoE variation, apoe

PREVENT status

Not a PREVENT input variable.

Causal support

observational only

Score components

lit volume: 16.7meta-analyses: 13.8trials: 0genetic: 20MR bonus:

Associated genes

APOE

References (46)

4 meta-analyses / systematic reviews

METAApolipoprotein E4 Polymorphism as a Risk Factor for Ischemic Stroke: A Systematic Review and Meta-Analysis. — Disease markers 2022 · PMID 35154509
METAIndependent ischemic stroke risk factors in older Americans: a systematic review — Aging 2019 · PMID 31127075
METAA systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease. — Atherosclerosis 2014 · PMID 25173947
METAMeta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. — Annals of internal medicine 2004 · PMID 15262670
The designer cytokine IC7Fc attenuates atherosclerosis development by targeting hyperlipidemia in mice. — Science advances 2025 · PMID 41134879
MicroRNA-26b-/- augments atherosclerosis, while mimic-loaded nanoparticles reduce atherogenesis. — Cardiovascular research 2025 · PMID 41223017
Dietary, macronutrient, micronutrient, and nutrigenetic factors impacting cardiovascular risk markers apolipoprotein B and apolipoprotein A1: a narrative review. — Nutrition reviews 2024 · PMID 37615981
Air pollution, APOE genotype and risk of dementia among individuals with cardiovascular diseases: A population-based longitudinal study. — Environmental pollution (Barking, Essex : 1987) 2024 · PMID 38492747
Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic. — Journal of translational medicine 2024 · PMID 38622667
Dysregulated RBM24 phosphorylation impairs APOE translation underlying psychological stress-induced cardiovascular disease. — Nature communications 2024 · PMID 39580475
Pyruvate dehydrogenase kinase regulates vascular inflammation in atherosclerosis and increases cardiovascular risk — Cardiovascular Research 2023 · PMID 36866436
Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease. — Biochemical pharmacology 2023 · PMID 37926268
An integrative analysis of single-cell and bulk transcriptome and bidirectional mendelian randomization analysis identified C1Q as a novel stimulated risk gene for Atherosclerosis. — Frontiers in immunology 2023 · PMID 38179058
Galectin 3 enhances platelet aggregation and thrombosis via Dectin-1 activation: a translational study. — European heart journal 2022 · PMID 35165707
Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study. — Journal of Alzheimer's disease : JAD 2022 · PMID 35527548
Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3 — Gut Microbes 2022 · PMID 35613310
Genetic and molecular architecture of familial hypercholesterolemia. — Journal of internal medicine 2022 · PMID 36196022
Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome — npj Biofilms and Microbiomes 2021 · PMID 33863898
APOE gene variants in primary dyslipidemia. — Atherosclerosis 2021 · PMID 34058468
Plasma levels of trimethylamine-N-oxide can be increased with ‘healthy’ and ‘unhealthy’ diets and do not correlate with the extent of atherosclerosis but with plaque instability — Cardiovascular Research 2020 · PMID 32267921
Effects of coal-fired PMon the expression levels of atherosclerosis-related proteins and the phosphorylation level of MAPK in ApoEmice. — BMC pharmacology & toxicology 2020 · PMID 32384920
Neutrophil extracellular traps induced by IL-8 aggravate atherosclerosis via activation NF-κB signaling in macrophages. — Cell cycle (Georgetown, Tex.) 2019 · PMID 31496351
