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Endothelial dysfunction

Inflammatory & ImmuneLab test / biomarkerriskmodifiable
59
evidence score

Also known as: Endothelial dysfunction markers, Endothelial dysfunction/activation, Endothelial inflammation, dysfunction of the vascular endothelium, endothelial cell activation, endothelial cell biology, endothelial cell dysfunction, endothelial dysfunction (RHI < 1.67), endothelial function, endothelial inflammation, endothelial markers, endothelium changes

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 24.5meta-analyses: 19.3trials: 15genetic: 0MR bonus:

References (283)

7 meta-analyses / systematic reviews

Clinical trials (63)

showing top 60
NCTTitleStatusTypeInterventions
NCT07460960A Randomized Controlled Trial of Statin Therapy Effect on Androgen Status and Erectile Function in Men With High and Very High Cardiovascular RiskRECRUITINGINTERVENTIONALPitavastatin 1-4 mg daily, Rosuvastatin 20-40 mg daily
NCT07487363A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled, Sequential Dose-Escalation Study of TB-500 (Thymosin Beta 4 17-23 Fragment) in Adults With Stable Atherosclerotic Cardiovascular Disease to Evaluate Safety, Tolerability, Pharmacokinetics, and Exploratory Cardiovascular BiomarkersRECRUITINGINTERVENTIONALTB-500, Placebo
NCT07245069Use of Dapagliflozin in Primary Prevention of Cardiotoxicity of Anthracycline Chemotherapy in Breast Cancer PatientsRECRUITINGINTERVENTIONALDapagliflozin 10 mg, Placebo
NCT05999851Multiparametric Assessment of Maternal Vascular Function as a New Diagnostic and Prognostic Tool for Hypertensive Disorders of Pregnancy and Preeclampsia - EDIPE StudyRECRUITINGINTERVENTIONALArterial applanation tonometry, In vivo endothelial glycocalyx measurement, Serum markers of angiogenesis and endothelial dysfunction
NCT05703126Clinical and Diagnostic Significance of Endothelial Dysfunction and Myocardial Contractility in Patients With Acute Myeloid LeukemiaRECRUITINGINTERVENTIONALHistory taking, Anthropometry, Complete blood count
NCT05611021Acute Responses to Arm-Crank Exercise on Cardiovascular Function of Patients With Peripheral Artery Disease: Randomized Crossover StudyCOMPLETEDINTERVENTIONALExercise
NCT05139914Assessment of Dapagliflozin on Vascular Health in Patients With Type 2 DiabetesTERMINATEDINTERVENTIONALDapagliflozin, Placebo
NCT05699915Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors: a Prospective Multicentre StudyTERMINATEDINTERVENTIONALCardiology consultation, Chest Computed Tomography (CT) without contrast, Non-invasive endothelial function tests
NCT05857085Impact of Additional Treatment With Empagliflozin or Semaglutide on Endothelial Function and Other Clinical Parameters and Biomarkers in T1DM PatientsCOMPLETEDINTERVENTIONALSemaglutide Pen Injector [Ozempic], Empagliflozin 10 MG
NCT04907214The Effect of SGLT2 Inhibition on Adipose Tissue Inflammation and Endothelial Function PilotCOMPLETEDINTERVENTIONALEmpagliflozin 25 MG
NCT04555876High Tone External Muscle Stimulation On Endothelial Dysfunction And Walking Parameters In Peripheral Arterial DiseaseUNKNOWNINTERVENTIONALhigh tone external muscle stimulation- stationary bicycle
NCT04302571Effects of Home-based Combined Aerobic and Resistance Training on Walking Capacity, Circulating Endothelial Progenitor Cells AND Endothelial Function in Patients With Intermittent ClaudicationUNKNOWNINTERVENTIONALcombined aerobic and resistance physical activity, sham exercise
