ASCVD Risk Atlas

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C

Elevated LDL cholesterol

Lipids & LipoproteinsLab test / biomarkerriskmodifiable

11

evidence score

Also known as: elevated LDL-C levels

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components

lit volume: 3meta-analyses: 0trials: 7.8genetic: 0MR bonus:

References (1)

0 meta-analyses / systematic reviews

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society. — European heart journal 2014 · PMID 25053660

Clinical trials (5)

NCT	Title	Status	Type	Interventions
NCT06597006	Two Part (Double-blind Inclisiran Versus Placebo [Year 1] Followed by Open-label Inclisiran [Year 2]) Randomized Multicenter Study to Evaluate Safety, Tolerability, and Efficacy of Inclisiran in Children (2 to Less Than 12 Years) With Homozygous Familial Hypercholesterolemia and Elevated LDL-cholesterol	RECRUITING	INTERVENTIONAL	Inclisiran, Placebo
NCT05614219	Can Biochemistry Interpretive Comments on Elevated Cholesterol Levels, Increase Referrals to Lipid Clinics and Detection Rate of Familial Hypercholesterolemia? A Step Wedge Cluster Randomized Controlled Trial.	RECRUITING	INTERVENTIONAL	Biochemistry interpretive comment on elevated LDL-C levels
NCT01959971	A Phase 1 Study of the Effects of Subcutaneous Doses of Alirocumab on Lipid and Lipoprotein Metabolism in Adults With Mildly Elevated LDL-Cholesterol	COMPLETED	INTERVENTIONAL	alirocumab, Placebo
NCT01004705	Cardiovascular Fixed Dose Combination Pill: A Pharmacodynamic Study of a Fixed Dose Combination of Acetylsalicylic Acid, Simvastatin, and Ramipril in Subjects With Elevated LDL Cholesterol	TERMINATED	INTERVENTIONAL	Cardiovascular fixed dose combination pill (acetylsalicylic acid, simvastatin and ramipril),, Simvastatin
NCT00529542	A Six-week Double Blinded, Randomized Trial of Atorvastatin for the Treatment of PCOS Women With Elevated LDL Cholesterol	COMPLETED	INTERVENTIONAL	Lipitor, Placebo

Genetic associations (0)

None linked.