A
Chronic obstructive pulmonary disease
Comorbid ConditionsDisease / conditionriskpartially modifiable
49
evidence score
Also known as: COPD, chronic obstructive pulmonary, copd
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 18.8meta-analyses: 15.8trials: 14.3genetic: 0MR bonus:
References (75)
5 meta-analyses / systematic reviews- METACardiovascular outcomes in patients with COPD-OSA overlap syndrome: A systematic review and meta-analysis. — Sleep medicine reviews 2022 · PMID 35413500
- METAAssociation of COPD exacerbations and acute cardiovascular events: a systematic review and meta-analysis. — Therapeutic advances in respiratory disease 2022 · PMID 35894441
- METAAssociation and Risk Factors for Obstructive Sleep Apnea and Cardiovascular Diseases: A Systematic Review — Diseases 2021 · PMID 34940026
- METARisk of cardiovascular comorbidity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis. — The Lancet. Respiratory medicine 2015 · PMID 26208998
- METASocioeconomic inequalities in non-communicable diseases and their risk factors: an overview of systematic reviews — BMC Public Health 2015 · PMID 26385563
- Health benefits of leisure-time physical activity by socioeconomic status, lifestyle risk, and mental health: a multicohort study. — The Lancet. Public health 2025 · PMID 39909687
- COPD and cardiovascular risk. — Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2025 · PMID 39909770
- [Update COPD and cardiovascular events]. — Deutsche medizinische Wochenschrift (1946) 2025 · PMID 39983766
- Impact of COPD on cardiovascular risk factors and outcomes in people with established cardiovascular disease. — Thorax 2025 · PMID 40032508
- Appraisal of β-Blocker Use in Patients with Cardiovascular Disease and Chronic Obstructive Pulmonary Disease. — American journal of cardiovascular drugs : drugs, devices, and other interventions 2025 · PMID 40252175
- Incidence and Risk of Heart Failure in Patients With Coronary Heart Disease and Stroke: A Population-Based Cohort Study. — The American journal of cardiology 2025 · PMID 40339776
- Additive impact of chronic obstructive pulmonary disease (COPD) and cardiovascular disease(CVD) on all-cause and disease-Specific mortality: a longitudinal nationwide population-based study. — BMC pulmonary medicine 2025 · PMID 40450235
- Timing of cardiovascular events in people with COPD with and without chronic respiratory failure. — Respiratory medicine 2025 · PMID 41092988
- Temporal Risk of Nonfatal Cardiovascular Events After Chronic Obstructive Pulmonary Disease Exacerbation: A Population-based Study. — American journal of respiratory and critical care medicine 2024 · PMID 38127850
- Cigarette smoke-induced galectin-3 as a diagnostic biomarker and therapeutic target in lung tissue remodeling. — Life sciences 2024 · PMID 38237765
- Prevalence of Cardiovascular Disease and Rate of Major Adverse Cardiovascular Events in Severe Alpha-1 Antitrypsin Deficiency COPD. — International journal of chronic obstructive pulmonary disease 2024 · PMID 38249829
- Multidisciplinary Management of Patients With Chronic Obstructive Pulmonary Disease and Cardiovascular Disease. — Archivos de bronconeumologia 2024 · PMID 38383272
- Cardiovascular disease and risk in COPD: a state of the art review. — Expert review of cardiovascular therapy 2024 · PMID 38529639
- Public Health Relevance of US EPA Air Quality Index Activity Recommendations. — JAMA network open 2024 · PMID 38587845
- Development and validation of a new algorithm for improved cardiovascular risk prediction. — Nature medicine 2024 · PMID 38637635
- Implications of Cardiopulmonary Risk for the Management of COPD: A Narrative Review. — Advances in therapy 2024 · PMID 38664329
- COPD is associated with increased cardiovascular disease risk independent of phenotype. — Respirology (Carlton, Vic.) 2024 · PMID 39019777
- Differentiation and Growth-Arrest-Related lncRNA (): Initial Characterization in Human Smooth Muscle and Fibroblast Cells. — International journal of molecular sciences 2024 · PMID 39273443
- Emerging Anti-Inflammatory COPD Treatments: Potential Cardiovascular Impacts. — International journal of chronic obstructive pulmonary disease 2024 · PMID 39606712