NCT04434365The Study of Berberine Affecting Metabolism, Inflammation Status, Endothelial Function and Thrombotic Events in Patients With Coronary Artery Disease by Remodeling Gut MicrobiotaUNKNOWNINTERVENTIONALBerberine, Aspirin, Clopidogrel
NCT04181398Low Grade Inflammation in Childhood Obesity : an Independent Risk Factor for Endothelial DysfunctionCOMPLETEDINTERVENTIONALAnthropometry, Blood pressure, Peripheral arterial tonometry
NCT03942744Molecular Mechanisms Involved in Cell Adhesion and Migration Process: Effect of Treatment of Chronic Kidney Disease on Endothelial DysfunctionCOMPLETEDINTERVENTIONALon-line hemodiafiltration
NCT04202172Six-month Endothelial and Microcirculatory Function of the Bioactive Sirolimus-eluting Combo Stent Versus the Polymer-free Biolimus-eluting Biofreedom Stent in Patients With ST-segment Elevation Myocardial InfarctionCOMPLETEDINTERVENTIONALStent implantation in the infart-related artery in patients with ST elevation myocardial infarction
NCT03500302Effect of Evolocumab on Coronary Endothelial FunctionCOMPLETEDINTERVENTIONALEvolocumab
NCT03376698A Randomized, Double-blind, Placebo-controlled Phase II Trial to Evaluate the Dose-dependent Effect of Colchicine on Inflammatory Response and Endothelial Function in Type 2 Diabetic Patients With Coronary Artery Disease and Leukocyte ActivationCOMPLETEDINTERVENTIONALColchicine 0.5 mg, Colchicine 0.25 mg, Placebo
NCT02992106Evolution of Maternal Weight During Pregnancy and Influence on the Endothelial Function in Her OffspringCOMPLETEDINTERVENTIONALParental questionnaires, Blood sample, Urine sample
NCT03376906The Effects of High Intensity Interval Exercise With 1- and 3- Min Recovery Times in ObeseCOMPLETEDINTERVENTIONALHIIE 1, HIIE 3, Control
NCT02587260Hunting for the Off-Target Properties of Ticagrelor on Endothelial Function and Other Circulating Biomarkers in HumansCOMPLETEDINTERVENTIONALTicagrelor, Prasugrel, Clopidogrel
NCT03288181Effects of Muscle Stretching on Vascular Endothelial Function in Patients With Peripheral Arterial DiseaseCOMPLETEDINTERVENTIONALMuscle Stretch
NCT02802280Personalized Medicine in HCV Chronic Infection. Endothelial Dysfunction and Subclinical Atheromatosis in Patients With HCV Infection. Characterization and Potential Reversibility With Direct Antiviral Agents.UNKNOWNINTERVENTIONALCardiovascular risk in HCV patients
NCT02487732Comparison of Ticagrelor vs. Prasugrel on Inflammation, Arterial Stiffness, Endothelial Function, and Circulating Endothelial Progenitor Cells in Diabetic Patients With Non-ST Elevation Acute Coronary Syndrome (NSTE-ACS) Requiring Coronary StentingCOMPLETEDINTERVENTIONALTicagrelor, Prasugrel
NCT02961972Effects of Oral Supplementation With Creatine on Plasma Homocysteine Levels and Systemic Microvascular Endothelial Function in Vegetarian IndividualsCOMPLETEDINTERVENTIONALmonohydrate and micronized creatine, placebo
NCT02650726Effect of Purification Anthocyanins on HDL and Endothelial Function in Subjects With Type 2 Diabetes Mellitus: A Randomized, Double-Blinded, Placebo-Controlled TrialCOMPLETEDINTERVENTIONALAnthocyanin, Placebo
NCT01984164CAndesartan vs LIsinopril Effects on the BRain and Endothelial Function in eXecutive MCI (CALIBREX)COMPLETEDINTERVENTIONALCandesartan, Lisinopril
NCT02123004Comparison of The Influence of Ticagrelor And Clopidogrel on Inflammatory Biomarkers And Vascular Endothelial Function For Patients With ST-Segment Elevation Myocardial Infarction Receiving Emergency Percutaneous Coronary InterventionUNKNOWNINTERVENTIONALTicagrelor, Clopidogrel
