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Blood pressure

Blood Pressure & HemodynamicsPhysical parameterriskmodifiablegenetic-causal
62
evidence score

Also known as: arterial blood pressure, blood pressure increases, elevated arterial pressure, elevated blood pressure, higher blood pressure, increased blood pressure

PREVENT status

Not a PREVENT input variable.

Causal support

genetic causal candidate

Score components
lit volume: 12.3meta-analyses: 9.1trials: 15genetic: 15.9MR bonus:
Associated genes
EDNRASH2B3

References (16)

2 meta-analyses / systematic reviews

Clinical trials (145)

showing top 60
NCTTitleStatusTypeInterventions
NCT07460154A Structured Health Assessment in Frequent COPD Exacerbators: To Optimise Management, Identify Comorbidities and Prevent Oral Corticosteroid Related HarmRECRUITINGINTERVENTIONALSputum sample, Venepuncture, Lung function test
NCT07279259Thrombolysis in Early Acute Ischemic Stroke Trial-Blood Pressure Management, EAST-BPRECRUITINGINTERVENTIONALAdjusted BP management group, Usual BP management group
NCT06891911Groceries for Residents of Southeastern USA to Stop HypertensionRECRUITINGINTERVENTIONALDietitian-Assisted DASH groceries, Self-directed shopping
NCT06962488Clinical Implementation of Blood Pressure Polygenic Risk ScoreRECRUITINGINTERVENTIONALRegular Care, SBP PRS Dissemination
NCT06677970Outcome in Patients Treated With Endovascular Thrombectomy - optIMAL Blood Pressure Control 2 (OPTIMAL-BP 2)RECRUITINGINTERVENTIONALBP lowering drugs (nicardipine, labetalol, urapidil), BP raising drug (phenylephrine) or BP lowering drugs (nicardipine, labetalol, urapidil)
NCT06352632A Multi-faCtorial, mulTi-arm, Multi-staGe, Randomised, gLOBal Adaptive pLatform Trial for Stroke (ACT-GLOBAL)RECRUITINGINTERVENTIONALStandard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase
NCT06579950The Effects of Cool Roofs on Health, Environmental, and Economic Outcomes: a Global Multi-center Cluster-randomized Controlled TrialRECRUITINGINTERVENTIONALCool roof
NCT06322056Exploring Approaches With Lower Targets of Blood Pressure and Lipid for Improving Renal Outcome in Advanced Chronic Kidney DiseaseRECRUITINGINTERVENTIONALIntensive control of SBP and intensive control of LDL-C, Intensive control of SBP and standard control of LDL-C, Standard control of SBP and intensive control of LDL-C
NCT04647292European Blood Pressure Intensive Control After Stroke - Pilot TrialRECRUITINGINTERVENTIONALanti-hypertensive, home blood pressure measurement, telemonitoring and medication titration, Standard of Care Blood Pressure Management with Antihypertensives
NCT06055036Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health InterventionRECRUITINGINTERVENTIONALBlack Impact Intervention
NCT05252208Is Stretching Superior to Aerobic Training for Reducing Blood Pressure?RECRUITINGINTERVENTIONALStretching exercise, Walking exercise
NCT04911491Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure in Midlife and Older Adults With Chronic Kidney DiseaseRECRUITINGINTERVENTIONALIMST, Sham Training
NCT07695220Efficacy and Safety of an Early Intensive Blood Pressure-Lowering Strategy Using Remifentanil and Dexmedetomidine in Patients With Spontaneous Intracerebral Hemorrhage: A Multicenter, Prospective, Superiority, Randomized Controlled TrialNOT YET RECRUITINGINTERVENTIONALRemifentanil and Dexmedetomidine, Guideline standard care
NCT07620808Medically Tailored Groceries for Cardiovascular HealthENROLLING BY INVITATIONINTERVENTIONALMedically Tailored Groceries
NCT07592117A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in Tavua, FijiNOT YET RECRUITINGINTERVENTIONALCool roof
NCT07206303The Effects of Bifidobacterium-based Probiotics in Reducing Blood Pressure in Middle-aged Chinese With Hypertension: a Single-term Feasibility Pilot StudyNOT YET RECRUITINGINTERVENTIONALBifidobacterium probiotics supplementation
NCT06834893A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in Colima, MexicoNOT YET RECRUITINGINTERVENTIONALCool roof
NCT07386535Innovative Tools to Expand Music-Inspired Strategies for Blood Pressure and Stroke PreventionACTIVE NOT RECRUITINGINTERVENTIONALMusic4Health Intervention
NCT07124728Impact of Syntrillo's Telehealth Service on Stroke Risk Factor Reduction in At-risk PatientsNOT YET RECRUITINGINTERVENTIONALTechnology-enabled Telehealth Care Plan, Blood Pressure Monitoring Device, Tenovi Smart Pillbox
