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Chronic psychological stress

Psychosocial & Mental HealthBehavior / exposureriskpartially modifiable
63
evidence score

Also known as: Chronic stress, chronic stress, perceived stress, psychological stress, stress, stress exposure

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 27.6meta-analyses: 20trials: 15genetic: 0MR bonus:

References (577)

26 meta-analyses / systematic reviews

Clinical trials (71)

showing top 60
NCTTitleStatusTypeInterventions
NCT07198789Randomized, Double-Blind, Placebo-Controlled Crossover Clinical Trial to Evaluate the Effect of a Functional Low-Glycemic Index Carbohydrates Versus Standard Wholegrain Carbohydrates on Glycolipid Metabolism and Vascular Stress Markers in Subjects With Suboptimal TriglyceridemiaRECRUITINGINTERVENTIONALAltograno® Bakery Foods, Standard Whole-Grain Bakery Foods
NCT05227183Prevention of Suicidal Behavior Through the VIGILANS Protocol: the Restoration of Social Connection HypothesisRECRUITINGINTERVENTIONALThe virtual version of the Social stress task : V-TSST
NCT06505109OPTImizing CArdiac REhabilitation by REfining Sleep and STressRECRUITINGINTERVENTIONALRESST
NCT06670768Myocardial Perfusion Quantification With Single Photon Emission Computed Tomography Using Multi-Pinhole Collimator Compared to Photon-Counting Coronary Computed Tomography AngiographyRECRUITINGINTERVENTIONALStress Dynamic MPI SPECT, Stress Static MPI SPECT, Rest Dynamic MPI SPECT
NCT06055036Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health InterventionRECRUITINGINTERVENTIONALBlack Impact Intervention
NCT05796739SMart Angioplasty Research Team-Pragmatic Randomized Trial for Comparing Routine Versus As-Needed EXercise or Pharmacologic Stress Testing in Asymptomatic Patients With High-Risk Coronary CalciuM (SMART-EXAM)RECRUITINGINTERVENTIONALNon-invasive stress test, Medical treatment without further testing
NCT06409949MitoQ Treatment of Claudication: Myofiber and Micro-vessel PathologyRECRUITINGINTERVENTIONALWalking assessment, QOL Survey, Ankle pressure at rest and after stress
NCT05703126Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With Acute Myeloid LeukemiaRECRUITINGINTERVENTIONALHistory taking, Anthropometry, Complete blood count
NCT04709900DYnamic CT Stress Myocardial perfusioN, CT Fractional Flow Reserve and Coronary CT Angiography for Optimized treatMent Strategy In Patients With sTable Chest Pain syndromEsRECRUITINGINTERVENTIONALCT angiography, FFR-CT and stress CT myocardial perfusion
NCT04496947Pilot Study Evaluating the Impact of Stress Reduction on Atherosclerotic : Heart and Mind StudyRECRUITINGINTERVENTIONALStress Reduction
NCT06912737Development of a Group Emotion-Focused Behavioral Intervention for Diabetes Distress and Glycemic Management in Patients With T2D.NOT YET RECRUITINGINTERVENTIONALGroup Emotion Focused Behavioral Intervention (G-EFBI), Group - With Every Heartbeat is Life (G-WEHL)
NCT06276569A Single-center, Randomized, Controlled, Study Evaluating the Efficacy and Safety of Sivelestat Sodium in Preventing Postoperative Acute Lung Injury or Acute Respiratory Distress Syndrome Following Cardiac SurgeryCOMPLETEDINTERVENTIONALSivelestat, placebo
NCT05839236COVID-19 Vaccination Detoxication in Low Density Lipoprotein CholesterolUNKNOWNINTERVENTIONALAtorvastatin Calcium Tablets
