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C

Cancer therapy-related cardiotoxicity (chemo/radiotherapy)

Comorbid ConditionsDisease / conditionriskpartially modifiable
31
evidence score

Also known as: Cardio-oncology therapy, anthracycline, cancer therapy, cardiotoxic, chemotherapy, radiotherapy

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 15.8meta-analyses: 0trials: 15genetic: 0MR bonus:

References (37)

0 meta-analyses / systematic reviews

Clinical trials (37)

NCTTitleStatusTypeInterventions
NCT07070765Sodium-glucose Transporter Type 2 Inhibition in Anthracycline-related Cardiotoxicity - SPRINTRECRUITINGINTERVENTIONALSodium-glucose transport-2 (SGLT-2) inhibitors, Standard medical treatment
NCT07245069Use of Dapagliflozin in Primary Prevention of Cardiotoxicity of Anthracycline Chemotherapy in Breast Cancer PatientsRECRUITINGINTERVENTIONALDapagliflozin 10 mg, Placebo
NCT06304857A Multicentre, Randomised, Double-blind, Placebo-controlled Phase III Study, Evaluating the Effect of Dapagliflozin on Prevention of Cardiotoxicity in Breast Cancer Patients Undergoing Anthracycline-based ChemotherapyRECRUITINGINTERVENTIONALDapagliflozin, Placebo
NCT05703126Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With Acute Myeloid LeukemiaRECRUITINGINTERVENTIONALHistory taking, Anthropometry, Complete blood count
NCT04162171Noninvasive Cardiac Radioablation for Ventricular TachycardiaRECRUITINGINTERVENTIONALStereotactic Body Radiotherapy (SBRT) ablation of VT
NCT07686796Anti-PCSK9 Antibody Tafolecimab and Anti-PD-1 Antibody Sintilimab Combined With Neoadjuvant Chemoradiotherapy for pMMR/ MSS Locally Advanced Rectal Cancer : A Prospective, Multicenter, Randomized, Open-Label, Parallel-Controlled TrialNOT YET RECRUITINGINTERVENTIONALShort-course radiotherapy, CAPOX (oxaliplatin/capecitabine), Sintilimab
NCT07436663A Comparative Clinical Study Evaluating the Efficacy of (SGLT2)Inhibitors Versus (DPP-4) Inhibitors in the Prevention of Doxorubicin-Induced Cardiotoxicity Among Egyptian Women With Breast CancerNOT YET RECRUITINGINTERVENTIONALDapagliflozin (5-10 mg daily) - SGLT2 Inhibitor Therapy, Sitagliptin (DPP4 inhibitor), Standard Care (in control arm)
NCT06933251Clinical Study of PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy in the Treatment of pMMR/MSS Locally Advanced Rectal CancerACTIVE NOT RECRUITINGINTERVENTIONALNeoadjuvant Chemoradiotherapy Combined with PD-1 inhibitor Immunotherapy and PCSK9 Inhibitor Therapy
NCT06385262Safety, Efficacy, and Tumor Immune Microenvironment Changes With Neoadjuvant Chemotherapy and Cemiplimab With or Without Alirocumab in Stage 1B-3A Non-Small Cell Lung Cancer: TOP 2301SUSPENDEDINTERVENTIONALAlirocumab, Cemiplimab, Chemotherapy
NCT06468254An Exploratory Clinical Study of Statins for Improving Chemotherapy and Maintenance in Patients With Ovarian Cancer: a Prospective, Multicenter Clinical StudyUNKNOWNINTERVENTIONALStatin, Sugar pill
NCT06241352A Prospective Clinical Trial of Statin Addition to Chemotherapy for Advanced Pancreatic CancerCOMPLETEDINTERVENTIONALstatin addition to chemotherapy
NCT06341842Study Phase II "Proof of Concept", National Multi-centered. Randomised 1:1, Evaluate Whether Dapagliflozin Reduces Chemotherapy Induced Cardiotoxicity in Participants With Breast Cancer Treated With (Neo-) Adjuvant Anthracycline-based Chemotherapy +/- TrastuzumabUNKNOWNINTERVENTIONALDapagliflozin 10mg Tab
NCT05699915Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors: a Prospective Multicentre StudyTERMINATEDINTERVENTIONALCardiology consultation, Chest Computed Tomography (CT) without contrast, Non-invasive endothelial function tests
NCT04879368A Randomised Phase III Open Label Study of Regorafenib + Nivolumab vs Standard Chemotherapy in Refractory Advanced Gastro-Oesophageal Cancer (AGOC)COMPLETEDINTERVENTIONALRegorafenib, Nivolumab, Docetaxel
NCT05728632Cardioprotective Effects of Nebivolol Versus Placebo in Patients Undergoing Chemotherapy With Anthracyclines (CONTROL Trial)UNKNOWNINTERVENTIONALNebivolol, Placebo
NCT04168320CLINICAL EXPLORATION OF THE NON-TARGETED EFFECTS OF STEREOTACTIC RADIOTHERAPY IN PATIENTS WITH UNRESECTABLE BULKY TUMORS TREATED BY PARTIAL HIGH-DOSE IRRADIATION OF HYPOXIC TUMOR SEGMENT: PHASE I PROOF OF PRINCIPLE TRIAL.TERMINATEDINTERVENTIONALSBRT-PATHY (SBRT-based PArtial Tumor irradiation targeting HYpoxic segment)
