B
Growth differentiation factor-15 (GDF-15)
Novel & Emerging BiomarkersLab test / biomarkerrisknon modifiable
26
evidence score
Also known as: GDF-15, gdf-15, growth differentiation factor 15, growth differentiation factor-15
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 16.5meta-analyses: 9.1trials: 0genetic: 0MR bonus:
References (44)
2 meta-analyses / systematic reviews- METACirculating GDF-15 in relation to the progression and prognosis of chronic kidney disease: A systematic review and dose-response meta-analysis. — European journal of internal medicine 2023 · PMID 36740468
- METAGrowth differentiation factor-15 and the risk of cardiovascular diseases and all-cause mortality: A meta-analysis of prospective studies. — Clinical cardiology 2019 · PMID 30697778
- Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker. — Current cardiology reviews 2025 · PMID 39781722
- GDF15 Analogues Acting as GFRAL Ligands. — ChemMedChem 2025 · PMID 39907315
- Cardiovascular Biomarkers: Tools for Precision Diagnosis and Prognosis. — International journal of molecular sciences 2025 · PMID 40244022
- A validated multivariable machine learning model to predict cardio-kidney risk in diabetic kidney disease. — Cardiovascular diabetology 2025 · PMID 40375260
- Growth-differentiation factor 15 (GDF-15) is associated with arterial stiffness and impaired endothelial function with mediation by albuminuria in the Singapore study of macroangiopathy and microvascular reactivity in type 2 diabetes (SMART2D) cohort. — Endocrine 2025 · PMID 40481928
- GDF15: An emerging disease target and biomarker of metabolic diseases. — Journal of endocrinological investigation 2025 · PMID 40569532
- GDF15: from biomarker to target in cancer cachexia. — Trends in cancer 2025 · PMID 40640073
- Growth and differentiation factor-15: A link between inflammaging and cardiovascular disease. — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 · PMID 38522236
- Circulating galectin-3 level association with cardiovascular risk factors during peritoneal dialysis. — Clinical and experimental nephrology 2024 · PMID 38643287
- Macrophages as a Source and Target of GDF-15. — International journal of molecular sciences 2024 · PMID 39000420
- Growth differentiation factor 15 alleviates diastolic dysfunction in mice with experimental diabetic cardiomyopathy. — Cell reports 2024 · PMID 39093701
- Heart Failure Risk Assessment Using Biomarkers in Patients With Atrial Fibrillation: Analysis From COMBINE-AF. — Journal of the American College of Cardiology 2024 · PMID 39230543
- GDF-15 improves the predictive capacity of steatotic liver disease non-invasive tests for incident morbidity and mortality risk for cardio-renal-metabolic diseases and malignancies. — Metabolism: clinical and experimental 2024 · PMID 39396641
- Growth differentiation factor 15 (GDF-15) in endocrinology. — Endocrine 2023 · PMID 37129758
- Growth Differentiation Factor 15 (GDF-15), a New Biomarker in Heart Failure Management. — Current heart failure reports 2023 · PMID 37289373
- Association of growth and differentiation factor-15 with coronary artery calcium score and ankle-brachial index in a middle-aged and elderly Caucasian population sample free of manifest cardiovascular disease. — GeroScience 2023 · PMID 37548881
- GDF-15 at admission predicts cardiovascular death, heart failure, and bleeding outcomes in patients with CAD. — ESC heart failure 2023 · PMID 37620152
- Diabetes, GDF-15 and incident heart failure: the atherosclerosis risk in communities study. — Diabetologia 2022 · PMID 35275240
- Circulating levels of GDF-15 for predicting cardiovascular and cancer morbidity and mortality in type 2 diabetes: Findings from Da Qing IGT and Diabetes Study. — Diabetes & metabolism 2022 · PMID 35918035
- GDF-15 as a Biomarker in Cardiovascular Disease. — Arquivos brasileiros de cardiologia 2021 · PMID 33566936
- GDF-15: Diagnostic, prognostic, and therapeutic significance in glioblastoma multiforme. — Journal of cellular physiology 2021 · PMID 33580506
- Growth Differentiation Factor (GDF)-15 and Cardiometabolic Outcomes among Older Adults: The Atherosclerosis Risk in Communities Study. — Clinical chemistry 2021 · PMID 33582779
- Dynamics of growth differentiation factor 15 in acute heart failure. — ESC heart failure 2021 · PMID 33938154
- GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease. — Nature reviews. Endocrinology 2021 · PMID 34381196
- GDF-15 Deficiency Reduces Autophagic Activity in Human Macrophages In Vitro and Decreases p62-Accumulation in Atherosclerotic Lesions in Mice. — Cells 2021 · PMID 34571994
- Cadmium exposure and growth differentiation factor-15 (GDF-15) levels in non-smoking older adults. — Environmental research 2021 · PMID 34695433
- GDF-15, a future therapeutic target of glucolipid metabolic disorders and cardiovascular disease. — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 · PMID 34959119
- GDF-15 as a Weight Watcher for Diabetic and Non-Diabetic People Treated With Metformin. — Frontiers in endocrinology 2020 · PMID 33312159
- Growth differentiation factor-15 and its role in diabetes and cardiovascular disease. — Cytokine & growth factor reviews 2020 · PMID 33317942
- GDF-15 in Pulmonary and Critical Care Medicine. — American journal of respiratory cell and molecular biology 2019 · PMID 30633545
- GDF-15 in solid vs non-solid treatment-naïve malignancies. — European journal of clinical investigation 2019 · PMID 31463975
- GDF-15, Galectin 3, Soluble ST2, and Risk of Mortality and Cardiovascular Events in CKD. — American journal of kidney diseases : the official journal of the National Kidney Foundation 2018 · PMID 29866459
- Protein Biomarkers of Cardiovascular Disease and Mortality in the Community — Journal of the American Heart Association 2018 · PMID 30006491
- Novel biomarkers of cardiovascular disease: Applications in clinical practice — Critical Reviews in Clinical Laboratory Sciences 2018 · PMID 30457415
- [Effects of growth differentiation factor-15 (GDF-15) on neurological systems, cardiovascular diseases, and cancer progression]. — Sheng li xue bao : [Acta physiologica Sinica] 2017 · PMID 28217814
- Novel biomarkers for cardiovascular risk prediction. — PubMed 2017 · PMID 28491088
- GFRAL is the receptor for GDF15 and the ligand promotes weight loss in mice and nonhuman primates. — Nature medicine 2017 · PMID 28846097
- The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin pathologies. — Archives of dermatological research 2015 · PMID 25690161
- GDF-15 as a Target and Biomarker for Diabetes and Cardiovascular Diseases: A Translational Prospective. — Journal of diabetes research 2015 · PMID 26273671
- GDF-15 for prognostication of cardiovascular and cancer morbidity and mortality in men. — PloS one 2013 · PMID 24312445
- Prognostic Utility of Novel Biomarkers of Cardiovascular Stress — Circulation 2012 · PMID 22907935
- Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction — European Heart Journal 2007 · PMID 17977844
Clinical trials (0)
None linked.
Genetic associations (0)
None linked.