A
Fibrinogen
Hemostatic & ThromboticLab test / biomarkerriskpartially modifiable
46
evidence score
Also known as: fibrinogen > or =400 mg/dL
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 19.4meta-analyses: 20trials: 7genetic: 0MR bonus:
References (86)
8 meta-analyses / systematic reviews- METABlood fibrinogen level as a biomarker of adverse outcomes in patients with coronary artery disease: A systematic review and meta-analysis. — Medicine 2022 · PMID 35984145
- METAChildhood socioeconomic status and inflammation: A systematic review and meta-analysis. — Brain, behavior, and immunity 2019 · PMID 30738842
- METAModerate alcohol consumption and atherosclerosis : Meta-analysis of effects on lipids and inflammation. — Wiener klinische Wochenschrift 2017 · PMID 28762059
- METAA systematic review and meta-analysis of the association between markers of hemostasis and abdominal aortic aneurysm presence and size. — Journal of vascular surgery 2014 · PMID 24461868
- METAExercise intervention and inflammatory markers in coronary artery disease: a meta-analysis. — American heart journal 2012 · PMID 22520533
- METAC-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. — Lancet (London, England) 2009 · PMID 20031199
- METAAssociation of beta-fibrinogen gene -148C/T and -455G/A polymorphisms and coronary artery disease in Chinese population: a meta analysis. — Science in China. Series C, Life sciences 2008 · PMID 18726528
- METADoes elevated plasma fibrinogen increase the risk of coronary heart disease? Evidence from a meta-analysis of genetic association studies. — Arteriosclerosis, thrombosis, and vascular biology 2005 · PMID 16123313
- D-Dimer as Biomarker for Prognosis of Coronary Artery Disease and Heart Failure: Reappraisal of Its Central Role. — Cardiology 2025 · PMID 40340891
- Fibrinogen-to-albumin ratio and long-term mortality in oldest-old patients undergoing percutaneous coronary intervention. — BMC geriatrics 2025 · PMID 40604420
- Association Between Fibrinogen-to-Albumin Ratio and Long-Term Mortality in Senile Patients with Coronary Artery Disease: A Prospective 10-Year Follow-up Study. — Clinical interventions in aging 2025 · PMID 41409519
- Synergetic impact of lipoprotein(a) and fibrinogen on stroke in coronary artery disease patients. — European journal of clinical investigation 2024 · PMID 38363025
- Impact of lipoprotein(a) and fibrinogen on prognosis in patients with coronary artery disease: A retrospective cohort study. — Technology and health care : official journal of the European Society for Engineering and Medicine 2024 · PMID 38848204
- Endothelial dysfunction markers syndecan-1 and thrombomodulin are associated with higher albuminuria levels in type 2 diabetes with no history of clinical cardiovascular disease. — Journal of diabetes and its complications 2024 · PMID 39405782
- The interplay between prolactin and cardiovascular disease. — Frontiers in endocrinology 2023 · PMID 36704037
- Impact of patient demographics and intraoperative characteristics on abdominal aortic aneurysm sac following endovascular repair. — Asian cardiovascular & thoracic annals 2023 · PMID 37264635
- Associations of habitual alcohol drinking with HDL cholesterol and D-dimer in patients with peripheral arterial disease. — Clinica chimica acta; international journal of clinical chemistry 2023 · PMID 37301276
- Cardiovascular manifestations of inflammatory bowel diseases and the underlying pathogenic mechanisms. — American journal of physiology. Regulatory, integrative and comparative physiology 2023 · PMID 37335014
- Fibrinogen/albumin ratio and carotid artery plaques in coronary heart disease patients with different glucose metabolic states: a RCSCD-TCM study. — Endocrine 2023 · PMID 37824044
- Assessment of the relationship between plasma fibrinogen-to-albumin ratio and slow coronary flow phenomenon in patients without obstructive coronary artery disease. — BMC cardiovascular disorders 2023 · PMID 37932710
- Fibrinogen-to-Albumin Ratio and Glucose Metabolic States in Patients With Coronary Heart Disease. — Angiology 2023 · PMID 37939004
- The association between fibrinogen levels and severity of coronary artery disease and long-term prognosis following percutaneous coronary intervention in patients with type 2 diabetes mellitus. — Frontiers in endocrinology 2023 · PMID 38093962
- Analysis of the Correlation Between the Ratio of Monocytes to High-Density Lipoprotein Cholesterol and in-Stent Restenosis in Patients with Premature Coronary Heart Disease. — Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2022 · PMID 35187964
- Ceramides and Cardiovascular Risk Factors, Inflammatory Parameters and Left Ventricular Function in AMI Patients. — Biomedicines 2022 · PMID 35203637
- Association between fibrinogen/albumin ratio and severity of coronary artery calcification in patients with chronic kidney disease: a retrospective study. — PeerJ 2022 · PMID 35694387
- Gut Microbiota and Coronary Plaque Characteristics. — Journal of the American Heart Association 2022 · PMID 36000423