NCT05794932Exercise Tolerance After Venous Recanalization for Post-thrombotic Syndrome: ETERecaVSPTCOMPLETEDINTERVENTIONALStress test
NCT07216729Evaluating the Effects of Lactobacillus Reuteri DSM 17938 on State and Trait Stress in Stressed AdultsCOMPLETEDINTERVENTIONALLactobacillus reuteri DSM 17938, Placebo
NCT05471687Evaluation of the Functional Impact of Coronary Stenoses in Diabetics by Spectral CTUNKNOWNINTERVENTIONALdual-energy dual-layer spectral scanner, Stress protocol with adenosin during dual-energy dual-layer spectral scanner
NCT05314725Treatment With SGLT-2 Inhibitor for Postoperative Hyperglycemia in Acute Abdominal Surgery - a Randomized TrialUNKNOWNINTERVENTIONALSGLT2 inhibitor, Placebo
NCT05365854Comparison of Hemodynamic Effects of Two Modalities of Alveolar Recruitment Maneuvers in Intensive Care Unit Patients Under Mechanical Ventilation. A Pilot Physiological StudyUNKNOWNINTERVENTIONALAlveolar Recruitment Maneuver (ARM)
NCT04424121Cardiac CT, Calcium Scoring and ECG Stress Testing in Patients With Suspected Coronary Artery Disease: Precision Phenotyping and Financial Evaluation (The DATASET-PRECISE Randomized Trial)UNKNOWNINTERVENTIONALCCTA
NCT04433546A Randomized, Double-Blind, Parallel Group Study to Assess the Efficacy and Safety of Once Weekly Subcutaneous Injections of Pemziviptadil (PB1046), a Sustained-Release VIP (Vasoactive Intestinal Peptide) ANalogue, in Hospitalized COVID-19 Patients at HiGh Risk for Rapid Clinical Deterioration and ARDS (PB1046 VANGARD Study)TERMINATEDINTERVENTIONALPemziviptadil (PB1046), Low Dose (10 mg) Control
NCT04123197Mental Stress and Myocardial Ischemia After MI: Sex Differences, Mechanisms and PrognosisCOMPLETEDINTERVENTIONALStress Challenge
NCT03972774Assessment of Patients With suspeCted Coronary Artery Disease by Coronary calciUm fiRst strATegy vErsus Usual Care ApproachTERMINATEDINTERVENTIONALPET Stress Test, Non-PET Medical Management
NCT04680338Early Detection of Silent Myocardial Ischemia and Cardiac Dysfunction in Asymptomatic Individuals With Increased Coronary Artery Calcium ScoresUNKNOWNINTERVENTIONALCMR stress perfusion imaging
NCT03565497Engaging Working Memory and Distress Tolerance to Aid Smoking CessationTERMINATEDINTERVENTIONALWellness Education Control Condition, Mindfulness Training, Mindfulness Training Plus IE
NCT03223545Stress Management to Support Women's HealthCOMPLETEDINTERVENTIONALMBCT-T, Usual Care
NCT03036644Effects of Electronic Cigarette Vaporization at High Temperature in Comparison to Tobacco Smoking on Cardiovascular Function and Oxidative Stress in Electronic Cigarette Users and Regular Tobacco SmokersCOMPLETEDINTERVENTIONALe-cigarette (PG+VG without nicotine; low temperature), e-cigarette (PG+VG with nicotine; low temperature), e-cigarette (PG+VG without nicotine; high temperature)
NCT02840357The Purple Wheat Intervention Study: Impact of Purple Wheat Consumption on Markers of Inflammation and Oxidative Stress in Adults.COMPLETEDINTERVENTIONALPurple Wheat Convenience Bars, Control Wheat Convenience Bars
NCT02443402Sitagliptin for the Prevention and Treatment of Stress Hyperglycemia in Non-Diabetic Patients Undergoing Cardiac SurgeryCOMPLETEDINTERVENTIONALSitagliptin, Placebo, Regular Human Insulin
NCT02953522Polymorphism C677T MTHFR and Diet With Folate in Oxidative Stress, Lipid Profile and HomocysteineCOMPLETEDINTERVENTIONAL191 mcg/day of Folate, 90 mcg / day of Folate
