B
Epicardial adipose tissue
Anthropometric & Body CompositionImaging markerriskpartially modifiable
33
evidence score
Also known as: Epicardial adipose tissue (imaging), epicardial adipose, epicardial fat, pericardial fat
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 16.8meta-analyses: 9.1trials: 7genetic: 0MR bonus:
References (47)
2 meta-analyses / systematic reviews- METAThe Relationship between Left Epicardial Adipose Tissue Attenuation at CT and Atrial Fibrillation: A Systematic Review and Meta-Analyses. — Radiology. Cardiothoracic imaging 2025 · PMID 41410573
- METAElevated Epicardial Adipose Tissue and Ischemic Stroke Risk: A Systematic Review and Meta-Analysis. — Medicina (Kaunas, Lithuania) 2025 · PMID 41470130
- Epicardial Fat Tissue: A Potential Marker for Coronary Microvascular Dysfunction. — Journal of the American Heart Association 2025 · PMID 39895522
- Epicardial Fat in Heart Failure and Preserved Ejection Fraction: Novel Insights and Future Perspectives. — Current heart failure reports 2025 · PMID 40106059
- Exploring the impact of metabolic comorbidities on epicardial adipose tissue in heart failure with preserved ejection fraction. — Cardiovascular diabetology 2025 · PMID 40121452
- The role of epicardial adipose tissue remodelling in heart failure with preserved ejection fraction. — Cardiovascular research 2025 · PMID 40238568
- Relationship between left atrium, epicardial fat and severity of atrial fibrillation. — The international journal of cardiovascular imaging 2025 · PMID 40281367
- Epicardial adipose tissue features as a biomarker and therapeutic target in coronary artery disease. — Scientific reports 2025 · PMID 40295726
- Epicardial Adipose Tissue and Heterogeneity Parameters Combined with Inflammatory Cells to Predict the Value of Heart Failure with Preserved Ejection Fraction Patients Post Myocardial Infarction. — Cardiovascular diabetology 2025 · PMID 40319313
- Epicardial adipose tissue volume, compositional plaque progression, and vulnerability in nonobstructive coronary artery disease. — Coronary artery disease 2025 · PMID 40521640
- Concomitant Diabetes and Atrial Fibrillation: Epicardial Fat and Macrophage-Related Mechanisms. — Diabetes/metabolism research and reviews 2025 · PMID 40587764
- Epicardial Fat Thickness as a Marker of Coronary Artery Disease in Diabetics: A Single Center Study. — Clinical cardiology 2025 · PMID 40616590
- Epicardial fat tissue in metabolically healthy and unhealthy obesity: culprit or bystander? — Minerva endocrinology 2025 · PMID 40635457
- Advances and challenges of targeting epicardial adipose tissue (EAT) and perivascular adipose tissue (PVAT). — Cardiovascular diabetology 2025 · PMID 40760703
- Association of epicardial fat volume index with coronary artery disease phenotypes based on anatomical and functional imaging: a linkage with the severity of coronary artery disease. — Cardiovascular diabetology 2025 · PMID 41063238
- Epicardial Fat Inflammation and GLP-1/GIP Receptor Analogs: Are we Shifting our Perspective? — Current cardiology reports 2025 · PMID 41307857
- The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias. — Cell reports. Medicine 2024 · PMID 38744275
- Single-Nucleus Transcriptomic Atlas of Human Pericoronary Epicardial Adipose Tissue in Normal and Pathological Conditions. — Arteriosclerosis, thrombosis, and vascular biology 2024 · PMID 38813696
- Carbohydrate antigen 125 on epicardial fat and its association with local inflammation and fibrosis-related markers. — Journal of translational medicine 2024 · PMID 38961436
- Excessive accumulation of epicardial adipose tissue promotes microvascular obstruction formation after myocardial ischemia/reperfusion through modulating macrophages polarization. — Cardiovascular diabetology 2024 · PMID 38970123
- Exploring the relationship between epicardial fat and coronary plaque burden and characteristics: insights from cardiac ct imaging. — The international journal of cardiovascular imaging 2024 · PMID 39008195
- Impact of epicardial fat on coronary vascular function, cardiac morphology, and cardiac function in women with suspected INOCA. — European heart journal. Cardiovascular Imaging 2024 · PMID 39129200
- Epicardial and liver fat implications in albuminuria: a retrospective study. — Cardiovascular diabetology 2024 · PMID 39175063
- Tissue-resident memory T cells in epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in atrial fibrillation. — Nature cardiovascular research 2024 · PMID 39271815
