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Chronic kidney disease

Renal & ElectrolyteDisease / conditionriskpartially modifiable
60
evidence score

Also known as: Chronic kidney disease (CKD), Hemodialysis/chronic kidney disease, Renal disease, chronic kidney disease (CKD), chronic kidney diseases in diabetes, chronic renal disease, ckd, hemodialysis, kidney dysfunction, renal complications, renal disease, renal disease/dysfunction

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 24.5meta-analyses: 20trials: 15genetic: 0MR bonus:

References (280)

16 meta-analyses / systematic reviews

Clinical trials (95)

showing top 60
NCTTitleStatusTypeInterventions
NCT07134335A Phase II Clinical Study to Evaluate the Efficacy and Safety of UBT251 Injection in Obese/Overweight Chronic Kidney Disease (CKD) PopulationRECRUITINGINTERVENTIONALUBT251, UBT251, UBT251
NCT07614659Uppsala Self-Screening of Cardiovascular Health: A Randomized Controlled Trial of Home-Based Multimodal Cardiovascular Screening Versus Usual Care in Middle-Aged and Older AdultsRECRUITINGINTERVENTIONALHome-based multimodal cardiovascular screening
NCT06203977Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR)RECRUITINGINTERVENTIONALColchicine
NCT06396416Obesity Management for Kidney TRANSPLANTation: a Vanguard Study for an Innovative Randomized Controlled Trial, Embedded in Routine Care (OK-TRANSPLANT 2)RECRUITINGINTERVENTIONALSemaglutide, Virtual Weight Management Coaching
NCT06322056Exploring Approaches With Lower Targets of Blood Pressure and Lipid for Improving Renal Outcome in Advanced Chronic Kidney DiseaseRECRUITINGINTERVENTIONALIntensive control of SBP and intensive control of LDL-C, Intensive control of SBP and standard control of LDL-C, Standard control of SBP and intensive control of LDL-C
NCT05786443A Phase II, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study to Assess the Safety, Tolerability, and Preliminary Efficacy of Empagliflozin Among Patients Initiating Hemodialysis for the Treatment of End-Stage Kidney DiseaseRECRUITINGINTERVENTIONALEmpagliflozin 10 MG, Placebo
NCT04911491Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure in Midlife and Older Adults With Chronic Kidney DiseaseRECRUITINGINTERVENTIONALIMST, Sham Training
NCT04788914Circulating Long Noncoding RNA as a Biomarker to Assess the Therapeutic Impact of Oral Uremic Toxin Absorbent ± Probiotics in Chronic Kidney Disease Patients With Peripheral Arterial DiseaseRECRUITINGINTERVENTIONALActive bamboo charcoal± probiotics
NCT03480568A Phase III Trial to Evaluate the Efficacy and Safety of Biweekly Alirocumab in Patients on a Stable Dialysis Regimen: The Alidial StudyRECRUITINGINTERVENTIONALAlirocumab 150 MG/ML [Praluent]
NCT07654231Reducing Inflammation to Improve Vascular and Bone Outcomes With Low-dose Colchicine in CKD: A Pilot Randomized Open-Label Trial (RESOLVE-CKD Trial)NOT YET RECRUITINGINTERVENTIONALLow-dose Colchicine at 0.5mg daily, Usual Care
NCT07585526Safety and Efficacy of Finerenone in Metabolic Dysfunction Associated Steatotic Liver Disease(MASLD/NAFLD) Related Cirrhosis Patients With Ascites in Prevention of Chronic Kidney Disease. A Randomized Control Trial.NOT YET RECRUITINGINTERVENTIONALFinerenone, Spironolactone, Standard Medical Treatment
NCT07391267Pathogenesis of Chronic Kidney Disease Associated With Metabolic Dysfunction- Associated Fatty Liver Disease (MAFLD) and Treatment Response of Oral Semaglutide - a Randomized Controlled Trial.NOT YET RECRUITINGINTERVENTIONALSemaglutide Oral Tablet, Placebo, Standard medical treatment
NCT07151430Development and Validation of a Comprehensive Management Service Package for Older Adults With Multimorbidity: A Randomized Controlled TrialNOT YET RECRUITINGINTERVENTIONALService Package Group
