A
D-dimer
Hemostatic & ThromboticLab test / biomarkerriskpartially modifiable
47
evidence score
Also known as: Fibrin D-dimer, fibrin D-dimer, fibrin degradation, high levels of d-dimer
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 17.9meta-analyses: 20trials: 9genetic: 0MR bonus:
References (60)
8 meta-analyses / systematic reviews- METADiagnostic accuracy of alternative biomarkers for acute aortic syndrome: a systematic review. — Emergency medicine journal : EMJ 2024 · PMID 39107052
- METAMeta-analysis of risk factors for cardiovascular disease in patients with rheumatoid arthritis. — Medicine 2023 · PMID 37960768
- METARisk factors and predictors for venous thromboembolism in people with ischemic stroke: A systematic review. — Journal of thrombosis and haemostasis : JTH 2022 · PMID 35815351
- METAPrognostic Value of Baseline d-Dimer Level in Patients With Coronary Artery Disease: A Meta-Analysis. — Angiology 2021 · PMID 34078130
- METADiagnostic accuracy of D-dimer to detect left atrial thrombus in patients with atrial fibrillation: A systematic review and meta-analysis. — Heart rhythm 2021 · PMID 34481076
- METAThe diagnostic value of D-dimer in acute aortic dissection: a meta-analysis. — Journal of cardiothoracic surgery 2021 · PMID 34838062
- METARole of D-dimer in the Development of Portal Vein Thrombosis in Liver Cirrhosis: A Meta-analysis. — Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 2015 · PMID 26021776
- METAA systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size. — Journal of vascular surgery 2014 · PMID 24461868
- D-Dimer as Biomarker for Prognosis of Coronary Artery Disease and Heart Failure: Reappraisal of Its Central Role. — Cardiology 2025 · PMID 40340891
- Peripheral Immunophenotype in the Diagnosis of Mesenteric Ischemia in Rats: An Experimental Study. — Journal of investigative surgery : the official journal of the Academy of Surgical Research 2025 · PMID 40415218
- Hydroxychloroquine does not affect endotheliopathy or coagulopathy biomarkers in COVID-19: longitudinal results from the DisCoVeRy randomized trial. — Angiogenesis 2025 · PMID 41353681
- Advancements in Serum Biomarkers for Early Diagnosis and Prognostic Assessment of Aortic Dissection. — Critical pathways in cardiology 2024 · PMID 38446088
- New Diagnostic Tools for Pulmonary Embolism Detection. — Methodist DeBakey cardiovascular journal 2024 · PMID 38765212
- Plasma Protein Biomarkers and Long-Term Cardiovascular Mortality Risk in Patients With Chronic Coronary Heart Disease. — Journal of the American Heart Association 2024 · PMID 39450716
- Menopausal Hormone Therapy and Subclinical Cardiovascular Disease in Women With and Without Human Immunodeficiency Virus. — Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 · PMID 35903868
- JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. — European heart journal 2023 · PMID 36469488
- The interplay between prolactin and cardiovascular disease. — Frontiers in endocrinology 2023 · PMID 36704037
- Selected inflammatory and coagulation biomarkers pre-viral suppression in people with human immunodeficiency virus (HIV) infection without overt cardiovascular disease: Is there a need to redefine reference indices? — Cytokine 2023 · PMID 36996538
- Associations of habitual alcohol drinking with HDL cholesterol and D-dimer in patients with peripheral arterial disease. — Clinica chimica acta; international journal of clinical chemistry 2023 · PMID 37301276
- Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease. — Cardiovascular toxicology 2023 · PMID 37982976
- Effects of Serum LDL-C, CysC, and D-D in Patients with Coronary Atherosclerotic Heart Disease. — Computational intelligence and neuroscience 2022 · PMID 35800677
- Thrombotic Complications of COVID-19 Infection: A Review. — Cardiology in review 2021 · PMID 32947478
- Prognostic value of cardiac biomarkers in COVID-19 infection. — Scientific reports 2021 · PMID 33654230
- A risk score for iliofemoral patients with deep vein thrombosis. — Journal of vascular surgery. Venous and lymphatic disorders 2021 · PMID 33894343
- Analysis of risk factors for different subtypes of acute coronary syndrome. — The Journal of international medical research 2021 · PMID 33969735
- Fibrinogen and a Triad of Thrombosis, Inflammation, and the Renin-Angiotensin System in Premature Coronary Artery Disease in Women: A New Insight into Sex-Related Differences in the Pathogenesis of the Disease. — Biomolecules 2021 · PMID 34356659
- The heart remembers what the mind forgets. — Acta clinica Belgica 2020 · PMID 31996105
- Prevalence and determinants of elevated D-dimer in patients with hypertrophic cardiomyopathy. — Biomarkers in medicine 2020 · PMID 32057272
- Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study — BMJ 2020 · PMID 32217556
- Clinico-radiological profile of CVT patients and its correlation with D-dimer. — Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 2020 · PMID 32336633
- COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options — Cardiovascular Research 2020 · PMID 32352535
- Diagnosis and management of acute aortic syndromes in the emergency department. — Internal and emergency medicine 2020 · PMID 32358680
- Thrombosis in Coronavirus disease 2019 (COVID-19) through the prism of Virchow's triad. — Clinical rheumatology 2020 · PMID 32654082
- Cardiovascular involvement in COVID-19: not to be missed. — Brazilian journal of cardiovascular surgery 2020 · PMID 32864934
