B
Gut microbiome composition
Novel & Emerging BiomarkersLab test / biomarkermixedmodifiable
44
evidence score
Also known as: Gut microbiome, gut microbiome, gut microbiota, intestinal microbiota
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 22.6meta-analyses: 9.1trials: 12genetic: 0MR bonus:
References (179)
2 meta-analyses / systematic reviews- METAPersonalized Nutrition Biomarkers and Dietary Strategies for Atherosclerosis Risk Management: A Systematic Review. — Nutrients 2025 · PMID 40944193
- METAEffect of Plant-Based Diets on Gut Microbiota: A Systematic Review of Interventional Studies. — Nutrients 2023 · PMID 36986240
- Non-traditional risk factors for atrial fibrillation: epidemiology, mechanisms, and strategies. — European heart journal 2025 · PMID 39716283
- Exercised gut microbiota improves vascular and metabolic abnormalities in sedentary diabetic mice through gut‒vascular connection. — Journal of sport and health science 2025 · PMID 39827989
- Trimethylamine-N-Oxide (TMAO) as a Rising-Star Metabolite: Implications for Human Health. — Metabolites 2025 · PMID 40278349
- Gut Microbiota Modulation Through Mediterranean Diet Foods: Implications for Human Health. — Nutrients 2025 · PMID 40289944
- Gut Microbiota and Cardiovascular Diseases: Unraveling the Role of Dysbiosis and Microbial Metabolites. — International journal of molecular sciences 2025 · PMID 40362500
- Gut microbiota and well-being: A comprehensive summary of the special issue. — Pharmacological research 2025 · PMID 40409520
- Gut Microbiota Improve the Prediction of Stroke-Associated Pneumonia Risk and Outcomes in Acute Ischemic Stroke. — Translational stroke research 2025 · PMID 40500582
- Microbiota in Gut-Heart Axis: Metabolites and Mechanisms in Cardiovascular Disease. — Comprehensive Physiology 2025 · PMID 40542540
- Prostaglandins and Inflammatory Bowel Disease: From Mechanism to Clinic. — Inflammatory bowel diseases 2025 · PMID 40556439
- Trimethylamine-N-oxide (TMAO) and risk of incident cardiovascular events in the multi ethnic study of Atherosclerosis. — Scientific reports 2025 · PMID 40603925
- Tanshinone regulated gut microbiota and TMAO to improve high-fat diet induced atherosclerosis in APOEmice. — BMC microbiology 2025 · PMID 40646462
- Lipid-lowering drug targets influence inflammatory bowel disease through gut microbiota and inflammatory cytokines. — Journal of lipid research 2025 · PMID 40769382
- Multi-omics integration reveals functional signatures of gut microbiome in atherosclerosis. — Gut microbes 2025 · PMID 40785047
- Cardiovascular disease and microbiome: focus on ischemic stroke. — Polish archives of internal medicine 2025 · PMID 40838552
- Akkermansia muciniphila: A key player in gut microbiota-based disease modulation. — Microbiological research 2025 · PMID 40845731
- Human breast milk and its impact on inflammatory bowel disease. — Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 2025 · PMID 40903241
- Forward and reverse cardio-oncology. — Physiological reviews 2025 · PMID 40983491
- Polycystic ovary syndrome in 2025-insights and innovations. — Fertility and sterility 2025 · PMID 40992713
- Gut microbiota-derived proinflammatory biomarkers and risk of coronary heart disease: a prospective study among United States males and females. — The American journal of clinical nutrition 2025 · PMID 41015192
- JA845 Postbiotics Alleviate Atherosclerosis via TMAO-Related Gut Microbiota Regulation and JAK/STAT3 Pathway Inhibition. — Nutrients 2025 · PMID 41097105
- Novel therapeutic targets and emerging treatments for atherosclerotic cardiovascular disease. — European heart journal. Cardiovascular pharmacotherapy 2024 · PMID 37813820
- Protocatechuic acid alleviates TMAO-aggravated atherosclerosismitigating inflammation, regulating lipid metabolism, and reshaping gut microbiota. — Food & function 2024 · PMID 38165856
- Trimethylamine-N-oxide and cerebral stroke risk: A review. — Neurobiology of disease 2024 · PMID 38286388
- Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder. — Frontiers in immunology 2024 · PMID 38343539
- Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases — Signal Transduction and Targeted Therapy 2024 · PMID 38360862
- Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria. — Cell 2024 · PMID 38569543
- Role of the microbiota-gut-heart axis between bile acids and cardiovascular disease. — Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 · PMID 38583340
- Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic. — Journal of translational medicine 2024 · PMID 38622667
- Puerarin alleviates atherosclerosis via the inhibition ofand its trimethylamine production. — Gut 2024 · PMID 38777572
- The human gut microbiome and aging — Gut Microbes 2024 · PMID 38831607
- Divergent age-associated and metabolism-associated gut microbiome signatures modulate cardiovascular disease risk. — Nature medicine 2024 · PMID 38844795
- Trimethylamine N-oxide promotes PERK-mediated endothelial-mesenchymal transition and apoptosis thereby aggravates atherosclerosis. — International immunopharmacology 2024 · PMID 39340998
- Gut microbiota and functional outcome after ischemic stroke: a Mendelian randomization study. — Frontiers in immunology 2024 · PMID 39376557
- The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer. — Nature reviews. Microbiology 2024 · PMID 39390291
- A gut feeling of statin. — Gut microbes 2024 · PMID 39470680
- Gut Microbe-Generated Metabolite Trimethylamine-N-Oxide and Ischemic Stroke. — Biomolecules 2024 · PMID 39595639
- The oral microbiome in the pathophysiology of cardiovascular disease. — Nature reviews. Cardiology 2023 · PMID 36624275
- Mechanistic insight: Linking cardiovascular complications of inflammatory bowel disease. — Trends in cardiovascular medicine 2023 · PMID 36702388
- The Gut Microbiome, Microbial Metabolites, and Cardiovascular Disease in People Living with HIV. — Current HIV/AIDS reports 2023 · PMID 36708497
- Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease? — International journal of molecular sciences 2023 · PMID 36768264
- The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease — International Journal of Molecular Sciences 2023 · PMID 36768722
- Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Causation or Association. — Cardiology in review 2023 · PMID 36825899
- Anthocyanins-gut microbiota-health axis: A review. — Critical reviews in food science and nutrition 2023 · PMID 36927343
- Role of the Gut Microbiome in the Development of Atherosclerotic Cardiovascular Disease — International Journal of Molecular Sciences 2023 · PMID 36982492
- Gut-Derived Metabolite, Trimethylamine-N-oxide (TMAO) in Cardio-Metabolic Diseases: Detection, Mechanism, and Potential Therapeutics — Pharmaceuticals 2023 · PMID 37111261
- The possible role of physical activity in the modulation of gut microbiota in chronic kidney disease and its impact on cardiovascular risk: a narrative review. — European review for medical and pharmacological sciences 2023 · PMID 37140322
- Gut Microbiota and Cardiovascular Disease: Evidence on the Metabolic and Inflammatory Background of a Complex Relationship. — International journal of molecular sciences 2023 · PMID 37240434
- Cardiovascular manifestations of inflammatory bowel diseases and the underlying pathogenic mechanisms. — American journal of physiology. Regulatory, integrative and comparative physiology 2023 · PMID 37335014
- Gut microbiota and microbiota-derived metabolites in cardiovascular diseases. — Chinese medical journal 2023 · PMID 37442759
- Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review — Internal and Emergency Medicine 2023 · PMID 37505311
- Activation of GPBAR1 attenuates vascular inflammation and atherosclerosis in a mouse model of NAFLD-related cardiovascular disease. — Biochemical pharmacology 2023 · PMID 37926268
- The Antiobesity Effects and Potential Mechanisms of. — Journal of medicinal food 2023 · PMID 38060708
- Microbiome and Cardiovascular Disease. — Handbook of experimental pharmacology 2022 · PMID 32185503
- Gut microbiome and health: mechanistic insights — Gut 2022 · PMID 35105664
- Gut microbiome and diabetic retinopathy. — European journal of ophthalmology 2022 · PMID 35266406
- Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis. — NPJ biofilms and microbiomes 2022 · PMID 35273169
- Atherosclerosis: Recent developments. — Cell 2022 · PMID 35504280
