A
Erectile dysfunction
Comorbid ConditionsDisease / conditionriskpartially modifiable
44
evidence score
Also known as: erectile dysfunction (ED)
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 20.3meta-analyses: 15.8trials: 7.8genetic: 0MR bonus:
References (107)
5 meta-analyses / systematic reviews- METAErectile Dysfunction Predicts Cardiovascular Events as an Independent Risk Factor: A Systematic Review and Meta-Analysis — The Journal of Sexual Medicine 2019 · PMID 31104857
- METAHigh prevalence of erectile dysfunction in diabetes: a systematic review and meta‐analysis of 145 studies — Diabetic Medicine 2017 · PMID 28722225
- METAThe role of statins in erectile dysfunction: a systematic review and meta-analysis. — Asian journal of andrology 2014 · PMID 24556747
- METAA systematic review of the association between erectile dysfunction and cardiovascular disease. — European urology 2013 · PMID 24011423
- METAErectile Dysfunction and Risk of Clinical Cardiovascular Events: A Meta-Analysis of Seven Cohort Studies — The Journal of Sexual Medicine 2010 · PMID 20367771
- Metabolic Syndrome-Associated Erectile Dysfunction: Multiple Vascular Endothelial Dysfunction Mechanisms and Potential Therapeutic Targets. — International journal of biological sciences 2025 · PMID 41079939
- Association between erectile dysfunction, cardiovascular risk factors, and coronary artery disease: Role of exercise stress testing and International Index of Erectile Function (IIEF-5) questionnaire — IJC Heart & Vasculature 2022 · PMID 35495580
- Pericyte-derived heme-binding protein 1 promotes angiogenesis and improves erectile function in diabetic mice. — Investigative and clinical urology 2022 · PMID 35796141
- Peptide amphiphile nanofiber hydrogel delivery of Sonic hedgehog protein to the penis and cavernous nerve suppresses intrinsic and extrinsic apoptotic signaling mechanisms, which are an underlying cause of erectile dysfunction. — Nanomedicine : nanotechnology, biology, and medicine 2021 · PMID 34314869
- Erectile dysfunction and diabetes: A melting pot of circumstances and treatments — Diabetes/Metabolism Research and Reviews 2021 · PMID 34514697
- The Prevalence of Erectile Dysfunction and Its Association with Cardiovascular Risk Factors in Patients after Myocardial Infarction — Medicina 2021 · PMID 34684140
- Update of the position paper on arterial hypertension and erectile dysfunction. — Journal of hypertension 2020 · PMID 32073535
- Erectile dysfunction and cardiovascular risk: a review of current findings. — Expert review of cardiovascular therapy 2020 · PMID 32192361
- Erectile Dysfunction as a Cardiovascular Risk Factor: Time to Step Up? — Current Vascular Pharmacology 2020 · PMID 32286949
- Longitudinal Risk of Developing Cardiovascular Diseases in Patients with Erectile Dysfunction—Which Patients Deserve More Attention? — The Journal of Sexual Medicine 2020 · PMID 32340919
- Erectile dysfunction links to cardiovascular disease-defining the clinical value. — Trends in cardiovascular medicine 2019 · PMID 30665816
- Long-term treatment with testosterone undecanoate injections in men with hypogonadism alleviates erectile dysfunction and reduces risk of major adverse cardiovascular events, prostate cancer, and mortality — The Aging Male 2019 · PMID 30782054
- Current diagnosis and management of erectile dysfunction — The Medical Journal of Australia 2019 · PMID 31099420
- The global prevalence of erectile dysfunction: a review — British Journal of Urology 2019 · PMID 31267639
- Erectile Dysfunction, Sleep Disorders, and Endothelial Function. — The Israel Medical Association journal : IMAJ 2019 · PMID 31280511
- Testosterone and the Heart. — European cardiology 2019 · PMID 31360231
- Endocan and Erectile Dysfunction. — American journal of men's health 2019 · PMID 31829075
- Erectile Dysfunction as an Independent Predictor of Future Cardiovascular Events — Circulation 2018 · PMID 29891569
- Erectile dysfunction, metabolic syndrome, and cardiovascular risks: facts and controversies — Translational Andrology and Urology 2017 · PMID 28217448