NCT02095522Does COlchicine Improve EnDothElial Function in Non ST Elevation Myocardial Infarction Patients?: A Prospective Randomized, Double-blind Placebo Controlled StudyWITHDRAWNINTERVENTIONALColchicine, Placebo
NCT02905630Effect of Aerobic High-intensity Exercise Training on Coronary Flow Reserve and Endothelial Function in Individuals With Chest Pain and Normal Coronary AngiogramUNKNOWNINTERVENTIONALExercise training
NCT01799057Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study of Metformin for the Assessment of Changes in Functional Capacity, Endothelial Function, and Hemodynamics in Individuals With Peripheral Artery Disease-Related Intermittent ClaudicationTERMINATEDINTERVENTIONALMetformin, Placebo
NCT02178501The Effect of Omega-3 Polyunsaturated Acids Supplementation on Endothelial Function, Oxidative Stress, Platelet Aggregation, Blood Coagulation and Inflammation in Patients With Type 2 Diabetes and Cardiovascular DiseaseCOMPLETEDINTERVENTIONALOmega-3 PUFA
NCT01310270The Effects of Omega-3 Fatty Acids Supplementation on Endothelial Function and InflammationCOMPLETEDINTERVENTIONALPro-Omega, Omega 3 Fatty Acid
NCT01367145OMEGA-3-POLYUNSATURATED FATTY-ACIDS (n3-PUFA) IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE: EFFECTS ON ENDOTHELIAL FUNCTION - A RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-BLIND TRIALCOMPLETEDINTERVENTIONALOMACOR, Placebo
NCT01162824Correlation Between Abnormal Coronary Vasoreactivity Testing, Expansion of CD4+CD28null T Cells and Biomarkers for Inflammation and Endothelial Dysfunction in Patients With Angina Despite Angiographically Normal Coronary Arteries.UNKNOWNINTERVENTIONALAcetylcholine, Adenosine
NCT01183442Effects of Vitamin D Supplementation in Coronary Artery Disease Patients With Postchallenge Hyperglycemia and Vitamin D Deficiency on Endothelial Function and Insulin SensitivityTERMINATEDINTERVENTIONALvitamin D
NCT01067339Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans AIM IIICOMPLETEDINTERVENTIONALdarapladib, placebo
NCT00905905Additive Effect of Ezetimibe Upon Simvastatin Treatment on Systemic Inflammatory Activity and Endothelial Function During Myocardial InfarctionCOMPLETEDINTERVENTIONALSimvastatin, Ezetimibe-Simvastatin
NCT00817843Multicenter,Double Blind,Randomized, 2-period, Crossover Study to Compare Ezetimibe/Simvastatin (10mg/10 mg) Combination Tablet Versus Simvastatin 80mg Tablet on Postprandial Arterial Endothelial Function in Patients With Metabolic SyndromeCOMPLETEDINTERVENTIONALSimvastatin, Simvastatin/Ezetimibe
NCT00721617Free Fatty Acids-Induced Hypertension, Endothelial Dysfunction, Inflammation, Insulin Resistance, and Autonomic Dysfunction in Lean and Obese SubjectsCOMPLETEDINTERVENTIONALIntralipid 20%, Normal Saline, Oral fat load
NCT00796822A Randomized, Placebo-Controlled Trial of Pentoxifylline to Improve Endothelial Function in HIV-Infected Patients Not Requiring Antiretroviral TherapyCOMPLETEDINTERVENTIONALPentoxifylline, Placebo
NCT00767572Effects of Statins on Endothelial Function in Patients With Coarctation of the AortaTERMINATEDINTERVENTIONALatorvastatin, Sugar pill
NCT02779127Impact of Ban on Smoking in Pubs, Restaurants and Nightclubs on Endothelial Function in Workers : Evaluation of Endothelial Vasomotoricity Before and After Cessation of Exposure to Passive Smoking : DILATER StudyCOMPLETEDINTERVENTIONALMedical interrogatory, Medical examination, Specific bioassay