NCT03186404Randomized Double Blind Placebo Controlled Trial of Statins for the Primary pREvention of Heart Failure in Patients With Cancer Receiving Anthracycline Based ChemotherapyUNKNOWNINTERVENTIONALAtorvastatin, Placebo oral tablet
NCT03297346Early Detection of Cardiovascular Changes After Radiotherapy for Breast Cancer (EARLY HEART Study) in the Frame of the Implications of MEDIcal Low Dose RADiation Exposure (MEDIRAD) European ProjectCOMPLETEDINTERVENTIONALCardiac imaging and circulating biomarkers
NCT03720015Concurrent Training and Nutritional Management Prevent Body Weight Loss During Radiotherapy in a Young Adult With Head and Neck Cancer: A Case Control StudyCOMPLETEDINTERVENTIONALPhysical exercise, Nutritional management
NCT03064854Phase Ib, Multicenter, Open Label Study of PDR001 in Combination With Platinum Doublet Chemotherapy and Other Immunooncology Agents in PD-L1 Unselected, Metastatic NSCLS Patients (ElevatION:NSCLC-101 Trial)TERMINATEDINTERVENTIONALPDR001, Cisplatin, Gemcitabine
NCT02022293Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis: A Multicenter, Double-blind, Placebo-Controlled, Randomized TrialSUSPENDEDINTERVENTIONALAtorvastatin, Placebo
NCT02203552Randomized Placebo Controlled Study of Minocycline for Amelioration of Chemotherapy Induced Affective DisordersCOMPLETEDINTERVENTIONALminocycline hydrochloride, placebo, laboratory biomarker analysis
NCT01849237Russian Single-center Open Randomized Clinical Trial of the Impact of Mesenchymal Stromal Cells Therapy on Organ Dysfunction and 28-day Mortality in Patients With Septic Shock and Severe Neutropenia.UNKNOWNINTERVENTIONALMesenchymal stromal cells, Standard therapy of septic shock
NCT00459771Prospective, Randomized, Pharmacological Intervention Study; Evaluating Effect of the Angiotensin II-receptor (AT1) Blocker Candesartan vs Placebo in Prevention of Trastuzumab-associated Cardiotoxicity in Patients Treated With TrastuzumabCOMPLETEDINTERVENTIONALAT1 blocker candesartan, Placebo
NCT00324727A Random-Assignment Study of Hepatic Arterial Infusion of Melphalan With Venous Filtration Via Peripheral Hepatic Perfusion (PHP) (Delcath System) Versus Best Alternative Care for Ocular and Cutaneous Melanoma Metastatic to the LiverCOMPLETEDINTERVENTIONALmelphalan, regional chemotherapy, systemic chemotherapy
NCT00292526Prevention of Chemotherapy-induced Cardiotoxicity in High-risk PatientsCOMPLETEDINTERVENTIONALEnalapril
NCT06443645Role of Sodium-glucose Linked Transporter 2 (SGLT2) and Its Inhibitor Over CARdiotoxicity Induced by Anthracyclines and Breast Cancer Tumorigenesis - SCARA-BRECRUITINGOBSERVATIONALAnthracycline
NCT06491082Evaluation of Chemotherapy Induced Neuropathy in Solid Cancer PatientsRECRUITINGOBSERVATIONALCisplatin, Carboplatin, Paclitaxel, Docetaxel
NCT07157670Cardiovascular Complications in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.NOT YET RECRUITINGOBSERVATIONAL
NCT06597045BIOMARKER and IMAGING CHARACTERISATION of INFLAMMATORY ATHEROMA in PATIENTS RECEIVING IMMUNOTHERAPY and ANGIOGENESIS INHIBITORSACTIVE NOT RECRUITINGOBSERVATIONALPET/CT with 18-FDG
NCT06556979Carotid Artery Stenosis and Ischemic Cerebrovascular Events After Radiotherapy in Patients With Head and Neck CancerCOMPLETEDOBSERVATIONALRadiotherapy
NCT04541212Identification and Evaluation of Patients at Risk of Developing Cardiotoxicity After Receiving Chemotherapy for Breast Cancer, Lymphoma or LeukemiaACTIVE NOT RECRUITINGOBSERVATIONALCardiac Imaging, Data Collection
NCT05118178Prognostic Significance of the Atherosclerosis in the Coronary Arteries Assessed in Computed Tomography on the Cardiotoxicity Development After Oncological TreatmentCOMPLETEDOBSERVATIONALechocardiography, computed tomography
NCT03575650Early Detection of Imaging-derived Subclinical Cardiac Injuries After Radiotherapy and Chemotherapy for Breast CancerUNKNOWNOBSERVATIONALCardiac imaging modalities
NCT03235427The CAROLE (CArdiac Related Oncologic Late Effects) StudyCOMPLETEDOBSERVATIONAL
NCT03206333Automated Quantification of Coronary Artery Calcifications on Radiotherapy Planning CTs for Cardiovascular Risk Prediction in Breast Cancer Patients: the BRAGATSTON StudyCOMPLETEDOBSERVATIONAL
NCT00885950Prevention of the Hepatic Sinusoidal Obstruction Syndrome Secondary to Oxaliplatin-based Neoadjuvant Chemotherapy for Colorectal Liver Metastases by Means of AnticoagulantsCOMPLETEDOBSERVATIONAL

Genetic associations (0)

None linked.