A
Arterial stiffness
Blood Pressure & HemodynamicsPhysical parameterriskpartially modifiable
55
evidence score
Also known as: aortic stiffness, arterial compliance (reduced), central arterial stiffness, large artery stiffness, loss of arterial elasticity, reduced arterial compliance, reduced arterial elasticity, systemic arterial compliance
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 22.8meta-analyses: 20trials: 12.3genetic: 0MR bonus:
References (190)
8 meta-analyses / systematic reviews- METAThe effects of acute exposure to prolonged sitting, with and without interruption, on central and peripheral pulse wave velocity: A systematic review and meta-analysis. — Vascular medicine (London, England) 2025 · PMID 40528700
- METAAssociation of serum galectin-3 levels with mortality and cardiovascular disease outcomes in hemodialysis patients: a systematic review and dose-response meta-analysis. — International urology and nephrology 2024 · PMID 38519721
- METAArterial Stiffness and Adult Onset Vasculitis: A Systematic Review. — Frontiers in medicine 2022 · PMID 35646970
- METAShift Work and Early Arterial Stiffness: A Systematic Review. — International journal of environmental research and public health 2022 · PMID 36361448
- METACardiovascular Responses to Muscle Stretching: A Systematic Review and Meta-analysis. — International journal of sports medicine 2021 · PMID 33440445
- METAPreclinical markers of atherosclerosis in acromegaly: a systematic review and meta-analysis. — Pituitary 2018 · PMID 30225826
- METACarotid-Femoral Pulse Wave Velocity in the Prediction of Cardiovascular Events and Mortality: An Updated Systematic Review and Meta-Analysis. — Angiology 2017 · PMID 29172654
- METAAssociation of Subjective and Objective Sleep Duration as well as Sleep Quality with Non-Invasive Markers of Sub-Clinical Cardiovascular Disease (CVD): A Systematic Review — Journal of Atherosclerosis and Thrombosis 2016 · PMID 27840384
- The association between estimated pulse wave velocity and cardio-cerebrovascular disease risk: a cohort study. — European journal of medical research 2025 · PMID 39780263
- Comparative Effects of Different Exercise Types on Cardiovascular Health and Executive Function in Sedentary Young Individuals. — Medicine and science in sports and exercise 2025 · PMID 39780353
- The synergistic effect of the triglyceride-glucose index and a body shape index on cardiovascular mortality: the construction of a novel cardiovascular risk marker. — Cardiovascular diabetology 2025 · PMID 39920683
- The cardiovascular consequences of chronic sleep fragmentation: Evidence from experimental models of obstructive sleep apnea. — Sleep medicine 2025 · PMID 40398206
- Growth-differentiation factor 15 (GDF-15) is associated with arterial stiffness and impaired endothelial function with mediation by albuminuria in the Singapore study of macroangiopathy and microvascular reactivity in type 2 diabetes (SMART2D) cohort. — Endocrine 2025 · PMID 40481928
- Association between pulse wave velocity and coronary atherosclerosis. — Coronary artery disease 2025 · PMID 40546041
- Nonatherosclerotic Cardiovascular Disease in Chronic Kidney Disease. — Cardiology clinics 2025 · PMID 40582730
- Arterial Stiffness and Cardiovascular Risk Reclassification in Patients with Autoimmune Rheumatic Diseases. — High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 2025 · PMID 40668329
- Hidden Cardiovascular Risk: Arterial Stiffness and Left Ventricular Remodeling as Potential Indicators of Masked Hypertension. — Journal of clinical hypertension (Greenwich, Conn.) 2025 · PMID 40685757
- Estimated pulse wave velocity and the risk of acute kidney injury in patients undergoing coronary revascularization: a retrospective cohort study from MIMIC-IV. — Renal failure 2025 · PMID 40731387
- Exercise-induced brachial-ankle pulse wave velocity changes before and after transcatheter aortic valve replacement. — Heart and vessels 2025 · PMID 40824385
- Platelet Activation and a Platelet Biosignature Are Associated With Cardiovascular Risk in Patients With Controlled Psoriasis. — Arteriosclerosis, thrombosis, and vascular biology 2025 · PMID 40905118
