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COVID-19

Inflammatory & ImmuneDisease / conditionrisknon modifiable
44
evidence score

Also known as: coronavirus disease, sars-cov-2

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 17.5meta-analyses: 11.6trials: 15genetic: 0MR bonus:

References (55)

3 meta-analyses / systematic reviews

Clinical trials (59)

NCTTitleStatusTypeInterventions
NCT05218356Phase IIa Randomized Placebo Controlled Clinical Study of Codivir in Hospitalized Patients with Moderate COVID-19RECRUITINGINTERVENTIONALCovidir injections, Quantitative PCR SARS-CoV-2, IgM and IgG dosage
NCT04381936Randomised Evaluation of COVID-19 TherapyRECRUITINGINTERVENTIONALLopinavir-Ritonavir, Corticosteroid, Hydroxychloroquine
NCT06847204EFFICACY OF COLCHICINE IN IMPROVING CLINICAL OUTCOMES IN PATIENTS WITH MILD TO MODERATE COVID-19 PNEUMONIA IN LAHORE: A RANDOMIZED CONTROL TRIALCOMPLETEDINTERVENTIONALColchicine 0.5 MG Oral Tablet
NCT07280572RECLAIM: an Adaptive Platform Trial for the Evaluation of Treatments for Post-Acute Sequelae of SARS-CoV-2 Infection (PASC)ENROLLING BY INVITATIONINTERVENTIONALMetformin, colchicine
NCT06231225Study on the Effect of Incentive Spirometer-based Respiratory Training on the Long COVID-19 Symptoms in Chronic Disease Patients After Recovery From COVID-19NOT YET RECRUITINGINTERVENTIONALIncentive Spirometer respiratory training
NCT05839236COVID-19 Vaccination Detoxication in Low Density Lipoprotein CholesterolUNKNOWNINTERVENTIONALAtorvastatin Calcium Tablets
NCT05246072Effect of Combined Use of Ivermectin and Colchicine in COVID-19 PatientsCOMPLETEDINTERVENTIONALIvermectin + colchicine, Colchicine
NCT05930002Role of Ivermectin and Colchicine in Treatment of COVID-19: Randomized Controlled Clinical TrialCOMPLETEDINTERVENTIONALIvermectin Tablets, Colchicine 0.5 MG, Standared managment
NCT04941105Impact of PCSK9 Inhibition on Clinical Outcome in Patients During the Inflammatory Stage of the COVID-19: the Randomized, Double-blind, Phase III IMPACT-SIRIO 5 Study.COMPLETEDINTERVENTIONALEvolocumab, Saline solution
NCT04867226Effectiveness of Colchicine Among Patients With COVID-19 InfectionCOMPLETEDINTERVENTIONALColchicine 0.5 MG, usual care treatment
NCT04539873Impact of Colchicine in Hospitalized Colombian Patients With COVID-19TERMINATEDINTERVENTIONALColchicine 0.5 MG, CONTROL GROUP
NCT04828434Virtual CST - A Collaborative Proof of Concept Study With FaceCog HK in Response to the Covid-19 PandemicUNKNOWNINTERVENTIONALVirtual Individual Cognitive Simulation Therapy
NCT05151614Adjuvant Use Of Colchicine With The Standard Therapy In Moderate And Severe Corona Virus Disease-19 Infection: Randomized Controlled Clinical TrialCOMPLETEDINTERVENTIONALColchicine 0.5 MG
NCT04818489Impact of Colchicine on the Clinical Outcome of COVID-19 and the Development of Post-COVID-19 Pulmonary Fibrosis: Randomized Controlled Clinical TrialUNKNOWNINTERVENTIONALColchicine 0.5 MG, the standard protocol only
NCT04756128Impact of Colchicine and Low-dose Naltrexone on COVID-19 Disease Progression and Clinical Course in Hospitalized PatientsCOMPLETEDINTERVENTIONALColchicine 0.6 mg, Naltrexone
NCT04898205Cardiopulmonary Rehabilitation in COVID-19 LonghaulersUNKNOWNINTERVENTIONALTreadmill Exercise, Concentrated Oxygen, Concentrated Air
NCT04516941Efficacy and Safety of Edoxaban and or Colchicine for Patients With SARS-CoV-2 Infection Managed in the Out of Hospital SettingTERMINATEDINTERVENTIONALEdoxaban Tablets, Colchicine Tablets
NCT04724629Prospective-randomized Adaptive Study, With Active Control to Evaluate the Efficacy and Safety of Interleukin (IL)-17 Inhibitor Treatment Versus Low Doses of IL-2 Versus Indirect IL-6 Inhibitor in Hospitalized Patients With Severe Forms of COVID-19COMPLETEDINTERVENTIONALIxekizumab, Aldesleukin, Colchicine
NCT04667780Study to Investigate the Treatment Effect of Colchicine in Patients With COVID-19COMPLETEDINTERVENTIONALColchicine, Standard COVID-19 care
NCT04510493Canakinumab in Patients With COVID-19 and Type 2 Diabetes - CanCovDia TrialCOMPLETEDINTERVENTIONALCanakinumab, Placebo
