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Family history of premature coronary heart disease

Genetic & Family HistoryGenetic / heritablerisknon modifiable
37
evidence score

Also known as: Family history of CHD, family history of cardiovascular, family history of coronary, family history of myocardial, family history of premature, parental history

PREVENT status

Not a PREVENT input variable.

Causal support

observational only

Score components
lit volume: 16.6meta-analyses: 0trials: 0genetic: 20MR bonus:
Associated genes
CDKN2B-AS1LPAPHACTR1HDAC9CELSR2TWIST1LINC01438ABOSMARCA4APOEATXN2LDLRCOL4A2TARIDY_RNA

References (45)

0 meta-analyses / systematic reviews

Clinical trials (0)

None linked.

Genetic associations (2742)

showing top 80 by significance
VariantGene(s)TraitpOR/βStudy
rs10901252ABOcoronary artery disorder1e-324GCST90129544
rs687621ABOcoronary artery disorder1e-324GCST90129543
rs1046205MCF2Lcoronary artery disorder1e-324GCST90129542
rs1046205MCF2LIschemic stroke1e-324GCST90129549
rs10793962ABOIschemic stroke1e-324GCST90129551
rs116552240ABOIschemic stroke1e-324GCST90129550
rs710446KNG1, HRG-AS1Ischemic stroke1e-307GCST90129552
rs75331444ABCG8coronary artery disorder1e-300GCST90428732
rs2891168CDKN2B-AS1coronary artery disorder1e-300GCST90451698
rs56266464ABCG5stroke disorder1e-300GCST90428731
chr9:22093299coronary atherosclerosis1e-3000.1686 unit decreaseGCST90475936
rs2891168CDKN2B-AS1coronary artery disorder1e-2950.177893 unit increaseGCST010866
rs710446KNG1, HRG-AS1coronary artery disorder1e-294GCST90129545
rs2891168CDKN2B-AS1coronary artery disorder1e-2780.84GCST90132314
rs102275TMEM258coronary artery calcification1e-264GCST001639
chr9:22093299coronary artery disorder1e-2600.1524 unit decreaseGCST90475929
rs4299376ABCG8coronary artery disorder1e-238GCST90428732
rs17042098PITX2, LINC01438cardioembolic stroke1e-23732.86 z score increaseGCST90132228
rs10455872LPAcoronary atherosclerosis1e-2340.2816 unit decreaseGCST90475936
rs4977574CDKN2B-AS1coronary artery disorder1e-2230.1788 unit decreaseGCST005195
rs35519679TCF7L2coronary artery disorder1e-218GCST90451699
rs10455872LPAcoronary artery disorder1e-2040.256 unit decreaseGCST90475929
rs2891168CDKN2B-AS1coronary artery disorder1e-2040.189 unit decreaseGCST005194
rs4253417F11Ischemic stroke1e-197GCST90129552
rs1333049CDKN2B-AS1coronary artery disorder1e-1920.1879 unit increaseGCST005196
rs4253417F11coronary artery disorder1e-189GCST90129545
rs2227402FGBIschemic stroke1e-189GCST90129553
rs10455872LPAcoronary artery disorder1e-1860.738GCST90132314
rs55730499LPAcoronary artery disorder1e-186GCST90132314
chr9:22093299coronary artery disorder1e-1820.1908 unit decreaseGCST90475198
rs2227402FGBcoronary artery disorder1e-182GCST90129546
rs1537371CDKN2B-AS1coronary atherosclerosis1e-1660.1568 unit decreaseGCST90480132
rs7598542ABCG8coronary artery disorder1e-161GCST90428732
rs1537372CDKN2B-AS1coronary artery disorder1e-158GCST90129546
rs13427362ABCG5coronary artery disorder1e-157GCST90428732
rs1537372CDKN2B-AS1coronary artery disorder1e-155GCST90129544
