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Coronary artery calcium score

Imaging & Subclinical DiseaseImaging markerrisknon modifiable
56
evidence score

Also known as: Coronary artery calcium, agatston, cac score, calcium score, coronary artery calcium, coronary artery calcium score >10, coronary calcium

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 21.3meta-analyses: 20trials: 15genetic: 0MR bonus:

References (135)

11 meta-analyses / systematic reviews

Clinical trials (53)

NCTTitleStatusTypeInterventions
NCT07696533Carotid Ultrasound Vs Computed Tomography (CT) Coronary Calcium Scoring to Reclassify Symptomatic Patients With Suspected Chronic Coronary Syndrome Using Risk Factor Clinical Likelihood for Obstructive Coronary Artery DiseaseRECRUITINGINTERVENTIONALCarotid Ultrasound
NCT06960902Study of the Determinants of Coronary Atherosclerosis in Familial HypercholesterolemiaRECRUITINGINTERVENTIONALCoronary CT scan with CAC score measurement
NCT06676280an Investigator-initiated, Multicenter, Open-label, 2-by-2 Factorial, and Randomized Trial to Evaluate the Role of Aspirin and High-intensity Statin Therapy, Respectively, in Individuals With Severe Coronary Calcification (Coronary Calcium Score ≥300) to Prevent Atherosclerotic Cardiovascular Disease (ASCVD) Events With Severe Coronary Calcification (CAC ≥300)RECRUITINGINTERVENTIONALAspirin, High-intensity statin, Guideline-directed statin therapy
NCT06235112AI Detection of Incidental Coronary Artery Calcium to Enhance Cardiovascular Disease Prevention: A Multicenter Randomized TrialRECRUITINGINTERVENTIONALElectronic health record-based notification of Nanox.AI Coronary Artery Calcification Assessment
NCT05961488Performance of Coronary CT Angiography to Rule Out Coronary Artery Disease After Out-of-hospital Cardiac ArrestRECRUITINGINTERVENTIONALCoronary Calcium Score and Coronary CT angiogram
NCT05845424Comparison of Efficacy and Safety of High-Intensity Statin and Ezetimibe Combination Versus StanDard carE in AsymptomatiC PatIentS wIth Presence of COroNary Artery CALCIUM (DECISION-CAL)RECRUITINGINTERVENTIONALGuideline directed statin therapy, High intensity statin plus ezetimibe therapy
NCT05796739SMart Angioplasty Research Team-Pragmatic Randomized Trial for Comparing Routine Versus As-Needed EXercise or Pharmacologic Stress Testing in Asymptomatic Patients With High-Risk Coronary CalciuM (SMART-EXAM)RECRUITINGINTERVENTIONALNon-invasive stress test, Medical treatment without further testing
NCT03604627Study of Coronary Calcium Score as a Marker of Post-radiation Vascular Dysplasia in Adults Treated During Childhood for Cancer With Mediastinal IrradiationRECRUITINGINTERVENTIONALCoronal calcium score measurement
NCT05359822Investigating the Impact of a Patient-directed Coronary Artery Calcium Score Report: A Randomized-controlled TrialNOT YET RECRUITINGINTERVENTIONALImage-Based Report
NCT05858879Notification of Incidental Coronary Artery Calcium in Patients With Atherosclerotic Cardiovascular Disease (NOTIFY-ASCVD)COMPLETEDINTERVENTIONALNotification of patients and clinicians
NCT06301009The AI-CAC Model for Subclinical Atherosclerosis Detection on Chest X-ray: Prospective Validation Study (AI-CAC-PVS)UNKNOWNINTERVENTIONALAI-CAC score
NCT06181240Modification of Coronary Calcium With Laser Based Intravascular Lithotripsy for Coronary Artery Disease (FRACTURE)ACTIVE NOT RECRUITINGINTERVENTIONALIntravascular lithotripsy
NCT06055972Impact of Patient-Centered Approach for Communicating Coronary Calcium on Cardiovascular HealthACTIVE NOT RECRUITINGINTERVENTIONALEducational Letter Post CT Examination
NCT05394181Notify 2: An Evaluation of the Impact of Notification of Incidental Coronary Artery Calcium on Statin RatesWITHDRAWNINTERVENTIONALNotification