NCT07209527Evaluation of Truway Health-Sourced Portable Diagnostic Devices for Early Detection of Chronic Conditions in Outpatient Primary Care Settings: A Prospective Interventional StudyENROLLING BY INVITATIONINTERVENTIONALTruway Portable Ultrasound Device, Truway Blood Glucose Monitor, Standard Oral Hypoglycemic Agent
NCT06780865Protection of Renal Function by Antihypertensive Treatment in Patients with Chronic Kidney Disease and Isolated Nighttime HypertensionNOT YET RECRUITINGINTERVENTIONALAntihypertensive treatment with Arotinolol or Amlodipine or Clonidine, Placebo-controlled group
NCT06362759A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Quarterly and Monthly TOUR006 in Participants With Chronic Kidney Disease and Elevated High-Sensitivity C-Reactive ProteinCOMPLETEDINTERVENTIONALTOUR006 - 50 MG, TOUR006 - 25 MG, TOUR006 - 15 MG
NCT06383390A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Event-Driven Study to Investigate the Effect of Retatrutide on the Incidence of Major Adverse Cardiovascular Events and Major Adverse Kidney Events in Participants With Body Mass Index ≥27 kg/m2 and Atherosclerotic Cardiovascular Disease and/or Chronic Kidney DiseaseACTIVE NOT RECRUITINGINTERVENTIONALRetatrutide, Placebo
NCT06268873A Phase III, Randomised, Double-Blind Study to Assess the Efficacy, Safety and Tolerability of Baxdrostat in Combination With Dapagliflozin Compared With Dapagliflozin Alone on Chronic Kidney Disease (CKD) Progression in Participants With CKD and High Blood PressureACTIVE NOT RECRUITINGINTERVENTIONALBaxdrostat/dapagliflozin, Dapagliflozin in combination with placebo
NCT05846490Impact of Obstructive Sleep Apnea Treatment on Blood Pressure Control in Chronic Kidney Disease: A Randomized TrialUNKNOWNINTERVENTIONALCPAP, Usual care
NCT06034691Exploratory Research of PCSK9 Inhibitor on Patency of Autogenous Arteriovenous Fistula After Percutaneous Transluminal Angioplasty With Paclitaxel Releasing BalloonUNKNOWNINTERVENTIONALpcsk9 inhibitor
NCT05884866Natriuretic-ureothelic Adaptation of Body Fluid Homeostasis During SGLT-2 Inhibition and/or Mineralocorticoid Receptor Modulation in Patients With Chronic Kidney Disease. A 4-arm, Double-blind, Double-dummy, Parallel-group, Phase 2 Study to Investigate the Mechanistic Effects of Dapagliflozin, Dapagliflozin + Balcinrenone, Balcinrenone and Placebo on Body Solute and Water Homeostasis and Energy Metabolism in Male and Female Participants Over 50 Years of Age With Chronic Kidney Disease.COMPLETEDINTERVENTIONALDapagliflozin 10mg Tab, Balcinrenone 50mg Capsule, Balcinrenone 100mg Capsule
NCT05807711Efficacy of L-methylfolate and Methylcobalamine in Treating Resistant Hypertension Associated With Elevated Serum Homocysteine in Hemodialysis Patients.COMPLETEDINTERVENTIONALL-Methyl Folate and methylcobalamine
NCT05614115Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKDCOMPLETEDINTERVENTIONALEmpagliflozin, Placebo
NCT05822960To Investigate the Effect of Far-infrared Radiation on Lower Extremity Acupoints on the Blood Circulation of Lower Extremities in Patients With HemodialysisCOMPLETEDINTERVENTIONALfar-infrared radiation
NCT05677555Colchicine Influence on Chronic Inflammation in Hemodialysis PatientsUNKNOWNINTERVENTIONALColchicine 0.5 MG, Placebo
NCT05735197Effect of Sodium-Glucose Co-transporter 2 Inhibitors on Kidney Disease Progression and Bone Mineral Metabolism in Non-diabetic Patients With Chronic Kidney DiseaseCOMPLETEDINTERVENTIONALDapagliflozin 10mg Tab, Placebo
NCT07344922Impact of Sodium-Glucose Co-transporter 2 Inhibitors on Cardiovascular System and Anemia in Non-diabetic Chronic Kidney Disease Patients. A Randomized-Controlled Clinical TrialCOMPLETEDINTERVENTIONALDapagliflozin (10Mg Tab) along with standard medical therapy, Placebo
