C
Carotid atherosclerosis
Imaging & Subclinical DiseaseImaging markerriskpartially modifiable
21
evidence score
Also known as: asymptomatic carotid atherosclerosis, carotid artery atherosclerosis, carotid artery disease
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 6meta-analyses: 0trials: 15genetic: 0MR bonus:
References (3)
0 meta-analyses / systematic reviews- Advances in noninvasive imaging for evaluating clinical risk and guiding therapy in carotid atherosclerosis. — Expert review of cardiovascular therapy 2012 · PMID 22149525
- Inflammation and Carotid Artery--Risk for Atherosclerosis Study (ICARAS). — Circulation 2005 · PMID 15851593
- Asymptomatic carotid bruit. — Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 2005 · PMID 15861909
Clinical trials (82)
showing top 60| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07200180 | Perioperative Argon Inhalation to Improve Neurocognitive Recovery After Carotid Surgery (PAIRS Trial) | RECRUITING | INTERVENTIONAL | Аrgon-oxygen breathing mixture, Nitrogen-oxygen breathing mixture |
| NCT06924593 | Study on the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System for Carotid Artery Revascularization During Endovascular Treatment | RECRUITING | INTERVENTIONAL | Trans-Carotid Artery Occlusion Shunt System |
| NCT07104487 | An Exploratory Study of [18F]AlF-NOTA-octreotide PET/MRI in Carotid Artery Disease | RECRUITING | INTERVENTIONAL | [18F]AlF-OC |
| NCT06590012 | Prospective, Double-blind, Comparative Randomized Placebo-controlled Multicenter Study Evaluating the Impact of Oral Administration of the Peroral Supplement "Tertinat" with Dosage of 330 Mg/day for Patients with Cardiovascular Diseases, the Cause of Which is Atherosclerosis, on the Background of Standard Treatment. | RECRUITING | INTERVENTIONAL | Placebo, Tertinat |
| NCT06959628 | Study on the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System Combined With Introducer Sets for Cerebral Protection During Carotid Angioplasty | RECRUITING | INTERVENTIONAL | Trans-Carotid Artery Occlusion Shunt System Combined with Introducer Sets |
| NCT06541691 | Coated or Chewable Aspirin in Patients with Established Atherosclerotic Disease and a Hybrid Strategy to Mitigate the Adverse Effects of Air Pollution: the COATED-AIR Randomized Clinical Trial | RECRUITING | INTERVENTIONAL | Enteric-coated aspirin, Plain aspirin, Hybrid strategy |
| NCT06511089 | Carotid Artery Stenting During Endovascular Treatment of Acute Ischemic Stroke: A Randomized Multicenter Clinical Trial in Patients With Acute Ischemic Stroke and Carotid Artery Stenosis Undergoing Endovascular Treatment | RECRUITING | INTERVENTIONAL | carotid artery stenting during EVT, no carotid artery stenting during EVT |
| NCT04261478 | A Multi-centre, Prospective, Randomized, Open-label, Blinded Endpoint (PROBE) Controlled Trial Comparing Cervical Internal Carotid Artery Stenting to no Stenting During Thrombectomy for Tandem Occlusion Stroke | RECRUITING | INTERVENTIONAL | Carotid artery stenting, Antiplatelet Agents |
| NCT02748941 | Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-control | RECRUITING | INTERVENTIONAL | HITS quantification, Ultrasound examinations, High Resolution MRI |
| NCT06864299 | Study on the Safety and Efficacy of the Trans-Carotid Artery Occlusion Shunt System Combined With Introducer Sets for Cerebral Protection During Carotid Angioplasty | COMPLETED | INTERVENTIONAL | Trans-Carotid Artery Occlusion Shunt System Combined with Introducer Sets |
| NCT06207643 | Conventional Vs. Eversion Carotid Endarterectomy Immediate and Short-Term Outcomes | UNKNOWN | INTERVENTIONAL | carotid endarterectomy |
