C
Cerebral inflammation
Inflammatory & ImmuneLab test / biomarkerriskmodifiable
18
evidence score
Also known as: inflammation
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 3meta-analyses: 0trials: 15genetic: 0MR bonus:
References (1)
0 meta-analyses / systematic reviews- Late-onset epilepsy and occult cerebrovascular disease. — Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014 · PMID 24517978
Clinical trials (130)
showing top 60| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07198789 | Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial to Evaluate the Effect of a Functional Low-Glycemic Index Carbohydrates Versus Standard Wholegrain Carbohydrates on Glycolipid Metabolism and Vascular Stress Markers in Subjects With Suboptimal Triglyceridemia | RECRUITING | INTERVENTIONAL | Altograno® Bakery Foods, Standard Whole-Grain Bakery Foods |
| NCT07287345 | Adjunctive Colchicine's Effect on Inflammatory Markers and Corresponding New-Onset Atrial Fibrillation Rates Post Coronary Artery Bypass Graft Procedure: A Pilot Study | RECRUITING | INTERVENTIONAL | Colchicine (Colcrys®), Placebo |
| NCT07331103 | RESOLving INflammation Through Diet for Health Multicenter, Prospective Randomized, Controlled and Open- Label to Examine the Impact of a Diet Enriched in Omega 3 Fatty Acids of Animal and Vegetal Origin on Circulating Lipid-driven Pro-/Antiinflammatory Balance in Subjects at Moderate to High Cardiovascular Risk. | RECRUITING | INTERVENTIONAL | Fish Oil, Camelina oil, Vitamin E |
| NCT07361887 | Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular Vesicles | RECRUITING | INTERVENTIONAL | White Wine, Red Wine, Water |
| NCT06203977 | Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR) | RECRUITING | INTERVENTIONAL | Colchicine |
| NCT06130059 | Pilot Study to Evaluate the Efficacy of Low Dose Colchicine (LoDoCo ®) to Improve Exercise Capacity Among Patients With Chronic Stable HFpEF and Systemic Inflammation | RECRUITING | INTERVENTIONAL | Low Dose Colchicine, Placebo |
| NCT05850247 | Plaque and Brain Inflammation in Symptomatic Carotid Stenosis: Role of the Ficolin-2 | RECRUITING | INTERVENTIONAL | [18F]DPA-714 PET/MRI |
| NCT05644301 | INflammation-based Stratification for Immune-Targeted Augmentation in Major Depressive | RECRUITING | INTERVENTIONAL | Celecoxib, Minocyclin, Placebo |
| NCT04073797 | PET Imaging of Inflammation and Lipid Lowering Study | RECRUITING | INTERVENTIONAL | Inclisiran, 68Ga-DOTATATE PET-MRI, Colchicine |
| NCT05641831 | A Randomized Double-Blind Placebo-Controlled Phase II Multi-Center Study of Inflammation Modification of Canakinumab to Prevent Leukemic Progression of Clonal Cytopenias of Unknown Significance (CCUS): IMPACT Study | RECRUITING | INTERVENTIONAL | Biospecimen Collection, Bone Marrow Aspiration and Biopsy, Canakinumab |
| NCT04774159 | Low Dose ColchicinE in pAtients With Peripheral Artery DiseasE to Address Residual Vascular Risk: A Randomized Trial | RECRUITING | INTERVENTIONAL | Colchicine 0.5 MG Oral Tablet, Colchicine-Placebo |
| NCT04496947 | Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind Study | RECRUITING | INTERVENTIONAL | Stress Reduction |
| NCT07461961 | CORTISHOCK-P: A Randomized Pilot Trial of Corticosteroids as a Pharmacologic Adjunct to Temporary Mechanical Circulatory Support in Inflammation-Enriched Heart Failure Cardiogenic Shock | NOT YET RECRUITING | INTERVENTIONAL | Methylprednisone, Standard of Care (SOC) |