Hepatocyte-derived extracellular vesicles promote endothelial inflammation and atherogenesis via microRNA-1. — Journal of hepatology 2019 · PMID 31568800
ApoE4 May be a Promising Target for Treatment of Coronary Heart Disease and Alzheimer's Disease. — Current drug targets 2018 · PMID 29623835
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer’s disease — Alzheimer s Research & Therapy 2018 · PMID 30579367
Potential injurious effects of the fine particulate PM2.5 on the progression of atherosclerosis in apoE-deficient mice by activating platelets and leukocytes. — Archives of medical science : AMS 2018 · PMID 30697277
Role of parnaparin in atherosclerosis. — International journal of experimental pathology 2017 · PMID 28205266
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score — PLoS Medicine 2017 · PMID 28323831
Triglyceride Rich Lipoprotein -LPL-VLDL Receptor and Lp(a)-VLDL Receptor Pathways for Macrophage Foam Cell Formation. — Journal of atherosclerosis and thrombosis 2017 · PMID 28428482
MicroRNA let-7g alleviates atherosclerosis via the targeting of LOX-1 in vitro and in vivo. — International journal of molecular medicine 2017 · PMID 28535009
Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort — JAMA Neurology 2017 · PMID 28783817
MicroRNA-30c Mimic Mitigates Hypercholesterolemia and Atherosclerosis in Mice. — The Journal of biological chemistry 2016 · PMID 27365390
Genetic Risk Factors for Ischemic and Hemorrhagic Stroke — Current Cardiology Reports 2016 · PMID 27796860
Chronic oral infection with major periodontal bacteria Tannerella forsythia modulates systemic atherosclerosis risk factors and inflammatory markers — Pathogens and Disease 2015 · PMID 25663343
Acute and persistent platelet and coagulant activities in atherothrombosis. — Journal of thrombosis and haemostasis : JTH 2015 · PMID 26149036
Inflammation, oxidative stress and renin angiotensin system in atherosclerosis — World Journal of Biological Chemistry 2015 · PMID 26322175
Insulin resistance aggravates atherosclerosis by reducing vascular smooth muscle cell survival and increasing CX3CL1/CX3CR1 axis. — Cardiovascular research 2014 · PMID 24788416
Emerging genomic applications in coronary artery disease. — JACC. Cardiovascular interventions 2011 · PMID 21596318
Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease — Arteriosclerosis Thrombosis and Vascular Biology 2010 · PMID 20864672
Cadmium Is a Novel and Independent Risk Factor for Early Atherosclerosis Mechanisms and In Vivo Relevance — Arteriosclerosis Thrombosis and Vascular Biology 2009 · PMID 19556524
Atheroprotective role of interleukin-6 in diet- and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model. — Atherosclerosis 2007 · PMID 17412346
Mouse Models for Atherosclerosis and Pharmaceutical Modifiers — Arteriosclerosis Thrombosis and Vascular Biology 2007 · PMID 17541027
Inflammation in Atherosclerosis — Circulation 2006 · PMID 16801460
Gene-environment interaction and its impact on coronary heart disease risk. — Nutrition, metabolism, and cardiovascular diseases : NMCD 2006 · PMID 17306734
Cardiovascular Effects of Pulmonary Exposure to Single-Wall Carbon Nanotubes — Environmental Health Perspectives 2006 · PMID 17431486
Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approaches. — The Lancet. Neurology 2004 · PMID 15039035