- Cystatin C in atherosclerotic cardiovascular disease. — Clinica chimica acta; international journal of clinical chemistry 2025 · PMID 41237923
- Atherosclerotic cardiovascular disease and inflammatory bowel disease: epidemiology, pathogenesis and risk assessment. — Best practice & research. Clinical gastroenterology 2025 · PMID 41350098
- Exploring pulse wave velocity as a vascular hemodynamic stress marker: more than just arterial stiffening? — American journal of physiology. Heart and circulatory physiology 2025 · PMID 41364544
- Integrating Vascular Aging and Genetic Risk: The Combined Impact of Estimated Pulse Wave Velocity and Genetic Predisposition on Coronary Artery Disease. — Journal of the American Heart Association 2025 · PMID 41368830
- Arterial stiffness tested by pulse wave velocity and augmentation index for cardiovascular risk stratification in antiphospholipid syndrome. — Rheumatology (Oxford, England) 2024 · PMID 37294733
- Albuminuria: An Underappreciated Risk Factor for Cardiovascular Disease. — Journal of the American Heart Association 2024 · PMID 38214258
- Arterial Stiffness and Carotid Intima-Media Thickness in Children Exposed to Smokeless Tobacco in Fetal Life. — Journal of the American Heart Association 2024 · PMID 38214274
- Association of COVID-19 and Arterial Stiffness Assessed using Cardiovascular Index (CAVI). — Current hypertension reviews 2024 · PMID 38258773
- Arterial Pulse Wave Velocity Signal Reconstruction Using Low Sampling Rates. — Biosensors 2024 · PMID 38392011
- Determinants of hand pulse wave velocity and hand pulse transit time in healthy adults. — Scientific reports 2024 · PMID 38698185
- Flexural pulse wave velocity in blood vessels. — The Journal of the Acoustical Society of America 2024 · PMID 38717204
- Implications of pulse wave velocity and central pulse pressure in heart failure with reduced ejection fraction. — Blood pressure 2024 · PMID 38819846
- Arterial Stiffness and Heart Failure With Preserved Ejection Fraction. — Journal of Korean medical science 2024 · PMID 38887204
- Arterial stiffness and cardiovascular risk in patients with nephrolithiasis: a 10-year prospective study. — Journal of hypertension 2024 · PMID 38934190
- Effects of low-pressure Valsalva maneuver on changes in cerebral arterial stiffness and pulse wave velocity. — PloS one 2024 · PMID 39331633
- Aortic-Femoral Stiffness Gradient and Cardiovascular Risk in Older Adults. — Hypertension (Dallas, Tex. : 1979) 2024 · PMID 39371003
- Inflammation and Arterial Stiffness as Drivers of Cardiovascular Risk in Kidney Disease. — Cardiorenal medicine 2024 · PMID 39631378
- Relationship of Arterial Stiffness and Central Hemodynamics With Cardiovascular Risk In Hypertension. — American journal of hypertension 2023 · PMID 36645322
- Increased arterial pressure volume index and cardiovascular risk score in China. — BMC cardiovascular disorders 2023 · PMID 36646995
- Cardio-ankle brachial index is associated with prolonged Tp-e interval in patients with arterial hypertension. — Journal of electrocardiology 2023 · PMID 36934493
- Markers of arterial stiffness and urinary metabolomics in young adults with early cardiovascular risk: the African-PREDICT study. — Metabolomics : Official journal of the Metabolomic Society 2023 · PMID 36988718
- A Critical Review on Vasoactive Nutrients for the Management of Endothelial Dysfunction and Arterial Stiffness in Individuals under Cardiovascular Risk. — Nutrients 2023 · PMID 37299579
- Blood pressure, arterial stiffness, and cardiovascular risk profiles in 8-12-year-old children following preeclampsia (FINNCARE-study). — Journal of hypertension 2023 · PMID 37337860
- Lifelong Heterogeneous Contribution of Cardiovascular Risk Factors to Slow and Fast Progression of Arterial Stiffness. — Hypertension (Dallas, Tex. : 1979) 2023 · PMID 37551598
- Arterial Stiffness and its Impact on Cardiovascular Health. — Current cardiology reports 2023 · PMID 37676581
- Subclinical Primary Aldosteronism and Cardiovascular Health: A Population-Based Cohort Study. — Circulation 2023 · PMID 38031887
- Update on the Use of Pulse Wave Velocity to Measure Age-Related Vascular Changes. — Current hypertension reports 2023 · PMID 38159167