- Deficiency of PSRC1 accelerates atherosclerosis by increasing TMAO production via manipulating gut microbiota and flavin monooxygenase 3 — Gut Microbes 2022 · PMID 35613310
- Gut–Skin Axis: Unravelling the Connection between the Gut Microbiome and Psoriasis — Biomedicines 2022 · PMID 35625774
- Gut microbiome mediates the protective effects of exercise after myocardial infarction. — Microbiome 2022 · PMID 35637497
- Cardiovascular risk factors and molecular routes underlying endothelial dysfunction: Novel opportunities for primary prevention. — Biochemical pharmacology 2022 · PMID 35643340
- Berberine treats atherosclerosis via a vitamine-like effect down-regulating Choline-TMA-TMAO production pathway in gut microbiota. — Signal transduction and targeted therapy 2022 · PMID 35794102
- The Gut Microbiota (Microbiome) in Cardiovascular Disease and Its Therapeutic Regulation. — Frontiers in cellular and infection microbiology 2022 · PMID 35795187
- Gut Microbiota and Coronary Plaque Characteristics. — Journal of the American Heart Association 2022 · PMID 36000423
- Gut microbiome-mediated mechanisms for reducing cholesterol levels: implications for ameliorating cardiovascular disease. — Trends in microbiology 2022 · PMID 36008191
- The anti-inflammatory effects of a Mediterranean diet: a review. — Current opinion in clinical nutrition and metabolic care 2022 · PMID 36039924
- Inflammatory Bowel Disease and Cardiovascular Diseases. — The American journal of medicine 2022 · PMID 36058305
- Shared Risk Factors between Dementia and Atherosclerotic Cardiovascular Disease. — International journal of molecular sciences 2022 · PMID 36077172
- Causal associations between gut microbiome and cardiovascular disease: A Mendelian randomization study — Frontiers in Cardiovascular Medicine 2022 · PMID 36110421
- Human gut microbiota in health and disease: Unveiling the relationship — Frontiers in Microbiology 2022 · PMID 36225386
- Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation. — Cell host & microbe 2022 · PMID 36228585
- The potential of tailoring the gut microbiome to prevent and treat cardiometabolic disease. — Nature reviews. Cardiology 2022 · PMID 36241728
- TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis. — International journal of molecular sciences 2022 · PMID 36292963
- Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses — Frontiers in Pharmacology 2022 · PMID 36353491
- The gut microbiome: a core regulator of metabolism — Journal of Endocrinology 2022 · PMID 36458804
- Gut microbiome and metabolites, the future direction of diagnosis and treatment of atherosclerosis? — Pharmacological Research 2022 · PMID 36460280
- Intermittent Fasting Improves Cardiometabolic Risk Factors and Alters Gut Microbiota in Metabolic Syndrome Patients. — The Journal of clinical endocrinology and metabolism 2021 · PMID 33017844
- A cross-talk between gut microbiome, salt and hypertension — Biomedicine & Pharmacotherapy 2021 · PMID 33401080
- Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review — Nutrients 2021 · PMID 33401598
- The gut microbiome modulates the protective association between a Mediterranean diet and cardiometabolic disease risk. — Nature medicine 2021 · PMID 33574608
- Role of Gut Microbiota, Probiotics and Prebiotics in the Cardiovascular Diseases. — Molecules (Basel, Switzerland) 2021 · PMID 33671813
- Trimethylamine N-oxide (TMAO) in human health. — EXCLI journal 2021 · PMID 33746664
- The role of short-chain fatty acids in the interplay between gut microbiota and diet in cardio-metabolic health. — Gut microbes 2021 · PMID 33764858
- The Gut Microbiome in Hypertension — Circulation Research 2021 · PMID 33793332
- Role and Mechanism of Gut Microbiota in Human Disease. — Frontiers in cellular and infection microbiology 2021 · PMID 33816335
- Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome — npj Biofilms and Microbiomes 2021 · PMID 33863898
- Alterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis — International Journal of Molecular Sciences 2021 · PMID 33924414
- The Influence of Gut Microbiota on the Cardiovascular System Under Conditions of Obesity and Chronic Stress. — Current hypertension reports 2021 · PMID 34014393