NCT05283538Comparison of Cardiovascular Risk Stratification in Young People With Type 1 Diabetes by Coronary Calcium Score to ESC/ESA2019 RecommendationsCOMPLETEDINTERVENTIONALCoronary Artery Calcification Realization
NCT05775822Coronary Artery Calcium and Cardiovascular Risk Factors Analysis After RT for Breast Cancer. A Gender-based Preventive Medicine ApproachCOMPLETEDINTERVENTIONALCT scan and blood sample collection
NCT05267990Impact of a Coronary Artery Calcium-guided Primary Prevention of Major Coronary Heart Disease for Asymptomatic Coronary Artery Disease in Diabetes: a Prospective Cohort StudyENROLLING BY INVITATIONINTERVENTIONALMulti-Detector Computed Tomography
NCT06880133Evaluation and Improvement of Diagnostic Accuracy of Seismocardiography and Gyrocardiography for Non-Invasive Coronary Artery Disease Diagnosis in Comparison With Coronary Artery Calcium Computed Tomography, Coronary Computed Tomography Angiography, and Invasive Coronary AngiographyCOMPLETEDINTERVENTIONALSeismocardiography (SCG) and Gyrocardiography (GCG) Screening
NCT06956924CT-Based Abdominal Aortic Calcium Score and CAD-RADS 2.0 in Elderly Chest Pain: A Cohort StudyCOMPLETEDINTERVENTIONALCCTA
NCT06880120Improvement of Diagnostic Accuracy of Seismocardiography and Gyrocardiography for Non-Invasive Coronary Artery Disease Diagnosis: A Comparison With Coronary Artery Calcium Computed Tomography, Coronary Computed Tomography Angiography, and Invasive Coronary AngiographyCOMPLETEDINTERVENTIONALSeismocardiography (SCG) and Gyrocardiography (GCG) Diagnostic Testing
NCT04604353Early Detection of Coronary Artery Disease by Polygenic and Metabolic Risk Scoring in at Risk Patients: Comparison With Coronary Computed TomographyCOMPLETEDINTERVENTIONALPolygenic Risk Score, Coronary Calcium Score
NCT03972774Assessment of Patients With suspeCted Coronary Artery Disease by Coronary calciUm fiRst strATegy vErsus Usual Care ApproachTERMINATEDINTERVENTIONALPET Stress Test, Non-PET Medical Management
NCT04680338Early Detection of Silent Myocardial Ischemia and Cardiac Dysfunction in Asymptomatic Individuals With Increased Coronary Artery Calcium ScoresUNKNOWNINTERVENTIONALCMR stress perfusion imaging
NCT03637231Ultra-low-dose Coronary Artery Calcium Scoring: Evaluation of Prognostic Performance and Impact of Physiological Factors on Quantification in a Large PopulationTERMINATEDINTERVENTIONALUltra low-dose CTAC
NCT03501875Study of Coronary Calcification in Subjects With Autosomal Dominant Familial Hypercholesterolemia HeterozygousCOMPLETEDINTERVENTIONALCAC Score
NCT03439267Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac EventsACTIVE NOT RECRUITINGINTERVENTIONALCoronary Artery Calcium Screening and Statin Treatment, Standard Treatment
NCT02855528Ultra Low-dose Coronary Artery Calcium Scoring Using Tin Filtration With Dual-source CTCOMPLETEDINTERVENTIONALTin Filter
NCT02376010Rivaroxaban Versus Warfarin in the Evaluation of Progression of Coronary CalciumCOMPLETEDINTERVENTIONALrivaroxaban, Warfarin
NCT01830062Atherosclerotic Coronary Vulnerable Plaque: Correlation With Coronary Artery CalciumWITHDRAWNINTERVENTIONALNIRS, CACS
NCT00294853MDCT Calcium Score of Heart Transplanted PatientsCOMPLETEDINTERVENTIONALMDCT calcium score
NCT00927693Early Identification of Subclinical Atherosclerosis Using Non-Invasive Imaging Research (EISNER)COMPLETEDINTERVENTIONALCoronary Artery Calcium (CAC) Scan
NCT07315997The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) StudyRECRUITINGOBSERVATIONALhigh sensitivity cardiac troponin
NCT03132129Prevalence and Determinants of Subclinical Cardiovascular Dysfunction in Adults With Type 2 Diabetes MellitusRECRUITINGOBSERVATIONALCardiovascular magnetic resonance (CMR) imaging and magnetic resonance spectroscopy, Transthoracic echocardiography, Computed tomography coronary artery calcium scoring
