A
Hemoglobin A1c
44
evidence score
Also known as: HbA1c, glycated haemoglobin (HbA(1c)), glycated hemoglobin, glycated hemoglobin (HbA1c), glycated hemoglobin A1c, glycated hemoglobin of 6.6%, glycosylated hemoglobin, hba1c
PREVENT status
✓ Used by PREVENT (optional input).
Causal support
observational only
Score components
lit volume: 21meta-analyses: 20trials: 3genetic: 0MR bonus:
References (125)
9 meta-analyses / systematic reviews- METAEffects of Periodontal Therapy on Cardiovascular Risk Biomarkers: A Systematic Review. — Oral health & preventive dentistry 2025 · PMID 40842443
- METAExercise training modalities in prediabetes: a systematic review and network meta-analysis. — Frontiers in endocrinology 2024 · PMID 38440785
- METAShared Decision-Making in Cardiovascular Risk Factor Management: A Systematic Review and Meta-Analysis. — JAMA network open 2024 · PMID 38530311
- METAEffects of phytosterols on cardiovascular risk factors: A systematic review and meta-analysis of randomized controlled trials. — Phytotherapy research : PTR 2024 · PMID 39572895
- METAEffectiveness of acupuncture on glycolipid metabolism in patients with coronary heart disease: A systematic review and meta-analysis. — Complementary therapies in medicine 2024 · PMID 39615634
- METAAssociations between dimensions of the social environment and cardiometabolic risk factors: Systematic review and meta-analysis. — SSM - population health 2023 · PMID 38148999
- METAGlycosylated hemoglobin levels and clinical outcomes in nondiabetic patients with coronary artery disease: A meta-analysis. — Medicine 2017 · PMID 28445316
- METAQuantifying cardiovascular disease risk factors in patients with psoriasis: a meta-analysis — British Journal of Dermatology 2013 · PMID 23815240
- METAMarkers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review. — PLoS medicine 2010 · PMID 20520805
- Glycemic control and coronary plaque characteristics in patients with acute myocardial infarction. — International journal of cardiology 2025 · PMID 39826579
- Current Status and Prospects of Regional Collaborative Pathways for Management of Acute Coronary Syndrome in Japan - A Nationwide Survey. — Circulation journal : official journal of the Japanese Circulation Society 2025 · PMID 39880656
- Telemedicine-supported lifestyle intervention for glycemic control in patients with CHD and T2DM: multicenter, randomized controlled trial. — Nature medicine 2025 · PMID 39920395
- The prognostic significance of stress hyperglycemia ratio in evaluating all-cause and cardiovascular mortality risk among individuals across stages 0-3 of cardiovascular-kidney-metabolic syndrome: evidence from two cohort studies. — Cardiovascular diabetology 2025 · PMID 40128747
- Diabetic Status and Thrombogenicity: Association and Prognostic Implications After Percutaneous Coronary Intervention. — JACC. Cardiovascular interventions 2025 · PMID 40139850
- Improved prediction and risk stratification of major adverse cardiovascular events using an explainable machine learning approach combining plasma biomarkers and traditional risk factors. — Cardiovascular diabetology 2025 · PMID 40176039
- Glycated hemoglobin levels and abdominal aortic aneurysm incidence in primary prevention populations. — Journal of vascular surgery 2025 · PMID 40222571
- Epidemiological and Translational Study of Calprotectin and Atherosclerotic Cardiovascular Disease. — JAMA cardiology 2025 · PMID 40332890
- Differential Effects of Visceral and Subcutaneous Adiposity on Peripheral Neuropathy. — Journal of the peripheral nervous system : JPNS 2025 · PMID 40345154
- Assessing prediabetes and cardiometabolic risk in Danish youth with obesity. — Journal of pediatric endocrinology & metabolism : JPEM 2025 · PMID 40418781
- Construction and evaluation of an aspirin resistance risk prediction model for ischemic stroke. — BMC neurology 2025 · PMID 40474099
- Causal association of modifiable factors with cardiometabolic multimorbidity: an exposome-wide Mendelian randomization investigation. — Cardiovascular diabetology 2025 · PMID 40481456
- The Association Between the Hemoglobin Glycation Index and Cardiometabolic Diseases: A Mini-Review. — Journal of clinical hypertension (Greenwich, Conn.) 2025 · PMID 40662995
- Chronic financial stress and cardiovascular disease risk: A prospective cohort study and Mendelian randomization analysis. — Atherosclerosis 2025 · PMID 40743770
- Environmental noise exposure and cardiovascular diseases in a Shanghai cohort. — Environment international 2025 · PMID 40876147
- Data-driven analysis of the relationship between the HbA1c/HDL-C ratio and coronary artery calcification: a cross-sectional study. — Scientific reports 2025 · PMID 40883347
- Efficacy and safety of Tongmai Jiangtang Capsule in the treatment of type 2 diabetes mellitus complicated with coronary heart disease with syndrome of damp - heat obstructing collaterals. — Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 · PMID 40961593
- Cathepsin K: a novel association with glucose intolerance, insulin resistance, and subclinical atherosclerosis in T2DM. — Journal of translational medicine 2025 · PMID 41039522
- Remnant Cholesterol and Cardiovascular Risk in Adults With Type 1 Diabetes: A Nested Case-Control Study. — Endocrinology, diabetes & metabolism 2025 · PMID 41058311
- Association between atherogenic index of plasma (AIP) and all-cause and cardiovascular mortality in patients with metabolic dysfunction-associated steatotic liver disease (MASLD): a cohort study based on NHANES 1999-2018. — Cardiovascular diabetology 2025 · PMID 41073997
- Coronary artery calcification in type 1 diabetes after 10-year ketogenic diet. — Journal of applied physiology (Bethesda, Md. : 1985) 2025 · PMID 41289606
