C
Choline
Novel & Emerging BiomarkersLab test / biomarkerriskmodifiable
16
evidence score
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 4.8meta-analyses: 0trials: 11.1genetic: 0MR bonus:
References (2)
0 meta-analyses / systematic reviews- Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis. — Nature medicine 2013 · PMID 23563705
- Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. — Nature 2011 · PMID 21475195
Clinical trials (12)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06758856 | ABC (Additional Betaine and Choline) Study: Effect of Betaine and Choline Intake on Biomarkers of Metabolic Health in Humans | COMPLETED | INTERVENTIONAL | Trimethylglycine, Eggs, Cellulose |
| NCT05122780 | PROgnostic Value of Precision Medicine in Patients With Myocardial Infarction and Non-obStructive Coronary artEries: the PROMISE Trial. | ACTIVE NOT RECRUITING | INTERVENTIONAL | Coronary angiography, OCT imaging, Percutaneous coronary intervention (PCI): |
| NCT03877003 | Plasma TMAO and Choline Levels in Individuals With Metabolic Syndrome - Comparison Between Eggs and Choline Supplement Intake | COMPLETED | INTERVENTIONAL | Eggs |
| NCT01667627 | A Double-blind, Placebo-controlled Study to Assess the Effect of Probiotic on Symptom Relief and Indices of Micro-inflammation and Cholinergic Status in IBS Patients With Diarrhea. | COMPLETED | INTERVENTIONAL | Bio-25, Placebo |
| NCT01371357 | The Effects of 8-week Choline, Betaine, and Folic Acid Supplementation on Plasma Homocysteine Concentration During Guanidinoacetic Acid Loading in Young Healthy Volunteers | COMPLETED | INTERVENTIONAL | TEST 1, TEST 2, TEST 3 |
| NCT00973271 | A Multi-Center, Randomized, Double-Blind, Placebo- and Active-Controlled Study Assessing the Efficacy, Safety and Tolerability of Diazoxide Choline Controlled-Release Tablet (DCCR) in Subjects Without Diabetes Mellitus Having Very High Fasting Triglyceride Levels, With Double-Blind Active-Controlled Extension Assessing Safety and Tolerability | WITHDRAWN | INTERVENTIONAL | 290 mg DCCR, 435 mg DCCR, 135 mg fenofibric acid |
| NCT01162824 | Correlation Between Abnormal Coronary Vasoreactivity Testing, Expansion of CD4+CD28null T Cells and Biomarkers for Inflammation and Endothelial Dysfunction in Patients With Angina Despite Angiographically Normal Coronary Arteries. | UNKNOWN | INTERVENTIONAL | Acetylcholine, Adenosine |
| NCT00921856 | Abnormal Coronary Vasomotion in Patients With Suspected CAD But Normal Coronary Arteries | UNKNOWN | INTERVENTIONAL | Intracoronary acetylcholine provocation test |
| NCT00102232 | Effect of Choline Supplemented as Phosphatidylcholine on Post-Methionine Loading and Fasting Concentrations of Plasma Homocysteine in Healthy Volunteers | COMPLETED | INTERVENTIONAL | supplementation with phosphatidylcholine |
| NCT05714319 | Intracoronary Provocative Test With Acetylcholine in Patients With Stable Myocardial Ischemia or Myocardial Infarction and Non-Obstructive Coronary Arteries: the "Provoke" Study | RECRUITING | OBSERVATIONAL | Data collection, Clinical follow-up |
| NCT06287177 | Multicenter Study on the Evaluation of Adherence, Persistence and Efficacy of Treatment With Inclisiran in Italy - CHOLINET (CHOLesterol Italian Inclisiran NETwork) | RECRUITING | OBSERVATIONAL | Inclisiran |
| NCT03416257 | Gut Microbial-related Choline Metabolite Trimethylamine-N-oxide is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection | COMPLETED | OBSERVATIONAL | No intervention |
Genetic associations (0)
None linked.