- Biomarkers associated with coronary high-risk plaques. — Journal of thrombosis and thrombolysis 2022 · PMID 36205839
- Exercise modulation in inflammation and metabolic hormonal disorders of COVID-19 to decrease risk factors in coronary heart disease. — Hormone molecular biology and clinical investigation 2022 · PMID 36560914
- Thrombotic Complications of COVID-19 Infection: A Review. — Cardiology in review 2021 · PMID 32947478
- Fibrinogen and a Triad of Thrombosis, Inflammation, and the Renin-Angiotensin System in Premature Coronary Artery Disease in Women: A New Insight into Sex-Related Differences in the Pathogenesis of the Disease. — Biomolecules 2021 · PMID 34356659
- Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease. — Cardiovascular diabetology 2020 · PMID 32192491
- Mechanisms underlying the association between periodontitis and atherosclerotic disease — Periodontology 2000 2020 · PMID 32385879
- Relation Between Globulin, Fibrinogen, and Albumin With the Presence and Severity of Coronary Artery Disease. — Angiology 2020 · PMID 32996325
- Association of fibrinogen/albumin ratio and coronary collateral circulation in stable coronary artery disease patients. — Biomarkers in medicine 2020 · PMID 33200965
- Night shift work and cardiovascular disease biomarkers in female nurses. — American journal of industrial medicine 2019 · PMID 31828843
- Association Between Anti-Citrullinated Fibrinogen Antibodies and Coronary Artery Disease in Rheumatoid Arthritis. — Arthritis care & research 2018 · PMID 28992379
- Hemostasis in Allergy. — Seminars in thrombosis and hemostasis 2018 · PMID 29920622
- Socioeconomic status and central adiposity as determinants of stress-related biological responses relevant to cardiovascular disease risk. — Brain, behavior, and immunity 2018 · PMID 30468859
- Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system. — International journal of nanomedicine 2018 · PMID 30538461
- Novel biomarkers for cardiovascular risk prediction. — PubMed 2017 · PMID 28491088
- Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases — Frontiers in Immunology 2017 · PMID 28912780
- Atherosclerotic Vessel Changes in Sarcoidosis. — Advances in experimental medicine and biology 2016 · PMID 26820732
- From C-Reactive Protein to Interleukin-6 to Interleukin-1: Moving Upstream To Identify Novel Targets for Atheroprotection. — Circulation research 2016 · PMID 26837745
- Relation of Plasma Fibrinogen Level With the Presence, Severity, and Complexity of Coronary Artery Disease. — Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis 2016 · PMID 26865586
- Correlation between the plasma fibrinogen concentration and coronary heart disease severity in Moroccan patients with type 2 diabetes. Prospective study. — Annales d'endocrinologie 2016 · PMID 26903037
- Influence of the β-fibrinogen-455G/A polymorphism on development of ischemic stroke and coronary heart disease. — Thrombosis research 2014 · PMID 24448059
- Cardiovascular Risk and Psoriasis — Angiology 2014 · PMID 24671131
- Periodontitis in coronary heart disease patients: strong association between bleeding on probing and systemic biomarkers. — Journal of clinical periodontology 2014 · PMID 24946826
- Inflammation, atherosclerosis, and psoriasis. — Clinical reviews in allergy & immunology 2013 · PMID 22359071
- Exploring causal associations between alcohol and coronary heart disease risk factors: findings from a Mendelian randomization study in the Copenhagen General Population Study — European Heart Journal 2013 · PMID 23492672
- Family history of coronary heart disease and markers of subclinical cardiovascular disease: where do we stand? — Atherosclerosis 2013 · PMID 23578356
- The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis — The Lancet 2012 · PMID 22421340
- C-Reactive Protein, Fibrinogen, and Cardiovascular Disease Prediction — New England Journal of Medicine 2012 · PMID 23034020
- Fibrinogen may mediate the association between long sleep duration and coronary heart disease. — Journal of sleep research 2012 · PMID 23217092
- Periodontal treatment effects on endothelial function and cardiovascular disease biomarkers in subjects with chronic periodontitis: protocol for a randomized clinical trial — Trials 2011 · PMID 21324167
- Can haemostatic factors predict atherothrombosis? — Internal and emergency medicine 2011 · PMID 21327550
- Loneliness, social isolation, and behavioral and biological health indicators in older adults. — Health psychology : official journal of the Division of Health Psychology, American Psychological Association 2011 · PMID 21534675
- Fibrinogen and cardiovascular disease: genetics and biomarkers. — Blood reviews 2011 · PMID 21652129
- Depressive symptoms, health behaviors, and subsequent inflammation in patients with coronary heart disease: prospective findings from the heart and soul study. — The American journal of psychiatry 2011 · PMID 21724664
