A
Cardiac autonomic dysfunction (reduced heart rate variability)
Novel & Emerging BiomarkersPhysical parameterriskpartially modifiable
41
evidence score
Also known as: Cardiac autonomic dysfunction, autonomic dysfunction, heart rate variability, resting heart rate
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 16.1meta-analyses: 13.8trials: 11.4genetic: 0MR bonus:
References (40)
4 meta-analyses / systematic reviews- METASedentary behaviour, physical activity and psychobiological stress reactivity: A systematic review. — Biological psychology 2022 · PMID 35667480
- METAThe effect of obstructive sleep apnea therapy on cardiovascular autonomic function: a systematic review and meta-analysis. — Sleep 2022 · PMID 36107126
- METACardiovascular Responses to Muscle Stretching: A Systematic Review and Meta-analysis. — International journal of sports medicine 2021 · PMID 33440445
- METALead exposure and cardiovascular disease--a systematic review. — Environmental health perspectives 2006 · PMID 17431501
- Concomitant Diabetes and Atrial Fibrillation: Epicardial Fat and Macrophage-Related Mechanisms. — Diabetes/metabolism research and reviews 2025 · PMID 40587764
- Depression and Anxiety Associate With Adverse Cardiovascular Events via Neural, Autonomic, and Inflammatory Pathways. — Circulation. Cardiovascular imaging 2025 · PMID 41404670
- Effects of shift work on sleep quality and cardiovascular function in Taiwanese police officers. — Chronobiology international 2024 · PMID 38421010
- Sex-specific and polygenic effects underlying resting heart rate and associated risk of cardiovascular disease. — European journal of preventive cardiology 2024 · PMID 38437179
- Paradoxical Associations of Occupational and Nonoccupational Sedentary Behavior With Cardiovascular Disease Risk Measures in Desk Workers. — Journal of occupational and environmental medicine 2023 · PMID 37130827
- Chronic obstructive pulmonary disease and cardiovascular disease: mechanistic links and implications for practice. — Current opinion in pulmonary medicine 2023 · PMID 38085609
- Diet quality trajectories and cardiovascular phenotypes/metabolic syndrome risk by 11-12 years. — International journal of obesity (2005) 2021 · PMID 33824404
- Exploring the Relationship Between Schizophrenia and Cardiovascular Disease: A Genetic Correlation and Multivariable Mendelian Randomization Study — Schizophrenia Bulletin 2021 · PMID 34730178
- Autonomic dysfunction and cardiovascular risk in post-traumatic stress disorder. — Autonomic neuroscience : basic & clinical 2021 · PMID 34844132
- Sex differences in post-traumatic stress disorder risk: autonomic control and inflammation. — Clinical autonomic research : official journal of the Clinical Autonomic Research Society 2020 · PMID 33021709
- The Cardiovascular Effects of Newer Antidepressants in Older Adults and Those With or At High Risk for Cardiovascular Diseases. — CNS drugs 2020 · PMID 33064291
- Effect of chronic stress on cardiovascular and ventilatory responses activated by both chemoreflex and baroreflex in rats. — The Journal of experimental biology 2019 · PMID 31558591
- Prognostic Cardiovascular Markers in Chronic Kidney Disease. — Kidney & blood pressure research 2018 · PMID 30153666
- Mercury Exposure and Heart Diseases. — International journal of environmental research and public health 2017 · PMID 28085104
- Pulse wave velocity and cardiac autonomic function in type 2 diabetes mellitus. — BMC endocrine disorders 2017 · PMID 28526073
- An Overview of Heart Rate Variability Metrics and Norms — Frontiers in Public Health 2017 · PMID 29034226
- Circadian misalignment increases cardiovascular disease risk factors in humans. — Proceedings of the National Academy of Sciences of the United States of America 2016 · PMID 26858430
- Potential Harmful Effects of PM2.5 on Occurrence and Progression of Acute Coronary Syndrome: Epidemiology, Mechanisms, and Prevention Measures. — International journal of environmental research and public health 2016 · PMID 27463723
- Racial and ethnic disparities in health: examining the contexts that shape resilience and risk. — Psychosomatic medicine 2015 · PMID 25551202
- Heart rate and cardiovascular protection. — European journal of internal medicine 2015 · PMID 25704330
- Autonomic and inflammatory consequences of posttraumatic stress disorder and the link to cardiovascular disease. — American journal of physiology. Regulatory, integrative and comparative physiology 2015 · PMID 26062635
- The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus — Cardiovascular Diabetology 2014 · PMID 24475922
