A
Carotid intima-media thickness
Imaging & Subclinical DiseaseImaging markerriskpartially modifiable
54
evidence score
Also known as: Carotid intima-media thickness (CIMT), carotid intima thickness, carotid intima-media thickness (CIMT), carotid intima-media thickness (IMT), carotid intima-media thickness (cIMT), carotid intimal-medial thickness, carotid intimal-medial wall thickness (IMT), cimt, imt, increased carotid IMT, intima-media thickness, intima-media thickness (IMT)
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 22.6meta-analyses: 20trials: 11.4genetic: 0MR bonus:
References (182)
29 meta-analyses / systematic reviews- METAThe correlation of perirenal fat and atherosclerosis: A systematic review and meta-analysis. — Science progress 2025 · PMID 40462631
- METAMetabolomics Signatures of Atherosclerosis in Cardiovascular Disease: A Narrative Systematic Review. — Journal of clinical medicine 2025 · PMID 41303064
- METAPhenotype-specific associations of circulating adipokine levels with carotid atherosclerosis: a systematic review and meta-analysis. — International journal of cardiology. Cardiovascular risk and prevention 2025 · PMID 41323746
- METAEffects of TNF-α Inhibitors on Subclinical Atherosclerosis and Endothelial Function in Patients with Psoriatic Arthritis: A Systematic Review. — La Tunisie medicale 2025 · PMID 41848140
- METAAtherosclerosis and depression: is carotid intima-media thicker in patients with depression compared to matched control individuals? A systematic review and meta-analysis. — Journal of psychiatric research 2024 · PMID 38552331
- METAPsoriasis treatments in the stabilization of atherosclerosis: a systematic review. — Archives of dermatological research 2024 · PMID 39739136
- METAOxidized low-density lipoprotein associates with cardiovascular disease by a vicious cycle of atherosclerosis and inflammation: A systematic review and meta-analysis. — Frontiers in cardiovascular medicine 2023 · PMID 36727024
- METAHomocysteine as a predictor and prognostic marker of atherosclerotic cardiovascular disease: a systematic review and meta-analysis. — European review for medical and pharmacological sciences 2023 · PMID 37782175
- METAVarying Definitions of Carotid Intima-Media Thickness and Future Cardiovascular Disease: A Systematic Review and Meta-Analysis. — Journal of the American Heart Association 2023 · PMID 38014663
- METAAssociation between osteoarthritis and atherosclerosis: A systematic review and meta-analysis. — Experimental gerontology 2022 · PMID 35151784
- METAAssociation between atherosclerosis and Alzheimer's disease: A systematic review and meta-analysis. — Brain and behavior 2020 · PMID 32162494
- METAGlobal and regional prevalence, burden, and risk factors for carotid atherosclerosis: a systematic review, meta-analysis, and modelling study — The Lancet Global Health 2020 · PMID 32353319
- METAPreclinical markers of atherosclerosis in acromegaly: a systematic review and meta-analysis. — Pituitary 2018 · PMID 30225826
- METAAssociation between Immune Markers and Surrogate Markers of Cardiovascular Disease in HIV Positive Patients: A Systematic Review. — PloS one 2017 · PMID 28085961
- METAThe association between blood pressure and carotid intima-media thickness in children: a systematic review. — Cardiology in the young 2017 · PMID 28376933
- METAAssociation between large artery atherosclerosis and cerebral microbleeds: a systematic review and meta-analysis. — Stroke and vascular neurology 2017 · PMID 28959485
- METAAssociation of Serum Vitamin D Level and Carotid Atherosclerosis: A Systematic Review and Meta-analysis. — Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2017 · PMID 29171066
- METAMatrix Metalloproteinases and Subclinical Atherosclerosis in Chronic Kidney Disease: A Systematic Review. — International journal of nephrology 2016 · PMID 27042350
- METASubclinical Atherosclerosis in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis. — Angiology 2016 · PMID 27252243
- METAAssociation of Subjective and Objective Sleep Duration as well as Sleep Quality with Non-Invasive Markers of Sub-Clinical Cardiovascular Disease (CVD): A Systematic Review — Journal of Atherosclerosis and Thrombosis 2016 · PMID 27840384