- Arterial Stiffness as a Cardiovascular Risk Factor for the Development of Preeclampsia and Pharmacopreventive Options. — Current vascular pharmacology 2022 · PMID 34615450
- Augmentation index and pulse wave velocity in normotensive versus preeclamptic pregnancies: a prospective case-control study using a new oscillometric method. — Annals of medicine 2022 · PMID 34935572
- Usefulness of estimated pulse wave velocity for identifying prevalent coronary heart disease: findings from a general Chinese population. — BMC cardiovascular disorders 2022 · PMID 35016632
- Serum Level of Lactate Dehydrogenase is Associated with Cardiovascular Disease Risk as Determined by the Framingham Risk Score and Arterial Stiffness in a Health-Examined Population in China — International Journal of General Medicine 2022 · PMID 35018110
- Incremental value of the measures of arterial stiffness in cardiovascular risk assessment. — Reviews in cardiovascular medicine 2022 · PMID 35092198
- Arterial Stiffness and Long-Term Risk of Health Outcomes: The Framingham Heart Study. — Hypertension (Dallas, Tex. : 1979) 2022 · PMID 35168368
- Stress and social isolation, and its relationship to cardiovascular risk in young adults with intellectual disability. — Disability and rehabilitation 2022 · PMID 35311428
- Differential Roles of Life-Course Cumulative Burden of Cardiovascular Risk Factors in Arterial Stiffness and Thickness. — The Canadian journal of cardiology 2022 · PMID 35314334
- Fitness and arterial stiffness in healthy aging: Modifiable cardiovascular risk factors contribute to altered default mode network patterns during executive function. — Neuropsychologia 2022 · PMID 35595064
- Arterial stiffness in patients with type 1 diabetes and its comparison to cardiovascular risk evaluation tools. — Cardiovascular diabetology 2022 · PMID 35681143
- Prediction of all-cause and cardiovascular mortality using ankle-brachial index and brachial-ankle pulse wave velocity in patients with type 2 diabetes. — Scientific reports 2022 · PMID 35773381
- Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes. — BMC cardiovascular disorders 2022 · PMID 35945498
- Arterial stiffness, endothelial dysfunction and impaired fibrinolysis are pathogenic mechanisms contributing to cardiovascular risk in ANCA-associated vasculitis. — Kidney international 2022 · PMID 35998848
- Arterial Stiffness as a Cardiovascular Risk Factor After Successful Kidney Transplantation in Diabetic and Nondiabetic Patients. — Transplantation proceedings 2022 · PMID 36064673
- Blood Pressure Responses During Exercise: Physiological Correlates and Clinical Implications. — Arteriosclerosis, thrombosis, and vascular biology 2022 · PMID 36384270
- Cardiovascular consequences of aircraft noise exposure. — Frontiers in public health 2022 · PMID 36530719
- Diabetes Mellitus, Arterial Stiffness and Cardiovascular Disease: Clinical Implications and the Influence of SGLT2i. — Current vascular pharmacology 2021 · PMID 32183678
- DPP4 Activity, Hyperinsulinemia, and Atherosclerosis. — The Journal of clinical endocrinology and metabolism 2021 · PMID 33570554
- Biologics and atherosclerotic cardiovascular risk in rheumatoid arthritis: a review of evidence and mechanistic insights. — Expert review of clinical immunology 2021 · PMID 33673792
- Arterial Stiffness and Cardiovascular Risk in Hypertension. — Circulation research 2021 · PMID 33793325
- Triglyceride Glucose Index Is Associated With Arterial Stiffness and 10-Year Cardiovascular Disease Risk in a Chinese Population — Frontiers in Cardiovascular Medicine 2021 · PMID 33816569
- Adipokines and Arterial Stiffness in Obesity. — Medicina (Kaunas, Lithuania) 2021 · PMID 34202323
- Arterial stiffness, the hidden face of cardiovascular risk in autoimmune and chronic inflammatory rheumatic diseases. — Autoimmunity reviews 2021 · PMID 34229047
- SPARTE Study: Normalization of Arterial Stiffness and Cardiovascular Events in Patients With Hypertension at Medium to Very High Risk — Hypertension 2021 · PMID 34455813
- Ambulatory monitoring of central arterial pressure, wave reflections, and arterial stiffness in patients at cardiovascular risk. — Journal of human hypertension 2021 · PMID 34518619
- Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children. — Kidney & blood pressure research 2021 · PMID 34657030
- Association between combat-related traumatic injury and cardiovascular risk. — Heart (British Cardiac Society) 2021 · PMID 34824088
- Arterial Stiffness and Coronary Ischemia: New Aspects and Paradigms. — Current hypertension reports 2020 · PMID 31925555
- The bidirectional relationship between chronic obstructive pulmonary disease and coronary artery disease. — Herz 2020 · PMID 32052074
- Determinants of Brachial-Ankle Pulse Wave Velocity and Vascular Aging in Healthy Older Subjects. — Medical science monitor : international medical journal of experimental and clinical research 2020 · PMID 32445331
- Ambulatory arterial stiffness index in diabetic patients. — Revista medica de Chile 2020 · PMID 32730458
- Uric Acid and Vascular Damage in Essential Hypertension: Role of Insulin Resistance. — Nutrients 2020 · PMID 32825165
- Arterial Stiffness Preceding Diabetes — Circulation Research 2020 · PMID 32985370
- Effects of Moderate Combined Resistance- and Aerobic-Exercise for 12 Weeks on Body Composition, Cardiometabolic Risk Factors, Blood Pressure, Arterial Stiffness, and Physical Functions, among Obese Older Men: A Pilot Study. — International journal of environmental research and public health 2020 · PMID 33022918
- Association between estimated pulse wave velocity and the risk of stroke in middle-aged men. — International journal of stroke : official journal of the International Stroke Society 2020 · PMID 33045935
- Long sleep duration and cardiovascular disease: Associations with arterial stiffness and blood pressure variability. — Journal of clinical hypertension (Greenwich, Conn.) 2020 · PMID 33377597
- Sex differences in mechanisms of arterial stiffness — British Journal of Pharmacology 2019 · PMID 30767200
- Ambulatory pulse pressure components: concept, determination and clinical relevance. — Journal of hypertension 2019 · PMID 30817458
- Current assessment of pulse wave velocity: comprehensive review of validation studies. — Journal of hypertension 2019 · PMID 30882597
- Arterial stiffness as a risk factor for cardiovascular events and all‐cause mortality in people with Type 2 diabetes — Diabetic Medicine 2019 · PMID 30920676
- Arterial stiffness and cardiovascular risk — The Korean Journal of Internal Medicine 2019 · PMID 31048659
- Pulse wave velocity can be accurately measured during transcatheter aortic valve implantation and used for post-procedure risk stratification. — Journal of hypertension 2019 · PMID 31157743
- Arterial stiffness in chronic kidney disease: a modifiable cardiovascular risk factor? — Current opinion in nephrology and hypertension 2019 · PMID 31361609
- Editorial: Arterial Stiffness, Central Haemodynamics and Non-Alcoholic Fatty Liver Disease: Links with Cardiovascular Risk and Effects of Drug Treatment. — Current vascular pharmacology 2018 · PMID 29210656
- Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness — Cardiovascular Research 2018 · PMID 29514202
- Association between triglyceride glucose index and arterial stiffness in Korean adults — Cardiovascular Diabetology 2018 · PMID 29562908
- Associations between normal range albuminuria, renal function and cardiovascular function in a population-based imaging study. — Atherosclerosis 2018 · PMID 29579673
- Aortic Pulse Pressure Does Not Adequately Index Cardiovascular Risk Factor-Related Changes in Aortic Stiffness and Forward Wave Pressure. — American journal of hypertension 2018 · PMID 29684105
- Arterial Stiffness in CKD: A Review. — American journal of kidney diseases : the official journal of the National Kidney Foundation 2018 · PMID 29908694
- Endothelial Dysfunction, Increased Arterial Stiffness, and Cardiovascular Risk Prediction in Patients With Coronary Artery Disease: FMD‐J (Flow‐Mediated Dilation Japan) Study A — Journal of the American Heart Association 2018 · PMID 30005558
- Arterial Flow, Pulse Pressure and Pulse Wave Velocity in Men and Women at Various Ages. — Advances in experimental medicine and biology 2018 · PMID 30051383
- Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence. — Mayo Clinic proceedings 2018 · PMID 30077204
- Prognostic Cardiovascular Markers in Chronic Kidney Disease. — Kidney & blood pressure research 2018 · PMID 30153666
Clinical trials (16)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07245069 | Use of Dapagliflozin in Primary Prevention of Cardiotoxicity of Anthracycline Chemotherapy in Breast Cancer Patients | RECRUITING | INTERVENTIONAL | Dapagliflozin 10 mg, Placebo |
| NCT07209527 | Evaluation of Truway Health-Sourced Portable Diagnostic Devices for Early Detection of Chronic Conditions in Outpatient Primary Care Settings: A Prospective Interventional Study | ENROLLING BY INVITATION | INTERVENTIONAL | Truway Portable Ultrasound Device, Truway Blood Glucose Monitor, Standard Oral Hypoglycemic Agent |
| NCT05857085 | Impact of Additional Treatment With Empagliflozin or Semaglutide on Endothelial Function and Other Clinical Parameters and Biomarkers in T1DM Patients | COMPLETED | INTERVENTIONAL | Semaglutide Pen Injector [Ozempic], Empagliflozin 10 MG |
| NCT03272737 | Effect of Low Intensity Strength Training Combined With Moderate Blood Flow Restriction on Muscle Vasodilatation and Arterial Stiffness in Elders With Low Gait Velocity. | COMPLETED | INTERVENTIONAL | 1RM Test, Speed gait test, Venous occlusion plethysmography protocol |
| NCT03273972 | INvestigating the Lowest Threshold of Vascular bENefits From LDL Cholesterol Lowering With a PCSK9 mAb InhibiTor (Alirocumab) in healthY Volunteers | COMPLETED | INTERVENTIONAL | Written Informed Consent, Inclusion/Exclusion check, Full Clinical Chemistry and Haematology Bloods |
| NCT02487732 | Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting | COMPLETED | INTERVENTIONAL | Ticagrelor, Prasugrel |
| NCT01312714 | A Randomized, Placebo-Controlled, Double Blind Study Evaluating the Effect of Cholecalciferol on Vasoactive Hormones, Heart Function, Arterial Stiffness, and Blood Pressure in Dialysis Patients. | COMPLETED | INTERVENTIONAL | Cholecalciferol, Placebo |
| NCT01371370 | Effects of Low-intensity Resistance Exercise Training and Diet on Central Hemodynamics and Arterial Stiffness in Obese Middle-aged Women With High Blood Pressure | COMPLETED | INTERVENTIONAL | Resistance exercise training, Hypocaloric diet, Resistance exercise training & diet |
| NCT06885970 | The Effect of Cytisine Treatment for Smoking Cessation on Cardiovascular Function in Adult Smokers of Conventional Combustible Cigarettes and New Tobacco Products-Observational Study. | RECRUITING | OBSERVATIONAL | Cytisinicline administration |
| NCT07589374 | Correlation Between Carotid-Femoral Pulse Wave Velocity and Triglyceride-Glucose Index and Its Derived Metrics | NOT YET RECRUITING | OBSERVATIONAL | |
| NCT04578522 | Correlation Between the Severity of Coronary Artery Disease and Peripheral Arterial Stiffness in Patients With Premature Coronary Heart Disease | UNKNOWN | OBSERVATIONAL | |
| NCT05479565 | The Association of Reduced Arterial Stiffness and Highly Sensitive C-reactive Protein With Gestational Diabetes Mellitus. | COMPLETED | OBSERVATIONAL | venous blood sample for determining the value of highly sensitive C-reactive C protein from serum |
| NCT03989011 | Tonometry (1) and Duplex Ultrasound (2) to Predict Abdominal Aorta Aneurysm (3) Progression and Cardiovascular Events in Aneurysm Patients | COMPLETED | OBSERVATIONAL | Carotid Artery Reactivity test (CAR test), Arterial stiffness |
| NCT05155514 | Comparison of the Relationship Between Preoperatively Measured Pulse Wave Velocity and Hemodynamic Changes During Anesthesia Induction in Hypertensive and Normotensive Patients. | COMPLETED | OBSERVATIONAL | Mobil-O-Graph PWA |
| NCT02226055 | An Investigation Into the Cardiovascular Risk and Aetiology of CKDu in Sri Lanka | COMPLETED | OBSERVATIONAL | Arterial Stiffness Assessment |
| NCT01106573 | Is There an Association Between the Presence of Diabetes, the Degree of Arterial Stiffness and a New Plasma Marker for Vascular Elasticity, Fibulin-1 in Patients Undergoing Heart- and Vascular Surgery? | UNKNOWN | OBSERVATIONAL |
Genetic associations (0)
None linked.