- Hypothyroidism and Moderate Subclinical Hypothyroidism Are Associated with Increased All-Cause Mortality Independent of Coronary Heart Disease Risk Factors: A PreCIS Database Study — Thyroid 2011 · PMID 21745107
- An Update on the Role of Markers of Inflammation in Atherosclerosis — Journal of Atherosclerosis and Thrombosis 2010 · PMID 20032572
- Risk factors for atherosclerosis in cases with severe periodontitis — Journal Of Clinical Periodontology 2009 · PMID 19538326
- Genome-wide association studies of cardiovascular risk factors: design, conduct and interpretation. — Journal of thrombosis and haemostasis : JTH 2009 · PMID 19630823
- Serum uric acid is an independent predictor of all‐cause mortality in patients at high risk of cardiovascular disease: A preventive cardiology information system (PreCIS) database cohort study — Arthritis & Rheumatism 2008 · PMID 18240236
- Association of fibrinogen and fibrinogen gene beta148 and beta854 polymorphisms with coronary heart disease. — Cardiology 2008 · PMID 18434720
- Hypercoagulability in cats with cardiomyopathy. — Journal of veterinary internal medicine 2008 · PMID 18466239
- [Rheology and coronary heart disease]. — Deutsche medizinische Wochenschrift (1946) 2008 · PMID 19085805
- Physical Activity and Reduced Risk of Cardiovascular Events — Circulation 2007 · PMID 17967770
- Inflammatory biomarkers, race/ethnicity and cardiovascular disease. — Nutrition reviews 2007 · PMID 18240555
- Retinal Vascular Caliber, Cardiovascular Risk Factors, and Inflammation: The Multi-Ethnic Study of Atherosclerosis (MESA) — Investigative Ophthalmology & Visual Science 2006 · PMID 16723443
- Fibrinogen and coronary heart disease: test of causality by 'Mendelian randomization'. — International journal of epidemiology 2006 · PMID 16870675
- Unfavourable endothelial and inflammatory state in erectile dysfunction patients with or without coronary artery disease — European Heart Journal 2006 · PMID 17056702
- Impact of Traditional and Novel Risk Factors on the Relationship Between Socioeconomic Status and Incident Cardiovascular Events — Circulation 2006 · PMID 17116764
- Traditional and Nontraditional Risk Factors Predict Coronary Heart Disease in Chronic Kidney Disease — Journal of the American Society of Nephrology 2005 · PMID 15625072
- Changes in cardiorespiratory fitness and coronary heart disease risk factors following 24 wk of moderate- or high-intensity exercise of equal energy cost — Journal of Applied Physiology 2005 · PMID 15640382
- Lipoprotein (a) and coronary heart disease among women: beyond a cholesterol carrier? — European heart journal 2005 · PMID 15824077
- Altered Blood Rheology in Obstructive Sleep Apnea as a Mediator of Cardiovascular Risk — Cardiology 2005 · PMID 16015032
- Which Hemostatic Markers Add to the Predictive Value of Conventional Risk Factors for Coronary Heart Disease and Ischemic Stroke? — Circulation 2005 · PMID 16286603
- Is there more than C-reactive protein and fibrinogen? The prognostic value of soluble CD40 ligand, interleukin-6 and oxidized low-density lipoprotein with respect to coronary and cerebral vascular disease. — Atherosclerosis 2005 · PMID 16360159
- The Prevalence of Nontraditional Risk Factors for Coronary Heart Disease in Patients with Chronic Kidney Disease — Annals of Internal Medicine 2004 · PMID 14706967
- Prevalence of and Risk Factors for Peripheral Arterial Disease in the United States — Circulation 2004 · PMID 15262830
- Obstructive sleep apnea and cardiovascular disease. — Mayo Clinic proceedings 2004 · PMID 15301332
- Education, socioeconomic and lifestyle factors, and risk of coronary heart disease: the PRIME Study. — International journal of epidemiology 2004 · PMID 15319403
- Carotid intima-media thickness, cardiovascular risk factors and albuminuria in a remote Australian Aboriginal community. — Atherosclerosis 2004 · PMID 15530919
- Plasma fibrinogen. — Annals of clinical biochemistry 2004 · PMID 15588432
- Inflammation, insulin resistance, and atherosclerosis. — Metabolic syndrome and related disorders 2004 · PMID 18370641
Clinical trials (4)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT05300672 | Fibrinogen Replacement to Prevent Intracranial Haemorrhage in Ischemic Stroke Patients After Thrombolysis: a Pilot Probe Randomized Controlled Trial (FibER) | COMPLETED | INTERVENTIONAL | fibrinogen infusion |
| NCT02291796 | Early Effect Of Bezafibrate On Fibrinogen Levels, Inflammatory Response And Clinical Impact, In Patients With ST Elevation Acute Myocardial Infarction | COMPLETED | INTERVENTIONAL | Bezafibrate |
| NCT01089530 | Clinical Intervention Study in the Primary Care Setting of Patients With High Plasma Fibrinogen in Primary Prevention of Cardiovascular Disease | COMPLETED | INTERVENTIONAL | Lifestyle intensive group |
| NCT04305171 | Effect of Non-surgical Periodontal Treatment on Plasma Fibrinogen, Plasminogen Activator Inhibitor 1 and C-reactive Protein Levels in Cardiovascular Disease Patients With Periodontitis | COMPLETED | OBSERVATIONAL | non-surgical periodontal treatment |
Genetic associations (0)
None linked.