| NCT07654231 | Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD: A Pilot Randomized Open-Label Trial (RESOLVE-CKD Trial) | NOT YET RECRUITING | INTERVENTIONAL | Low-dose Colchicine at 0.5mg daily, Usual Care |
| NCT07566325 | Effects of Avocado Consumption on Inflammation and Insulin Sensitivity in Adults With Elevated High Sensitivity-C-reactive Protein (Hs-CRP): A Randomized, Controlled Crossover Trial | NOT YET RECRUITING | INTERVENTIONAL | Avocado, Control |
| NCT06604611 | Efficacy and Safety of Colchicine in Patients With Heart Failure With Preserved Ejection Fraction and Inflammation | NOT YET RECRUITING | INTERVENTIONAL | Colchicine 0.5 MG Oral Tablet Once Daily |
| NCT06812429 | Effects of Sodium-Glucose Co-transporter 2 Inhibitors on Inflammation | COMPLETED | INTERVENTIONAL | Dapagliflozin (DAPA) |
| NCT06432868 | Effects of Solarplast (R) Supplementation on Biomarkers of Muscle Damage, Inflammation and Recovery of Physical Performance Following High-intensity Resistance Exercise | UNKNOWN | INTERVENTIONAL | Solarplast (R), Placebo |
| NCT07230873 | The Impact of Stationary Combined Exercise on Adiponectin and High-Sensitivity C-Reactive Protein Levels in Overweight Women | COMPLETED | INTERVENTIONAL | Combined Exercise Group, No Structured Exercise |
| NCT06051461 | Deciphering the Role of Dietary Fatty Acids on Extracellular Vesicles-mediated Intercellular Communication and Their Implication in Atherosclerosis and Metabolic Syndrome: a Multi-omics Approach to Precision Nutrition | ACTIVE NOT RECRUITING | INTERVENTIONAL | Oral lipid emulsions |
| NCT05162742 | Does Colchicine Reduce Progression of Aortic Valve Stenosis? | ACTIVE NOT RECRUITING | INTERVENTIONAL | Colchicine, Placebo |
| NCT05677555 | Colchicine Influence on Chronic Inflammation in Hemodialysis Patients | UNKNOWN | INTERVENTIONAL | Colchicine 0.5 MG, Placebo |
| NCT05253794 | Effect of Colchicine on the Progression of Aortic Valve Stenosis - A Pilot Study | COMPLETED | INTERVENTIONAL | Colchicine 0.6 mg, Placebo |
| NCT05347316 | Colchicine Effect on Perivascular Inflammation Index on Coronary CTA(COPIX Trial) | UNKNOWN | INTERVENTIONAL | Colchicine |
| NCT05279690 | Colchicine to Suppress Pro-tumorigenic Inflammation in Patients with Urothelial Cancer and Other Solid Tumors | COMPLETED | INTERVENTIONAL | Colchicine |
| NCT04554498 | Toxins Removal and Inflammatory State modulAtion During Online Hemodiafiltration: Comparison of Two Different Dialyzers | UNKNOWN | INTERVENTIONAL | 1) high flux hemodiafiltration thrice -weekly during a 24 month follow-up |
| NCT05017571 | COLSIO Trial: Phase II Randomized, Controlled Trial of Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity | COMPLETED | INTERVENTIONAL | Colchicine, Placebo |
| NCT04907214 | The Effect of SGLT2 Inhibition on Adipose Tissue Inflammation and Endothelial Function Pilot | COMPLETED | INTERVENTIONAL | Empagliflozin 25 MG |
| NCT05614362 | The Effect of Channa Striatus Extract on Serum Albumin and High Sensitive C-Reactive Protein in End-Stage Renal Disease Patients | COMPLETED | INTERVENTIONAL | Channa Striatus extract, Maltodextrin |
| NCT04613167 | Genetic, Biochemical and Functional Markers of Cardiovascular Risk in Patients With Premature Coronary Artery Disease and Treatment Options | UNKNOWN | INTERVENTIONAL | Alirocumab, Evolocumab, Control group |