rs1537372CDKN2B-AS1coronary artery disorder1e-155GCST90129543
rs1537372CDKN2B-AS1coronary artery disorder1e-155GCST90129542
rs1537372CDKN2B-AS1coronary artery disorder1e-154GCST90129545
rs55730499LPAcoronary artery disorder1e-1540.337 unit increaseGCST005194
rs55730499LPAcoronary artery disorder1e-1540.3368 unit increaseGCST005196
rs55730499LPAcoronary artery disorder1e-1530.3122 unit increaseGCST005195
rs247617CETP, HERPUD1coronary artery disorder1e-149GCST004045
rs10455872LPAcoronary artery disorder1e-1480.3173 unit decreaseGCST90475198
chr9:22093299coronary artery disorder1e-1430.1827 unit decreaseGCST90475199
rs2891168CDKN2B-AS1myocardial infarction1e-1411.21GCST011365
rs1537371CDKN2B-AS1coronary artery disorder1e-1390.1383 unit decreaseGCST90480134
rs6025F5Ischemic stroke1e-1372.927GCST003390
rs10455872LPAcoronary atherosclerosis1e-1340.279 unit decreaseGCST90480132
rs1333042CDKN2B-AS1coronary artery disorder1e-1290.1814 unit decreaseGCST90479543
rs4977574CDKN2B-AS1myocardial infarction1e-1280.8381GCST90432175
rs55730499LPAcoronary artery disorder1e-124GCST90129546
rs55730499LPAcoronary artery disorder1e-122GCST90129544
rs55730499LPAcoronary artery disorder1e-122GCST90129543
rs55730499LPAcoronary artery disorder1e-122GCST90129542
rs55730499LPAcoronary artery disorder1e-122GCST90129545
rs10455872LPAcoronary artery disorder1e-121GCST90129547
rs10455872LPAcoronary artery disorder1e-121GCST90129548
rs10455872LPAcoronary artery disorder1e-1210.3078 unit decreaseGCST90475199
rs2891168CDKN2B-AS1myocardial infarction1e-1200.2022 unit increaseGCST90018877
rs10455872LPAcoronary artery disorder1e-1170.2528 unit decreaseGCST90480134
rs186696265LPA, PLGcoronary artery disorder1e-1161.677GCST90132314
rs9349379PHACTR1coronary artery disorder1e-1140.892GCST90132314
rs4977574CDKN2B-AS1abdominal aortic aneurysm1e-1140.182 unit decreaseGCST90432152
rs2891168CDKN2B-AS1coronary artery disorder1e-1110.06921224 unit increaseGCST90449059
rs10455872LPAcoronary artery disorder1e-1100.3099 unit decreaseGCST90479543
rs1333042CDKN2B-AS1coronary artery disorder1e-1090.174 unit decreaseGCST90479542
rs964184ZPR1coronary artery disorder1e-108GCST004045
rs9349379PHACTR1coronary artery disorder1e-1040.110473 unit increaseGCST010866
rs1532085ALDH1A2coronary artery calcification1e-104GCST001639
rs56393506LPA, PLGcoronary artery disorder1e-1030.14927 unit increaseGCST010866
chr9:22093299myocardial infarction1e-1030.1574 unit decreaseGCST90475932
rs2891168CDKN2B-AS1coronary artery disorder1e-1011.19GCST004787
rs671ALDH2myocardial infarction1e-1010.3344 unit increaseGCST90018877
rs671ALDH2myocardial infarction1e-1010.33438632 unit increaseGCST90018657
rs10455872LPAcoronary artery disorder1e-980.3031 unit decreaseGCST90479542
rs2891168CDKN2B-AS1coronary artery disorder1e-981.21GCST003116
chr9:22093299myocardial infarction1e-980.1589 unit decreaseGCST90475211
rs9349379PHACTR1coronary atherosclerosis1e-960.09356 unit decreaseGCST90475936
rs10455872LPAmyocardial infarction1e-940.273 unit decreaseGCST90475932