NCT02522481A Prospective Multicenter Phase III Clinical Evaluation of the Safety and Efficacy of Lumason™/SonoVue® in Subjects Undergoing Pharmacologic Stress Echocardiography With Dobutamine for the Diagnosis of Coronary Artery DiseaseCOMPLETEDINTERVENTIONALLumason
NCT02321579The Effects of Vitamin B-6 and Glutathione on Inflammatory Responses, Homocysteine Metabolism, Oxidative Stress and Antioxidant Capacities in Patients With Liver Cirrhosis or Hepatocellular CarcinomaUNKNOWNINTERVENTIONALvitamin B-6, Glutathione, Dextrins
NCT02115308Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance ImagingCOMPLETEDINTERVENTIONALRegadenoson
NCT03402204Efficacy of High-Dose and Low-Dose Simvastatin on Vascular Oxidative Stress and Neurological Outcomes in Patients With Acute Ischemic Stroke: A Randomized, Double-Blind, Parallel, Controlled TrialCOMPLETEDINTERVENTIONALSimvastatin 10 mg, Simvastatin 40 mg
NCT01784796Mindfulness Based Stress Reduction for Women at Risk for Cardiovascular DiseaseCOMPLETEDINTERVENTIONALMindfulness Based Stress Reduction, Health Education Program
NCT02178501The Effect of Omega-3 Polyunsaturated Acids Supplementation on Endothelial Function, Oxidative Stress, Platelet Aggregation, Blood Coagulation and Inflammation in Patients With Type 2 Diabetes and Cardiovascular DiseaseCOMPLETEDINTERVENTIONALOmega-3 PUFA
NCT01875315EXACT-COST: Exercise CMR's Accuracy for Cardiovascular Stress Testing-Comparative Effectiveness of Stress TestsCOMPLETEDINTERVENTIONALDiagnostic Cardiac Imaging
NCT02862860Influence of Glycaemic Variability on Oxidative Stress and High-density Lipoprotein (HDL) Function in Type-1 DiabetesCOMPLETEDINTERVENTIONALblood sample, urine sample, installation of Holter
NCT01424761Coenzyme Q10 in Relation to the Antioxidative Vitamins, Oxidative Stress and Inflammation in Coronary Artery Disease Patients During Statin TherapyCOMPLETEDINTERVENTIONALCoenzyme Q10, Placebo
NCT01426490The Effects of Vitamin B-6 Status on Homocysteine, Oxidative Stress, One-carbon Metabolism and Methylation: Cross-section, Case-control, Intervention and Follow-up Studies in Colorectal CancerUNKNOWNINTERVENTIONALVitamin C, Vitamin B6, Folic acid
NCT01374061Pre Hospital Evaluation of Video Laryngoscopy : a Comparative Study of Macintosh and GLIDESCOPE Ranger®WITHDRAWNINTERVENTIONALClassical intubation, GLIDESCOPE
NCT02165228A Stress Reduction Strategy for Decreasing CVD Risk Through C-reactive Protein ReductionCOMPLETEDINTERVENTIONALMindfulness-based stress reduction, Nutrition Enhancement
NCT00970606Randomized, Placebo Controlled Trial of the Effectiveness of Statins for Preventing Mortality Following ICU Admission for Influenza ComplicationsTERMINATEDINTERVENTIONALRosuvastatin (crestor), Placebo
NCT00981591A Randomized, Double Blind, Placebo-controlled Pilot Study of the Safety and Effective Dosing of Inhaled Iloprost in Pediatric Patients With Pulmonary Hypertension Treated With Inhaled Nitric OxideWITHDRAWNINTERVENTIONALIloprost, Placebo
NCT00954902Development of a Dynamic Model of Inflammation for Studying the Anti-inflammatory Effects of Culinary Spices in Human ParticipantsCOMPLETEDINTERVENTIONALHigh Antioxidant Spice Blend, Trier Psychological Stressor, Placebo antioxidant concentrate
NCT01703156Stress Testing Versus Non-Stress Testing Based Strategy in Patients Hospitalized With Low-Risk Acute Coronary Syndromes: A Randomized, Single-Center Pilot StudyCOMPLETEDINTERVENTIONALStress Test, No Stress Test