NCT04492358Phase 2/3, Randomized, Open Study to Compare the Efficacy and Safety of Colchicine and Glucocorticoids Compared With the Standard of Treatment for Moderate/Severe COVID-19 in a Fragile and Vulnerable Population, Admitted to a Geriatric Hospital Unit or in a Transicional Care CenterTERMINATEDINTERVENTIONALColchicine, Prednisone tablet, standard of care
NCT04662684Medically Ill Hospitalized Patients for COVID-19 THrombosis Extended ProphyLaxis With Rivaroxaban ThErapy: The MICHELLE TrialCOMPLETEDINTERVENTIONALRivaroxaban 10 MG
NCT04508985Management of Renin-Angiotensin-Aldosterone System Blockade in Patients Admitted in Hospital With Confirmed Coronavirus Disease (COVID-19) Infection: The McGill RAAS-COVID-19 Randomized Controlled TrialCOMPLETEDINTERVENTIONALTemporarily holding the RAAS inhibitor [intervention], RAAS inhibitor [continued standard of care]
NCT04505774A Multicenter, Adaptive, Randomized Controlled Platform Trial of the Safety and Efficacy of Antithrombotic and Additional Strategies in Hospitalized Adults With COVID-19COMPLETEDINTERVENTIONALtheraputic heparin, prophylactic heparin, P2Y12
NCT04359095Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia: A Pragmatic Randomized Controlled TrialCOMPLETEDINTERVENTIONALEmtricitabine/tenofovir, Colchicine Pill, Rosuvastatin
NCT04493359Switch or Maintenance of Renin-Angiotensin System Inhibitors in Patients With Covid-19: A Randomized Proof of Concept TrialTERMINATEDINTERVENTIONALRenin-angiotensin system inhibitors
NCT04433546A Randomized, Double-Blind, Parallel Group Study to Assess the Efficacy and Safety of Once Weekly Subcutaneous Injections of Pemziviptadil (PB1046), a Sustained-Release VIP (Vasoactive Intestinal Peptide) ANalogue, in Hospitalized COVID-19 Patients at HiGh Risk for Rapid Clinical Deterioration and ARDS (PB1046 VANGARD Study)TERMINATEDINTERVENTIONALPemziviptadil (PB1046), Low Dose (10 mg) Control
NCT04527562Colchicine in Moderate Symptomatic COVID-19 Patients: Double Blind, Randomized, Placebo Controlled Trial to Observe the EfficacyCOMPLETEDINTERVENTIONALColchicine, Placebo
NCT04393246mulTi-Arm Therapeutic Study in Pre-ICu Patients Admitted With Covid-19 - Experimental Drugs and Mechanisms (TACTIC-E)COMPLETEDINTERVENTIONALEDP1815, Dapagliflozin, Ambrisentan
NCT04647604Resolving Inflammatory Storm in COVID-19 Patients by Omega-3 Polyunsaturated Fatty Acids - A Single-blind, Randomized, Placebo-controlled Feasibility StudyCOMPLETEDINTERVENTIONALOmegaven®, Sodium chloride
NCT04412018An Investigation on the Effects of Icosapent Ethyl (VascepaTM) on Inflammatory Biomarkers in Individuals With COVID-19 (VASCEPA-COVID-19)COMPLETEDINTERVENTIONALIcosapent ethyl
NCT04403243COLchicine Versus Ruxolitinib and Secukinumab in Open-label Prospective Randomized Trial in Patients With COVID-19COMPLETEDINTERVENTIONALColchicine, Ruxolitinib 5 MG, Secukinumab 150 MG/ML Subcutaneous Solution [COSENTYX]
NCT04355143Randomized, Open-Label, Controlled Trial of Colchicine to Reduce Cardiac Injury in Hospitalized COVID-19 (Coronavirus Disease 2019) Patients (COLHEART-19)COMPLETEDINTERVENTIONALColchicine Tablets, Current care per UCLA treating physicians
NCT04362813Phase 3 Multicenter, Randomized, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of Canakinumab on Cytokine Release Syndrome in Patients With COVID-19-induced Pneumonia (CAN-COVID)COMPLETEDINTERVENTIONALCanakinumab, Placebo
NCT04350320Administration of Colchicine Plus Standard Treatment vs. Standard Therapy, in Hospitalized Patients With COVID-19, Within the First 48 Hours, and no Severity Criteria.COMPLETEDINTERVENTIONALColchicine Tablets, Standard therapy for COVID-19 according to the stablished hospital protocols.
NCT04365153Canakinumab to Reduce Deterioration of Cardiac and Respiratory Function in SARSCoV2 Associated Acute Myocardial Injury With Heightened InflammationCOMPLETEDINTERVENTIONALCanakinumab Injection 600mg, Canakinumab Injection 300mg, Placebos
NCT04328480The ECLA PHRI COLCOVID TrialCOMPLETEDINTERVENTIONALColchicine, Local standard of care