| NCT04181996 | The Canadian Study of Arterial Inflammation in Patients With Diabetes and Recent Vascular Events: EvaluatioN of Colchicine Effectiveness (CADENCE) | COMPLETED | INTERVENTIONAL | Colchicine Oral Product, Placebo oral capsule |
| NCT04433546 | A Randomized, Double-Blind, Parallel Group Study to Assess the Efficacy and Safety of Once Weekly Subcutaneous Injections of Pemziviptadil (PB1046), a Sustained-Release VIP (Vasoactive Intestinal Peptide) ANalogue, in Hospitalized COVID-19 Patients at HiGh Risk for Rapid Clinical Deterioration and ARDS (PB1046 VANGARD Study) | TERMINATED | INTERVENTIONAL | Pemziviptadil (PB1046), Low Dose (10 mg) Control |
| NCT04365153 | Canakinumab to Reduce Deterioration of Cardiac and Respiratory Function in SARSCoV2 Associated Acute Myocardial Injury With Heightened Inflammation | COMPLETED | INTERVENTIONAL | Canakinumab Injection 600mg, Canakinumab Injection 300mg, Placebos |
| NCT06054100 | The Effect of Colchicine on Inflammation in Acute Coronary Syndrome Patients | COMPLETED | INTERVENTIONAL | Colchicine Tablets |
| NCT04307979 | Impact of Bulletproof Coffee on Metabolism, Inflammation and Cognitive Function | UNKNOWN | INTERVENTIONAL | High-fat coffee, Black coffee |
| NCT04034160 | A Comparison of the Rise of Serum Lipids, Glucose, and Hs-CRP Levels After Consumption of a Beef Burger Versus a Vegetarian Burger | COMPLETED | INTERVENTIONAL | vegetarian burger, beef burger |
| NCT02995642 | Targeted PET/CT and PET/MRI Imaging of Vascular Inflammation | WITHDRAWN | INTERVENTIONAL | 18F-FPPRGD2, Positron emission tomography, Computed tomography |
| NCT04126330 | Effect of Omega-3 and Probiotic Dietary Supplements on Elevated High Sensitivity C-reactive Protein (Hs-CRP) as a Marker of Low-grade Inflammation: Targeting Inflammation and Intestinal Barrier Function in the Elderly and Obese | COMPLETED | INTERVENTIONAL | Probiotic, Omega-3, Vitamin D supplement, Placebo |
| NCT04073927 | The Butyful Study. Effect of Butyrate on Inflammation and Albuminuria in Patients With Albuminuria, Type 1 Diabetes and Intestinal Inflammation A Randomized, Double-blind, Placebo-controlled Study | UNKNOWN | INTERVENTIONAL | Sodium butyrate |
| NCT04434365 | The Study of Berberine Affecting Metabolism, Inflammation Status, Endothelial Function and Thrombotic Events in Patients With Coronary Artery Disease by Remodeling Gut Microbiota | UNKNOWN | INTERVENTIONAL | Berberine, Aspirin, Clopidogrel |
| NCT05095480 | Does Adding Red Yeast Rice to Statin Can Improve Lipid Profile or Vascular Inflammation? A Randomized Clinical Trial | COMPLETED | INTERVENTIONAL | Red Yeast Rice Pill, Placebo |
| NCT04181398 | Low Grade Inflammation in Childhood Obesity : an Independent Risk Factor for Endothelial Dysfunction | COMPLETED | INTERVENTIONAL | Anthropometry, Blood pressure, Peripheral arterial tonometry |
| NCT03735134 | Colchicine in Periprocedural Myocardial Infarction: the Role of Alpha Defensin | UNKNOWN | INTERVENTIONAL | Colchicine Loading Dose, Standard of care treatment prior to elective PCI |
| NCT03704181 | Effect of Colchicine on Inflammation and Myocardial Fibrosis Assessed by Magnetic Resonance Imaging in Patients With Chagas' Heart Disease | UNKNOWN | INTERVENTIONAL | Colchicine 0.5 MG twice day for one year, Placebo Oral Tablet |