Clinical trials (0)

None linked.

Genetic associations (229)

showing top 80 by significance

Variant	Gene(s)	Trait	p	OR/β	Study
	APOE		1e-9629	—	GCST90239655
	APOE		1e-6283	0.515782 unit decrease	GCST90239658
	APOE		1e-6067	0.7518 unit decrease	GCST90019496
	APOE		1e-4987	—	GCST90239667
	APOE		1e-4551	—	GCST90239673
	APOE, APOC1		1e-3891	0.51 mmol/L decrease	GCST90501250
	APOE		1e-3838	0.6015 unit decrease	GCST90019512
	APOE, APOC1		1e-3832	0.47 % decrease	GCST90501251
	APOE, APOC1		1e-3647	0.47 % decrease	GCST90501124
	APOE, APOC1		1e-3449	0.45 % increase	GCST90501257
	APOE, APOC1		1e-3399	0.45 % decrease	GCST90501122
	APOE		1e-3351	0.45319 unit decrease	GCST90239670
	APOE, APOC1		1e-3203	0.43 % increase	GCST90501132
	APOE, APOC1		1e-3173	0.46 mmol/L decrease	GCST90501254
	APOE, APOC1		1e-3109	0.43 % increase	GCST90501205
	APOE		1e-3040	0.477 unit decrease	GCST90018961
	APOE, APOC1		1e-2947	0.44 mmol/L decrease	GCST90501175
	APOE, APOC1		1e-2916	0.41 % decrease	GCST90501267
	APOE, APOC1		1e-2876	0.41 % increase	GCST90501157
	APOE		1e-2868	0.34826 unit decrease	GCST90239676
	APOE, APOC1		1e-2849	0.44 mmol/L decrease	GCST90501198
	APOE, APOC1		1e-2776	0.42 mmol/L decrease	GCST90501150
	APOE, APOC1		1e-2754	0.42 mmol/L decrease	GCST90501123
	APOE, APOC1		1e-2697	0.39 % decrease	GCST90501263
	APOE, APOC1		1e-2643	0.41 mmol/L decrease	GCST90501121
	APOE, APOC1		1e-2641	0.4 % decrease	GCST90501147
	APOE, APOC1		1e-2623	0.4 % increase	GCST90501243
	APOE, APOC1		1e-2594	0.4 % decrease	GCST90501235
	APOE, APOC1		1e-2509	0.37 % decrease	GCST90501321
	APOE, APOC1		1e-2487	0.37 % decrease	GCST90501139
	APOE, APOC1		1e-2484	0.37 % decrease	GCST90501319
	APOE, APOC1		1e-2430	0.4 mmol/L decrease	GCST90501104
	APOE, APOC1		1e-2410	0.37 % increase	GCST90501329
	APOE, APOC1		1e-2391	0.4 mmol/L decrease	GCST90501178
	APOE		1e-2358	0.4758 unit decrease	GCST90019501
	APOE, APOC1		1e-2350	0.39 mmol/L decrease	GCST90501146
	APOE, APOC1		1e-2324	0.37 % increase	GCST90501269
	APOE, APOC1		1e-2309	0.39 mmol/L decrease	GCST90501154
	APOE, APOC1		1e-2258	0.38 % increase	GCST90501130
	APOE, APOC1		1e-2248	0.35 % decrease	GCST90501199
	APOE, APOC1		1e-2219	0.37 mmol/L decrease	GCST90501125
	APOE, APOC1		1e-2214	0.37 mmol/L decrease	GCST90501127
	APOE, APOC1		1e-2200	0.38 mmol/L decrease	GCST90501152
	APOE		1e-2168	0.38 mmol/L decrease	GCST90501148
	APOE, APOC1		1e-2156	0.38 mmol/L decrease	GCST90501128
	APOE		1e-2155	0.38 mmol/L decrease	GCST90501173
	APOE		1e-2054	0.37 mmol/L decrease	GCST90501176
	APOE, APOC1		1e-2043	0.37 mmol/L decrease	GCST90501252
	APOE		1e-2042	0.37 mmol/L decrease	GCST90501202
	APOE, APOC1		1e-1999	0.35 % decrease	GCST90501259
	APOE, APOC1		1e-1987	0.505845 mmol/L decrease	GCST90499700
	APOE		1e-1953	0.26396 unit increase	GCST009777
	APOE, APOC1		1e-1952	0.33 % decrease	GCST90501151
	APOE		1e-1937	0.36 mmol/L decrease	GCST90501246
	APOE, APOC1		1e-1891	0.35 % decrease	GCST90501255
	APOE, APOC1		1e-1879	0.33 % decrease	GCST90501239
	APOE, APOC1		1e-1868	0.35 % increase	GCST90501249
	APOE		1e-1844	0.35 mmol/L decrease	GCST90501174
	APOE		1e-1829	0.34 mmol/L decrease	GCST90501129
	APOE		1e-1765	0.3451 unit decrease	GCST90018974
	APOE, APOC1		1e-1672	0.3 % decrease	GCST90501209
	APOE, APOC1		1e-1669	0.31 % increase	GCST90501217
	APOE, APOC1		1e-1665	0.31 % decrease	GCST90501207
	APOE		1e-1645	0.33 mmol/L decrease	GCST90501220
	APOE, APOC1		1e-1636	0.3 % decrease	GCST90501295
	APOE, APOC1		1e-1628	0.31 % decrease	GCST90501237
	APOE		1e-1627	0.33 mmol/L decrease	GCST90501194
	APOE, APOC1		1e-1612	0.32 % decrease	GCST90501297
	APOE		1e-1609	1.256 unit increase	GCST90249769
	APOE		1e-1608	0.33 mmol/L decrease	GCST90501200
	APOE, APOC1		1e-1607	0.443421 % increase	GCST90499917
	APOE, APOC1		1e-1606	0.445809 % increase	GCST90499483
	APOE, APOC1		1e-1597	0.32 % decrease	GCST90501203
	APOE		1e-1597	0.33 mmol/L decrease	GCST90501153
	APOE, APOC1		1e-1573	1.582 unit increase	GCST90250187
	APOE		1e-1534	1.251 unit increase	GCST90248673
	APOE		1e-1526	0.32 mmol/L decrease	GCST90501208
	APOE, APOC1		1e-1510	0.3 % decrease	GCST90501211
	APOE		1e-1496	0.31 mmol/L decrease	GCST90501275
	APOE, APOC1		1e-1493	0.3 % decrease	GCST90501215