- Homocysteine and Non-Cardiac Vascular Disease. — Current pharmaceutical design 2017 · PMID 28317478
- Association Between Cardiovascular Health and Endothelial Function With Future Erectile Dysfunction: The Multi-Ethnic Study of Atherosclerosis. — American journal of hypertension 2017 · PMID 28430921
- Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study — BMJ 2017 · PMID 28536104
- [Bibliometric analysis on relations between cardiovascular disease and erectile dysfunction]. — Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2017 · PMID 28647988
- Relationship between treatment of erectile dysfunction and future risk of cardiovascular disease: A nationwide cohort study — European Journal of Preventive Cardiology 2017 · PMID 28656785
- Erectile dysfunction, diabetes and cardiovascular risk — British Journal of Diabetes 2016
- Erectile dysfunction, loss of libido and low sexual frequency increase the risk of cardiovascular disease in men with low testosterone — The Aging Male 2016 · PMID 26755067
- Risk Factors for Sexual Dysfunction Among Women and Men: A Consensus Statement From the Fourth International Consultation on Sexual Medicine 2015 — The Journal of Sexual Medicine 2016 · PMID 26953830
- Risk factors for erectile dysfunction in patients with cardiovascular disease — Journal of International Medical Research 2016 · PMID 26960674
- Animal models of erectile dysfunction. — Journal of pharmacological and toxicological methods 2015 · PMID 26279495
- Erectile dysfunction and cardiovascular risk factors in a Mediterranean diet cohort — Internal Medicine Journal 2015 · PMID 26482327
- Erectile dysfunction. — Internal medicine journal 2014 · PMID 24450519
- Physical activity on endothelial and erectile dysfunction: a literature review. — The aging male : the official journal of the International Society for the Study of the Aging Male 2014 · PMID 24894579
- Should we expand the concept of coronary heart disease equivalents? — Current opinion in cardiology 2014 · PMID 25029454
- Changes in Erectile Dysfunction Over Time in Relation to Framingham Cardiovascular Risk in the Boston Area Community Health (BACH) Survey — The Journal of Sexual Medicine 2014 · PMID 25293632
- Biomarkers, erectile dysfunction, and cardiovascular risk prediction: the latest of an evolving concept — Asian Journal of Andrology 2014 · PMID 25412676
- Prediction of Cardiovascular Events and All-Cause Mortality With Erectile Dysfunction — Circulation Cardiovascular Quality and Outcomes 2013 · PMID 23300267
- Diagnosis and Treatment of Erectile Dysfunction for Reduction of Cardiovascular Risk — The Journal of Urology 2013 · PMID 23313195
- Erectile Dysfunction Severity as a Risk Marker for Cardiovascular Disease Hospitalisation and All-Cause Mortality: A Prospective Cohort Study — PLoS Medicine 2013 · PMID 23382654
- Erectile dysfunction in the cardiovascular patient — European Heart Journal 2013 · PMID 23616415
- Metabolic Syndrome in Men with Low Testosterone Levels: Relationship with Cardiovascular Risk Factors and Comorbidities and with Erectile Dysfunction — The Journal of Sexual Medicine 2013 · PMID 23898860
- Frequency of sexual activity and cardiovascular risk in subjects with erectile dysfunction: cross-sectional and longitudinal analyses — Andrology 2013 · PMID 24127288
- Organic Causes of Erectile Dysfunction in Men Under 40 — Urologia Internationalis 2013 · PMID 24281298
- Pharmacologic therapy for erectile dysfunction and its interaction with the cardiovascular system. — Journal of cardiovascular pharmacology and therapeutics 2013 · PMID 24281316
- All men with vasculogenic erectile dysfunction require a cardiovascular workup. — The American journal of medicine 2013 · PMID 24423973
- Testosterone and cardiovascular risk in patients with erectile dysfunction. — PubMed 2012 · PMID 22082753
- Erectile Dysfunction and Hypertension: Impact on Cardiovascular Risk and Treatment — International Journal of Hypertension 2012 · PMID 22649713
