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Carotid atherosclerotic plaque

Imaging & Subclinical DiseaseImaging markerrisknon modifiable
55
evidence score

Also known as: Carotid plaque, carotid atherosclerosis, carotid plaque, carotid stenosis, increased plaque occurrence

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 20meta-analyses: 20trials: 15genetic: 0MR bonus:

References (98)

13 meta-analyses / systematic reviews

Clinical trials (183)

showing top 60
NCTTitleStatusTypeInterventions
NCT07412249Remote Ischemic Conditioning Plus Stenting for Symptomatic Carotid Artery Stenosis (RICSICAS): A Prospective, Randomized Controlled, Blind Endpoint, Single-Center StudyRECRUITINGINTERVENTIONALRemote ischemic conditioning
NCT07054060Endarterectomy Versus Stenting in Patients With Symptomatic Severe Carotid Stenosis - 2RECRUITINGINTERVENTIONALcarotid endarterectomy, Carotid artery stenting
NCT06590012Prospective, Double-blind, Comparative Randomized Placebo-controlled Multicenter Study Evaluating the Impact of Oral Administration of the Peroral Supplement "Tertinat" with Dosage of 330 Mg/day for Patients with Cardiovascular Diseases, the Cause of Which is Atherosclerosis, on the Background of Standard Treatment.RECRUITINGINTERVENTIONALPlacebo, Tertinat
NCT06541691Coated or Chewable Aspirin in Patients with Established Atherosclerotic Disease and a Hybrid Strategy to Mitigate the Adverse Effects of Air Pollution: the COATED-AIR Randomized Clinical TrialRECRUITINGINTERVENTIONALEnteric-coated aspirin, Plain aspirin, Hybrid strategy
NCT06873321Incidence of Venous Thromboembolism After Lower Limb Revascularization in Patients Receiving Rivaroxaban 2.5 Mg Bid + Aspirin 100 Mg Versus Single Antiplatelet Treatment - a Randomized Clinical TrialRECRUITINGINTERVENTIONALrivaroxaban 2.5 mg bid + aspirin 100 mg, clopidogrel 75 mg od for 3 months followed by aspirin 100 mg od for endovascular procedures or aspirin for open procedures
NCT05850247Plaque and Brain Inflammation in Symptomatic Carotid Stenosis: Role of the Ficolin-2RECRUITINGINTERVENTIONAL[18F]DPA-714 PET/MRI
NCT05922137Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) Diet in Patients With Intracranial / Carotid Stenosis : a Randomized Controlled TrialRECRUITINGINTERVENTIONALUsual Diet advice, Oriental Intervention for Enhanced Neurocognitive Health (ORIENT) diet
NCT06511089Carotid Artery Stenting During Endovascular Treatment of Acute Ischemic Stroke: A Randomized Multicenter Clinical Trial in Patients With Acute Ischemic Stroke and Carotid Artery Stenosis Undergoing Endovascular TreatmentRECRUITINGINTERVENTIONALcarotid artery stenting during EVT, no carotid artery stenting during EVT
NCT05436600Asymptomatic Carotid Stenosis and Mobility Function With Exercise InterventionRECRUITINGINTERVENTIONALExercise Intervention
NCT04261478A Multi-centre, Prospective, Randomized, Open-label, Blinded Endpoint (PROBE) Controlled Trial Comparing Cervical Internal Carotid Artery Stenting to no Stenting During Thrombectomy for Tandem Occlusion StrokeRECRUITINGINTERVENTIONALCarotid artery stenting, Antiplatelet Agents
NCT02748941Carotid Atherosclerosis : Innovative Imaging Biomarkers. Study Case-controlRECRUITINGINTERVENTIONALHITS quantification, Ultrasound examinations, High Resolution MRI
NCT07586540Alirocumab for Stabilisation of Symptomatic Vulnerable Carotid Plaque: A Multicentre, Randomised, Double-Blind, Placebo-Controlled Trial With High-Resolution Vessel-Wall MRI and Clinical EndpointsNOT YET RECRUITINGINTERVENTIONALAlirocumab, Placebo, Atorvastatin