- [Cardiopulmonary axis and cardiovascular mortality in patients with COPD]. — Semergen 2023 · PMID 36796228
- Clonal haematopoiesis and dysregulation of the immune system. — Nature reviews. Immunology 2023 · PMID 36941354
- Assessing the relationship between cardiovascular and small airway disease and acute events in COPD: The ARCADIA study protocol. — Pulmonary pharmacology & therapeutics 2023 · PMID 37414133
- Chronic obstructive pulmonary disease and cardiovascular disease: mechanistic links and implications for practice. — Current opinion in pulmonary medicine 2023 · PMID 38085609
- Chronic obstructive pulmonary disease and atherosclerosis: common mechanisms and novel therapeutics. — Clinical science (London, England : 1979) 2022 · PMID 35319068
- Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses — Frontiers in Pharmacology 2022 · PMID 36353491
- Loneliness, Social Isolation, and Chronic Disease Outcomes. — Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 2021 · PMID 32865550
- COPD and Cardiovascular Disease: A Review of Association, Interrelationship, and Basic Principles for Integrated Management. — Critical care nursing quarterly 2021 · PMID 33234862
- Beta Blockers and Chronic Obstructive Pulmonary Disease (COPD): Sum of Evidence. — Current hypertension reviews 2021 · PMID 33302840
- Examining Predictors of Myocardial Infarction. — International journal of environmental research and public health 2021 · PMID 34769805
- Association of clonal hematopoiesis with chronic obstructive pulmonary disease — Blood 2021 · PMID 34855941
- The bidirectional relationship between chronic obstructive pulmonary disease and coronary artery disease. — Herz 2020 · PMID 32052074
- Environmental and Health Impacts of Air Pollution: A Review — Frontiers in Public Health 2020 · PMID 32154200
- Chronic Dyspnea: Diagnosis and Evaluation. — American family physician 2020 · PMID 32352727
- Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 — The Lancet Respiratory Medicine 2020 · PMID 32526187
- Periodontitis is an inflammatory disease of oxidative stress: We should treat it that way — Periodontology 2000 2020 · PMID 32844417
- Flavonoids and Reduction of Cardiovascular Disease (CVD) in Chronic Obstructive Pulmonary Disease (COPD). — Current medicinal chemistry 2019 · PMID 29756566
- GDF-15 in Pulmonary and Critical Care Medicine. — American journal of respiratory cell and molecular biology 2019 · PMID 30633545
- Airflow Obstruction and Cardio-metabolic Comorbidities. — COPD 2019 · PMID 31131642
- Exacerbations of Chronic Obstructive Pulmonary Disease and Cardiac Events. A Post Hoc Cohort Analysis from the SUMMIT Randomized Clinical Trial. — American journal of respiratory and critical care medicine 2018 · PMID 29442524
- Oxidative stress, aging, and diseases — Clinical Interventions in Aging 2018 · PMID 29731617
- Cardiovascular disease and COPD: dangerous liaisons? — European respiratory review : an official journal of the European Respiratory Society 2018 · PMID 30282634
- COPD and Cardiovascular Disease. — Pulmonology 2018 · PMID 30527374
- Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 — The Lancet 2017 · PMID 28408086
- Therapeutic effects of the combination of inhaled beta2-agonists and beta-blockers in COPD patients with cardiovascular disease. — Heart failure reviews 2017 · PMID 28840400
- Cardiovascular risk, chronic obstructive pulmonary disease and pulmonary rehabilitation: Can we learn from cardiac rehabilitation? — Chronic respiratory disease 2016 · PMID 27081189
- Proceedings of the 3rd IPLeiria's International Health Congress : Leiria, Portugal. 6-7 May 2016. — BMC health services research 2016 · PMID 27409075
- Acute exacerbation of COPD: is it the "stroke of the lungs"? — International journal of chronic obstructive pulmonary disease 2016 · PMID 27471380
- Managing comorbidities in COPD. — International journal of chronic obstructive pulmonary disease 2015 · PMID 25609943
- Cardiovascular risk factors for acute stroke: Risk profiles in the different subtypes of ischemic stroke — World Journal of Clinical Cases 2015 · PMID 25984516
- Work Stress as a Risk Factor for Cardiovascular Disease. — Current cardiology reports 2015 · PMID 26238744