| NCT05845710 | Protection Against Emboli During caRotid Artery Stenting Using a Neuroguard IEP® Direct 3-in-1 Delivery System Comprised oF a pOst-dilation Balloon, integRated eMbolic Filter, and A Novel Carotid stEnt - the PERFORMANCE III Study | COMPLETED | INTERVENTIONAL | Neuroguard IEP Direct System |
| NCT05574972 | A Prospective, Multi-center and Randomized Controlled Clinical Trial to Evaluate the Efficacy and Safety of Timing Carotid Stent for Carotid Artery Stenosis（Timing Trial） | UNKNOWN | INTERVENTIONAL | Timing Carotid Stent, Carotid Wallstent |
| NCT05416853 | Radial Versus Femoral Access For Carotid Artery Stenting In Patients With Carotid-Artery Stenosis ：a Prospective, Randomized, Multicenter, Noninferiority Trial | ACTIVE NOT RECRUITING | INTERVENTIONAL | Carotid Artery Stenting (CAS) |
| NCT05126238 | A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction: A Double-Blind, Placebo Control Randomized Trial (BINOS) | TERMINATED | INTERVENTIONAL | Lithium Carbonate, Placebo |
| NCT04470687 | Innovative Applications of Ultrafast Ultrasound Imaging in Peripheral Vascular Pathology: Evaluation of Carotid Plaque Vulnerability by Quantification of Neovascularization | COMPLETED | INTERVENTIONAL | contrast enhanced ultrafast ultrasound imaging |
| NCT04730973 | CARotid plaqUe StabilizatiOn and Regression With Evolocumab: the CARUSO Study | UNKNOWN | INTERVENTIONAL | Evolocumab, lipid-lowering therapy (LLT) |
| NCT04201132 | Protection Against Emboli During Carotid Artery Stenting Using a 3-in-1 Delivery System Comprised of a Post-dilation Balloon, Integrated Embolic Filter and a Novel Carotid Stent - the PERFORMANCE II Study | ACTIVE NOT RECRUITING | INTERVENTIONAL | Carotid artery stenting with Neuroguard IEP System |
| NCT02995642 | Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation | WITHDRAWN | INTERVENTIONAL | 18F-FPPRGD2, Positron emission tomography, Computed tomography |
| NCT04255316 | Modified Method of Eversion Carotid Endarterectomy in Patients With Extensive Atherosclerotic Disease of Carotid Bifurcation | COMPLETED | INTERVENTIONAL | Modified method of eversion carotid endarterectomy, Standard method of eversion carotid endarterectomy |
| NCT03141580 | Long-term Follow-up Near-infrared Spectroscopy and Intravascular Ultrasound Imaging of Internal Carotid Artery Stenosis Treated With Stenting | COMPLETED | INTERVENTIONAL | Near-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS) |
| NCT04835571 | CARotid Mri of Atherosclerosis | COMPLETED | INTERVENTIONAL | Optimization of cardiovascular risk management |
| NCT04271033 | Long-term Outcomes of MicroNet-covered Stent Routine Use for Stroke Prevention in Symptomatic and Increased-risk Asymptomatic Carotid Stenosis Patients Requiring Revascularization by Neurovascular Team Decision: PARADIGM-EXTEND | UNKNOWN | INTERVENTIONAL | Carotid Artery Stenting |
| NCT02722720 | Prospective, Randomized, Single Center Study of Atherothrombotic and Thromboembolic Events After Carotid Artery Stenting Using Transfemoral and Transradial Approach | COMPLETED | INTERVENTIONAL | Transradial carotid artery stenting, Transfemoral carotid artery stenting |
| NCT03764306 | New Ischemic Cerebral Lesions Revealed by the Imaging Magnetic Resonance Imaging After Endarterectomy vs. Stenting Under Proximal Protection for the Treatment of Symptomatic Carotid Stenosis: Results of a Randomised Prospective Trial | TERMINATED | INTERVENTIONAL | Carotid Artery Stenting, Endarterectomy carotid artery |