- Chronic kidney disease — The Lancet 2021 · PMID 34175022
- Targeting TMAO and its metabolic pathway for cardiovascular diseases treatment. — Journal of diabetes and metabolic disorders 2021 · PMID 34178875
- Leaky Gut: Effect of Dietary Fiber and Fats on Microbiome and Intestinal Barrier — International Journal of Molecular Sciences 2021 · PMID 34299233
- The Role of Gut Microbiota on Cholesterol Metabolism in Atherosclerosis — International Journal of Molecular Sciences 2021 · PMID 34360839
- What Links an Increased Cardiovascular Risk and Inflammatory Bowel Disease? A Narrative Review. — Nutrients 2021 · PMID 34444821
- Gut microbiota dependent trimethylamine N-oxide aggravates angiotensin II-induced hypertension. — Redox biology 2021 · PMID 34474396
- [Atherosclerosis and cardiovascular risk in patients with inflammatory bowel disease]. — Terapevticheskii arkhiv 2021 · PMID 36286684
- The progress of gut microbiome research related to brain disorders — Journal of Neuroinflammation 2020 · PMID 31952509
- The gut microbiome in coronary artery disease and heart failure: Current knowledge and future directions — EBioMedicine 2020 · PMID 32062353
- Gut microbiome and cardiovascular disease. — Current opinion in cardiology 2020 · PMID 32068612
Clinical trials (15)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06615986 | Evaluation of a Human Milk Oligosaccharide-Based Synbiotic Supplement for Intestinal Microbiota Dysbiosis | RECRUITING | INTERVENTIONAL | Cardiosyn |
| NCT05776329 | Randomized Controlled Clinical Trial on the Anti-inflammatory Effect of a Sustainable Dietary Strategy in Adults With Obesity | COMPLETED | INTERVENTIONAL | AIA-D, CONV-D |
| NCT04434365 | The Study of Berberine Affecting Metabolism, Inflammation Status, Endothelial Function and Thrombotic Events in Patients With Coronary Artery Disease by Remodeling Gut Microbiota | UNKNOWN | INTERVENTIONAL | Berberine, Aspirin, Clopidogrel |
| NCT02956369 | Chronic Effect of Daily Intake of SATIOSTAT Over 6 Weeks on Weight Loss, Glucose Tolerance, Gastrointestinal Tolerance and Gut Microbiota. | COMPLETED | INTERVENTIONAL | Control, SATIOSTAT |
| NCT03441802 | Gut Microbiota as a Novel Therapeutic Target for Prevention of Cardiovascular Diseases in Obese and Non-obese Adult Subjects | COMPLETED | INTERVENTIONAL | High quality extra virgin olive oil |
| NCT01355575 | RiFL: Rifaximin in Fatty Liver Disease. Does Modulation of Gut Microbiota Reduce Hepatic Inflammation in Non-Alcoholic Steatohepatitis (NASH)? | TERMINATED | INTERVENTIONAL | Rifaximin |
| NCT03029572 | Micro-nutritional Status and Gut Microbiota in Morbidly Obese Patients Before and After Gastric Bypass With and Without Micro-nutritional Supplementation | COMPLETED | INTERVENTIONAL | Diet supplementation, Bariatric surgery |
| NCT06539832 | Correlation Analysis of Intestinal Flora and Immune Function in Patients With Monoclonal Immunoglobulinaemia Co-infection | RECRUITING | OBSERVATIONAL | |
| NCT04820556 | The Development of Preventive Methods for Chronic Noncommunicable Diseases Based on Modulation of Gut Microbiota Composition and Function | COMPLETED | OBSERVATIONAL | |
| NCT04451148 | Gut Microbiome As Target of Intervention Against Obesity and Metabolic Syndrome | UNKNOWN | OBSERVATIONAL | Obese with or without metabolic syndromesubjects |
| NCT04151849 | Complementary Effects of New Diabetes Medications on Adrenal Function and Intestinal Microbiota | COMPLETED | OBSERVATIONAL | GLP-1 receptor agonist, SGLT2 inhibitor |
| NCT03378765 | Gut Microbiota, Short Chain Fatty Acids, and Adiposity Across The Epidemiological Transition | UNKNOWN | OBSERVATIONAL | Diet and physical activity monitoring |
| NCT03204799 | Metagenomic Analysis of Human Gut Microbiota in Patients With Metabolic Diseases Including Diabetes. | UNKNOWN | OBSERVATIONAL | Metformin, SGLT2 inhibitor, ezetimibe |
| NCT02188381 | The Role of Gut Microbiota in Hypertension: Brain-Gut Microbiome-Immune Axis in Hypertension | COMPLETED | OBSERVATIONAL | Stool Sample and Blood Sample |
| NCT02008604 | Influence of Stroke on the Composition of Intestinal Microbiota (GUTSTROKE) | COMPLETED | OBSERVATIONAL |
Genetic associations (0)
None linked.