- Effect of Weight Loss on the Cardiovascular Risk Profile of Obese Patients with Psoriasis — Acta Dermato Venereologica 2014 · PMID 24556829
- Associations of Chronotype and Sleep With Cardiovascular Diseases and Type 2 Diabetes — Chronobiology International 2013 · PMID 23281716
- Reducing Personal Exposure to Particulate Air Pollution Improves Cardiovascular Health in Patients with Coronary Heart Disease — Environmental Health Perspectives 2012 · PMID 22389220
- Air Pollution and Autonomic and Vascular Dysfunction in Patients With Cardiovascular Disease: Interactions of Systemic Inflammation, Overweight, and Gender — American Journal of Epidemiology 2012 · PMID 22763390
- Depression and heart rate variability in patients with coronary heart disease. — Cleveland Clinic journal of medicine 2009 · PMID 19376975
- Air pollution and cardiovascular disease. — Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 2009 · PMID 19697799
- Work stress and coronary heart disease: what are the mechanisms? — European heart journal 2008 · PMID 18216031
- Analysis of potential predictors of depression among coronary heart disease risk factors including heart rate variability, markers of inflammation, and endothelial function — European Heart Journal 2008 · PMID 18400765
- Obstructive sleep apnea. — Annals of internal medicine 2005 · PMID 15684207
- Cardiovascular Effects of Secondhand Smoke — Circulation 2005 · PMID 15911719
- Depression and Heart Rate Variability in Patients With Stable Coronary Heart Disease — Archives of General Psychiatry 2005 · PMID 15939843
- Depression, the autonomic nervous system, and coronary heart disease. — Psychosomatic medicine 2005 · PMID 15953797
- Coronary artery disease and depression. — European heart journal 2004 · PMID 14683736
- Obstructive sleep apnea and cardiovascular disease. — Mayo Clinic proceedings 2004 · PMID 15301332
Clinical trials (13)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06579950 | The Effects of Cool Roofs on Health, Environmental, and Economic Outcomes: a Global Multi-center Cluster-randomized Controlled Trial | RECRUITING | INTERVENTIONAL | Cool roof |
| NCT07592117 | A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in Tavua, Fiji | NOT YET RECRUITING | INTERVENTIONAL | Cool roof |
| NCT06834893 | A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in Colima, Mexico | NOT YET RECRUITING | INTERVENTIONAL | Cool roof |
| NCT06570993 | A Cluster Randomised Controlled Trial (cRCT) Evaluating the Effects of Cool Roofs on Health, Environmental and Economic Outcomes in Niue | COMPLETED | INTERVENTIONAL | Cool roof |
| NCT05612776 | High Intensity Interval Training (HIIT) vs Heart Rate Variability (HRV) Training for Cardiac and Functional Rehabilitation After Stroke | UNKNOWN | INTERVENTIONAL | HIIT, HRV |
| NCT01864824 | Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial | COMPLETED | INTERVENTIONAL | methyl donor, Placebo |
| NCT00721617 | Free Fatty Acids-Induced Hypertension, Endothelial Dysfunction, Inflammation, Insulin Resistance, and Autonomic Dysfunction in Lean and Obese Subjects | COMPLETED | INTERVENTIONAL | Intralipid 20%, Normal Saline, Oral fat load |
| NCT06740942 | Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke | RECRUITING | OBSERVATIONAL | |
| NCT05502094 | Identification of the Effects of Post Covid Syndrome on the Autonomic Nervous System With Heart Rate Variability | COMPLETED | OBSERVATIONAL | Heart Rate Variability Measurement |
| NCT05247840 | INvesTigation the Abnormality of Detrusor ConTractility by Uroflowmetry in Diabetic Children (INTACT Trial) - a Prospective, Cross-sectional, Observational, Controlled Study | NOT YET RECRUITING | OBSERVATIONAL | uroflowmetry, Cardiovascular autonomic dysfunction test proposed by Ewing et al., peripheral nerve conduction test |
| NCT05164523 | The Effect of SGLT2 Inhibitors on Heart Rate Variability, Sympathetic and Parasympathetic Activity and a Neuroinflammatory Biomarker, Brain-Derived Neurotrophic Factor Levels in Patients With Type 2 Diabetes | COMPLETED | OBSERVATIONAL | 24-hour rhythm Holter, 36 item Short Form Survey (SF-36) |
| NCT01993745 | The Analysis of Heart Rate Variability With 24hrs Holter ECG and Serum Cardiac Fibrosis Markers in Critical Illness Patients Who Are With Cardiogenic Shock, With ECMO or IABP Support, or With APACH II Score >25) | COMPLETED | OBSERVATIONAL | |
| NCT00005399 | Cohort Study of Heart Rate Variability | COMPLETED | OBSERVATIONAL | No interventions |
Genetic associations (0)
None linked.