- Prognostic utility of erectile dysfunction for cardiovascular disease in younger men and those with diabetes. — American heart journal 2012 · PMID 22795278
- Lack of Exercise Is a Major Cause of Chronic Diseases — Comprehensive physiology 2012 · PMID 23798298
- Cardiovascular risk, drugs and erectile function - a systematic analysis — International Journal of Clinical Practice 2011 · PMID 21314866
- Erectile dysfunction and coronary artery disease in patients with diabetes. — Current diabetes reviews 2011 · PMID 21348816
- Physical activity and erectile dysfunction in middle-aged men. — Journal of andrology 2011 · PMID 21597089
- [Endothelial injury and erectile dysfunction]. — Zhonghua nan ke xue = National journal of andrology 2011 · PMID 21898999
- The Effect of Lifestyle Modification and Cardiovascular Risk Factor Reduction on Erectile Dysfunction — Archives of Internal Medicine 2011 · PMID 21911624
- Should patients with erectile dysfunction be evaluated for cardiovascular disease? — Asian journal of andrology 2011 · PMID 22120928
- Evaluation of erectile dysfunction and associated cardiovascular risk using structured questionnaires in Chinese type 2 diabetic men — International Journal of Andrology 2010 · PMID 20059584
- Implants, mechanical devices, and vascular surgery for erectile dysfunction. — The journal of sexual medicine 2010 · PMID 20092450
- Erectile Dysfunction Predicts Cardiovascular Events in High-Risk Patients Receiving Telmisartan, Ramipril, or Both — Circulation 2010 · PMID 20231536
- Male Sexuality and Cardiovascular Risk. A Cohort Study in Patients with Erectile Dysfunction — The Journal of Sexual Medicine 2010 · PMID 20233287
- Is Obesity a Further Cardiovascular Risk Factor in Patients with Erectile Dysfunction? — The Journal of Sexual Medicine 2010 · PMID 20456622
- Erectile dysfunction and coronary artery disease prediction: evidence-based guidance and consensus — International Journal of Clinical Practice 2010 · PMID 20584218
- Severe Depressive Symptoms and Cardiovascular Risk in Subjects with Erectile Dysfunction — The Journal of Sexual Medicine 2010 · PMID 20633210
- Cardiovascular and metabolic syndrome risk among men with and without erectile dysfunction: case-control study — Sao Paulo Medical Journal 2010 · PMID 20963365
- Erectile dysfunction and cardiovascular diseases. — Archivos espanoles de urologia 2010 · PMID 21045247
- Erectile dysfunction and cardiovascular disease: efficacy and safety of phosphodiesterase type 5 inhibitors in men with both conditions. — Mayo Clinic proceedings 2009 · PMID 19181648
- Erectile Dysfunction in Type 2 Diabetic Men: Relationship to Exercise Fitness and Cardiovascular Risk Factors in the Look AHEAD Trial — The Journal of Sexual Medicine 2009 · PMID 19192106
- Erectile dysfunction and its relationship with cardiovascular risk factors and disease. — Saudi medical journal 2009 · PMID 19198703
- Erectile Dysfunction and Mortality — The Journal of Sexual Medicine 2009 · PMID 19538544
- Endothelial dysfunction and erectile dysfunction in the aging man. — International journal of urology : official journal of the Japanese Urological Association 2009 · PMID 20002226
- Erectile dysfunction and dyslipidemia: relevance and role of phosphodiesterase type-5 inhibitors and statins. — The journal of sexual medicine 2008 · PMID 18331271
- The Dark Side of Testosterone Deficiency: I. Metabolic Syndrome and Erectile Dysfunction — Journal of Andrology 2008 · PMID 18641413
- New horizons in erectile and endothelial dysfunction research and therapies. — International journal of impotence research 2008 · PMID 19002115
- The triad: erectile dysfunction--endothelial dysfunction--cardiovascular disease. — Current pharmaceutical design 2008 · PMID 19128223
- Erectile dysfunction correlates with left ventricular function and precedes cardiovascular events in cardiovascular high-risk patients — International Journal of Clinical Practice 2007 · PMID 17313601
- The erectile-endothelial dysfunction nexus: new opportunities for cardiovascular risk prevention. — Nature clinical practice. Cardiovascular medicine 2007 · PMID 17457350
