B
Family history of premature coronary heart disease
Genetic & Family HistoryGenetic / heritablerisknon modifiable
37
evidence score
Also known as: Family history of CHD, family history of cardiovascular, family history of coronary, family history of myocardial, family history of premature, parental history
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 16.6meta-analyses: 0trials: 0genetic: 20MR bonus:
Associated genes
CDKN2B-AS1LPAPHACTR1HDAC9CELSR2TWIST1LINC01438ABOSMARCA4APOEATXN2LDLRCOL4A2TARIDY_RNA
References (45)
0 meta-analyses / systematic reviews- Why, how and in whom should we measure levels of lipoprotein(a): A review of the latest evidence and clinical implications. — Diabetes, obesity & metabolism 2025 · PMID 40437821
- Acute coronary syndrome patterns in the Young: risk factor profile and in-hospital outcomes in a tertiary referral hospital in Kenya. — BMC cardiovascular disorders 2024 · PMID 38570757
- Risk factor profile and outcomes of premature acute coronary syndrome after percutaneous coronary intervention: A 1-year prospective design. — Clinical cardiology 2023 · PMID 37818995
- Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review. — Journal of the American College of Cardiology 2022 · PMID 35210038
- Lipoprotein(a): a risk factor for atherosclerosis and an emerging therapeutic target. — Heart (British Cardiac Society) 2022 · PMID 35288443
- Premature Myocardial Infarction: A Rising Threat. — Balkan medical journal 2022 · PMID 35330552
- Illness perception and cardiovascular risk factors in patients with myocardial infarction undergoing percutaneous coronary intervention in Iran. — BMC cardiovascular disorders 2022 · PMID 35655125
- Distribution of risk factors differs from coronary heart disease and stroke in China: a national population survey. — BMJ open 2022 · PMID 36424109
- Sibling Risk Factor Study in Premature Coronary Artery Disease. — The Journal of the Association of Physicians of India 2021 · PMID 34472803
- Incidence, risk factors and outcome of young patients with myocardial infarction. — Heart (British Cardiac Society) 2020 · PMID 32111640
- Is family history of coronary artery disease important in the emergency department triage? — International emergency nursing 2020 · PMID 32241722
- Family history of coronary artery disease is associated with acute coronary syndrome in 28,188 chest pain patients. — European heart journal. Acute cardiovascular care 2019 · PMID 31124704
- HEART UK consensus statement on Lipoprotein(a): A call to action. — Atherosclerosis 2019 · PMID 31704552
- Shift work, parental cardiovascular disease and myocardial infarction in males. — Occupational medicine (Oxford, England) 2018 · PMID 29444274
- [Family history and risk of coronary heart disease]. — Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2018 · PMID 29495200
- Plasma Ceramides. — Arteriosclerosis, thrombosis, and vascular biology 2018 · PMID 29903731
- Does pregnancy complication history improve cardiovascular disease risk prediction? Findings from the HUNT study in Norway — European Heart Journal 2018 · PMID 30596987
- Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study — BMJ 2017 · PMID 28536104
- Role of Coronary Artery Calcium Score of Zero and Other Negative Risk Markers for Cardiovascular Disease — Circulation 2016 · PMID 26801055
- Prevalence and correlates of coronary heart disease: first population-based study in Lebanon. — Vascular health and risk management 2016 · PMID 27051290
- Myocardial Infarction in the "Young": Risk Factors, Presentation, Management and Prognosis. — Heart, lung & circulation 2016 · PMID 27265644