NCT06960057Exploring Virtual Reality as a Clinical Tool for Blood Pressure Reduction and Assessment of White Coat Hypertension/Effect: A Pre- and Post-Intervention Study With ABPM ValidationCOMPLETEDINTERVENTIONALVirtual Reality Exposure
NCT06692764A Phase II Study to Assess the Effect of AZD0780 on Ambulatory Blood Pressure in Participants With Atherosclerotic Cardiovascular Disease or Risk Equivalents and Elevated Low-Density Lipoprotein CholesterolCOMPLETEDINTERVENTIONALPlacebo, AZD0780
NCT05993481The Effect of More Frequent Noninvasive Blood Pressure Measurement on the Detection of Intraoperative HypotensionENROLLING BY INVITATIONINTERVENTIONALBlood Pressure Measurement
NCT06570993A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in NiueCOMPLETEDINTERVENTIONALCool roof
NCT05917275Multi-Omics to Predict the Blood Pressure Response to AntihypertensivesUNKNOWNINTERVENTIONALAmlodipine, Olmesartan, Hydrochlorothiazide
NCT06268873A Phase III, Randomised, Double-Blind Study to Assess the Efficacy, Safety and Tolerability of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on Chronic Kidney Disease (CKD) Progression in Participants With CKD and High Blood PressureACTIVE NOT RECRUITINGINTERVENTIONALBaxdrostat/dapagliflozin, Dapagliflozin in combination with placebo
NCT06898567EFFECT OF BLOOD PRESSURE MEASUREMENT IN DIFFERENT POSITIONS ON BLOOD PRESSURE VALUES AND ANXIETY LEVELS IN PREGNANT WOMEN WITH PREECLAMPSIACOMPLETEDINTERVENTIONALRight Lateral Position, Left Lateral Position, Semi Fowler Position (45° Fowler)
NCT06124716Collaboration Oriented Approach to Controlling High Blood PressureACTIVE NOT RECRUITINGINTERVENTIONALEnhanced COACH CDS Tool, Usual Care COACH CDS Tool
NCT05846490Impact of Obstructive Sleep Apnea Treatment on Blood Pressure Control in Chronic Kidney Disease: A Randomized TrialUNKNOWNINTERVENTIONALCPAP, Usual care
NCT05814068Active Screening of Arterial Hypertension by Community Outreach Workers in the Cayenne Metropolitan Area to Reduce the Incidence of Cardiovascular DiseaseUNKNOWNINTERVENTIONALantihypertensive drug treatment
NCT05690997Effect of Intensive Blood Pressure Control on Cerebral Blood Flow and Cognition in Ischaemic Stroke Patients With Severe Cerebral Small Vessel DiseaseUNKNOWNINTERVENTIONALIntensive treatment, Standard treatment
NCT04524325Mechanisms of Blood Pressure Dysfunction in Transmen Receiving TestosteroneWITHDRAWNINTERVENTIONALTrans men
NCT06295848The Effects of 6-week Cardiac Rehabilitation Programme on Cardiovascular Disease Risk, Systolic and Diastolic Blood Pressure and Disease Activity in Hypertensive Rheumatoid Arthritis Patients : A Randomised Controlled TrialCOMPLETEDINTERVENTIONALExercise
NCT04197700PRotocolized vs pErsonalized Blood preSSUre peRi-operative paramEters in Coronary Artery Bypass Grafting Surgery: The PRESSURE CABG Cardiac Surgery TrialCOMPLETEDINTERVENTIONALTarget MAP Management
NCT07085637Intravenous Hydrogen Nanobubbles Effect on Cardiac Physiology and Quality of Life: a Single Blind, Dose-response StudyCOMPLETEDINTERVENTIONALintravenous infusion of hydrogen nanobubbles (HNB) administered twice weekly over a 5-week period
NCT05352633Effects of Intensive Systolic Blood Pressure Lowering Treatment on Out-of-office Blood Pressure - an Ancillary Study to Effects of Intensive Systolic Blood Pressure Lowering Treatment in Reducing RIsk of Vascular evenTs (ESPRIT) StudyUNKNOWNINTERVENTIONALIntensive BP Arm, Standard BP Arm
NCT05611021Acute Responses to Arm-Crank Exercise on Cardiovascular Function of Patients With Peripheral Artery Disease: Randomized Crossover StudyCOMPLETEDINTERVENTIONALExercise
NCT05397535Traditional Exercise as Convenient Approach to Improve Health 1-Baduanjin Lower Elevated Blood PreSsure StudyCOMPLETEDINTERVENTIONALBaduanjin, Brisk walking
NCT05365854Comparison of Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers in Intensive Care Unit Patients Under Mechanical Ventilation. A Pilot Physiological StudyUNKNOWNINTERVENTIONALAlveolar Recruitment Maneuver (ARM)
NCT05141175The Duke Primary Care Tailored to You (TTY) Blood Pressure Control Pilot StudyCOMPLETEDINTERVENTIONALHypertension medication algorithm, Impedance Cardiography
