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Coronary artery plaque burden (CCTA)

Imaging & Subclinical DiseaseImaging markerriskpartially modifiable
36
evidence score

Also known as: Coronary CT angiography plaque, coronary plaque, plaque burden

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 15.1meta-analyses: 9.1trials: 11.7genetic: 0MR bonus:

References (31)

2 meta-analyses / systematic reviews

Clinical trials (14)

NCTTitleStatusTypeInterventions
NCT07613294A Phase 3, Randomized, Double-Blind, Placebo-Controlled Trial of Lepodisiran to Investigate the Effect on Coronary Plaque in Adults With Elevated Lp(a) Who Have Established Atherosclerotic Cardiovascular Disease or Are at Risk for a First Cardiovascular EventRECRUITINGINTERVENTIONALLepodisiran, Placebo
NCT07349875Colchicine Treatment for Non-Flow-Limiting Coronary Plaque by Coronary CTA: A Randomized Controlled TrialRECRUITINGINTERVENTIONALColchicine combined with Guideline-Directed Medical Therapy
NCT06013722Strategy for Unstable Coronary Plaque in Patients Presenting to the Emergency Department for Chest Pain Suspected of Coronary Artery Disease. A Trial in Primary Prevention and Cardiovascular Risks EvaluationACTIVE NOT RECRUITINGINTERVENTIONAL18F-Na PET Scan
NCT04848857The Efficacy and Safety of Colchicine in Improving the Stability of Coronary Plaque in Patients With Acute Coronary SyndromeCOMPLETEDINTERVENTIONALColchicine, Placebo
NCT04851769Impact of PCSK9 Inhibitors on Coronary Plaque Composition and Vulnerability in Patients With Coronary Artery Disease Assessed by Optical Coherence TomographyCOMPLETEDINTERVENTIONALPCSK9 inhibitor plus statin, standard statin therapy, Coronary imaging follow-up
NCT03745729A Single-center, Prospective, Randomized, Double-blind, Controlled Trial for the Effect of Allopurinol Sustained-release Capsules on the Stability of Coronary Plaques in Patients With Acute Coronary SyndromeCOMPLETEDINTERVENTIONALallopurinol sustained-release capsules, placebo capsules
NCT03570697High-Resolution Assessment of Coronary Plaques in a Global Evolocumab Randomized Study (HUYGENS)COMPLETEDINTERVENTIONALEvolocumab, Placebo, Statin therapy
NCT01325818The Effects of Pravastatin and Rosuvastatin on the Tissue Characteristics and Morphology of Coronary Plaques in Patients With Stable Angina PectorisUNKNOWNINTERVENTIONALpravastatin, rosuvastatin
NCT00997880Effect of High-Dose and Low-Dose Statin for Coronary Plaque ModificationCOMPLETEDINTERVENTIONALRosuvastatin calcium 40mg, Rosuvastatin calcium10mg
NCT06681155A Prospective Cohort Study on the Identification of High-Risk Coronary Plaque by Multimodality Intravascular Imaging(PlaqueVision Study)NOT YET RECRUITINGOBSERVATIONALAssessment of plaque morphology, structure, and stability in non-culprit lesions
NCT06933745Ultrasound of Carotid and Femoral Plaque Burden and Non-alcoholic Fatty Liver Disease as Predictors of Cardiovascular DiseaseCOMPLETEDOBSERVATIONAL
NCT04680689Assessment of Lesion-Associated Myocardial Ischemia Based on Fusion Coronary CT Imaging- the FUSE-HEART Study: Protocol for a Non-randomised Clinical TrialCOMPLETEDOBSERVATIONAL128 Multislice CT coronary angiography, 2D Cardiac Transthoracic Echocardiography, Laboratory Blood tests
NCT04397198New Imaging-Derived Biomarkers Based On Tridimensional CTA/MRI Hybrid Models For Complex Assessment Of Myocardial Viability After Myocardial Infarction-the HYBRIDHEART StudyCOMPLETEDOBSERVATIONALSpeckle Tracking echocardiography
NCT04525508Coronary Artery Plaque Burden in Asymptomatic Danish Men Aged 65-75 Years and the Relation to Glycemic Status. A Coronary CT Angiography (CCTA) Study.COMPLETEDOBSERVATIONAL

Genetic associations (0)

None linked.