NCT04361552Tociluzumab for Cytokine Release Syndrome With SARS-CoV-2: An Open-Labeled, Randomized Phase 3 TrialWITHDRAWNINTERVENTIONALBest Practice, Tocilizumab
NCT04326790The GReek Study in the Effects of Colchicine in Covid-19 cOmplications PreventionTERMINATEDINTERVENTIONALColchicine, Standard treatment
NCT04392141Application of Colchicine Plus Herbal Phenolic Monoterpene Fractions to Treat COVID-19COMPLETEDINTERVENTIONALStandard Treatment, Oral administration of Colchicine plus Herbal Phenolic Monoterpene Fractions
NCT04325867Integrated Distance Management Strategy for Patients With Cardiovascular Disease (Ischaemic Coronary Artery Disease, High Blood Pressure, Heart Failure) in the Context of the COVID-19 PandemicUNKNOWNINTERVENTIONALTele-medicine platform
NCT04360980Effects of Standard Protocol Therapy With or Without Colchicine in Covid-19 Infection: A Randomized Double Blind Clinical TrialCOMPLETEDINTERVENTIONALColchicine Tablets
NCT05043324Prevention and Treatment of Patient Before, During, and After Covid-19 InfectionCOMPLETEDINTERVENTIONALAntiCov-220, AntiCov-220 (placebo)
NCT04278404Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied DrugsRECRUITINGOBSERVATIONALThe POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
NCT04987853Assessment of the Influence of Clinical, Functional, Immunological, and Genetic Factors on the Severity of the Course of Coronavirus Infection With SARS-CoV-2 and Post Covid SyndromeUNKNOWNOBSERVATIONALClinical and functional analysis, Neurological analysis, Immunological analysis:
NCT05226377High Atherogenic Index of Plasma At-admission of COVID-19 Patients Can Predict Upcoming Cardiac Morbidity and Mortality in Non-Cardiac PatientsCOMPLETEDOBSERVATIONALAtherogenic Index of Plasma
NCT04823182Study of HEarT DiseAse and ImmuNiTy After COVID-19 in IrelandUNKNOWNOBSERVATIONALCardiovascular Magnetic Resonance Imaging
NCT04694703Changing of Trace Element, Homocysteine, Oxidative Stress Parameters and Physical Activity Levels in Patients Diagnosed With COVID-19 Before and After COVID-19 TreatmentCOMPLETEDOBSERVATIONALCovid-19 group
NCT04695158Determination of Hemoglobin A1c, Lipid Profiles, Homocysteine, Oxidative Stress Parameters and Physical Activity Levels in Patients With Type II Diabetes and/or COVID-19UNKNOWNOBSERVATIONALCOVID-19 group (Group I), Type II Diabetes Mellitus and COVID-19 group (Group II)
NCT05496816COVID-19 Associated Coagulopathy (CAC) in Septic Critically Ill Patients- a Retrospective Cohort StudyCOMPLETEDOBSERVATIONALCAC in septic patients
NCT05715879The Long-term Effects of the Covid-19 Infection on Cardiac Symptoms, Should We Have a Realistic Concern?COMPLETEDOBSERVATIONALcovid infection, admission to hispital
NCT04492384Analysis of Chronic Non-infectious Diseases Dynamics After COVID-19 Infection in Adult PatientsCOMPLETEDOBSERVATIONALnon-interventional
NCT04912934The Relationship Between Coronavirus Anxiety Level and Emotional Eating in Individuals With Metabolic SyndromeCOMPLETEDOBSERVATIONALA survey form was applied to individuals included in the study face-to-face.
NCT04407273Statin Therapy and COVID-19 Infection (STACOV PROJECT)COMPLETEDOBSERVATIONALobservational
NCT04411511The Influence of the Covid-19 Pandemia on the Health Behaviour of Primary School Children (and Their Parents) - COVID-19, Obesity and Lifestyle in ChildrenUNKNOWNOBSERVATIONALExposure to the Dutch measures due to the Covid-19 pandemic.
NCT04412655International Study on Acute Coronary Syndromes - ST-segment Elevation Myocardial Infarction COVID 19UNKNOWNOBSERVATIONALPercutaneous Coronary Revascularization for STEMI
NCT04379310Evaluation of Demographic and Clinical Parameters on Admission and Medications Used for Comorbidities in Patients With Covid-19 Pneumonia: A Single Center Experience in TurkeyCOMPLETEDOBSERVATIONALACE Inhibitors and Calcium Channel Blockers
NCT04496076Severe Neurologic Injury Outcomes During COVID-19 CrisisCOMPLETEDOBSERVATIONAL
NCT04947046Carotid Stenosis Management During COVID-19 Era - Best Medical Intervention Alone (CASCOM Pilot Study): A Prospective Observational StudyUNKNOWNOBSERVATIONAL

Genetic associations (0)

None linked.