A
Clonal hematopoiesis of indeterminate potential
Genetic & Family HistoryGenetic / heritablerisknon modifiable
37
evidence score
Also known as: Clonal hematopoiesis, chip, clonal haematopoiesis, clonal hematopoiesis
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 20.3meta-analyses: 11.6trials: 4.8genetic: 0MR bonus:
References (105)
3 meta-analyses / systematic reviews- METAClonal hematopoiesis of indeterminate potential as a prognostic factor: a systematic review and meta-analysis. — Blood advances 2024 · PMID 38838228
- METAClonal hematopoiesis of indeterminate potential (CHIP) and cardiovascular diseases—an updated systematic review — Journal of Genetic Engineering and Biotechnology 2021 · PMID 34279740
- METATranslating Evidence from Clonal Hematopoiesis to Cardiovascular Disease: A Systematic Review — Journal of Clinical Medicine 2020 · PMID 32748835
- Non-traditional risk factors for atrial fibrillation: epidemiology, mechanisms, and strategies. — European heart journal 2025 · PMID 39716283
- Clonal haematopoiesis in cardiovascular disease: prognostic role and novel therapeutic target. — Nature reviews. Cardiology 2025 · PMID 40175709
- Mitochondrial metabolism sustains DNMT3A-R882-mutant clonal haematopoiesis. — Nature 2025 · PMID 40239706
- Genetic Associations of Clonal Hematopoiesis With Cardioembolic Stroke: Insights From Genome-Wide Mendelian Randomization, Bulk RNA, Single-Cell RNA Sequencing. — CNS neuroscience & therapeutics 2025 · PMID 40702735
- Clonal Hematopoiesis and Cardiovascular Outcomes in Older Women. — Journal of the American College of Cardiology 2025 · PMID 40864016
- [Clonal hematopoiesis]. — [Rinsho ketsueki] The Japanese journal of clinical hematology 2025 · PMID 41034053
- Human plasma proteomic profile of clonal hematopoiesis. — Nature communications 2025 · PMID 41309676
- Jak2 V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talk. — Blood 2024 · PMID 38142422
- Somatic and Germline Variants and Coronary Heart Disease in a Chinese Population. — JAMA cardiology 2024 · PMID 38198131
- Clonal Hematopoiesis Risk Score and All-Cause and Cardiovascular Mortality in Older Adults — JAMA Network Open 2024 · PMID 38231513
- Clonal Hematopoiesis and Cardiovascular Risk: Atherosclerosis, Thrombosis, and beyond. — Hamostaseologie 2024 · PMID 38417801
- Clonal hematopoiesis of indeterminate potential is associated with acute kidney injury. — Nature medicine 2024 · PMID 38454125
- Combined Effects of Clonal Hematopoiesis and Carotid Stenosis on Cardiovascular Mortality. — Journal of the American College of Cardiology 2024 · PMID 38692825
- Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss. — Cell 2024 · PMID 38838669
- Challenges and advances in the management of inflammation in atherosclerosis. — Journal of advanced research 2024 · PMID 38909884
- JAK2-mutant clonal hematopoiesis is associated with venous thromboembolism. — Blood 2024 · PMID 39102652
- Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences. — Nature genetics 2024 · PMID 39192095
- Unidirectional association of clonal hematopoiesis with atherosclerosis development — Nature Medicine 2024 · PMID 39215150
- Clonal hematopoiesis and atherosclerosis. — The Journal of clinical investigation 2024 · PMID 39352379
- Aging drives Tet2+/- clonal hematopoiesis via IL-1 signaling. — Blood 2023 · PMID 36379023
- CHIP Happens: Clonal Hematopoiesis of Indeterminate Potential and Its Relationship to Solid Tumors. — Clinical cancer research : an official journal of the American Association for Cancer Research 2023 · PMID 36454121
- A new risk factor associated with cardiovascular disease: clonal hematopoiesis of indeterminate potential. — Molecular biology reports 2023 · PMID 36595120
- Human Immunodeficiency Virus and Clonal Hematopoiesis. — Cells 2023 · PMID 36899822
- Clonal haematopoiesis and dysregulation of the immune system. — Nature reviews. Immunology 2023 · PMID 36941354
- Clonal haematopoiesis and risk of chronic liver disease. — Nature 2023 · PMID 37046084
- Obesity-induced inflammation exacerbates clonal hematopoiesis. — The Journal of clinical investigation 2023 · PMID 37071471
- Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease. — Journal of the American College of Cardiology 2023 · PMID 37197843
- Clonal hematopoiesis is associated with protection from Alzheimer's disease. — Nature medicine 2023 · PMID 37322115
- Associations between Ambient Air Pollutants and Clonal Hematopoiesis of Indeterminate Potential. — Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2023 · PMID 37466697
- Prediction of Risk for Myeloid Malignancy in Clonal Hematopoiesis — NEJM Evidence 2023 · PMID 37483562
