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Cancer

Comorbid ConditionsDisease / conditionrisknon modifiable
41
evidence score

Also known as: cancer patients, cancer survivor, malignancy

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 16.4meta-analyses: 9.1trials: 15genetic: 0MR bonus:

References (43)

2 meta-analyses / systematic reviews

Clinical trials (145)

showing top 60
NCTTitleStatusTypeInterventions
NCT07543601Enhanced COPD Management in Suspected Lung Cancer Patients - Improving Outcomes Through Timely InterventionRECRUITINGINTERVENTIONALTailored COPD consultations
NCT07070765Sodium-glucose Transporter Type 2 Inhibition in Anthracycline-related Cardiotoxicity - SPRINTRECRUITINGINTERVENTIONALSodium-glucose transport-2 (SGLT-2) inhibitors, Standard medical treatment
NCT07217938TRADstat: Novel Treatment of Radiation Associated Dysphagia With StatinsRECRUITINGINTERVENTIONALPravastatin 40 Mg Oral Tablet
NCT07171190Targeted Abdominal CT in Conjunction With Lung Cancer Screening - a Pilot Study (TACTICAL1): a Randomised Controlled Pilot Study of Adding Abdominal Non-contrast CT to Lung Cancer Screening CT Thorax Amongst High Lung Cancer Risk Ever-smokers Aged 55-70.RECRUITINGINTERVENTIONALLung Cancer Screening Invitation Intervention, Abdominal scan intervention
NCT07076823Safety and Efficacy of Canagliflozin in Patients With Metastatic High Microsatellite Instability (MSI-H) Colorectal Cancer: a Phase I TrialRECRUITINGINTERVENTIONALCanagliflozin
NCT07245069Use of Dapagliflozin in Primary Prevention of Cardiotoxicity of Anthracycline Chemotherapy in Breast Cancer PatientsRECRUITINGINTERVENTIONALDapagliflozin 10 mg, Placebo
NCT06517212Adjuvant Tirzepatide Plus Standard of Care Endocrine Therapy in Patients With Obesity or Overweight Who Have Hormone Receptor-positive, HER2-negative, Node-positive Early Breast Cancer, With Molecular Residual Disease (MRD), as Determined by Circulating Tumor DNA (ctDNA)RECRUITINGINTERVENTIONALTirzepatide
NCT06649331Platform Study of ADC Rechallenge in ADC-treated Metastatic Breast Cancer：A Prospective, Open-label, Phase 2 TrialRECRUITINGINTERVENTIONALSHR-A1811, SHR-A1921, SHR-A2009
NCT06626178ARtificial Intelligence for heAlth and Prevention of Smoking-related DiseasesRECRUITINGINTERVENTIONALComputed tomography (CT) scan low dose, Blood sampling, Tissue sampling (lung)
NCT04915183Phase II Interventional Study Using Atorvastatin to Reduce Cisplatin-Induced Hearing Loss Among Individuals With Head and Neck CancerRECRUITINGINTERVENTIONALPlacebo, Atorvastatin
NCT06304857A Multicentre, Randomised, Double-blind, Placebo-controlled Phase III Study, Evaluating the Effect of Dapagliflozin on Prevention of Cardiotoxicity in Breast Cancer Patients Undergoing Anthracycline-based ChemotherapyRECRUITINGINTERVENTIONALDapagliflozin, Placebo
NCT06682390Contribution of Race to Nutritional Approach to Lower Cardiovascular Risk Factors in Men Undergoing Androgen Deprivation TherapyRECRUITINGINTERVENTIONALHypocaloric anti-inflammatory diet
NCT04789681Single Arm Phase II Trial Using Canakinumab for the Prevention of Lung Cancer (Can-Prevent-Lung)RECRUITINGINTERVENTIONALCanakinumab, Quality-of-Life Assessment
NCT03604627Study of Coronary Calcium Score as a Marker of Post-radiation Vascular Dysplasia in Adults Treated During Childhood for Cancer With Mediastinal IrradiationRECRUITINGINTERVENTIONALCoronal calcium score measurement
NCT07686796Anti-PCSK9 Antibody Tafolecimab and Anti-PD-1 Antibody Sintilimab Combined With Neoadjuvant Chemoradiotherapy for pMMR/ MSS Locally Advanced Rectal Cancer : A Prospective, Multicenter, Randomized, Open-Label, Parallel-Controlled TrialNOT YET RECRUITINGINTERVENTIONALShort-course radiotherapy, CAPOX (oxaliplatin/capecitabine), Sintilimab