NCT04075162Community Benefit of No-charge Calcium Score Screening ProgramRECRUITINGOBSERVATIONAL
NCT07662161Coronary Artery Calcium Score in HIV Mexican Population (The CACsHIVMex Study)NOT YET RECRUITINGOBSERVATIONALSimple coronary CT scan
NCT07594392Clinical Assessment and Targeted Imaging to Characterize High-Risk Atherosclerotic Cardiovascular Disease of Survivors in the St. Jude Lifetime Cohort (SJLIFE)NOT YET RECRUITINGOBSERVATIONALCoronary Artery Calcium Scan, Carotid Artery Ultrasound, Lipoprotein(a) Measurement
NCT05314140Towards Optimal Screening and Management of Coronary Artery Disease in Diabetes: TOSCANA StudyWITHDRAWNOBSERVATIONALCoronary artery calcium score evaluation
NCT06311071The Utility of Coronary Artery Calcium Score for the Prediction of Coronary Artery Disease in Patients With Cardiac Symptoms; a Diagnostic StudyCOMPLETEDOBSERVATIONALcalcium score, Invasive coronary angiography
NCT03835793Favourable and Unfavourable Health Effects of Risk-Reducing Salpingo-Oophorectomy in Women With a High Genetic Risk of Ovarian CancerUNKNOWNOBSERVATIONALCAC-score
NCT03449888Arm Exercise Versus Pharmacologic Stress Testing for Clinical Outcome PredictionTERMINATEDOBSERVATIONALRegadenoson myocardial perfusion imaging stress test, Arm exercise electrocardiographic stress test, Treadmill electrocardiographic stress test
NCT02636062Predictors of Coronary Artery Calcium Progression in Adults With a Prior Zero Coronary Artery Calcium ScoreWITHDRAWNOBSERVATIONAL
NCT03206333Automated Quantification of Coronary Artery Calcifications on Radiotherapy Planning CTs for Cardiovascular Risk Prediction in Breast Cancer Patients: the BRAGATSTON StudyCOMPLETEDOBSERVATIONAL
NCT03548753Functional and Anatomical Testing in Intermediate Risk Chest Pain Patients With Severe Coronary Calcium ScoreCOMPLETEDOBSERVATIONAL
NCT02208648Coronary Assessment for Mortality PredictionCOMPLETEDOBSERVATIONAL
NCT02913144Implication of a Coronary Calcium Screening Examination, Incidence of Cardiovascular Events and Progression of Coronary Artery Calcium Over up to 7 Year of Follow-up in a Danish Middle-aged General PopulationCOMPLETEDOBSERVATIONAL
NCT02009930Assessment of Coronary Artery Calcium in Active Duty Enlisted Military Members With 10 or More Years of ServiceTERMINATEDOBSERVATIONAL
NCT05563116Coronary Artery Calcium Score in People Living With HIV: the French HIV-CAC Cohort StudyCOMPLETEDOBSERVATIONALComputed tomography coronary artery calcium (CAC) score (part of routine workup)
NCT01645228Could Non-invasive Biochemical, Image or Physiological Index Predict Significant Coronary Arterial Stenosis in Symptomatic Adults?UNKNOWNOBSERVATIONALcoronary calcium score measurement, high sensitivity C reactive protein measurement, ankle brachial index measurement
NCT01932671Optimising Risk Assessment With CT-angiography or Calcium Score in Patients at High Risk for a Cardiovascular EventUNKNOWNOBSERVATIONAL
NCT01660594Comparison of CT Coronary Artery Calcium Scoring With Traditional Assessment in Patients Presenting to the Rapid Access Chest Pain Clinic With Non-acute Chest Pain and Its Prognostic ValueCOMPLETEDOBSERVATIONALCT calcium scoring
NCT03139071Coffee Consumption and Coronary Artery Calcium Score: Results From the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)COMPLETEDOBSERVATIONAL
NCT00628446Prevalence and Risk of Coronary Heart Disease as Measured by Coronary Calcium Score Among Individuals With Chronic Traumatic Spinal Cord Injury(SCI): A Pilot StudyCOMPLETEDOBSERVATIONAL
NCT00005562Coronary Artery Calcium, Exercise Tests, and CHD OutcomeCOMPLETEDOBSERVATIONAL

Genetic associations (0)

None linked.