- Risk factors for coronary artery disease and acute coronary syndrome in patients ≤40 years old. — Future cardiology 2016 · PMID 27492147
- Coronary artery calcium screening: does it perform better than other cardiovascular risk stratification tools? — International journal of molecular sciences 2015 · PMID 25807266
- Familial hypercholesterolaemia in children and adolescents: gaining decades of life by optimizing detection and treatment. — European heart journal 2015 · PMID 26009596
- Family history of coronary heart disease is more strongly associated with coronary than with carotid atherosclerosis in healthy asymptomatic adults. — Atherosclerosis 2014 · PMID 24534453
- Coronary artery calcification and family history of myocardial infarction in the Dallas heart study. — JACC. Cardiovascular imaging 2014 · PMID 24954461
- Reflex syncope, anxiety level, and family history of cardiovascular disease in young women: case-control study. — Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 2014 · PMID 25179650
- Family history of coronary heart disease and markers of subclinical cardiovascular disease: where do we stand? — Atherosclerosis 2013 · PMID 23578356
- Association between low-dose folic acid supplementation and blood lipids concentrations in male and female subjects with atherosclerosis risk factors — Medical Science Monitor 2013 · PMID 24002360
- Family history of coronary heart disease and the incidence and progression of coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA). — Atherosclerosis 2013 · PMID 24468150
- A Genetic Risk Score Is Associated With Incident Cardiovascular Disease and Coronary Artery Calcium — Circulation Cardiovascular Genetics 2012 · PMID 22235037
- Prognostic utility of erectile dysfunction for cardiovascular disease in younger men and those with diabetes. — American heart journal 2012 · PMID 22795278
- Comparison of Novel Risk Markers for Improvement in Cardiovascular Risk Assessment in Intermediate-Risk Individuals — JAMA 2012 · PMID 22910756
- Should your family history of coronary heart disease scare you? — The Mount Sinai journal of medicine, New York 2012 · PMID 23239210
- Family history of coronary heart disease, health care and health behaviors. — Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 2011 · PMID 21958994
- Number of coronary heart disease risk factors and mortality in patients with first myocardial infarction. — JAMA 2011 · PMID 22089719
- Lipoprotein(a) as a cardiovascular risk factor: current status. — European heart journal 2010 · PMID 20965889
- Cardiovascular Disease Risk Prediction With and Without Knowledge of Genetic Variation at Chromosome 9p21.3 — Annals of Internal Medicine 2009 · PMID 19153409
- 25-Hydroxyvitamin D and Risk of Myocardial Infarction in Men<subtitle>A Prospective Study</subtitle> — Archives of Internal Medicine 2008 · PMID 18541825
- C-Reactive Protein and Parental History Improve Global Cardiovascular Risk Prediction — Circulation 2008 · PMID 18997194
- Family history of premature coronary heart disease and coronary artery calcification: Multi-Ethnic Study of Atherosclerosis (MESA). — Circulation 2007 · PMID 17646582
- Metabolic Syndrome in Childhood Predicts Adult Cardiovascular Disease 25 Years Later: The Princeton Lipid Research Clinics Follow-up Study — PEDIATRICS 2007 · PMID 17671060
- Khat chewing is a risk factor for acute myocardial infarction: a case‐control study — British Journal of Clinical Pharmacology 2005 · PMID 15842556
- Family history of coronary heart disease: evidence-based applications. — Primary care 2005 · PMID 16326224
- Erectile Dysfunction and Subsequent Cardiovascular Disease — JAMA 2005 · PMID 16414947
Clinical trials (0)
None linked.