NCT06705010Non-Invasive Monitoring of Brain Metabolites Using Novel and Adapted Proton and Deuterium MR TechniquesNOT YET RECRUITINGINTERVENTIONALApplication of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
NCT05980195Cognitive Improvement After cARotid stEnting in HyperBaric Oxygen Therapy Trial (CARE-HBOT)NOT YET RECRUITINGINTERVENTIONALHyperbaric oxygen therapy, Standard medical treatment, Risk factor management
NCT06123767Evaluation of Diagnostic and Predictive Capabilities of Novel Application of Carotid Carotid Stenosis Pressure Gradient Measurement in Patients Undergoing Percutaneous Carotid Angioplasty and Stenting (CAS).NOT YET RECRUITINGINTERVENTIONALCAS + Intravascular measuring the pressure gradient, CAS (standard), Doppler ultrasonound of cephalic arteries
NCT06207643Conventional Vs. Eversion Carotid Endarterectomy Immediate and Short-Term OutcomesUNKNOWNINTERVENTIONALcarotid endarterectomy
NCT05845710Protection Against Emboli During caRotid Artery Stenting Using a Neuroguard IEP® Direct 3-in-1 Delivery System Comprised oF a pOst-dilation Balloon, integRated eMbolic Filter, and A Novel Carotid stEnt - the PERFORMANCE III StudyCOMPLETEDINTERVENTIONALNeuroguard IEP Direct System
NCT05905848Pre-operative Antihypertensive Drugs and Persistent Hypotension in Carotid Artery Stenting Comorbid With Hypertension Patients --- a Multicenter, Randomized, Open Label, Blinded Ended Point Clinic TrailUNKNOWNINTERVENTIONALadministering RASI (the trade name or universal name will not be stipulated) before stenting, administering CCB (the trade name or universal name will not be stipulated) before stenting
NCT05835869Electrophysiological and Morphofunctional Changes of Retina and Choroid Vascularization After Carotid Endarterectomy, a Pilot StudyUNKNOWNINTERVENTIONALOptical coherence tomography angiography and pattern electroretinogram
NCT05623904Carotid Revascularization Versus Best Medical Treatment for Asymptomatic Carotid Stenosis: a Multicenter, Open, Randomized Controlled Trial in Chinese PopulationUNKNOWNINTERVENTIONALCarotid Revascularization, Medical Treatment
NCT05437991Ultrasonographic Morphology Assessment of Low-grade Carotid StenosisCOMPLETEDINTERVENTIONALIndependent morphological quantifications by echo-doppler using ECST method
NCT04904250SpiderFX Versus Emboshield Nav6 Distal Protection on Cerebral Microembolization in Vulnerable Plaque During Carotid Artery StentingUNKNOWNINTERVENTIONALEmboshield, Spider
NCT05416853Radial Versus Femoral Access For Carotid Artery Stenting In Patients With Carotid-Artery Stenosis ：a Prospective, Randomized, Multicenter, Noninferiority TrialACTIVE NOT RECRUITINGINTERVENTIONALCarotid Artery Stenting (CAS)
NCT05355259ACCESS : ACtive Catheterization for EndovaScular TreatmentSCOMPLETEDINTERVENTIONALGECKO Active Guidewire
NCT04091074Safety and Effectiveness of Ticagrelor in Patients Undergoing Carotid StentingUNKNOWNINTERVENTIONALTicagrelor, Clopidogrel, Carotid stenting
NCT04470687Innovative Applications of Ultrafast Ultrasound Imaging in Peripheral Vascular Pathology: Evaluation of Carotid Plaque Vulnerability by Quantification of NeovascularizationCOMPLETEDINTERVENTIONALcontrast enhanced ultrafast ultrasound imaging
NCT04730973CARotid plaqUe StabilizatiOn and Regression With Evolocumab: the CARUSO StudyUNKNOWNINTERVENTIONALEvolocumab, lipid-lowering therapy (LLT)
