A
Cystatin C
Renal & ElectrolyteLab test / biomarkerriskpartially modifiable
37
evidence score
Also known as: Higher cystatin C levels, cystatin-c
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 17.4meta-analyses: 19.3trials: 0genetic: 0MR bonus:
References (54)
7 meta-analyses / systematic reviews- METADiagnostic and prognostic value of cystatin C in acute coronary syndrome: An up-to-date meta-analysis. — Cardiology journal 2025 · PMID 39976389
- METADiscordance in Creatinine- and Cystatin C-Based eGFR and Clinical Outcomes: A Meta-Analysis. — JAMA 2025 · PMID 41202182
- METACystatin C and mortality risk in the general population: systematic review and dose response meta-analysis. — Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2022 · PMID 34847805
- METACystatin C for predicting all-cause mortality and rehospitalization in patients with heart failure: a meta-analysis. — Bioscience reports 2019 · PMID 30643006
- METAAssociation Between Cystatin C and the Risk of Ischemic Stroke: a Systematic Review and Meta-analysis. — Journal of molecular neuroscience : MN 2019 · PMID 31313057
- METAAssociation Between Increased Levels of Cystatin C and the Development of Cardiovascular Events or Mortality: A Systematic Review and Meta-Analysis. — Arquivos brasileiros de cardiologia 2018 · PMID 30281693
- METACystatin C and cardiovascular or all-cause mortality risk in the general population: A meta-analysis. — Clinica chimica acta; international journal of clinical chemistry 2015 · PMID 26192218
- Interplay of Chronic Kidney Disease and the Effects of Tirzepatide in Patients With Heart Failure, Preserved Ejection Fraction, and Obesity: The SUMMIT Trial. — Journal of the American College of Cardiology 2025 · PMID 40162940
- Improved prediction and risk stratification of major adverse cardiovascular events using an explainable machine learning approach combining plasma biomarkers and traditional risk factors. — Cardiovascular diabetology 2025 · PMID 40176039
- Association of intra-individual differences in estimated GFR by creatinine versus cystatin C with incident cardiovascular disease. — Nutrition, metabolism, and cardiovascular diseases : NMCD 2025 · PMID 40274428
- Association Between the Serum Creatinine to Cystatin C Ratio and Cardiovascular Disease in Middle-Aged and Older Adults in China: A Nationwide Cohort Study. — Journal of the American Heart Association 2025 · PMID 40281656
- Identification of cystatin C as a new marker of glomerular filtration rate, and of shrunken pore syndrome - a new kidney disorder defining selective glomerular hypofiltration syndromes - calls for expansion of the international KDIGO guidelines. — Scandinavian journal of clinical and laboratory investigation 2025 · PMID 40888652
- Cystatin C in atherosclerotic cardiovascular disease. — Clinica chimica acta; international journal of clinical chemistry 2025 · PMID 41237923
- Incident cardiovascular diseases and changes in the ratio of serum creatinine to cystatin C: the sarcopenia index. — Nutrition, metabolism, and cardiovascular diseases : NMCD 2025 · PMID 41241623
- Diabetes mellitus: association of cystatin C- versus creatinine-based estimated glomerular filtration rate with mortality and cardiovascular events. — Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2024 · PMID 38317440
- Cystatin C Is a Predictor for Long-Term, All-Cause, and Cardiovascular Mortality in US Adults With Metabolic Syndrome. — The Journal of clinical endocrinology and metabolism 2024 · PMID 38597157
- Cystatin C and sarcopenia index are associated with cardiovascular and all-cause death among adults in the United States. — BMC public health 2024 · PMID 39044229
- Plasma Protein Biomarkers and Long-Term Cardiovascular Mortality Risk in Patients With Chronic Coronary Heart Disease. — Journal of the American Heart Association 2024 · PMID 39450716
- Differential Associations of Cystatin C Versus Creatinine-Based Kidney Function With Risks of Cardiovascular Event and Mortality Among South Asian Individuals in the UK Biobank. — Journal of the American Heart Association 2023 · PMID 36695320
- Modification of Association of Cystatin C With Kidney and Cardiovascular Outcomes by Obesity. — American journal of kidney diseases : the official journal of the National Kidney Foundation 2023 · PMID 37866793
- Association and pathways between shift work and cardiovascular disease: a prospective cohort study of 238 661 participants from UK Biobank. — International journal of epidemiology 2022 · PMID 34414428
- Lipocalin-2, S100A8/A9, and cystatin C: Potential predictive biomarkers of cardiovascular complications in COVID-19. — Experimental biology and medicine (Maywood, N.J.) 2022 · PMID 35466734