Genetic associations (2742)
showing top 80 by significance| Variant | Gene(s) | Trait | p | OR/β | Study |
|---|---|---|---|---|---|
| rs10901252 | ABO | coronary artery disorder | 1e-324 | — | GCST90129544 |
| rs687621 | ABO | coronary artery disorder | 1e-324 | — | GCST90129543 |
| rs1046205 | MCF2L | coronary artery disorder | 1e-324 | — | GCST90129542 |
| rs1046205 | MCF2L | Ischemic stroke | 1e-324 | — | GCST90129549 |
| rs10793962 | ABO | Ischemic stroke | 1e-324 | — | GCST90129551 |
| rs116552240 | ABO | Ischemic stroke | 1e-324 | — | GCST90129550 |
| rs710446 | KNG1, HRG-AS1 | Ischemic stroke | 1e-307 | — | GCST90129552 |
| rs75331444 | ABCG8 | coronary artery disorder | 1e-300 | — | GCST90428732 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-300 | — | GCST90451698 |
| rs56266464 | ABCG5 | stroke disorder | 1e-300 | — | GCST90428731 |
| chr9:22093299 | coronary atherosclerosis | 1e-300 | 0.1686 unit decrease | GCST90475936 | |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-295 | 0.177893 unit increase | GCST010866 |
| rs710446 | KNG1, HRG-AS1 | coronary artery disorder | 1e-294 | — | GCST90129545 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-278 | 0.84 | GCST90132314 |
| rs102275 | TMEM258 | coronary artery calcification | 1e-264 | — | GCST001639 |
| chr9:22093299 | coronary artery disorder | 1e-260 | 0.1524 unit decrease | GCST90475929 | |
| rs4299376 | ABCG8 | coronary artery disorder | 1e-238 | — | GCST90428732 |
| rs17042098 | PITX2, LINC01438 | cardioembolic stroke | 1e-237 | 32.86 z score increase | GCST90132228 |
| rs10455872 | LPA | coronary atherosclerosis | 1e-234 | 0.2816 unit decrease | GCST90475936 |
| rs4977574 | CDKN2B-AS1 | coronary artery disorder | 1e-223 | 0.1788 unit decrease | GCST005195 |
| rs35519679 | TCF7L2 | coronary artery disorder | 1e-218 | — | GCST90451699 |
| rs10455872 | LPA | coronary artery disorder | 1e-204 | 0.256 unit decrease | GCST90475929 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-204 | 0.189 unit decrease | GCST005194 |
| rs4253417 | F11 | Ischemic stroke | 1e-197 | — | GCST90129552 |
| rs1333049 | CDKN2B-AS1 | coronary artery disorder | 1e-192 | 0.1879 unit increase | GCST005196 |
| rs4253417 | F11 | coronary artery disorder | 1e-189 | — | GCST90129545 |
| rs2227402 | FGB | Ischemic stroke | 1e-189 | — | GCST90129553 |
| rs10455872 | LPA | coronary artery disorder | 1e-186 | 0.738 | GCST90132314 |
| rs55730499 | LPA | coronary artery disorder | 1e-186 | — | GCST90132314 |
| chr9:22093299 | coronary artery disorder | 1e-182 | 0.1908 unit decrease | GCST90475198 | |
| rs2227402 | FGB | coronary artery disorder | 1e-182 | — | GCST90129546 |
| rs1537371 | CDKN2B-AS1 | coronary atherosclerosis | 1e-166 | 0.1568 unit decrease | GCST90480132 |
| rs7598542 | ABCG8 | coronary artery disorder | 1e-161 | — | GCST90428732 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-158 | — | GCST90129546 |
| rs13427362 | ABCG5 | coronary artery disorder | 1e-157 | — | GCST90428732 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-155 | — | GCST90129544 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-155 | — | GCST90129543 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-155 | — | GCST90129542 |
| rs1537372 | CDKN2B-AS1 | coronary artery disorder | 1e-154 | — | GCST90129545 |
| rs55730499 | LPA | coronary artery disorder | 1e-154 | 0.337 unit increase | GCST005194 |
| rs55730499 | LPA | coronary artery disorder | 1e-154 | 0.3368 unit increase | GCST005196 |