- METAIs white-coat hypertension a risk factor for carotid atherosclerosis? A review and meta-analysis. — Blood pressure monitoring 2015 · PMID 25405819
- METAAssociation of Exposure to particular matter and Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis. — International journal of environmental research and public health 2015 · PMID 26501300
- METAIncreased carotid intima-media thickness in rheumatoid arthritis: an update meta-analysis. — Clinical rheumatology 2015 · PMID 26614535
- METACarotid intima-media thickness in patients with inflammatory bowel disease: a systematic review. — Angiology 2013 · PMID 23423851
- METAThe role of intima-media-thickness, ankle-brachial-index and inflammatory biochemical parameters for stroke risk prediction: a systematic review. — European journal of neurology 2011 · PMID 21895882
- METARheumatic disease and carotid intima-media thickness: a systematic review and meta-analysis. — Arteriosclerosis, thrombosis, and vascular biology 2010 · PMID 20150560
- METAEmerging Risk Factors for Coronary Heart Disease: A Summary of Systematic Reviews Conducted for the U.S. Preventive Services Task Force — Annals of Internal Medicine 2009 · PMID 19805772
- METAPlasma triglyceride levels and risk of stroke and carotid atherosclerosis: a systematic review of the epidemiological studies. — Atherosclerosis 2008 · PMID 18954872
- METAMarkers of Systemic Bacterial Exposure in Periodontal Disease and Cardiovascular Disease Risk: A Systematic Review and Meta‐Analysis — Journal of Periodontology 2007 · PMID 18052701
- Metabolic dysfunction-associated steatotic liver disease and cardiovascular risk factors in rheumatoid arthritis. — Clinical rheumatology 2025 · PMID 39962010
- Traditional Lipid Ratios and Carotid Atherosclerosis in Patients with Ischemic Stroke. — Cerebrovascular diseases (Basel, Switzerland) 2025 · PMID 40273898
- Differential Effects of Visceral and Subcutaneous Adiposity on Peripheral Neuropathy. — Journal of the peripheral nervous system : JPNS 2025 · PMID 40345154
- Cardiometabolic determinants of aortic and carotid intima-media thickness in adolescence. — Atherosclerosis 2025 · PMID 40413966
- Sex Differences in Atherosclerotic Cardiovascular Disease Risk in Obstructive Sleep Apnea. — Current atherosclerosis reports 2025 · PMID 40498397
- Cathepsin K: a novel association with glucose intolerance, insulin resistance, and subclinical atherosclerosis in T2DM. — Journal of translational medicine 2025 · PMID 41039522
- Cystatin C in atherosclerotic cardiovascular disease. — Clinica chimica acta; international journal of clinical chemistry 2025 · PMID 41237923
- Atherosclerotic cardiovascular disease and inflammatory bowel disease: epidemiology, pathogenesis and risk assessment. — Best practice & research. Clinical gastroenterology 2025 · PMID 41350098
- Cardiovascular Manifestations in Inflammatory Bowel Disease. — Current cardiology reviews 2024 · PMID 38018203
- Arterial Stiffness and Carotid Intima-Media Thickness in Children Exposed to Smokeless Tobacco in Fetal Life. — Journal of the American Heart Association 2024 · PMID 38214274
- Transcription Factor Regulation of Gene Expression Network byandin Carotid Atherosclerosis. — Genes 2024 · PMID 38397203
- Diagnostic and prognostic role of serum interleukin-6 and carotid ultrasonography to detect subclinical atherosclerosis in patients with RA and ANCA-associated vasculitis. — Rheumatology international 2024 · PMID 38554194
- Machine Learning-Assisted Analysis of Sublingual Microcirculatory Dysfunction for Early Cardiovascular Risk Evaluation and Cardiovascular-Kidney-Metabolic Syndrome Stage in Patients With Type 2 Diabetes Mellitus. — Diabetes/metabolism research and reviews 2024 · PMID 39081178
- Inflammation, Oxidative Stress, and Endothelial Dysfunction in the Pathogenesis of Vascular Damage: Unraveling Novel Cardiovascular Risk Factors in Fabry Disease. — International journal of molecular sciences 2024 · PMID 39125842
- Ankle-brachial index and carotid ultrasound as surrogates for coronary artery disease diagnosis. — Journal of clinical ultrasound : JCU 2024 · PMID 39189340
- Similar Pathophysiological Mechanisms Between Osteoarthritis and Vascular Disease. — Frontiers in bioscience (Landmark edition) 2024 · PMID 39344315