NCT07625930RESTAGE (REpurposing STAtins to Improve Outcomes in GastroEsophageal Cancer) Trial: A Phase II Randomized Open-Label Trial of Perioperative Simvastatin Plus Standard-of-Care Systemic Therapy in Gastroesophageal AdenocarcinomaNOT YET RECRUITINGINTERVENTIONALFLOT (Fluorouracil+Leucovorin+Oxaliplatin+Docetaxel), Simvastatin, Durvalumab
NCT07313397Nurse-led and GP-supported Self-management Interventions to Reduce Cardiovascular Risks in Breast Cancer Survivors With Cardiovascular DiseasesNOT YET RECRUITINGINTERVENTIONALSelf-management Interventions
NCT07685938Pharmacologic Therapies to Mitigate Radiation- Associated Heart DiseaseNOT YET RECRUITINGINTERVENTIONALAtorvastatin and Lisinopril, Placebo
NCT07621562Efficacy and Safety of a PCSK9 Inhibitor (Tafolecimab) Combined With Sintilimab and SOX in the Treatment of pMMR/MSS Gastric Cancer: A Multicenter, Prospective, Single-Arm Exploratory StudyNOT YET RECRUITINGINTERVENTIONALTafolecimab plus Sintilimab combined with SOX
NCT06160947Impact of Chiropractic Care on Opioid Use Among Adults With Chronic Non-Cancer Spinal Pain: A Pilot Cluster Randomized Controlled Trial (ACCESS-DC Pilot)NOT YET RECRUITINGINTERVENTIONALUsual Medical Care, Usual Medical Care + Chiropractic Care
NCT07436663A Comparative Clinical Study Evaluating the Efficacy of (SGLT2)Inhibitors Versus (DPP-4) Inhibitors in the Prevention of Doxorubicin-Induced Cardiotoxicity Among Egyptian Women With Breast CancerNOT YET RECRUITINGINTERVENTIONALDapagliflozin (5-10 mg daily) - SGLT2 Inhibitor Therapy, Sitagliptin (DPP4 inhibitor), Standard Care (in control arm)
NCT07261098A Prospective Study of the Efficacy and Safety of Angiotensin Receptor-neprilysin Inhibitor in Patients With Advanced Lung Cancer and Concurrent HypertensionNOT YET RECRUITINGINTERVENTIONALARNI, Anti-hypertensive drugs except ARNI
NCT07014215A Phase II Study Evaluating the Safety and Efficacy of Sintilimab Plus Bevacizumab and Tafolecimab in Patients With Advanced NSCLC Who Have Progressed After Anti- PD- 1/L1 TherapyNOT YET RECRUITINGINTERVENTIONALSintilimab combined with Bevacizumab and tafolecimab
NCT06852560GEM: A Single-Arm Trial Assessing Feasibility of Allostatic Load Biomarkers and CVD Risk Among Black Breast Cancer SurvivorsWITHDRAWNINTERVENTIONALGratitude, exercise, and mindfulness program
NCT06933251Clinical Study of PCSK9 Inhibitor and PD-1 Inhibitor Combined With Neoadjuvant Chemoradiotherapy in the Treatment of pMMR/MSS Locally Advanced Rectal CancerACTIVE NOT RECRUITINGINTERVENTIONALNeoadjuvant Chemoradiotherapy Combined with PD-1 inhibitor Immunotherapy and PCSK9 Inhibitor Therapy
NCT06385262Safety, Efficacy, and Tumor Immune Microenvironment Changes With Neoadjuvant Chemotherapy and Cemiplimab With or Without Alirocumab in Stage 1B-3A Non-Small Cell Lung Cancer: TOP 2301SUSPENDEDINTERVENTIONALAlirocumab, Cemiplimab, Chemotherapy
NCT06468254An Exploratory Clinical Study of Statins for Improving Chemotherapy and Maintenance in Patients With Ovarian Cancer: a Prospective, Multicenter Clinical StudyUNKNOWNINTERVENTIONALStatin, Sugar pill
NCT06391905PCSK9 Inhibitors in Combination With Advanced Treatment Strategies for the Treatment of Advanced Colorectal Cancer With pMMR/MSSNOT YET RECRUITINGINTERVENTIONALPCSK9 inhibitor in combination with standard advanced first-line regimen group, standard advanced first-line regimen group
NCT06241352A Prospective Clinical Trial of Statin Addition to Chemotherapy for Advanced Pancreatic CancerCOMPLETEDINTERVENTIONALstatin addition to chemotherapy