| rs55730499 | LPA | coronary artery disorder | 1e-153 | 0.3122 unit increase | GCST005195 |
| rs247617 | CETP, HERPUD1 | coronary artery disorder | 1e-149 | — | GCST004045 |
| rs10455872 | LPA | coronary artery disorder | 1e-148 | 0.3173 unit decrease | GCST90475198 |
| chr9:22093299 | coronary artery disorder | 1e-143 | 0.1827 unit decrease | GCST90475199 | |
| rs2891168 | CDKN2B-AS1 | myocardial infarction | 1e-141 | 1.21 | GCST011365 |
| rs1537371 | CDKN2B-AS1 | coronary artery disorder | 1e-139 | 0.1383 unit decrease | GCST90480134 |
| rs6025 | F5 | Ischemic stroke | 1e-137 | 2.927 | GCST003390 |
| rs10455872 | LPA | coronary atherosclerosis | 1e-134 | 0.279 unit decrease | GCST90480132 |
| rs1333042 | CDKN2B-AS1 | coronary artery disorder | 1e-129 | 0.1814 unit decrease | GCST90479543 |
| rs4977574 | CDKN2B-AS1 | myocardial infarction | 1e-128 | 0.8381 | GCST90432175 |
| rs55730499 | LPA | coronary artery disorder | 1e-124 | — | GCST90129546 |
| rs55730499 | LPA | coronary artery disorder | 1e-122 | — | GCST90129544 |
| rs55730499 | LPA | coronary artery disorder | 1e-122 | — | GCST90129543 |
| rs55730499 | LPA | coronary artery disorder | 1e-122 | — | GCST90129542 |
| rs55730499 | LPA | coronary artery disorder | 1e-122 | — | GCST90129545 |
| rs10455872 | LPA | coronary artery disorder | 1e-121 | — | GCST90129547 |
| rs10455872 | LPA | coronary artery disorder | 1e-121 | — | GCST90129548 |
| rs10455872 | LPA | coronary artery disorder | 1e-121 | 0.3078 unit decrease | GCST90475199 |
| rs2891168 | CDKN2B-AS1 | myocardial infarction | 1e-120 | 0.2022 unit increase | GCST90018877 |
| rs10455872 | LPA | coronary artery disorder | 1e-117 | 0.2528 unit decrease | GCST90480134 |
| rs186696265 | LPA, PLG | coronary artery disorder | 1e-116 | 1.677 | GCST90132314 |
| rs9349379 | PHACTR1 | coronary artery disorder | 1e-114 | 0.892 | GCST90132314 |
| rs4977574 | CDKN2B-AS1 | abdominal aortic aneurysm | 1e-114 | 0.182 unit decrease | GCST90432152 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-111 | 0.06921224 unit increase | GCST90449059 |
| rs10455872 | LPA | coronary artery disorder | 1e-110 | 0.3099 unit decrease | GCST90479543 |
| rs1333042 | CDKN2B-AS1 | coronary artery disorder | 1e-109 | 0.174 unit decrease | GCST90479542 |
| rs964184 | ZPR1 | coronary artery disorder | 1e-108 | — | GCST004045 |
| rs9349379 | PHACTR1 | coronary artery disorder | 1e-104 | 0.110473 unit increase | GCST010866 |
| rs1532085 | ALDH1A2 | coronary artery calcification | 1e-104 | — | GCST001639 |
| rs56393506 | LPA, PLG | coronary artery disorder | 1e-103 | 0.14927 unit increase | GCST010866 |
| chr9:22093299 | myocardial infarction | 1e-103 | 0.1574 unit decrease | GCST90475932 | |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-101 | 1.19 | GCST004787 |
| rs671 | ALDH2 | myocardial infarction | 1e-101 | 0.3344 unit increase | GCST90018877 |
| rs671 | ALDH2 | myocardial infarction | 1e-101 | 0.33438632 unit increase | GCST90018657 |
| rs10455872 | LPA | coronary artery disorder | 1e-98 | 0.3031 unit decrease | GCST90479542 |
| rs2891168 | CDKN2B-AS1 | coronary artery disorder | 1e-98 | 1.21 | GCST003116 |
| chr9:22093299 | myocardial infarction | 1e-98 | 0.1589 unit decrease | GCST90475211 | |
| rs9349379 | PHACTR1 | coronary atherosclerosis | 1e-96 | 0.09356 unit decrease | GCST90475936 |
| rs10455872 | LPA | myocardial infarction | 1e-94 | 0.273 unit decrease | GCST90475932 |