- Improved vascular health linked to increased physical activity levels and reduced sedentary behavior in rheumatoid arthritis. — American journal of physiology. Heart and circulatory physiology 2024 · PMID 39485295
- Associations Between Atherosclerosis and Subsequent Cognitive Decline: A Prospective Cohort Study. — Journal of the American Heart Association 2024 · PMID 39494555
- IL-6 and Cardiovascular Risk: A Narrative Review. — Current atherosclerosis reports 2024 · PMID 39589436
- Menopausal Hormone Therapy and Subclinical Cardiovascular Disease in Women With and Without Human Immunodeficiency Virus. — Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 · PMID 35903868
- The interplay between prolactin and cardiovascular disease. — Frontiers in endocrinology 2023 · PMID 36704037
- Fibroblast Growth Factor-23 and Risk of Cardiovascular Diseases: A Mendelian Randomization Study. — Clinical journal of the American Society of Nephrology : CJASN 2023 · PMID 36719157
- Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study. — Journal of atherosclerosis and thrombosis 2023 · PMID 36775331
- A Potential Strategy for Atherosclerosis Prevention in Modernizing China - Hyperhomocysteinemia, MTHFR C677T Polymorphism and Air Pollution (PM2.5) on Atherogenesis in Chinese Adults. — The journal of nutrition, health & aging 2023 · PMID 36806868
- Is There a Role for Imaging Youth at Risk of Atherosclerosis? — Current atherosclerosis reports 2023 · PMID 36848015
- Insulin Resistance Indices and Carotid Intima-media Thickness in Physically Fit Adults: CHIEF Atherosclerosis Study. — Endocrine, metabolic & immune disorders drug targets 2023 · PMID 36967464
- Could SCUBE-1 be a marker for subclinical atherosclerosis other than carotid artery intima-media thickness in patients with psoriasis? — Anais brasileiros de dermatologia 2023 · PMID 37198010
- Associations of habitual alcohol drinking with HDL cholesterol and D-dimer in patients with peripheral arterial disease. — Clinica chimica acta; international journal of clinical chemistry 2023 · PMID 37301276
- Cardiovascular Risk Assessment in Women With Rheumatoid Arthritis Through Carotid and Femoral Artery Doppler Ultrasound. — Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2022 · PMID 34054072
- Evaluation of carotid intima media thickness measurement from ultrasound images. — Medical & biological engineering & computing 2022 · PMID 34988763
- Physical activity and carotid atherosclerosis risk reduction in population with high risk for cardiovascular diseases: a cross-sectional study. — BMC public health 2022 · PMID 35130854
- Cardiovascular risk assessment with carotid ultrasound in rheumatoid arthritis. — Medicina clinica 2022 · PMID 35277271
- Differential Roles of Life-Course Cumulative Burden of Cardiovascular Risk Factors in Arterial Stiffness and Thickness. — The Canadian journal of cardiology 2022 · PMID 35314334
- Psoriasis and Cardiovascular Risk in Children: The Usefulness of Carotid Intima-Media Thickness. — Pediatric cardiology 2022 · PMID 35316356
- Age and Gender Differences Between Carotid Intima-Media Thickness and Serum Uric Acid. — The American journal of cardiology 2022 · PMID 35317928
- Association of HbA1c with carotid artery plaques in patients with coronary heart disease: a retrospective clinical study. — Acta cardiologica 2022 · PMID 35356852
- Carotid Intima-Media Thickness and Amyloid-β Deposition: The ARIC-PET Study. — Journal of Alzheimer's disease : JAD 2022 · PMID 35527548
- PMinduce the defective efferocytosis and promote atherosclerosis via HIF-1α activation in macrophage. — Nanotoxicology 2022 · PMID 35653618
- Arterial stiffness in patients with type 1 diabetes and its comparison to cardiovascular risk evaluation tools. — Cardiovascular diabetology 2022 · PMID 35681143
- The Relationship between Arterial Elasticity Parameters of Ascending Aorta, Abdominal Aorta and Carotid Arteries with Carotid Intima Media Thickness in Children with Bicuspid Aortic Valve. — Anatolian journal of cardiology 2022 · PMID 35703483
- Brachial flow-mediated dilation and carotid intima-media thickness in glaucoma patients. — BMC ophthalmology 2022 · PMID 35739540
- Polyvascular Subclinical Atherosclerosis: Correlation Between Ankle Brachial Index and Carotid Atherosclerosis in a Population-Based Sample. — Angiology 2022 · PMID 35758047
- Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis. — Cell reports. Medicine 2022 · PMID 35858591
- Cardio-ankle vascular index is more closely associated than brachial-ankle pulse wave velocity with arterial damage and risk of cardiovascular disease in patients with diabetes. — BMC cardiovascular disorders 2022 · PMID 35945498
- Carotid intima media thickness (CIMT) in adults in the AWI-Gen Nairobi site study: Profiles and predictors. — Hipertension y riesgo vascular 2022 · PMID 36153304
- Relationship between carotid intima-media thickness and periodontal disease in a Japanese urban population with and without hypertension: The Suita Study. — Journal of clinical periodontology 2022 · PMID 36330666
- Carotid atherosclerosis: An independent risk factor for small fiber nerve dysfunction in patients with type 2 diabetes mellitus. — Journal of diabetes investigation 2022 · PMID 36350031
- Measures of carotid atherosclerosis and fall-related hospitalization risk: The Perth Longitudinal Study of Ageing Women. — Nutrition, metabolism, and cardiovascular diseases : NMCD 2022 · PMID 36411216
- The impact of particulate matter air pollution (PM2.5) on atherosclerosis in modernizing China: a report from the CATHAY study. — International journal of epidemiology 2021 · PMID 33349857
- Increased Carotid Intima-Media Thickness and Endothelial Cell-Specific Molecule-1 (Endocan) Levels in Obese Children. — Angiology 2021 · PMID 33715456
- Diet quality trajectories and cardiovascular phenotypes/metabolic syndrome risk by 11-12 years. — International journal of obesity (2005) 2021 · PMID 33824404
- Carotid intima-media thickness and epicardial fat thickness predict precoronary artery disease status in psoriasis. — Indian journal of dermatology, venereology and leprology 2021 · PMID 33871214
- Patterns of Immune Activation in HIV and Non HIV Subjects and Its Relation to Cardiovascular Disease Risk. — Frontiers in immunology 2021 · PMID 34290695
- Beta-2-Microglobulin is an Independent Risk Factor for Asymptomatic Carotid Atherosclerosis in Patients with Primary Aldosteronism. — Journal of atherosclerosis and thrombosis 2021 · PMID 34305082
- Vasomotor symptoms and carotid artery intima-media thickness among Korean midlife women. — Maturitas 2021 · PMID 35337608
- Interleukin-6 gene polymorhisms and interleukin-6 levels are associated with atherosclerosis in CKD patients. — Clinical nephrology 2020 · PMID 31426909
- Cardiovascular Disease Risk Factor Burden During the Menopause Transition and Late Midlife Subclinical Vascular Disease: Does Race/Ethnicity Matter? — Journal of the American Heart Association 2020 · PMID 32063114
- Non-HDL Cholesterol Levels in Childhood and Carotid Intima-Media Thickness in Adulthood. — Pediatrics 2020 · PMID 32209701
- Plasma levels of trimethylamine-N-oxide can be increased with ‘healthy’ and ‘unhealthy’ diets and do not correlate with the extent of atherosclerosis but with plaque instability — Cardiovascular Research 2020 · PMID 32267921
- Long-Term Blood Pressure Variability in Young Adulthood and Coronary Artery Calcium and Carotid Intima-Media Thickness in Midlife: The CARDIA Study. — Hypertension (Dallas, Tex. : 1979) 2020 · PMID 32594795
- Carotid intima-media thickness and subclinical left heart dysfunction in the general population. — Atherosclerosis 2020 · PMID 32629183
- Differential risk factor profile of diabetes and atherosclerosis in rural, sub-urban and urban regions of South India: The KMCH-Non-communicable disease studies. — Diabetic medicine : a journal of the British Diabetic Association 2020 · PMID 33236348
- JCL roundtable: Coronary artery calcium scoring and other vascular imaging for risk assessment. — Journal of clinical lipidology 2019 · PMID 30773212
- Hypertension with primary aldosteronism is associated with increased carotid intima-media thickness and endothelial dysfunction. — Journal of clinical hypertension (Greenwich, Conn.) 2019 · PMID 31187936
- Atherosclerosis assessment and rheumatoid arthritis. — Zeitschrift fur Rheumatologie 2018 · PMID 27913876
- Associations between normal range albuminuria, renal function and cardiovascular function in a population-based imaging study. — Atherosclerosis 2018 · PMID 29579673
- High-density lipoprotein (HDL) functionality and its relevance to atherosclerotic cardiovascular disease — Drugs in Context 2018 · PMID 29623098