NCT06212700Virtual Multimodal Hub for Patients Undergoing Major Gastrointestinal Cancer Surgery - PRIORITY-CONNECT 2 Pilot Randomised Type I Hybrid Effectiveness-Implementation TrialUNKNOWNINTERVENTIONALPreoperative Exercise, Postoperative Exercise, Preoperative Nutrition
NCT06341842Study Phase II "Proof of Concept", National Multi-centered. Randomised 1:1, Evaluate Whether Dapagliflozin Reduces Chemotherapy Induced Cardiotoxicity in Participants With Breast Cancer Treated With (Neo-) Adjuvant Anthracycline-based Chemotherapy +/- TrastuzumabUNKNOWNINTERVENTIONALDapagliflozin 10mg Tab
NCT06046755Evaluation of Changes in the Methylome and Prognosis of Obesity-related Breast Cancer After Nutritional Intervention-induced Weight Loss During the Oncological TreatmentUNKNOWNINTERVENTIONALVery low calorie ketogenic diet (VLCKD), Group educational intervention program (IGOBE)
NCT05976893Study on the Composite Endpoint Event of PCSK9 Inhibitor in Patients With Very High Risk of ASCVD and CancerUNKNOWNINTERVENTIONALEvolocumab, Statin
NCT05984602A Phase IB Study to Determine the Safety and Tolerability of Canakinumab and Tislelizumab in Combination With Nab-Paclitaxel and Gemcitabine in the Neo-adjuvant Treatment of Patients With Pancreatic CancerACTIVE NOT RECRUITINGINTERVENTIONALCanakinumab, Tislelizumab, Nab-Paclitaxel
NCT05553834A Phase II Study of PCSK9 Inhibitor Alirocumab and PD-1 Inhibitor Cemiplimab in Patients With Metastatic, Refractory To Prior Anti PD-1 Non-small Cell Lung Cancer: TOP2201ACTIVE NOT RECRUITINGINTERVENTIONALAlirocumab and Cemiplimab
NCT05444062Quebec Lung Cancer Screening PLUS Trial - a Randomized Controlled Trial of an Educational Intervention for Untreated Chronic Obstructive Pulmonary Disease (COPD) and/or Cardiovascular Disease (CVD) Identified During Lung Cancer ScreeningACTIVE NOT RECRUITINGINTERVENTIONALEducational material and treatment recommendations for patients, general practitioners and pharmacists
NCT05718284High Flow Nasal Cannula Oxygen Administration Versus Standard Care After Esophagectomy for Cancer: a Randomized Controlled Trial.UNKNOWNINTERVENTIONALAIRVO2, STANDARD CARE
NCT05565638PROlonged Nightly FASTing for Obesity Reduction and Prevention of Disease Prevention in Precursor Multiple Myeloma (PROFAST)COMPLETEDINTERVENTIONALProlonged Fasting Intervention, EDUCATION CONTROL
NCT05766046Early Diagnosis of Lung Cancer of the Italian Pulmonary Screening Network (RISP): Comparative Analysis for the Use of Low Dose Computed Tomography and Promotion of Primary Prevention Interventions in Subjects at High Risk for Lung CancerACTIVE NOT RECRUITINGINTERVENTIONALearly lung cancer detection, blood test
NCT02201381A Non Randomised, Non Blinded Real World Trial of the Safety, Tolerability and Effectiveness of Metabolic Medicines for the Treatment of Cancer Compared Against Matched ControlsWITHDRAWNINTERVENTIONALMetabolic treatment
NCT05331807The Effects of Combined Omega-3 and Vitamin D Supplementation on Nutritional Status, Quality of Life and Inflammatory Markers Among the Breast Cancer Women in Gaza StripCOMPLETEDINTERVENTIONALOmega-3 FA, Vitamin D, Combined Omega-3 and Vitamin D Supplementation
NCT05775822Coronary Artery Calcium and Cardiovascular Risk Factors Analysis After RT for Breast Cancer. A Gender-based Preventive Medicine ApproachCOMPLETEDINTERVENTIONALCT scan and blood sample collection
NCT05144529A Randomized Pilot Study to Investigate the Safety and Immunologic Impact of Evolocumab When Given in Combination With Ipilimumab and Nivolumab in Treatment-Naïve Patients With Metastatic Non-Small Cell Lung CancerTERMINATEDINTERVENTIONALNivolumab, Ipilimumab, Evolocumab
NCT05279690Colchicine to Suppress Pro-tumorigenic Inflammation in Patients with Urothelial Cancer and Other Solid TumorsCOMPLETEDINTERVENTIONALColchicine