- Exercise as medicine – evidence for prescribing exercise as therapy in 26 different chronic diseases — Scandinavian Journal of Medicine and Science in Sports 2015 · PMID 26606383
- Arterial stiffness in COPD. — Chest 2014 · PMID 24687708
- Cardiovascular disease is associated with COPD severity and reduced functional status and quality of life. — COPD 2014 · PMID 24831864
- Social inequality in chronic disease outcomes. — Danish medical journal 2014 · PMID 25370965
- Expert position paper on air pollution and cardiovascular disease — European Heart Journal 2014 · PMID 25492627
- Cardiovascular disease in COPD: mechanisms. — Chest 2013 · PMID 23460157
- Periodontitis and systemic diseases: a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases — Journal Of Clinical Periodontology 2013 · PMID 23627330
- Chronic obstructive pulmonary disease and cardiovascular disease. — Translational research : the journal of laboratory and clinical medicine 2013 · PMID 23727296
- Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease — American Journal of Respiratory and Critical Care Medicine 2012 · PMID 22878278
- Sympathetic overactivity and cardiovascular disease in patients with chronic obstructive pulmonary disease (COPD). — Discovery medicine 2012 · PMID 23272688
- Risk factors, inpatient care, and outcomes of pneumonia after ischemic stroke — Neurology 2011 · PMID 21940613
- [Comorbidities in COPD]. — Archivos de bronconeumologia 2010 · PMID 21316557
- Pulmonary rehabilitation and cardiovascular disease. — Seminars in respiratory and critical care medicine 2009 · PMID 19941225
- Cystatin C and aging success. — Archives of internal medicine 2008 · PMID 18227360
- Psoriasis: cardiovascular risk factors and other disease comorbidities. — PubMed 2008 · PMID 18459519
- Cardiovascular injury and repair in chronic obstructive pulmonary disease. — Proceedings of the American Thoracic Society 2008 · PMID 19017737
- Arterial Stiffness and Osteoporosis in Chronic Obstructive Pulmonary Disease — American Journal of Respiratory and Critical Care Medicine 2007 · PMID 17363772
- Increased arterial stiffness in patients with chronic obstructive pulmonary disease: a mechanism for increased cardiovascular risk — Thorax 2007 · PMID 18024535
- Evidence for prescribing exercise as therapy in chronic disease — Scandinavian Journal of Medicine and Science in Sports 2006 · PMID 16451303
- Fine Particulate Air Pollution and Hospital Admission for Cardiovascular and Respiratory Diseases — JAMA 2006 · PMID 16522832
Clinical trials (26)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07543601 | Enhanced COPD Management in Suspected Lung Cancer Patients - Improving Outcomes Through Timely Intervention | RECRUITING | INTERVENTIONAL | Tailored COPD consultations |
| NCT06529185 | Effect of Breather on Ventilatory and Vascular Function in Chronic Obstructive Pulmonary Disease Patients With Intermittent Claudication. | RECRUITING | INTERVENTIONAL | The BREATHER, pharmacological treatment |
| NCT07104136 | Improvement of Adherence to Treatment Among COPD Patients in Primary Care by Physician-directed Intervention | ENROLLING BY INVITATION | INTERVENTIONAL | COPD-care seminar |
| NCT05444062 | Quebec Lung Cancer Screening PLUS Trial - a Randomized Controlled Trial of an Educational Intervention for Untreated Chronic Obstructive Pulmonary Disease (COPD) and/or Cardiovascular Disease (CVD) Identified During Lung Cancer Screening | ACTIVE NOT RECRUITING | INTERVENTIONAL | Educational material and treatment recommendations for patients, general practitioners and pharmacists |
| NCT05766046 | Early Diagnosis of Lung Cancer of the Italian Pulmonary Screening Network (RISP): Comparative Analysis for the Use of Low Dose Computed Tomography and Promotion of Primary Prevention Interventions in Subjects at High Risk for Lung Cancer | ACTIVE NOT RECRUITING | INTERVENTIONAL | early lung cancer detection, blood test |
| NCT05562037 | Stepped Care vs Center-based Cardiopulmonary Rehabilitation for Older Frail Adults Living in Rural MA | COMPLETED | INTERVENTIONAL | Stepped Care |