| NCT03398577 | Effects of SGLT2 Inhibitor on Markers of Inflammation, Atherosclerosis and Left Ventricular Strain in Diabetic Patients With Coronary Artery Disease | UNKNOWN | INTERVENTIONAL | Dapagliflozin 10 MG [Farxiga], Placebo Oral Tablet |
| NCT03308747 | Effects of Low-grade Systemic Inflammation on Muscle Protein Synthesis and Breakdown in the Aged Skeletal Muscle. | COMPLETED | INTERVENTIONAL | Instantized Whey Protein Isolate |
| NCT03231397 | Noninvasive Assessment of Abdominal Aortic Aneurysm (AAA) Wall Structural Integrity and Inflammation as Predictors of Expansion and/or Rupture | TERMINATED | INTERVENTIONAL | Assess AAA rupture risk by PET-CTA scans, 18F-fludeoxyglucose (FDG), 11C-PBR28 |
| NCT03376698 | A Randomized, Double-blind, Placebo-controlled Phase II Trial to Evaluate the Dose-dependent Effect of Colchicine on Inflammatory Response and Endothelial Function in Type 2 Diabetic Patients With Coronary Artery Disease and Leukocyte Activation | COMPLETED | INTERVENTIONAL | Colchicine 0.5 mg, Colchicine 0.25 mg, Placebo |
| NCT03590769 | Arterial Imaging of Inflammation and Resolution After Endovascular Surgery | COMPLETED | INTERVENTIONAL | 18F-FDG |
| NCT03068442 | Amyloid Deposition and Preexisting Vulnerable Carotid Plaque Features Predicting Cognitive Improvement After Surgery | ACTIVE NOT RECRUITING | INTERVENTIONAL | Imaging with flutemetamol F 18 PET/CT |
| NCT02898610 | CONVINCE - (COlchicine for preventioN of Vascular Inflammation in Non- CardioEmbolic Stroke) - a Randomised Clinical Trial of Low-dose Colchicine for Secondary Prevention After Stroke | COMPLETED | INTERVENTIONAL | Colchicine |
| NCT03208920 | Omega EVAR: Use of Fish Oil to Reduce Inflammation During Endovascular Abdominal Aortic Repair. | COMPLETED | INTERVENTIONAL | Pro-Omega, ProOmega Placebo |
| NCT02941016 | Vascular Inflammation and Cholesterol Lowering Therapy | WITHDRAWN | INTERVENTIONAL | Evolocumab or Alirocumab |
| NCT02998918 | Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL | COMPLETED | INTERVENTIONAL | PolyResveratrol Supplementation, Curcumin Supplementation |
| NCT02840357 | The Purple Wheat Intervention Study: Impact of Purple Wheat Consumption on Markers of Inflammation and Oxidative Stress in Adults. | COMPLETED | INTERVENTIONAL | Purple Wheat Convenience Bars, Control Wheat Convenience Bars |
| NCT02781675 | Effects of a Modified High-fat Mediterranean Dietary Pattern on Lipoprotein and Inflammatory Markers of CVD Risk in Adults | COMPLETED | INTERVENTIONAL | Dietary Intervention |
| NCT02706262 | Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and Health | ACTIVE NOT RECRUITING | INTERVENTIONAL | Metabolically abnormal obese - Mediterranean diet, Metabolically abnormal obese - Low carbohydrate ketogenic diet, Metabolically abnormal obese - Plant-based, very-low-fat diet |
| NCT02576067 | Cardiovascular Inflammation Reduction Trial (CIRT) - Inflammation Imaging Study | COMPLETED | INTERVENTIONAL | Low dose methotrexate, Placebo |
| NCT02394730 | A Double Blind Randomised Comparison of Vorapaxar Versus Placebo for the Treatment of HIV Associated Inflammation and Coagulopathy in Patients With Well Controlled HIV Replication | COMPLETED | INTERVENTIONAL | vorapaxar, Placebo |
| NCT02487732 | Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary Stenting | COMPLETED | INTERVENTIONAL | Ticagrelor, Prasugrel |
Genetic associations (0)
None linked.