NCT04758650Phase II Study to Evaluate the Clinical Potential of 68GaNOTA-Anti-MMR-VHH2 for in Vivo Imaging of MMR-expressing Macrophages by Means of Positron Emission Tomography (PET) in Oncological Lesions,Cardiovascular Atherosclerosis,Syndrome With Abnormal Immune Activation and sarcoïdosisTERMINATEDINTERVENTIONAL68GaNOTA-Anti-MMR-VHH2
NCT04201132Protection Against Emboli During Carotid Artery Stenting Using a 3-in-1 Delivery System Comprised of a Post-dilation Balloon, Integrated Embolic Filter and a Novel Carotid Stent - the PERFORMANCE II StudyACTIVE NOT RECRUITINGINTERVENTIONALCarotid artery stenting with Neuroguard IEP System
NCT02995642Targeted PET/CT and PET/MRI Imaging of Vascular InflammationWITHDRAWNINTERVENTIONAL18F-FPPRGD2, Positron emission tomography, Computed tomography
NCT03931161Effect of Evolocumab on Carotid Plaque Composition in Asymptomatic Carotid Artery StenosisUNKNOWNINTERVENTIONALEvolocumab Auto-Injector [Repatha], Placebo Auto-Injector
NCT04063709Transcutaneous ARFI Ultrasound for Differentiating Carotid Plaque With High Stroke RiskACTIVE NOT RECRUITINGINTERVENTIONALAcoustic Radiation Force Impulse (ARFI) ultrasound
NCT03757507Investigation of Plaque Instability: Identification of Atherosclerotic Plaque Angiogenesis Using Bevacizumab-800CW and Optoacoustic Imaging: a Single Center Proof of Concept Study (CAROTID-OPTOLIGHT)UNKNOWNINTERVENTIONALMultiSpectral Optoacoustic Tomography
NCT03755362Treatment of Periodontitis to Prevent Dementia in Older Adults With Asymptomatic Carotid Artery Stenosis and Mild Cognitive ImpairmentTERMINATEDINTERVENTIONALStandard Treatment, Intensive Treatment
NCT03840265Evaluation of Cerebrovascular Events in Patients With Occlusive Carotid Artery Disorders Based on Morphological and Hemodynamical FeaturesUNKNOWNINTERVENTIONALcarotid endarterectomy
NCT04662177Co-administration of Dexmedetomidine in Carotid Endarterectomy (CEA) With Intraoperative SSEP and MEP Monitoring: A Single-centre Prospective Randomized Controlled TrialCOMPLETEDINTERVENTIONALDexmedetomidine
NCT03353103Assessment of Unstable Carotid Plaque Using PET and MR Imaging in Patient Referred to Endarterectomy: The CAROTEP StudyUNKNOWNINTERVENTIONALSodium fluoride F-18 PET imaging
NCT03929354Intensive Lifestyle Modification Programme Versus Standard Care for Risk Factor Reduction and Stroke Prevention in Patients With Asymptomatic Carotid Artery Stenosis. A Prospective Randomised Controlled TrialUNKNOWNINTERVENTIONALRisk Factors Modification Programme, Standard Care
NCT03121209Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis Trial - HemodynamicsCOMPLETEDINTERVENTIONALRevascularization, Intensive Medical Management (IMM) alone
NCT03335033New Technologies to Determine Carotid Plaque Vulnerability: A Pilot Study to Assess Contrast-Enhanced Ultrasound (CEUS) and Shear Wave Elastography (SWE) in Patients With Significant Carotid PlaquesCOMPLETEDINTERVENTIONALContrast-enhanced ultrasound, Shear Wave Elastography, Ultrasound Examination
NCT04255316Modified Method of Eversion Carotid Endarterectomy in Patients With Extensive Atherosclerotic Disease of Carotid BifurcationCOMPLETEDINTERVENTIONALModified method of eversion carotid endarterectomy, Standard method of eversion carotid endarterectomy
NCT03303534Short-Term Endogenous Hydrogen Sulfide UpregulationCOMPLETEDINTERVENTIONALScandiShake
NCT03419767The Problem of Insulin Resistance in Patients After Carotid RevascularizationUNKNOWNINTERVENTIONALMelatonin, blank
NCT03141580Long-term Follow-up Near-infrared Spectroscopy and Intravascular Ultrasound Imaging of Internal Carotid Artery Stenosis Treated With StentingCOMPLETEDINTERVENTIONALNear-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS)