| NCT04789057 | Non-commercial Clinical Trial of Statins CAncer Preventive and Pleiotropic TherApy IN Smokers With Chronic Obstructive Pulmonary Disease (COPD) | ACTIVE NOT RECRUITING | INTERVENTIONAL | Atorvastatin 40 Mg Oral Tablet, Placebo |
| NCT04474717 | Clinical and Biochemical Assessment of the Course of Chronic Obstructive Pulmonary Disease in Combination With Atherosclerosis | COMPLETED | INTERVENTIONAL | Breath Condensate Collection, clinical examination, spirometry, blood monocyte assay |
| NCT04361552 | Tociluzumab for Cytokine Release Syndrome With SARS-CoV-2: An Open-Labeled, Randomized Phase 3 Trial | WITHDRAWN | INTERVENTIONAL | Best Practice, Tocilizumab |
| NCT03988322 | Computed Tomography Screening for Early Lung Cancer, COPD and Cardiovascular Disease in Shanghai: a Population-based Comparative Study | UNKNOWN | INTERVENTIONAL | Low-dose CT screening with quantitative assessment and management of imaging biomarkers, Low-dose CT screening with visual assessment and management of imaging biomarkers |
| NCT06801951 | Effects of Oral Nutritional Supplement and Acute Resistance Exercise in Chronic Obstructive Pulmonary Disease | COMPLETED | INTERVENTIONAL | acute resistance exercise with oral nutrition supplementation, stable tracer infusion |
| NCT03333395 | Efficacy of Nebulized Heparin and Salbutamol in Mechanically Ventilated Patients With Acute Exacerbation Chronic Obstructive Pulmonary Disease: a Randomized Clinical Trial | COMPLETED | INTERVENTIONAL | Nebulized heparin and salbutamol, Nebulized salbutamol |
| NCT02789800 | Patient-Centred Innovations for Persons With Multimorbidity - Quebec | COMPLETED | INTERVENTIONAL | DIMAC02 |
| NCT02780219 | The Effects of Acute Resistance Exercise on Protein and Amino Acid Metabolism in Chronic Obstructive Pulmonary Disease | COMPLETED | INTERVENTIONAL | stable amino acid infusion, acute exercise with amino acid infusion, 24-hour post exercise amino acid infusion |
| NCT02742597 | Patient-Centred Innovations for Persons With Multimorbidity - Ontario | COMPLETED | INTERVENTIONAL | TIP / IMPACT Plus Care Coordination |
| NCT03487406 | Anti-platelet Therapy in the Primary Prevention of Cardiovascular Disease in Patients With Chronic Obstructive Pulmonary Disease | COMPLETED | INTERVENTIONAL | Ticagrelor, Aspirin, Placebo Aspirin |
| NCT02070133 | Pilot Study on the Efficacy of Statins for the Treatment of Chronic Obstructive Pulmonary Disease | COMPLETED | INTERVENTIONAL | Simvastatin, Placebo |
| NCT02888886 | Role of Systemic Inflammation in Increase of Cardio-vascular Risk in Chronic Obstructive Pulmonary Disease | COMPLETED | INTERVENTIONAL | Questionnaires about food habits and tobacco, Spirometry, Carotid echography |
| NCT00581945 | A Randomized, Double-blind, Placebo Controlled, Exploratory Study to Assess the Safety and Efficacy of Multiple Doses of ACZ885 in Chronic Obstructive Pulmonary Disease (COPD) Patients | COMPLETED | INTERVENTIONAL | Canakinumab, Placebo |
| NCT06473168 | Walking-related Mobility Assessment in Older People With Multimorbidity | UNKNOWN | OBSERVATIONAL | |
| NCT07363980 | Coronary Computed Tomography Angiography In Rheumatoid Arthritis Study | ENROLLING BY INVITATION | OBSERVATIONAL | |
| NCT04903639 | Obstructive Sleep Apnea Prevalence in Patients With Chronic Obstructive Pulmonary Diseases | COMPLETED | OBSERVATIONAL | sleep study |
| NCT02214056 | Mobile Unit Screening of Pathologies Associated With Chronic Diseases - Part I Feasibility | COMPLETED | OBSERVATIONAL | Patient recruitment, Mobile team exam |
| NCT02162095 | Is Chronic Obstructive Pulmonary Disease a Risk Factor for Cardiovascular Disease? | COMPLETED | OBSERVATIONAL | |
| NCT01785537 | Multicentric 5-year Follow-up Study to Assess the Efficacy of E-cigarettes as a Tool for Smoking Cessation and to Compare the Risk of Smoking-related Diseases Among Electronic and Traditional Cigarette Smokers, and Smokers of Both. | UNKNOWN | OBSERVATIONAL | |
| NCT07332156 | Lung Cancer Incidence in Patients With Type 2 Diabetes and COPD: A Real-World Retrospective Cohort Study Comparing SGLT2 Inhibitors and Sulfonylureas | COMPLETED | OBSERVATIONAL | SGLT2 inhibitor, Sulfonylureas (SU), DPP4 inhibitors |
Genetic associations (0)
None linked.