NCT00597376A Six-month, Double-blind, Placebo-controlled, Single Site Study of Cerefolin NAC on Blood Homocysteine, Oxidative Stress, and Beta-amyloid Biomarkers That May Potentiate Inflammation and Neuronal Damage in Older Individuals With Memory Complaints Who Have Not Been Clinically Diagnosed With Mild Cognitive Impairment, Vascular Dementia, or Alzheimer's DiseaseCOMPLETEDINTERVENTIONALCerefolin NAC (a medical food), Cerefolin NAC placebo
NCT00493389Improving The Assessment of Hypothalamic Pituitary Adrenal Function In Acute StressUNKNOWNINTERVENTIONALAdrenocorticotrophic hormone
NCT00384618Effect of an Oxidative-Stress-Reducing Strategy Consisting of Pravastatin, Vitamin E and Homocysteine-Lowering on Carotid Intima-Media Thickness in Patients With Mild-to-Moderate Chronic Kidney DiseaseTERMINATEDINTERVENTIONALpravastatin, vitamin E
NCT05373732Stress Reduction in the Prevention of Left Ventricular Hypertrophy: A Randomized Controlled Trial of Transcendental Meditation and Health Education in Hypertensive African AmericansCOMPLETEDINTERVENTIONALmeditation, Health education control
NCT06585761Effect of Sodium Glucose Co-tansporter 2 Inhibitors (SGLT2I) on Inflammatory and Oxidative Stress Markers Level in Heart Failure PatientsRECRUITINGOBSERVATIONALSGLT2 inhibitor, echo cardiogram
NCT06443268Cerebrovascular Disease: Quality of Life (CODE: QoL)RECRUITINGOBSERVATIONALquestionnaire, hair samples, blood samples, clinical exam
NCT07450846Incidence and Evolution of Heart-lung Interaction in Acute Respiratory Distress Syndrome: the IVOLIA StudyRECRUITINGOBSERVATIONAL
NCT06076551Sex Difference of Coronary Microvascular Dysfunction Evaluated by Coronary Flow Reserve in Patients With Non-obstructive Coronary Artery DiseaseRECRUITINGOBSERVATIONALAdenosine stress echocardiography
NCT05692115Ischemia and Inflammatory Markers Among Patients With Coronary Artery EctasiaUNKNOWNOBSERVATIONALstress ECG
NCT04853511Biological Interconnection Between Stress-associated Neurobiological Activity and Atherosclerotic Plaque Instability: A Prospective Cohort Study With OCT-FLIM Dual-modal Intravascular Imaging and Serial 18F-FDG-PET/CT AssessmentUNKNOWNOBSERVATIONALOCT-FLIM (optical coherence tomography-fluorescence life time)
NCT05230264Examination of Sex-specific Differences in the Stress Response to Abdominal Aortic Aneurysm Repair - A Prospective Cohort StudyUNKNOWNOBSERVATIONALElective AAA Repair
NCT04947215The Association Between LPCAT1 Genetic Polymorphism and Stress Biomarkers in Neonatal Respiratory Distress SyndromeUNKNOWNOBSERVATIONALstress biomarkers
NCT04694703Changing of Trace Element, Homocysteine, Oxidative Stress Parameters and Physical Activity Levels in Patients Diagnosed With COVID-19 Before and After COVID-19 TreatmentCOMPLETEDOBSERVATIONALCovid-19 group
NCT04695158Determination of Hemoglobin A1c, Lipid Profiles, Homocysteine, Oxidative Stress Parameters and Physical Activity Levels in Patients With Type II Diabetes and/or COVID-19UNKNOWNOBSERVATIONALCOVID-19 group (Group I), Type II Diabetes Mellitus and COVID-19 group (Group II)
NCT05652426The Effect of Hypoxic and Normoxic Cerebral Oximetry Levels and Oxidative Stress on Cognitive Functions After Carotid EndarterectomyCOMPLETEDOBSERVATIONAL

Genetic associations (0)

None linked.