A
Gout
Comorbid ConditionsDisease / conditionriskpartially modifiable
33
evidence score
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 18.8meta-analyses: 13.8trials: 0genetic: 0MR bonus:
References (74)
4 meta-analyses / systematic reviews- METAIdentified risk factors for dry eye syndrome: A systematic review and meta-analysis. — PloS one 2022 · PMID 35984830
- METAAssociation between antihypertensive treatment and adverse events: systematic review and meta-analysis. — BMJ (Clinical research ed.) 2021 · PMID 33568342
- METAThe incidence and prevalence of cardiovascular diseases in gout: a systematic review and meta-analysis. — Rheumatology international 2021 · PMID 33987709
- METAMeta-Analysis of 28,141 Individuals Identifies Common Variants within Five New Loci That Influence Uric Acid Concentrations — PLoS Genetics 2009 · PMID 19503597
- Hyperuricemia and Cardiovascular Risk: Insights and Implications. — Critical pathways in cardiology 2025 · PMID 40062919
- Gout: one year in review 2025. — Clinical and experimental rheumatology 2025 · PMID 40153315
- Ceramide-based risk score: A novel laboratory tool for cardiovascular risk stratification in hyperuricemia and gout. — Vascular pharmacology 2025 · PMID 40239856
- Colchicine and the risk of major adverse cardiovascular events in patients with gout and Type 2 diabetes: A nationwide cohort study. — Journal of internal medicine 2025 · PMID 40847662
- Cardiovascular morbidity and mortality in gout: is gout an independent risk factor? — Expert opinion on pharmacotherapy 2025 · PMID 41320643
- Gout: one year in review 2023. — Clinical and experimental rheumatology 2024 · PMID 38306017
- Early-onset gout. — Joint bone spine 2024 · PMID 38336273
- Gout and incidence of 12 cardiovascular diseases: a case-control study including 152 663 individuals with gout and 709 981 matched controls. — The Lancet. Rheumatology 2024 · PMID 38383089
- Uric acid and cardiovascular diseases: a reappraisal. — Postgraduate medicine 2024 · PMID 38973128
- The Prevalence and Factors Associated with Coronary Heart Disease in Patients with Gout. — Doklady. Biochemistry and biophysics 2024 · PMID 39002009
- Controversies and practical management of patients with gout and chronic kidney disease. — Kidney international 2024 · PMID 39033815
- Asymptomatic hyperuricemia: to treat or not a threat? A clinical and evidence-based approach to the management of hyperuricemia in the context of cardiovascular diseases. — Journal of hypertension 2024 · PMID 39051476
- [Gout and Nutrition]. — Therapeutische Umschau. Revue therapeutique 2024 · PMID 39508812
- [Hyperuricemia]. — No shinkei geka. Neurological surgery 2024 · PMID 39622322
- Insights into renal damage in hyperuricemia: Focus on renal protection (Review). — Molecular medicine reports 2024 · PMID 39717954
- Hyperuricemia, A new cardiovascular risk. — Nutrition, metabolism, and cardiovascular diseases : NMCD 2024 · PMID 39939254
- [Update Gout]. — Therapeutische Umschau. Revue therapeutique 2023 · PMID 36659847
- Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients — New England Journal of Medicine 2023 · PMID 36876740
- Clonal haematopoiesis and dysregulation of the immune system. — Nature reviews. Immunology 2023 · PMID 36941354
- Uric Acid and Risk of Cardiovascular Disease and Mortality: A Longitudinal Cohort Study. — Journal of Korean medical science 2023 · PMID 37750373
- EULAR recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, including systemic lupus erythematosus and antiphospholipid syndrome. — Annals of the rheumatic diseases 2022 · PMID 35110331
- [Gout]. — Zeitschrift fur Rheumatologie 2022 · PMID 35596003
- <i>TET2</i>-mutant clonal hematopoiesis and risk of gout — Blood 2022 · PMID 35714308
- Association Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout. — JAMA 2022 · PMID 35916846
- Serum Uric Acid and Diabetes: From Pathophysiology to Cardiovascular Disease. — Current pharmaceutical design 2021 · PMID 33397230
- [Gout]. — Der Internist 2021 · PMID 33721041
- Dietary and Lifestyle-Centered Approach in Gout Care and Prevention. — Current rheumatology reports 2021 · PMID 34196878
- Molecular Biological and Clinical Understanding of the Pathophysiology and Treatments of Hyperuricemia and Its Association with Metabolic Syndrome, Cardiovascular Diseases and Chronic Kidney Disease — International Journal of Molecular Sciences 2021 · PMID 34502127
- Mechanosensitive TRPV4 is required for crystal-induced inflammation. — Annals of the rheumatic diseases 2021 · PMID 34663597
- Uric Acid in Inflammation and the Pathogenesis of Atherosclerosis. — International journal of molecular sciences 2021 · PMID 34830282
- Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. — Lancet (London, England) 2020 · PMID 32061315
- Pharmacologic Management of Gout in Patients with Cardiovascular Disease and Heart Failure. — American journal of cardiovascular drugs : drugs, devices, and other interventions 2020 · PMID 32090301
- Gout epidemiology and comorbidities. — Seminars in arthritis and rheumatism 2020 · PMID 32620196
- Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial. — Lancet (London, England) 2020 · PMID 33181081
- Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective — Frontiers in Pharmacology 2020 · PMID 33304270
- Uric Acid as a Risk Factor for Chronic Kidney Disease and Cardiovascular Disease ― Japanese Guideline on the Management of Asymptomatic Hyperuricemia ― — Circulation Journal 2020 · PMID 33342914
- Uric acid and cardiovascular disease: A clinical review. — Journal of cardiology 2020 · PMID 33388217
- Gout and cardiovascular disease: crystallized confusion. — Current opinion in rheumatology 2019 · PMID 30601229
- Cardiovascular Disease in Gout and the Protective Effect of Treatments Including Urate-Lowering Therapy. — Drugs 2019 · PMID 30868398
- Genetically determined serum urate levels and cardiovascular and other diseases in UK Biobank cohort: A phenome-wide mendelian randomization study — PLoS Medicine 2019 · PMID 31626644
- Update on colchicine, 2017. — Rheumatology (Oxford, England) 2018 · PMID 29272515
- Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout. — The New England journal of medicine 2018 · PMID 29527974
- Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 — The Lancet 2017 · PMID 28919117
- [Hyperuricemia, gout and cardiovascular diseases]. — Therapeutische Umschau. Revue therapeutique 2016 · PMID 27008446
- Serum uric acid levels and cardiovascular disease: the Gordian knot — Journal of Thoracic Disease 2016 · PMID 28066631
- Hyperuricemia, gout, and cardiovascular disease: an update. — Current rheumatology reports 2015 · PMID 25740704
- Gout. — Nursing standard (Royal College of Nursing (Great Britain) : 1987) 2015 · PMID 25804180
- [GOUT AND HYPERTENSION]. — Likars'ka sprava 2015 · PMID 26118024
- Serum uric acid and the risk of cardiovascular and renal disease. — Journal of hypertension 2015 · PMID 26136207
- The role of uric acid in the development of cardiovascular disease. — Current medical research and opinion 2015 · PMID 26414729
- Hyperuricemia and cardiovascular risk. — High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 2014 · PMID 24554489
- Improving cardiovascular and renal outcomes in gout: what should we target? — Nature reviews. Rheumatology 2014 · PMID 25136785
- Mechanism of action of colchicine in the treatment of gout. — Clinical therapeutics 2014 · PMID 25151572
- [Gout and cardiovascular risk]. — Vnitrni lekarstvi 2014 · PMID 25382012
- Chronic hyperuricemia, uric acid deposit and cardiovascular risk. — Current pharmaceutical design 2013 · PMID 23173592
- Uric acid and chronic kidney disease: which is chasing which? — Nephrology Dialysis Transplantation 2013 · PMID 23543594
- Beyond gout: uric acid and cardiovascular diseases — Current Medical Research and Opinion 2013 · PMID 23611366
- High plasma uric acid concentration: causes and consequences — Diabetology & Metabolic Syndrome 2012 · PMID 22475652
- Uric acid, hyperuricemia and vascular diseases — Frontiers in bioscience 2011 · PMID 22201767
- Inflammation, oxidative stress and lipids: the risk triad for atherosclerosis in gout — Lara D. Veeken 2010 · PMID 20202928
- Uric acid transport and disease — Journal of Clinical Investigation 2010 · PMID 20516647
- Axial gouty arthropathy. — The American journal of the medical sciences 2009 · PMID 19680018
- Gout. — Lancet (London, England) 2009 · PMID 19692116
- Lifestyle and gout. — Current opinion in rheumatology 2008 · PMID 18349748
- Gout and coronary artery disease: epidemiologic clues. — Current rheumatology reports 2008 · PMID 18638434
- Gout and mortality. — Clinical and experimental rheumatology 2008 · PMID 19026153
- Altered uric acid levels and disease states. — The Journal of pharmacology and experimental therapeutics 2007 · PMID 17890445
- Gout and the risk of acute myocardial infarction. — Arthritis and rheumatism 2006 · PMID 16871533
- Uric Acid and Diet — Insights into the Epidemic of Cardiovascular Disease — New England Journal of Medicine 2004 · PMID 15014177
- Uric Acid Level as a Risk Factor for Cardiovascular and All-Cause Mortality in Middle-aged Men — Archives of Internal Medicine 2004 · PMID 15277287
Clinical trials (0)
None linked.
Genetic associations (0)
None linked.