- Genetic modification of inflammation- and clonal hematopoiesis-associated cardiovascular risk. — The Journal of clinical investigation 2023 · PMID 37498674
- BRCC3-Mediated NLRP3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis inClonal Hematopoiesis. — Circulation 2023 · PMID 37781816
- Causes and consequences of clonal hematopoiesis — Blood 2023 · PMID 37931207
- Clonal Hematopoiesis and Cardiovascular Disease in Patients With Multiple Myeloma Undergoing Hematopoietic Cell Transplant — JAMA Cardiology 2023 · PMID 37938837
- Clonal hematopoiesis and vascular disease. — Seminars in immunopathology 2022 · PMID 35122117
- <i>TET2</i>-Driven Clonal Hematopoiesis and Response to Canakinumab — JAMA Cardiology 2022 · PMID 35385050
- Atherosclerosis: Recent developments. — Cell 2022 · PMID 35504280
- Longitudinal profiling of clonal hematopoiesis provides insight into clonal dynamics — Immunity & Ageing 2022 · PMID 35610705
- Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention. — Biochemical pharmacology 2022 · PMID 35643340
- Somatic Mutations and Clonal Hematopoiesis as Drivers of Age-Related Cardiovascular Risk — Current Cardiology Reports 2022 · PMID 35657494
- <i>TET2</i>-mutant clonal hematopoiesis and risk of gout — Blood 2022 · PMID 35714308
- Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. — Nature genetics 2022 · PMID 35835912
- Clinical Significance of Clonal Hematopoiesis of Indeterminate Potential in Hematology and Cardiovascular Disease — Diagnostics 2022 · PMID 35885518
- Clonal hematopoiesis, somatic mosaicism, and age-associated disease. — Physiological reviews 2022 · PMID 36049115
- Clonal hematopoiesis of indeterminate potential and cardiovascular disease. — Translational research : the journal of laboratory and clinical medicine 2022 · PMID 36067904
- Clonal hematopoiesis of indeterminate potential, DNA methylation, and risk for coronary artery disease. — Nature communications 2022 · PMID 36097025
- Clonal hematopoiesis and cardiovascular disease in cancer patients and survivors. — Thrombosis research 2022 · PMID 36210552
- Genomic Aging, Clonal Hematopoiesis, and Cardiovascular Disease. — Arteriosclerosis, thrombosis, and vascular biology 2022 · PMID 36353993
- Clonal hematopoiesis and cardiovascular disease: deciphering interconnections. — Basic research in cardiology 2022 · PMID 36355225
- Common and rare variant associations with clonal haematopoiesis phenotypes. — Nature 2022 · PMID 36450978
- Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in monocyte and macrophage biology and atherosclerotic cardiovascular disease — Current Opinion in Hematology 2021
- The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. — Nature 2021 · PMID 33731931
- The changing landscape of atherosclerosis. — Nature 2021 · PMID 33883728
- Myelodysplasia Syndrome, Clonal Hematopoiesis and Cardiovascular Disease — Cancers 2021 · PMID 33921778
- Association of Diet Quality With Prevalence of Clonal Hematopoiesis and Adverse Cardiovascular Events — JAMA Cardiology 2021 · PMID 34106216
- Innate immune pathways and inflammation in hematopoietic aging, clonal hematopoiesis, and MDS — The Journal of Experimental Medicine 2021 · PMID 34129017
- Clonal hematopoiesis of indeterminate potential (CHIP): Linking somatic mutations, hematopoiesis, chronic inflammation and cardiovascular disease. — Journal of molecular and cellular cardiology 2021 · PMID 34298011
- Clonal hematopoiesis and associated diseases: A review of recent findings — Cancer Science 2021 · PMID 34328684
- Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease. — Leukemia 2021 · PMID 34413458
- Emerging Role of Acquired Mutations and Clonal Hematopoiesis in Atherosclerosis　- Beyond Conventional Cardiovascular Risk Factors. — Circulation journal : official journal of the Japanese Circulation Society 2021 · PMID 34433749
- Is There a Causal Link Between Periodontitis and Cardiovascular Disease? A Concise Review of Recent Findings — International Dental Journal 2021 · PMID 34565546
- Telomere Attrition and Clonal Hematopoiesis of Indeterminate Potential in Cardiovascular Disease — International Journal of Molecular Sciences 2021 · PMID 34576030
- Clonal hematopoiesis is associated with risk of severe Covid-19 — Nature Communications 2021 · PMID 34645798
- Clonal Hematopoiesis Is Associated With Higher Risk of Stroke — Stroke 2021 · PMID 34743536
- Association of clonal hematopoiesis with chronic obstructive pulmonary disease — Blood 2021 · PMID 34855941
- Clonal hematopoiesis and atherosclerotic cardiovascular disease: A primer. — Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2021 · PMID 34879980