NCT04908917Reducing AIR Pollution Exposure to Lower Blood PRESSUREUNKNOWNINTERVENTIONALPortable Air Cleaner with a HEPA Filter, Portable Air Cleaner without a HEPA Filter
NCT04789733Tight Perioperative Blood Pressure Management to Reduce Serious Cardiovascular, Renal, and Cognitive Complications: The GUARDIAN Pilot TrialACTIVE NOT RECRUITINGINTERVENTIONALTight pressure management, Routine pressure management
NCT04283565Health-economic Evaluation of the Care Pathway in General Medicine for High Cardiovascular Risk Patients Based on the Detection of Asymptomatic Lower Limb Peripherial Arterial Disease (AOMI) by the Blood Pressure Index (BPI).COMPLETEDINTERVENTIONALSystematic screening of AOMI by BPI measurement., Management of CVRF by a motivationnal interviewing.
NCT04758858Carbohydrates Under Target for Type 1 Diabetes ManagementWITHDRAWNINTERVENTIONALInsulin treatment optimization with participant's usual diet, Abbott's FreeStyle Libre, Three-day food journal
NCT04505150Lowering Blood Pressure by Changing Lifestyle Through a Motivational Education Program: a Cluster RCT Study ProtocolUNKNOWNINTERVENTIONALLifestyle changes, e.g., take part in regular exercise, quitting smoking, and reduce salt consumption
NCT04484350Blood Pressure Management in Stroke Following Endovascular TreatmentCOMPLETEDINTERVENTIONALLabetalol, Hydralazine, Enalapril
NCT04575194Cardiovascular and Metabolic Effects of Drugs for the Treatment of ObesityUNKNOWNINTERVENTIONALLiraglutide 6 MG/ML [Saxenda], Naltrexone-Bupropion Combination
NCT04205305Outcome in Patients Treated with Intraarterial Thrombectomy - OptiMAL Blood Pressure Control (OPTIMAL-BP)COMPLETEDINTERVENTIONALconventional blood pressure control (labetalol, nicardipine), intensive blood pressure control (labetalol, nicardipine)
NCT04325867Integrated Distance Management Strategy for Patients With Cardiovascular Disease (Ischaemic Coronary Artery Disease, High Blood Pressure, Heart Failure) in the Context of the COVID-19 PandemicUNKNOWNINTERVENTIONALTele-medicine platform
NCT04116112Blood Pressure After Endovascular Stroke Therapy-II: A Randomized TrialCOMPLETEDINTERVENTIONALNicardipine, Labetalol, Hydralazine
NCT04181398Low Grade Inflammation in Childhood Obesity : an Independent Risk Factor for Endothelial DysfunctionCOMPLETEDINTERVENTIONALAnthropometry, Blood pressure, Peripheral arterial tonometry
NCT03808311Blood Pressure Control Target in Diabetes (BPROAD): a Multicenter, Open-label, Parallel-group, Randomized Controlled TrialCOMPLETEDINTERVENTIONALTreatment strategy regarding different systolic BP goals
NCT04226157Home Blood Pressure Self-Management in Hypertensive Stroke Survivors: a Pilot StudyUNKNOWNINTERVENTIONALHome Blood Pressure Monitoring Device (Qardio Arm), Primary Care Provider Blood Pressure Management
NCT03790722Comparison of Pulse Wave and Blood Pressure Parameters Before, During and After Exercise Ergometry in Healthy Male Subjects - a Randomized, Controlled, Single-blind StudyCOMPLETEDINTERVENTIONALErgometry H, Ergometry L
NCT04715698Effectiveness of A Hemodynamic-Guided Treatment Strategy to Improve Blood Pressure ControlCOMPLETEDINTERVENTIONALICG-guided drug selection, empirical drug selection
NCT03859076Mindfulness Based Blood Pressure Reduction: Stage 2a Randomized Controlled TrialCOMPLETEDINTERVENTIONALMB-BP, Enhanced Usual Care Control
NCT03453268Impact of Reducing Antihypertensive Treatment on Mortality in Frail Subjects With Low Systolic Blood Pressure (SBP). Multicenter, Randomized Controlled Study of Subjects Aged 80 and Over, Living in Nursing Homes and Other IMS.COMPLETEDINTERVENTIONALSTEP DOWN strategy, Control
NCT03634813Perioperative Blood Pressure Screening to Improve Long-term Cardiovascular HealthCOMPLETEDINTERVENTIONALHigh Blood Pressure Monitor, Usual Care
NCT03483662Dissemination and Implementation of the SPRINT Study Findings in Underserved PopulationsCOMPLETEDINTERVENTIONALMulticomponent Intervention, Enhanced Usual Care
NCT03919201Impacts of 12 Weeks of Resistance Band Exercise Training on Body Composition, Aging-related Hormones, and Blood Pressure in Postmenopausal Women With HypertensionCOMPLETEDINTERVENTIONALResistance band exercise intervention, No exercise intervention group
NCT03459807BOLD: A Trial of Blood Pressure Lowering in DialysisCOMPLETEDINTERVENTIONALAnti-Hypertensive medications, Dry Weight Adjustment