NCT04789057Non-commercial Clinical Trial of Statins CAncer Preventive and Pleiotropic TherApy IN Smokers With Chronic Obstructive Pulmonary Disease (COPD)ACTIVE NOT RECRUITINGINTERVENTIONALAtorvastatin 40 Mg Oral Tablet, Placebo
NCT05725343A Phase III Prevention Trial of Canakinumab in Subjects at High Risk for Lung Cancer _ CANAL StudyTERMINATEDINTERVENTIONALCanakinumab, Placebo
NCT05699915Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors: a Prospective Multicentre StudyTERMINATEDINTERVENTIONALCardiology consultation, Chest Computed Tomography (CT) without contrast, Non-invasive endothelial function tests
NCT04205786A Randomized Study of Oral Vitamin B12 for the Treatment of Aromatase Inhibitors (AI)-Associated Musculoskeletal Symptoms (AIMSS) in Women With Early Stage Breast CancerWITHDRAWNINTERVENTIONALVitamin B12, Blood collection, Brief Pain Inventory - Short Form survey
NCT04780477Fiber-rich Foods to Treat Obesity and Prevent Colon CancerACTIVE NOT RECRUITINGINTERVENTIONALHigh Fiber Diet Featuring Legumes (HLD), Healthy American Diet
NCT04825288A Phase I/II Randomized, Double-blind, Placebo-controlled Trial (1-BETTER) Examining XB2001 (Anti-IL-1⍺ True Human Antibody) in Combination With ONIVYDE + 5-FU/LV (+Folinic Acid) in Advanced Pancreatic CancerACTIVE NOT RECRUITINGINTERVENTIONALXB2001 or Placebo
NCT04913155HANSE - Holistic Implementation Study Assessing a Northern German Interdisciplinary Lung Cancer Screening Effort, Population-based Screening Study -Prospective, Randomized Comparator ControlledACTIVE NOT RECRUITINGINTERVENTIONALLow-dose CT screening
NCT04879368A Randomised Phase III Open Label Study of Regorafenib + Nivolumab vs Standard Chemotherapy in Refractory Advanced Gastro-Oesophageal Cancer (AGOC)COMPLETEDINTERVENTIONALRegorafenib, Nivolumab, Docetaxel
NCT04758650Phase II Study to Evaluate the Clinical Potential of 68GaNOTA-Anti-MMR-VHH2 for in Vivo Imaging of MMR-expressing Macrophages by Means of Positron Emission Tomography (PET) in Oncological Lesions,Cardiovascular Atherosclerosis,Syndrome With Abnormal Immune Activation and sarcoïdosisTERMINATEDINTERVENTIONAL68GaNOTA-Anti-MMR-VHH2
NCT04229004Precision Promise Platform Trial for Metastatic Pancreatic CancerCOMPLETEDINTERVENTIONALGemcitabine combined with nab-paclitaxel, Dose -mFOLFIRINOX, Dose - Pamrevlumab combined with gemcitabine and nab-paclitaxel
NCT03661047OMICC: OMega-3 Fatty Acid for the Immune Modulation of Colorectal CancerWITHDRAWNINTERVENTIONALAMR101 (VASCEPA, icosapent ethyl)
NCT03968419A Randomized, Open-label, Phase II Study of Canakinumab or Pembrolizumab as Monotherapy or in Combination as Neoadjuvant Therapy in Subjects With Resectable Non-small Cell Lung Cancer (CANOPY-N)TERMINATEDINTERVENTIONALCanakinumab, Pembrolizumab
NCT04184713A Clinical Trial With Nutritional Intervention to Evaluate the Effect of an Specific Oral Nutritional Supplement on the Nutritional Status in Patients With Cancer and MalnutritionCOMPLETEDINTERVENTIONALExperimental Group, Control Group
NCT03742349A Phase Ib, Multicenter, Open-label Dose Escalation and Expansion Platform Study of Select Immunotherapy Combinations in Adult Patients With Triple-negative Breast CancerTERMINATEDINTERVENTIONALspartalizumab, LAG525, NIR178
NCT05728632Cardioprotective Effects of Nebivolol Versus Placebo in Patients Undergoing Chemotherapy With Anthracyclines (CONTROL Trial)UNKNOWNINTERVENTIONALNebivolol, Placebo
NCT03785808The Impact of Diet Quality on Biomarkers Associated With Lung Cancer Outcomes: Reducing Insulin, Growth Hormones, and Tumors (RIGHT Study)TERMINATEDINTERVENTIONALSpecial Diet Therapy (low-carb), Special Diet Therapy (low-fat), Special Diet Therapy (USDA control)

Genetic associations (0)

None linked.