NCT05240443Effect of Bariatric Surgery on Chronic Renal Disease (BARICADE): A Pilot Randomized Controlled TrialUNKNOWNINTERVENTIONALBariatric Surgery + Medical Management of CKD., Medical Management for CKD
NCT06959927Risk Factors and Application of Risk Management Strategies in Hemodialysis Patients Complicated With Heart FailureCOMPLETEDINTERVENTIONALStandard Care Group, Risk-Stratified Management Group
NCT04554498Toxins Removal and Inflammatory State modulAtion During Online Hemodiafiltration: Comparison of Two Different DialyzersUNKNOWNINTERVENTIONAL1) high flux hemodiafiltration thrice -weekly during a 24 month follow-up
NCT05225077Effect of Short-term Dapagliflozin on Renal Function After Heart Catheterization or Percutaneous Coronary Intervention in Patients With Chronic Kidney DiseaseUNKNOWNINTERVENTIONALDapagliflozin 10 MG [Farxiga]
NCT04143581Evaluating the Short-Term Renal and Systemic Effects of SGLT2 Inhibition in Non-Diabetic Patients at Risk of Accelerated GFR Decline Because of Glomerular Hyperfiltration: a Sequential OFF-ON-OFF Study With One-Month Empagliflozin Therapy Followed by One-Month Recovery PeriodWITHDRAWNINTERVENTIONALEmpagliflozin 10 MG
NCT04764097A Multi-centre, Randomised, Double-blind, Placebo-controlled Trial to Determine the Effect of Dapagliflozin 10mg Once Daily on Cardiovascular Outcomes in Haemodialysis for Patients With End Stage Renal Disease (ESRD)WITHDRAWNINTERVENTIONALDapagliflozin, Placebo
NCT05614362The Effect of Channa Striatus Extract on Serum Albumin and High Sensitive C-Reactive Protein in End-Stage Renal Disease PatientsCOMPLETEDINTERVENTIONALChanna Striatus extract, Maltodextrin
NCT07249229Investigating the Effect of Oral L-Carnitine on Inflammatory and Nutritional Factors in Patients With Advanced Kidney Failure Undergoing Chronic HemodialysisCOMPLETEDINTERVENTIONALL-carnitine 1000 Mg, Placebo
NCT04659525Phase IV Study for Efficacy and Safety of Evolocumab Added to Ezetimibe (Standard of Care) in High Cardiovascular Risk Haemodialized Statin Intolerant Patients With HypercholesterolemiaUNKNOWNINTERVENTIONALEvolocumab, Ezetimibe, Placebo
NCT04085562Effect of Amlodipine Versus Bisoprolol on Hypertensive Patients With End-stage Renal Disease on Maintenance Hemodialysis.COMPLETEDINTERVENTIONALBisoprolol Fumarate 5-10 mg, Amlodipine 5-10 mg
NCT03942744Molecular Mechanisms Involved in Cell Adhesion and Migration Process: Effect of Treatment of Chronic Kidney Disease on Endothelial DysfunctionCOMPLETEDINTERVENTIONALon-line hemodiafiltration
NCT03459807BOLD: A Trial of Blood Pressure Lowering in DialysisCOMPLETEDINTERVENTIONALAnti-Hypertensive medications, Dry Weight Adjustment
NCT03190694A Study to Assess the Renoprotective Effects of the SGLT2 Inhibitor Dapagliflozin in Non-Diabetic Patients With Proteinuria: a Randomized Double Blind 6-Weeks Cross-Over TrialCOMPLETEDINTERVENTIONALDapagliflozin 10mg
NCT03202407Effect of Non-calcium Phosphate Binders Versus Calcium Based Binders on Chronic Kidney Disease -Mineral and Bone Disorder in Children on Regular HemodialysisUNKNOWNINTERVENTIONALCalcium acetate and sevelamer hydrochloride
NCT03226899A Phase 4, Study to Evaluate the Safety and Efficacy of Lesinurad 200 mg in Combination With a Xanthine Oxidase Inhibitor (XOI), Compared With an XOI Alone, in Subjects With Gout and Estimated Creatinine Clearance (eCrCl) 30 to <60 mL/Min Who Have Not Achieved Target Serum Uric Acid Levels (sUA) on an XOI AloneTERMINATEDINTERVENTIONALLesinurad, XOI, Placebo
NCT02622308The Effects of Intermittent Negative Pressure on Peripheral Circulation in Dialysis Patients and Patients With Lower Limb Ischemia and Leg UlcersTERMINATEDINTERVENTIONALFlowOx™