Genetic associations (38)

VariantGene(s)TraitpOR/βStudy
rs6841473EDNRAcoronary artery disorder1e-380.0815677 unit increaseGCST010866
rs7310615SH2B3coronary artery disorder1e-35—GCST90129546
rs3184504SH2B3, ATXN2coronary artery disorder1e-300.0742 unit increaseGCST005196
rs6841581EDNRA, PRMT5P1coronary artery disorder1e-301.082GCST90132314
rs3184504SH2B3, ATXN2Ischemic stroke1e-27—GCST90129553
rs72957606EDNRA, PRMT5P1myocardial infarction1e-210.1028 unit increaseGCST90018877
rs3184504SH2B3, ATXN2coronary atherosclerosis1e-180.0366 unit increaseGCST90475936
rs3184504SH2B3, ATXN2Ischemic stroke1e-16—GCST90129551
rs3184504SH2B3, ATXN2Ischemic stroke1e-15—GCST90129552
rs3184504SH2B3, ATXN2Ischemic stroke1e-15—GCST90129554
rs3184504SH2B3, ATXN2Ischemic stroke1e-15—GCST90129549
rs3184504SH2B3, ATXN2Ischemic stroke1e-15—GCST90129550
rs3184504SH2B3, ATXN2myocardial infarction1e-140.0556 unit increaseGCST90475211
rs3184504SH2B3, ATXN2Ischemic stroke1e-14—GCST90129555
rs3184504SH2B3, ATXN2Ischemic stroke1e-14—GCST006908
rs3184504SH2B3, ATXN2Ischemic stroke1e-14—GCST005843
rs72957606EDNRA, PRMT5P1atherosclerosis1e-140.09749 unit decreaseGCST90480200
rs6841581EDNRA, PRMT5P1atherosclerosis1e-130.1071 unit decreaseGCST90480198
rs3184504SH2B3, ATXN2stroke disorder1e-12—GCST006906
rs3184504SH2B3, ATXN2stroke disorder1e-12—GCST005838
rs72957606EDNRA, PRMT5P1atherosclerosis1e-120.125 unit decreaseGCST90480197
rs1878406EDNRA, PRMT5P1atherosclerosis1e-120.1993 unit increaseGCST001231
rs17612742EDNRAlarge artery stroke1e-11—GCST005840
rs11413744EDNRA, PRMT5P1peripheral arterial disease1e-100.1102 unit increaseGCST90018890
rs11413744EDNRA, PRMT5P1carotid atherosclerosis1e-100.1586 unit decreaseGCST007435
rs1878406EDNRA, PRMT5P1large artery stroke1e-91.08GCST90162544
rs6841581EDNRA, PRMT5P1peripheral arterial disease1e-91.07GCST008474
rs6842241EDNRA, PRMT5P1peripheral arterial disease1e-91.18GCST003154
rs78049276EDNRA, GTF2F2P1carotid plaque build1e-90.158 unit increaseGCST90503076
rs6841581EDNRA, PRMT5P1large artery stroke1e-8—GCST002290
rs17612742EDNRAperipheral arterial disease1e-81.1579436GCST90013689
rs3184504SH2B3, ATXN2small vessel stroke1e-71.1068798GCST010156
rs3184504SH2B3, ATXN2large artery stroke1e-6—GCST005840
rs3184504SH2B3, ATXN2small vessel stroke1e-61.0874183GCST010153
rs3184504SH2B3, ATXN2small vessel stroke1e-6—GCST005841
rs3184504SH2B3, ATXN2peripheral arterial disease1e-61.09GCST90061375
rs17612742EDNRAlarge artery stroke1e-6—GCST006907
rs1878406EDNRA, PRMT5P1large artery stroke1e-61.16GCST90104542