- Tet2-mediated clonal hematopoiesis in nonconditioned mice accelerates age-associated cardiac dysfunction — JCI Insight 2020 · PMID 32154790
- The Clinical Challenge of Clonal Hematopoiesis, a Newly Recognized Cardiovascular Risk Factor — JAMA Cardiology 2020 · PMID 32459358
- Clonal hematopoiesis and nonhematologic disorders. — Blood 2020 · PMID 32736379
- Clonal Hematopoiesis: Mechanisms Driving Dominance of Stem Cell Clones — Blood 2020 · PMID 32746453
- [Clonal haematopoiesis is possibly a risk factor for cardiovascular disease]. — Ugeskrift for laeger 2020 · PMID 32800058
- Clonal Hematopoiesis in Liquid Biopsy: From Biological Noise to Valuable Clinical Implications — Cancers 2020 · PMID 32823942
- Inherited causes of clonal haematopoiesis in 97,691 whole genomes. — Nature 2020 · PMID 33057201
- TET2-Loss-of-Function-Driven Clonal Hematopoiesis Exacerbates Experimental Insulin Resistance in Aging and Obesity — Cell Reports 2020 · PMID 33113366
- Clonal Hematopoiesis, Cardiovascular Diseases and Hematopoietic Stem Cells — International Journal of Molecular Sciences 2020 · PMID 33114351
- Clonal Hematopoiesis–Driver DNMT3A Mutations Alter Immune Cells in Heart Failure — Circulation Research 2020 · PMID 33155517
- Premature Menopause, Clonal Hematopoiesis, and Coronary Artery Disease in Postmenopausal Women — Circulation 2020 · PMID 33161765
- Taking the next steps to implement polygenic risk scoring for improved risk stratification and primary prevention of coronary artery disease — European Journal of Preventive Cardiology 2020 · PMID 33624063
- Connections Between Clonal Hematopoiesis, Cardiovascular Disease, and Cancer: A Review. — JAMA cardiology 2019 · PMID 30865214
- Clonal haematopoiesis: connecting ageing and inflammation in cardiovascular disease. — Nature reviews. Cardiology 2019 · PMID 31406340
- Comorbid and inflammatory characteristics of genetic subtypes of clonal hematopoiesis — Blood Advances 2019 · PMID 31434682
- Clonal hematopoiesis in human aging and disease. — Science (New York, N.Y.) 2019 · PMID 31672865
- Cardiovascular Disease, Aging, and Clonal Hematopoiesis. — Annual review of pathology 2019 · PMID 31689371
- Genetic Interleukin 6 Signaling Deficiency Attenuates Cardiovascular Risk in Clonal Hematopoiesis — Circulation 2019 · PMID 31707836
- JAK2V617F-Mediated Clonal Hematopoiesis Accelerates Pathological Remodeling in Murine Heart Failure — JACC Basic to Translational Science 2019 · PMID 31709318
- Somatic Mutations and Clonal Hematopoiesis — Circulation Research 2018 · PMID 29420212
- Atherosclerosis and clonal hematopoyesis: A new risk factor. — Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2018 · PMID 29699715
- CRISPR-Mediated Gene Editing to Assess the Roles of Tet2 and Dnmt3a in Clonal Hematopoiesis and Cardiovascular Disease — Circulation Research 2018 · PMID 29728415
- Clonal Hematopoiesis Confers Predisposition to Both Cardiovascular Disease and Cancer: A Newly Recognized Link Between Two Major Killers — Annals of Internal Medicine 2018 · PMID 29809241
- Clonal Hematopoiesis — Circulation Genomic and Precision Medicine 2018 · PMID 29987111
- Clonal Hematopoiesis and Its Impact on Cardiovascular Disease — Circulation Journal 2018 · PMID 30185689
- Clonal hematopoiesis: Genes and underlying mechanisms in cardiovascular disease development — Journal of Cellular Physiology 2018 · PMID 30417440
- Clinical consequences of clonal hematopoiesis of indeterminate potential — Blood Advances 2018 · PMID 30482770
- Clinical consequences of clonal hematopoiesis of indeterminate potential — Hematology 2018 · PMID 30504320
- Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure — JAMA Cardiology 2018 · PMID 30566180
- Clonal Hematopoiesis Associated With Adverse Outcomes After Autologous Stem-Cell Transplantation for Lymphoma — Journal of Clinical Oncology 2017 · PMID 28068180
- Clonal hematopoiesis associated with TET2 deficiency accelerates atherosclerosis development in mice — Science 2017 · PMID 28104796
Clinical trials (2)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07362966 | Precision Colchicine Intervention to Suppress Atherosclerosis in TET2 Clonal Hematopoiesis : a Pilot Clinical Trial (PRECISE) | RECRUITING | INTERVENTIONAL | Colchicine 0.5 mg orally once daily for 12 months., SoC therapy |
| NCT04987268 | Clonal Hematopoiesis of Indeterminate Potential and Residual Cardiovascular Event Tendency After Smoking Cessation | COMPLETED | OBSERVATIONAL | clonal hematopoiesis of indeterminate potential |
Genetic associations (0)
None linked.