- Diabetic Cardiomyopathy: Role of Cell Death, Exosomes, Fibrosis and Epicardial Adipose Tissue. — International journal of molecular sciences 2024 · PMID 39273428
- Epicardial fat density obtained with computed tomography imaging - more important than volume? — Cardiovascular diabetology 2024 · PMID 39472958
- Cardio-Lipotoxicity of Epicardial Adipose Tissue. — Biomolecules 2024 · PMID 39595641
- Increased epicardial adipose tissue is associated with left ventricular reverse remodeling in dilated cardiomyopathy. — Cardiovascular diabetology 2024 · PMID 39696268
- Epicardial Adipose Tissue and Diabetic Cardiomyopathy. — Journal of cardiovascular pharmacology and therapeutics 2023 · PMID 36752345
- Deep-Learning for Epicardial Adipose Tissue Assessment With Computed Tomography: Implications for Cardiovascular Risk Prediction. — JACC. Cardiovascular imaging 2023 · PMID 36881425
- Epicardial fat links obesity to cardiovascular diseases. — Progress in cardiovascular diseases 2023 · PMID 37105279
- Epicardial fat and ventricular arrhythmias. — Heart rhythm 2023 · PMID 37972673
- Epicardial fat and atrial fibrillation: the perils of atrial failure. — Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2022 · PMID 35274140
- Browning Epicardial Adipose Tissue: Friend or Foe? — Cells 2022 · PMID 35326442
- Epicardial fat and incident heart failure with preserved ejection fraction in patients with coronary artery disease. — International journal of cardiology 2022 · PMID 35395282
- Profiling of Non-Coding Regulators and Their Targets in Epicardial Fat from Patients with Coronary Artery Disease. — International journal of molecular sciences 2022 · PMID 35628106
- Cellular cross talk between epicardial fat and cardiovascular risk. — Journal of basic and clinical physiology and pharmacology 2022 · PMID 36220013
- Association of Epicardial Fat Volume With the Extent of Coronary Atherosclerosis and Cardiovascular Adverse Events in Asymptomatic Patients With Diabetes. — Angiology 2021 · PMID 33467865
- Epicardial fat and coronary artery disease: Role of cardiac imaging. — Atherosclerosis 2021 · PMID 33636676
- Non-alcoholic fatty liver disease, insulin resistance, metabolic syndrome and their association with vascular risk. — Metabolism: clinical and experimental 2021 · PMID 33864798
- Carotid intima-media thickness and epicardial fat thickness predict precoronary artery disease status in psoriasis. — Indian journal of dermatology, venereology and leprology 2021 · PMID 33871214
- Association of Region-Specific Cardiac Adiposity With Dysglycemia and New-Onset Diabetes. — Journal of the American Heart Association 2021 · PMID 34889106
- Metabolic and cardiovascular risk factors in Klinefelter syndrome. — American journal of medical genetics. Part C, Seminars in medical genetics 2020 · PMID 32452627
- Epicardial Adipose Tissue May Mediate Deleterious Effects of Obesity and Inflammation on the Myocardium. — Journal of the American College of Cardiology 2018 · PMID 29773163
- Role of Epicardial Adipose Tissue in Health and Disease: A Matter of Fat? — Comprehensive Physiology 2017 · PMID 28640452
- Cystatin-C and epicardial adipose tissue as noninvasive predictors of cardiovascular risk in acromegaly. — Clinical endocrinology 2016 · PMID 27910111
- Pericardial Adipose Tissue Determined by Dual Source CT Is a Risk Factor for Coronary Atherosclerosis — Arteriosclerosis Thrombosis and Vascular Biology 2009 · PMID 19229071
Clinical trials (4)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07567378 | Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts (CARTIZ): A Prospective Observational Multi-Institutional Registry of the VAT-Articular-Cardiac-Aging Axis in Adults Exposed to Tirzepatide in Mexico, With Quantitative Knee Cartilage T2 Mapping, Cardiac CT Epicardial Adipose Tissue Radiomic Phenotyping, HLA Stratification, Longitudinal Multi-Frequency Bioimpedance Body Composition, and a Prespecified Surgical Tissue Acquisition Subcohort | NOT YET RECRUITING | OBSERVATIONAL | Tirzepatide |
| NCT06128096 | The Effect of SGLT-2 Inhibitors on Epicardial Adipose Tissue and Cardiac Function in T2DM Patients With CAD (EpiCAD) | UNKNOWN | OBSERVATIONAL | Sodium Glucose Co-transporter 2 (SGLT2) Inhibitor |
| NCT03322332 | The Role of Adipokines Secreted by Epicardial Adipose Tissue in the Atherosclerosis of Coronary Arteries | UNKNOWN | OBSERVATIONAL | |
| NCT03693261 | Epicardial Fat as Brown Fat in Coronary Artery Disease | COMPLETED | OBSERVATIONAL | Coronary artery bypass grafting (CABG), Valve replacement |
Genetic associations (0)
None linked.