NCT02664519Mechanisms of Muscle Blood Flow Dysregulation and Exercise Intolerance in Chronic Kidney DiseaseTERMINATEDINTERVENTIONALForearm exercise training
NCT02579655Assessing Outcomes of Enhanced Chronic Disease Care Through Patient Education and a Value-based Formulary StudyCOMPLETEDINTERVENTIONALCopayment Elimination, Personalized Education
NCT02284230Glycaemic and Cardiovascular Efficacy of Liraglutide in Prediabetic Patients With End-stage Renal DiseaseWITHDRAWNINTERVENTIONALLiraglutide, Placebo
NCT02275156Phase 1, Open-label, Single-dose Study of Evolocumab (AMG 145) Administered Subcutaneously to Subjects With Normal Renal Function or Severe Renal Impairment or End Stage Renal Disease Receiving HemodialysisCOMPLETEDINTERVENTIONALEvolocumab
NCT01985360International Study of Comparative Health Effectiveness With Medical and Invasive Approaches-Chronic Kidney Disease TrialCOMPLETEDINTERVENTIONALCardiac Catheterization, Coronary Artery Bypass Graft Surgery, Percutaneous Coronary Intervention
NCT01979471The Alberta Vascular Risk Reduction Community Pharmacy Project: RxEACHCOMPLETEDINTERVENTIONALAdvanced Care
NCT02190318The Effects of Losartan and Spironolactone on Residual Renal Function Preservation in Peritoneal Dialysis PatientsUNKNOWNINTERVENTIONALLosartan, spirolactone, blank control
NCT01766882Fluid-Weight, Volume, Sodium, Blood Pressure Management in Hemodialysis by Limiting Intradialytic and Inter-dialytic Exposure to Sodium and Protocol-based Challenge of Post-dialysis Target Weight: A Pilot and Feasibility TrialCOMPLETEDINTERVENTIONALLower sodium intervention, Progressive Challenge to Post Dialysis Weight
NCT01593527A Randomized Double-blind Active-controlled Trial of Canakinumab Versus Triamcinolone Acetonide on Reducing the Proportion of Patients With Any New Gouty Arthritis Flare(s) in Patients With Chronic Kidney DiseaseWITHDRAWNINTERVENTIONALACZ885, Triamcinelone acetonide
NCT01312714A Randomized, Placebo-Controlled, Double Blind Study Evaluating the Effect of Cholecalciferol on Vasoactive Hormones, Heart Function, Arterial Stiffness, and Blood Pressure in Dialysis Patients.COMPLETEDINTERVENTIONALCholecalciferol, Placebo
NCT02275468Fu-zheng-qu-zhuo Oral Liquid Combined With Integrated Therapy Improves Renal Function in Patients of Chronic Kidney Disease Stage 3 and 4，a Randomized Placebo-Control Clinical TrialCOMPLETEDINTERVENTIONALFu-zheng-qu-zhuo (FZQZ) oral liquid
NCT01709994Effect of Aspirin in Primary Prevention of Cardiovascular Risk in Patients With Chronic Kidney Disease (AASER Study)UNKNOWNINTERVENTIONALAspirin
NCT01084278Single-Dose, Open-Label Study of the Pharmacokinetics, Safety, and Tolerability of Colcrys (Colchicine, USP) Tablets 0.6 mg Administered to Healthy Subjects and Subjects With Mild, Moderate, Severe Renal Impairment, and End-Stage Renal DiseaseCOMPLETEDINTERVENTIONALColchicine
NCT01101698Influence of Vitamin K2 Administration on Vessel Calcification Markers in Patients With Chronic Kidney DiseaseUNKNOWNINTERVENTIONALVitamin K2+10μg cholecalciferol, Vitamin D
NCT00741585Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk AssessmentCOMPLETEDINTERVENTIONALAny antihypertensive medication alone or in combination, Any antihypertensive medication alone or in combination, Ambulatory blood pressure monitoring
NCT00568399The Effect of Sodium Thiosulfate Treatment on Vascular Calcification in End Stage Renal Failure PatientsCOMPLETEDINTERVENTIONALsodium thiosulfate
NCT00582777African American Study of Kidney Disease and Hypertension ABPM Pilot StudyCOMPLETEDINTERVENTIONALUSUAL - take your BP Meds as you usually do, HS DOSING, ADD On Dosing

Genetic associations (0)

None linked.