NCT00986986Prospective Randomized Pilot Study of the Effect of Niaspan on Endothelial Function in HIV-infected Subjects With Low HDL Cholesterol LevelsCOMPLETEDINTERVENTIONALextended release niacin
NCT00150722HDL Modulation and Endothelial FunctionCOMPLETEDINTERVENTIONALatorvastatin (or other tolerated statin + Niaspan/placebo)
NCT00693589Effect of Homocysteine-lowering Therapy With Folic Acid, Vitamin B12, and Vitamin B6 on Endothelium-dependent Vasodilatation of Forearm Resistance Vessels in Patients With Coronary Heart DiseaseCOMPLETEDINTERVENTIONALfolic acid, vitamin B12 and B6 and rosuvastatin
NCT00660634The Effect of Angioplasty in Peripheral Arterial Disease on Endothelial FunctionCOMPLETEDINTERVENTIONALEndovascular Revascularization
NCT00491751Clinical Utility of Endothelial Dysfunction in PADTERMINATEDINTERVENTIONALatorvastatin, ascorbic acid, Placebo
NCT00648453Effect of Plavix Treatment on NO Production Measured by Laser Doppler Method Referring to Endothelial Function in Patients With Severe Coronary Heart DiseaseCOMPLETEDINTERVENTIONALClopidogrel (Plavix)
NCT06885970The Effect of Cytisine Treatment for Smoking Cessation on Cardiovascular Function in Adult Smokers of Conventional Combustible Cigarettes and New Tobacco Products-Observational Study.RECRUITINGOBSERVATIONALCytisinicline administration
NCT06890013Identifying the Role of Flow Mediated Dilatation Assessment in Acute Coronary Syndromes - Evaluation of the Cor-IS Technology (the FLARE-ACS Trial)RECRUITINGOBSERVATIONALObservation group
NCT06889454The Effect of Different Treatment Options on Markers of Vascular, Myocardial and Endothelial Function in Women With Polycystic Ovary Syndrome and the Association With Metabolic and Hormonal Abnormalities of the SyndromeRECRUITINGOBSERVATIONALGLP-1 receptor agonist, Oral contraceptive, Metformin
NCT06866119Effects of Estrogen Replacement on Cardiometabolic Endpoints in Women With Primary Ovarian InsufficiencyNOT YET RECRUITINGOBSERVATIONAL
NCT07363187Evaluation of Microvascular Changes by Nailfold Capillaroscopy and Serum ADMA, Von Willebrand Factor, Hs-CRP, and D-dimer Levels in Healthcare Workers Exposed to Chronic Low-Dose Ionizing RadiationNOT YET RECRUITINGOBSERVATIONAL
NCT07602348Assessment of Retinal-Angio Findings in Patients With Diabetes Type II Treated With Novel Antidiabetic TherapiesACTIVE NOT RECRUITINGOBSERVATIONAL
NCT05193981Role of Homocysteine Metabolism, Endothelial Function and Microvascular Rarefaction on Renal Disease Severity and Progression in ADPKDACTIVE NOT RECRUITINGOBSERVATIONAL
NCT02636062Predictors of Coronary Artery Calcium Progression in Adults With a Prior Zero Coronary Artery Calcium ScoreWITHDRAWNOBSERVATIONAL
NCT04455204Implication of Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in the Pathogenesis of Preeclampsia and in Pregnancy Related ComplicationsCOMPLETEDOBSERVATIONALSerum asymmetteric dimethyl arginine, serum lipid profiles, Serum vaspin
NCT02221466Measurements of Endothelial Function by Means of Peripheral Arterial Tonometry in Diabetic Foot Ulcer Patients Undergoing Hyperbaric Oxygen Therapy.COMPLETEDOBSERVATIONAL
NCT02019680Effects of Dietary Blackcurrant Extract and PCSO-524 (PernaCanaliculus Supercritical Oil) on Endothelial Function and Biomarkers of Vascular HealthWITHDRAWNOBSERVATIONAL

Genetic associations (0)

None linked.