- Carotid intima media thickness and ankle brachial index are inversely associated in subjects with and without diabetes. — Scandinavian journal of clinical and laboratory investigation 2018 · PMID 30073874
- Submaximal exercise blood pressure and cardiovascular structure in adolescence. — International journal of cardiology 2018 · PMID 30509371
- Cardiovascular disease risk prediction by the American College of Cardiology (ACC)/American Heart Association (AHA) Atherosclerotic Cardiovascular Disease (ASCVD) risk score among HIV-infected patients in sub-Saharan Africa — PLoS ONE 2017 · PMID 28235058
- Carotid intima-media thickness and arterial stiffness in pediatric systemic lupus erythematosus. — Lupus 2017 · PMID 28420050
Clinical trials (13)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT03273972 | INvestigating the Lowest Threshold of Vascular bENefits From LDL Cholesterol Lowering With a PCSK9 mAb InhibiTor (Alirocumab) in healthY Volunteers | COMPLETED | INTERVENTIONAL | Written Informed Consent, Inclusion/Exclusion check, Full Clinical Chemistry and Haematology Bloods |
| NCT01872845 | A Trial Comparing the Effect of Pravastatin and Rosuvastatin on Atherosclerosis Progression Measured by Carotid Intima Media Thickness in Patients With Coronary Artery Disease After Biolimus Eluting Stent (Nobori®) Implantation: CPR IMT | COMPLETED | INTERVENTIONAL | Pravastatin 40mg, Rosuvastatin |
| NCT01534533 | The Effects of Lutein Supplementation on Subclinical Atherosclerosis | COMPLETED | INTERVENTIONAL | Placebo, Lutein group, Combination group |
| NCT00970918 | Prevalence of Atherosclerotic Disease in Asian Subjects Not on Lipid-lowering Agents, But With at Least Two CVD Risk Factors | COMPLETED | INTERVENTIONAL | Measurement of the Carotid Intima Media thickness, Blood sample testing for hs-CRP |
| NCT00723320 | Effect of Atorvastatin and Lifestyle Intervention on Progression of Carotid Intima-Media Thickness in Chinese People Without Manifest Atherosclerotic Disease | UNKNOWN | INTERVENTIONAL | Atorvastatin, Aggressive lifestyle intervention |
| NCT01203982 | Effect of Intensive Lipid Lowering Treatment Compared to Moderate Lipid Lowering Treatment on Carotid Intima Media Thickness and Its Relation to Plaque Components of the Coronary Arteries in Patients With ST-Segment Elevation Acute Myocardial Infarction | COMPLETED | INTERVENTIONAL | Rosuvastatin, Rosuvastatin |
| NCT00228176 | Randomized, Multicenter, Double-blind, Placebo-controlled, Two-arm Parallel Group Trial of Rimonabant 20-mg od, for Inhibition of Atherosclerosis Progression Assessed by Carotid Artery Intima-media Thickness (CIMT), in Overweight Patients With Additional Risk Factors | TERMINATED | INTERVENTIONAL | Rimonabant, Placebo (for Rimonabant) |
| NCT00570856 | Clinical Trial of Effectiveness of Folic Acid Therapy on Homocysteine Level and Carotid Intima-Media Thickness After Kidney Transplantation | TERMINATED | INTERVENTIONAL | Folic acid, Placebo |
| NCT00384618 | Effect of an Oxidative-Stress-Reducing Strategy Consisting of Pravastatin, Vitamin E and Homocysteine-Lowering on Carotid Intima-Media Thickness in Patients With Mild-to-Moderate Chronic Kidney Disease | TERMINATED | INTERVENTIONAL | pravastatin, vitamin E |
| NCT07558239 | Association of Traditional Cardiovascular and Dialysis-Specific Risk Factors With Carotid Intima-Media Thickness in Hemodialysis Patients: A Cross-Sectional Study" | NOT YET RECRUITING | OBSERVATIONAL | Ultrasound measurements of carotid intima- media thickness |
| NCT05214872 | Assessment of the Impact of Selected Factors on the Cardiovascular System in Patients With Different Chronic Kidney Disease Stages | COMPLETED | OBSERVATIONAL | laboratory parameters - complete blood count, body mass index (BMI) [kg/m^2] calculation, selected parameters of oxidative stress (1) |
| NCT02951949 | Exposure to Endogenous Estrogens and Imaging Parameters of Atherosclerosis Burden in Postmenopausal Women | COMPLETED | OBSERVATIONAL | |
| NCT00976014 | Effects of Long-term Therapy With LDL-lowering Plus HDL Raising on Carotid Intima-media Thickness (CIMT) - Carotid Ultrasound Sub-Study of the Familial Atherosclerosis Study-observational Study | COMPLETED | OBSERVATIONAL |
Genetic associations (0)
None linked.