| NCT02097186 | Preconditioning Shields Against Vascular Events in Surgery: A Multi-centre Feasibility Trial of Preconditioning Against Adverse Events in Major Vascular Surgery (Preconditioning-SAVES) | UNKNOWN | INTERVENTIONAL | Remote ischaemic preconditioning |
| NCT02629653 | Body Cooling During Carotid Endarterectomy: No-profit, Open, Mono-centric, Feasibility Study | COMPLETED | INTERVENTIONAL | endovascular cooling (Zoll system) |
| NCT01968226 | An Exploratory, Phase II, Open Label, Single-Center, Non-Randomized Study Of [F-18] RGD-K5 Positron Emission Tomography (PET) In Participants With Carotid Artery Stenosis | TERMINATED | INTERVENTIONAL | [F-18] RDG-K5 |
| NCT03333330 | Non Invasive Vascular Imaging Combined With Systemic Biomarkers and Brain Magnetic Resonance Imaging for Identification of Asymptomatic Patients With Unstable Carotid Atherosclerosis | COMPLETED | INTERVENTIONAL | Visipaque 320 and SonoVue |
| NCT01691911 | Preconditioning Shields Against Vascular Events in Surgery. A Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgery | COMPLETED | INTERVENTIONAL | Remote preconditioning |
| NCT01445613 | CANOPY: Carotid Artery Stenting Outcomes in the Standard Risk Population for Carotid Endarterectomy | COMPLETED | INTERVENTIONAL | RX Acculink Carotid Stent System (RX Acculink) |
| NCT01414387 | Effects of Cerebral Protection With Filters vs. Flow Reversal on Cerebral Embolization After Carotid Artery Stenting | TERMINATED | INTERVENTIONAL | Carotid filter, Carotid reversal of flow |
| NCT01133327 | Adapt™ Monorail™ Carotid Stent System: A Postmarket Clinical Follow-up Study | COMPLETED | INTERVENTIONAL | Carotid Artery Stenting |
| NCT01534533 | The Effects of Lutein Supplementation on Subclinical Atherosclerosis | COMPLETED | INTERVENTIONAL | Placebo, Lutein group, Combination group |
| NCT01210937 | Early Warning and Optimization Strategy in Carotid Endarterectomy | UNKNOWN | INTERVENTIONAL | CEA and TCD monitoring |
| NCT02133807 | A 72-week, Prospective, Parallel-group, Partially Blinded, Controlled Phase IIIb Study Evaluating the Impact of Specific Lp(a) Apheresis on Atherosclerotic Disease Burden in Coronary Heart Disease Patients With High Lipoprotein(a) Level. | COMPLETED | INTERVENTIONAL | Specific Lp(a) apheresis |
| NCT00723307 | A Randomised Placebo-controlled Trial of Metformin on Progression of Carotid Atherosclerosis in Non-diabetic Patients With Cardiovascular Disease Treated With Conventional Risk Reducing Agents | COMPLETED | INTERVENTIONAL | Metformin, Placebo |
| NCT01203982 | Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima Media Thickness and Its Relation to Plaque Components of the Coronary Arteries in Patients With ST-Segment Elevation Acute Myocardial Infarction | COMPLETED | INTERVENTIONAL | Rosuvastatin, Rosuvastatin |
| NCT00711919 | Pitavastatin Evaluation of Atherosclerosis Regression by Intensive Cholesterol-Lowering Therapy | UNKNOWN | INTERVENTIONAL | Pitavastatin, Pitavastatin |
| NCT00287508 | Emboshield and Xact Post Approval Carotid Stent Trial Using the Emboshield® BareWire™ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System | COMPLETED | INTERVENTIONAL | Carotid artery stenting with filter (interventional) |
| NCT00147251 | Stop Atherosclerosis in Native Diabetics Study | COMPLETED | INTERVENTIONAL | FDA approved drugs to treat blood pressure and cholesterol |
| NCT00178672 | A Single Center IDE Study on Carotid Stenting With Distal Protection for the Treatment of Obstructive Carotid Artery Disease | COMPLETED | INTERVENTIONAL | Angioguard XP distal protection device, Heart Catheterization -Angioplasty, stenting |