- ED2: erectile dysfunction = endothelial dysfunction. — Endocrinology and metabolism clinics of North America 2007 · PMID 17543729
- Inflammation, metabolic syndrome, erectile dysfunction, and coronary artery disease: common links. — European urology 2007 · PMID 17707576
- The temporal relationship between erectile dysfunction and cardiovascular disease — International Journal of Clinical Practice 2007 · PMID 17997808
- The relationship between erectile dysfunction and cardiovascular disease. Part I: pathophysiology and mechanisms. — Reviews in cardiovascular medicine 2007 · PMID 18192944
- The Second Princeton Consensus on Sexual Dysfunction and Cardiac Risk: New Guidelines for Sexual Medicine — The Journal of Sexual Medicine 2006 · PMID 16409215
- The Prevalence of Erectile Dysfunction in the Primary Care Setting — Archives of Internal Medicine 2006 · PMID 16432091
- Erectile dysfunction and statin treatment in high cardiovascular risk patients — International Journal of Clinical Practice 2006 · PMID 16451283
- Endothelial dysfunction in diabetic erectile dysfunction. — International journal of impotence research 2006 · PMID 16775612
- Cardiovascular disease, metabolic syndrome and erectile dysfunction. — Current opinion in urology 2006 · PMID 17053524
- Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease — European Heart Journal 2006 · PMID 17056702
- Comparing Vardenafil and Sildenafil in the Treatment of Men with Erectile Dysfunction and Risk Factors for Cardiovascular Disease: A Randomized, Double-Blind, Pooled Crossover Study — The Journal of Sexual Medicine 2006 · PMID 17100937
- Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension* — Journal of Hypertension 2005 · PMID 15662207
- Endothelial dysfunction links erectile dysfunction to heart disease — International Journal of Clinical Practice 2005 · PMID 15854201
- CHAPTER 1: THE MANAGEMENT OF ERECTILE DYSFUNCTION: AN AUA UPDATE — The Journal of Urology 2005 · PMID 15947645
- Vascular aetiology of erectile dysfunction. — International journal of andrology 2005 · PMID 16236062
- Metabolic syndrome, endothelial dysfunction, and erectile dysfunction: association and management. — Current urology reports 2005 · PMID 16238922
- Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: common pathways and treatments? — The American journal of cardiology 2005 · PMID 16387560
- Sexual dysfunction and cardiovascular disease: integrative concepts and strategies. — The American journal of cardiology 2005 · PMID 16387569
- Linking erectile dysfunction and coronary artery disease. — International journal of impotence research 2005 · PMID 16391538
- Erectile dysfunction as an early sign of cardiovascular disease. — International journal of impotence research 2005 · PMID 16391539
- Erectile Dysfunction and Subsequent Cardiovascular Disease — JAMA 2005 · PMID 16414947
Clinical trials (5)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07460960 | A Randomized Controlled Trial of Statin Therapy Effect on Androgen Status and Erectile Function in Men With High and Very High Cardiovascular Risk | RECRUITING | INTERVENTIONAL | Pitavastatin 1-4 mg daily, Rosuvastatin 20-40 mg daily |
| NCT07563647 | A Randomized, Allocation-concealed, Assessor-blinded, Parallel-group Trial Evaluating the Association Between Erectile Dysfunction and Left Ventricular Diastolic Dysfunction and Comparing the Effects of Tadalafil, SGLT2 Inhibitors, and Their Combination in Patients With Metabolic Syndrome. | COMPLETED | INTERVENTIONAL | Tadalafil 5 mg, SGLT-2 inhibitor, Tadalafil plus SGLT2 inhibitors |
| NCT06403423 | Screening for Infra-renal Abdominal Aortic Aneurysms in 65-year-old Men in Inland, Norway | ENROLLING BY INVITATION | OBSERVATIONAL | |
| NCT01190904 | Hormones and Sexual Function Predict Outcomes in Revascularized Men With Diabetes | COMPLETED | OBSERVATIONAL | |
| NCT00743613 | Predicting Peripheral Arterial Disease in Men With Erectile Dysfunction | COMPLETED | OBSERVATIONAL | Sexual Health Inventory for Men (SHIM), Ankle-Brachial Index (ABI) |
Genetic associations (0)
None linked.