- The coagulopathy, endotheliopathy, and vasculitis of COVID-19. — Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2020 · PMID 32918567
- [COVID-19 and stroke]. — Rinsho shinkeigaku = Clinical neurology 2020 · PMID 33229838
- Cardiovascular aspects of COVID-19. — Swiss medical weekly 2020 · PMID 33382450
- Prevalence and prognostic value of D-dimer elevation in patients with AL amyloidosis. — American journal of hematology 2019 · PMID 31292986
- Deep vein sclerosis following sclerotherapy: Ultrasonic and d-dimer criteria. — Phlebology 2019 · PMID 31510866
- Hemostasis in Allergy. — Seminars in thrombosis and hemostasis 2018 · PMID 29920622
- Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system. — International journal of nanomedicine 2018 · PMID 30538461
- The Diagnosis and Management of Early Deep Vein Thrombosis. — Advances in experimental medicine and biology 2017 · PMID 27638622
- Pleuritic Chest Pain: Sorting Through the Differential Diagnosis. — American family physician 2017 · PMID 28925655
- How to use D-dimer in acute cardiovascular care. — European heart journal. Acute cardiovascular care 2016 · PMID 26450781
- D-dimer and factor VIIa in atrial fibrillation - prognostic values for cardiovascular events and effects of anticoagulation therapy. A RE-LY substudy. — Thrombosis and haemostasis 2016 · PMID 26818781
- Atherosclerotic Vessel Changes in Sarcoidosis. — Advances in experimental medicine and biology 2016 · PMID 26820732
- Competitive assessments of pulmonary embolism: Noninvasiveness versus the golden standard. — Vascular 2015 · PMID 26038123
- Biomarkers in stable coronary heart disease, their modulation and cardiovascular risk: The LIPID biomarker study. — International journal of cardiology 2015 · PMID 26318511
- Circulating microRNAs in Sera Correlate with Soluble Biomarkers of Immune Activation but Do Not Predict Mortality in ART Treated Individuals with HIV-1 Infection: A Case Control Study — PLoS ONE 2015 · PMID 26465293
- D-dimer predicts major bleeding, cardiovascular events and all-cause mortality during warfarin treatment. — Clinical biochemistry 2014 · PMID 24636802
- Family history of coronary heart disease and markers of subclinical cardiovascular disease: where do we stand? — Atherosclerosis 2013 · PMID 23578356
- Can haemostatic factors predict atherothrombosis? — Internal and emergency medicine 2011 · PMID 21327550
- Associations of D-dimer and von Willebrand factor with atherosclerosis in Japanese and white men. — Acta cardiologica 2010 · PMID 20821938
- [Pulmonary thromboembolism]. — Archivos de bronconeumologia 2010 · PMID 21316548
- Associations of factor VIIIc, D-dimer, and plasmin-antiplasmin with incident cardiovascular disease and all-cause mortality. — American journal of hematology 2009 · PMID 19472201
- Hypercoagulability in cats with cardiomyopathy. — Journal of veterinary internal medicine 2008 · PMID 18466239
- Traditional and Novel Cardiovascular Risk Factors for Retinal Vein Occlusion: The Multiethnic Study of Atherosclerosis — Investigative Ophthalmology & Visual Science 2008 · PMID 18539932
- D-dimer and pulmonary arterial hypertension in systemic sclerosis. — Journal of the Medical Association of Thailand = Chotmaihet thangphaet 2007 · PMID 18041419
- Which Hemostatic Markers Add to the Predictive Value of Conventional Risk Factors for Coronary Heart Disease and Ischemic Stroke? — Circulation 2005 · PMID 16286603
- [Interpretation of increased D-dimer values]. — Hamostaseologie 2004 · PMID 15136879
Clinical trials (7)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT05638867 | A Randomized Controlled Clinical Trial of PARIS Coronary Thrombosis Risk Score Combined With D-dimer to Guide New Oral Anticoagulant Antithrombotic Therapy in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention | RECRUITING | INTERVENTIONAL | Aspirin + Clopidogrel + Rivaroxaban, Aspirin + Clopidogrel |
| NCT03704766 | Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic Arthritis | UNKNOWN | INTERVENTIONAL | Synovial Alpha-defensin assay, Synovial Neutrophil elastase assay, Synovial lactate assay |
| NCT02282098 | Targeting Inflammation in Atrial Fibrillation to Prevent Ischemic Stroke: A Feasibility Study Evaluating the Effect of Colchicine on D-dimer and Hs-CRP in Anticoagulated Patients With Atrial Fibrillation | COMPLETED | INTERVENTIONAL | Colchicine, Placebo |
| NCT00895505 | Safety and Efficacy of a D-Dimer-Guided Strategy for Extension of Secondary Prophylaxis of Venous Thromboembolism - a Prospective and Randomized Management Trial | UNKNOWN | INTERVENTIONAL | Phenprocoumon, Warfarin-Natrium |
| NCT00437892 | The Effect of Statins on D-dimer Levels in Patients With a Previous Venous Thromboembolic Event | TERMINATED | INTERVENTIONAL | atorvastatin, atorvastatin, diet |
| NCT07363187 | Evaluation of Microvascular Changes by Nailfold Capillaroscopy and Serum ADMA, Von Willebrand Factor, Hs-CRP, and D-dimer Levels in Healthcare Workers Exposed to Chronic Low-Dose Ionizing Radiation | NOT YET RECRUITING | OBSERVATIONAL | |
| NCT07130721 | Assessment of Blood Biomarkers (D-dimer and C-Reactive Protein) in Predicting Cardiovascular Complications Among Hemodialysis Patients: A Cross-Sectional Study | NOT YET RECRUITING | OBSERVATIONAL | C-Reactive Protein (CRP) Test, D-dimer Test, Electrocardiogram (ECG) |
Genetic associations (0)
None linked.