| NCT00316108 | Boston Scientific EPI: A Carotid Stenting Trial for High-Risk Surgical Patients | COMPLETED | INTERVENTIONAL | WALLSTENT® Endoprosthesis™ |
| NCT00001368 | Cytokine and Leukocyte Activation Profile as a Risk Factor for Cerebral Vascular Disease and Stroke | COMPLETED | INTERVENTIONAL | cytokine and leukocyte activation profile |
| NCT07166731 | High Coverage CARotid Stenting vs. Medical Management Alone to Prevent EmboliSm From symptomaTic Non-stenotic cARotid Disease (SyNC) - CARESTAR | RECRUITING | OBSERVATIONAL | |
| NCT07296965 | The Role of the Oral Microbiome in Carotid Atherosclerosis: Investigating in a Cross-sectional Study the Microbial Influence on Plaque Development and Vulnerability Based on Biobank Data | RECRUITING | OBSERVATIONAL | Sample Collection |
| NCT06546761 | Selective Coronary Revascularization in Carotid Artery Disease Patients After Carotid Revascularization (SCORECAD Trial) | RECRUITING | OBSERVATIONAL | Coronary CT angiography and FFRct analysis |
| NCT05800821 | Prediction of Cerebral Hyperperfusion Syndrome After Carotid Revascularization Using Deep Learning | RECRUITING | OBSERVATIONAL | Carotid revascularization |
| NCT05838547 | PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With Cu[64]-25%-CANF-Comb-II | RECRUITING | OBSERVATIONAL | 64Cu-25%-CANF-Comb, 64Cu-25%-CANF-Comb |
| NCT05539781 | Change of Hemodynamics and Cerebral Functions After Carotid Artery Revascularization | RECRUITING | OBSERVATIONAL | |
| NCT06882954 | The Management of Asymptomatic Carotid Stenosis: Monocentric Experience | RECRUITING | OBSERVATIONAL | |
| NCT06211725 | The VANGAS-Trial. The Value of Neurofilament Light Chain and Glial Fibrillary Acid Protein in the Blood of Patients With Asymptomatic Carotid Artery Stenosis | UNKNOWN | OBSERVATIONAL | |
| NCT06058507 | "The Incidence of Carotid Web and Its Radiological Classification, Determination of Its Relationship With Ischemic Stroke by Evaluating the Clinical Data and Vascular Risk Factors of Carotid Web Cases" | COMPLETED | OBSERVATIONAL | CT angiography |
| NCT05296876 | Multi-dimensional Evaluation of Carotid Artery Stenosis and Prediction of Brain Function After Endarterectomy by SSPC System | UNKNOWN | OBSERVATIONAL | Carotid endarterectomy (CEA) |
| NCT05623293 | Prognostic Predictors of Cardiovascular and Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis Undergoing Carotid Endarterectomy With Regional Anesthesia - A Prospective Study | UNKNOWN | OBSERVATIONAL | eye - Optcial coherence tomography |
| NCT03668821 | Vascular Frailty - An Observational Cohort Study | UNKNOWN | OBSERVATIONAL | Questionnaire |
| NCT04679727 | Detecting the Vulnerable Carotid Plaque: "The Carotid Artery Multi-modality Imaging Prognostic (CAMP) Study" - Implications for Stroke and Cognitive Decline Prediction in Asymptomatic Carotid Artery Disease | UNKNOWN | OBSERVATIONAL | |
| NCT04821700 | Carotid Artery Atherosclerosis in Ischemic Stroke Patients With Atrial Fibrillation.(Atrial Fibrillation and Carotid Atherosclerosis in Ischemic Stroke Patients- AFCAS) | UNKNOWN | OBSERVATIONAL | Carotid Stenosis |
| NCT04947046 | Carotid Stenosis Management During COVID-19 Era - Best Medical Intervention Alone (CASCOM Pilot Study): A Prospective Observational Study | UNKNOWN | OBSERVATIONAL | |
| NCT04234854 | OPTIMAl Endovascular Exclusion of High-risk Carotid Plaque Using the CGuard™ Stent in Patients With Symptoms or Signs of Carotid Stenosis-related Brain Injury: IVUS Controlled Investigator Initiated Multcentric Multi-specialty Study | UNKNOWN | OBSERVATIONAL | Intravascular Utrasound (IVUS) of Carotid Artery after implantation of CGuard stent |
Genetic associations (0)
None linked.