- Effects of Serum LDL-C, CysC, and D-D in Patients with Coronary Atherosclerotic Heart Disease. — Computational intelligence and neuroscience 2022 · PMID 35800677
- Association of Cystatin C Kidney Function Measures With Long-term Deficit-Accumulation Frailty Trajectories and Physical Function Decline. — JAMA network open 2022 · PMID 36178684
- Cystatin C and Urine Albumin to Creatinine Ratio Predict 5-Year Mortality and Cardiovascular Events in People Living With HIV. — The Journal of infectious diseases 2021 · PMID 32691827
- Beta-2-Microglobulin is an Independent Risk Factor for Asymptomatic Carotid Atherosclerosis in Patients with Primary Aldosteronism. — Journal of atherosclerosis and thrombosis 2021 · PMID 34305082
- Clonal myelopoiesis promotes adverse outcomes in chronic kidney disease. — Leukemia 2021 · PMID 34413458
- The difference between cystatin C- and creatinine-based eGFR is associated with adverse cardiovascular outcome in patients with chronic kidney disease. — Atherosclerosis 2021 · PMID 34571286
- Pulse Wave Velocity, Central Haemodynamic Parameters, and Markers of Kidney Function in Children. — Kidney & blood pressure research 2021 · PMID 34657030
- Cystatin C and Muscle Mass in Patients With Heart Failure. — Journal of cardiac failure 2020 · PMID 32750487
- Worsening Renal Function in Patients With Acute Heart Failure Undergoing Aggressive Diuresis Is Not Associated With Tubular Injury. — Circulation 2018 · PMID 29352071
- Cardiovascular Risk Prediction in CKD. — Seminars in nephrology 2018 · PMID 29753398
- Cardiovascular risk prediction in people with chronic kidney disease. — Current opinion in nephrology and hypertension 2016 · PMID 27517136
- Cystatin-C and epicardial adipose tissue as noninvasive predictors of cardiovascular risk in acromegaly. — Clinical endocrinology 2016 · PMID 27910111
- Biomarkers in stable coronary heart disease, their modulation and cardiovascular risk: The LIPID biomarker study. — International journal of cardiology 2015 · PMID 26318511
- Association of cystatin C with measures of obesity and its impact on cardiovascular events among healthy US adults. — Metabolic syndrome and related disorders 2014 · PMID 25118891
- Cystatin C: an emerging biomarker in cardiovascular disease. — Current topics in medicinal chemistry 2013 · PMID 23470076
- How to understand the association between cystatin C levels and cardiovascular disease: Imbalance, counterbalance, or consequence? — Journal of cardiology 2013 · PMID 23849291
- Association between serum cystatin C levels and cardiovascular disease in type 2 diabetic patients. — Annales de biologie clinique 2013 · PMID 23906571
- GDF-15 for prognostication of cardiovascular and cancer morbidity and mortality in men. — PloS one 2013 · PMID 24312445
- [The importance of NGAL and cystatin C biomarkers in cardiovascular diseases]. — Vnitrni lekarstvi 2012 · PMID 22559802
- Should eGFR and Albuminuria Be Added to the Framingham Risk Score Chronic Kidney Disease and Cardiovascular Disease Risk Prediction — Nephron Clinical Practice 2011 · PMID 21811078
- Cystatin C as risk factor for cardiovascular events and all-cause mortality in the general population. The Tromsø Study. — Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011 · PMID 22207328
- Cystatin C and the risk for cardiovascular events in patients with asymptomatic carotid atherosclerosis. — Stroke 2010 · PMID 20150544
- Cathepsins and cystatin C in atherosclerosis and obesity. — Biochimie 2010 · PMID 20417681
- Cystatin C, adipokines and cardiovascular risk in HIV infected patients. — Current HIV research 2010 · PMID 20426756
- Novel and Conventional Biomarkers for Prediction of Incident Cardiovascular Events in the Community — JAMA 2009 · PMID 19567439
- Cystatin C and cardiovascular risk. — Clinical chemistry 2009 · PMID 19713275
- Cystatin C and aging success. — Archives of internal medicine 2008 · PMID 18227360
- Cystatin C and cathepsins in cardiovascular disease. — Frontiers in bioscience : a journal and virtual library 2008 · PMID 18508621
- Cystatin C is associated with cardiovascular risk factors and metabolic syndrome in Aboriginal youth. — Pediatric nephrology (Berlin, Germany) 2007 · PMID 17394021
- Cystatin C, kidney function and cardiovascular disease. — Pediatric nephrology (Berlin, Germany) 2006 · PMID 16838182
- Cystatin C and prognosis for cardiovascular and kidney outcomes in elderly persons without chronic kidney disease. — Annals of internal medicine 2006 · PMID 16908914
- Cystatin C and the risk of death and cardiovascular events among elderly persons. — The New England journal of medicine 2005 · PMID 15901858
Clinical trials (0)
None linked.
Genetic associations (0)
None linked.