NCT03068442Amyloid Deposition and Preexisting Vulnerable Carotid Plaque Features Predicting Cognitive Improvement After SurgeryACTIVE NOT RECRUITINGINTERVENTIONALImaging with flutemetamol F 18 PET/CT
NCT04835571CARotid Mri of AtherosclerosisCOMPLETEDINTERVENTIONALOptimization of cardiovascular risk management
NCT02022293Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From Carotid Stenosis: A Multicenter, Double-blind, Placebo-Controlled, Randomized TrialSUSPENDEDINTERVENTIONALAtorvastatin, Placebo
NCT03665818The Influence of Mandibular Advancement Device Treating OSAHS on Primary Prevention of Ischemic StrokeCOMPLETEDINTERVENTIONALoral appliance treatment
NCT02915328Role of the Type of Carotid Stent and Cerebral Protection on Cerebral Microembolization During Carotid Artery Stenting. A Randomized Study Comparing Carotid Wallstent vs Roadsaver® Stent and Distal vs Proximal Protection.UNKNOWNINTERVENTIONALFilterwire EZ™, MO.MA Ultra, Stent Roadsaver®
NCT02448355Ocular Effects of Carotid Endarterectomy A Cohort Longitudinal StudyUNKNOWNINTERVENTIONALOCT swept source DRI-Atlantis, Topcon
NCT04271033Long-term Outcomes of MicroNet-covered Stent Routine Use for Stroke Prevention in Symptomatic and Increased-risk Asymptomatic Carotid Stenosis Patients Requiring Revascularization by Neurovascular Team Decision: PARADIGM-EXTENDUNKNOWNINTERVENTIONALCarotid Artery Stenting
NCT02722720Prospective, Randomized, Single Center Study of Atherothrombotic and Thromboembolic Events After Carotid Artery Stenting Using Transfemoral and Transradial ApproachCOMPLETEDINTERVENTIONALTransradial carotid artery stenting, Transfemoral carotid artery stenting
NCT02609087Comparison the Effect on Cerebral Oxygenation by Sevoflurane-remifentanil or Propofol-remifentanil Anesthesia Using Near-infrared Spectroscopy in Patients Undergoing Carotid Endarterectomy)COMPLETEDINTERVENTIONALSevoflurane, Propofol
NCT03764306New Ischemic Cerebral Lesions Revealed by the Imaging Magnetic Resonance Imaging After Endarterectomy vs. Stenting Under Proximal Protection for the Treatment of Symptomatic Carotid Stenosis: Results of a Randomised Prospective TrialTERMINATEDINTERVENTIONALCarotid Artery Stenting, Endarterectomy carotid artery
NCT04845334Complementary and Alternative Medicine Interventions in Targeting PainCOMPLETEDINTERVENTIONALRR intervention
NCT02117661ECoM Study: Effect of Carnitine Supplementation on Progression of Carotid Plaque in the Metabolic Syndrome.COMPLETEDINTERVENTIONALL-carnitine capsules, Cellulose capsules
NCT02089217Carotid Revascularization and Medical Management for Asymptomatic Carotid Stenosis TrialCOMPLETEDINTERVENTIONALCarotid endarterectomy (CEA), Carotid Stenting (CAS), Intensive Medical Management - no CEA
NCT02097186Preconditioning Shields Against Vascular Events in Surgery: A Multi-centre Feasibility Trial of Preconditioning Against Adverse Events in Major Vascular Surgery (Preconditioning-SAVES)UNKNOWNINTERVENTIONALRemote ischaemic preconditioning
NCT01968226An Exploratory, Phase II, Open Label, Single-Center, Non-Randomized Study Of [F-18] RGD-K5 Positron Emission Tomography (PET) In Participants With Carotid Artery StenosisTERMINATEDINTERVENTIONAL[F-18] RDG-K5
NCT01923012Phase 2 Study Randomized Placebo Controlled With Vitamin K2 in Asymptomatic Calcified Carotid StenosisUNKNOWNINTERVENTIONALVitamin K2 (Menaquinone)

Genetic associations (0)

None linked.