- Associations of combined polygenic risk score and glycemic status with atrial fibrillation, coronary artery disease and ischemic stroke — Cardiovascular Diabetology 2024 · PMID 38172896
- Risk analysis of the association between different hemoglobin glycation index and poor prognosis in critical patients with coronary heart disease-A study based on the MIMIC-IV database. — Cardiovascular diabetology 2024 · PMID 38555454
- Associations between sleep duration, sleep disturbance and cardiovascular disease biomarkers among adults in the United States — BMC Public Health 2024 · PMID 38566084
- Visceral-to-peripheral adiposity ratio: a critical determinant of sex and ethnic differences in cardiovascular risks among Asian Indians and African Creoles in Mauritius. — International journal of obesity (2005) 2024 · PMID 38615158
- Association of physical activity and screen time with cardiovascular disease risk in the Adolescent Brain Cognitive Development Study. — BMC public health 2024 · PMID 38762449
- Label-free electrochemical detection of glycated hemoglobin (HbA1c) and C-reactive protein (CRP) to predict the maturation of coronary heart disease due to diabetes. — Bioelectrochemistry (Amsterdam, Netherlands) 2024 · PMID 38788312
- Long-term risk factor management and adverse events in patients with early-onset myocardial infarction-a "real-world" study. — Clinical research in cardiology : official journal of the German Cardiac Society 2024 · PMID 38896124
- Comprehensive analysis of the association between triglyceride-glucose index and coronary artery disease severity across different glucose metabolism states: a large-scale cross-sectional study from an Asian cohort. — Cardiovascular diabetology 2024 · PMID 39003471
- Joint effects of physical frailty and traditional cardiovascular risk factor control on cardiovascular disease in patients with diabetes. — The journal of nutrition, health & aging 2024 · PMID 39180942
- Hemoglobin glycation index and cardiovascular outcomes in patients with diabetes and coronary artery disease: insights from a large cohort study. — Nutrition & diabetes 2024 · PMID 39191777
- Effects of Interrupting Prolonged Sitting with Light-Intensity Physical Activity on Inflammatory and Cardiometabolic Risk Markers in Young Adults with Overweight and Obesity: Secondary Outcome Analyses of the SED-ACT Randomized Controlled Crossover Trial. — Biomolecules 2024 · PMID 39199416
- Insulin resistance assessed by estimated glucose disposal rate and risk of atherosclerotic cardiovascular diseases incidence: the multi-ethnic study of atherosclerosis. — Cardiovascular diabetology 2024 · PMID 39342205
- Prediabetes and cardiovascular risk factors: the effectiveness of a guided self-determination counselling approach in primary health care, a randomized controlled trial. — BMC public health 2024 · PMID 39487428
- Different associations of atherogenic index of plasma, triglyceride glucose index, and hemoglobin A1C levels with the risk of coronary artery calcification progression according to established diabetes. — Cardiovascular diabetology 2024 · PMID 39563338
- Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study. — Journal of atherosclerosis and thrombosis 2023 · PMID 36775331
- Correlation of asprosin and Nrg-4 with type 2 diabetes Mellitus Complicated with Coronary Heart Disease and the Diagnostic Value. — BMC endocrine disorders 2023 · PMID 36915073
- Diagnosis and Management of Prediabetes: A Review. — JAMA 2023 · PMID 37039787
- Twenty Years of Cardiovascular Complications and Risk Factors in Patients With Type 2 Diabetes: A Nationwide Swedish Cohort Study. — Circulation 2023 · PMID 37154040
- SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe. — European heart journal 2023 · PMID 37247330
- Physiology of sedentary behavior. — Physiological reviews 2023 · PMID 37326297
- Increased ultra-processed food consumption is associated with worsening of cardiometabolic risk factors in adults with metabolic syndrome: Longitudinal analysis from a randomized trial. — Atherosclerosis 2023 · PMID 37343432
- Intensified glycemic control by HbA1c for patients with coronary heart disease and Type 2 diabetes: a review of findings and conclusions. — Cardiovascular diabetology 2023 · PMID 37349787
- Joint association of loneliness and traditional risk factor control and incident cardiovascular disease in diabetes patients. — European heart journal 2023 · PMID 37385629
- Ceramides as Risk Markers for Future Cardiovascular Events and All-Cause Mortality in Long-standing Type 1 Diabetes. — Diabetes 2023 · PMID 37478203
- Trends in cardiovascular burden and mortality among adults with prediabetes in the US, 1999-2018. — Diabetes & vascular disease research 2023 · PMID 37545055
- Association of growth and differentiation factor-15 with coronary artery calcium score and ankle-brachial index in a middle-aged and elderly Caucasian population sample free of manifest cardiovascular disease. — GeroScience 2023 · PMID 37548881
- Lifelong Heterogeneous Contribution of Cardiovascular Risk Factors to Slow and Fast Progression of Arterial Stiffness. — Hypertension (Dallas, Tex. : 1979) 2023 · PMID 37551598
- Development and Validation of the American Heart Association's PREVENT Equations. — Circulation 2023 · PMID 37947085
- Novel Prediction Equations for Absolute Risk Assessment of Total Cardiovascular Disease Incorporating Cardiovascular-Kidney-Metabolic Health: A Scientific Statement From the American Heart Association. — Circulation 2023 · PMID 37947094
- Prediabetes increases the risk of major limb and cardiovascular events. — Cardiovascular diabetology 2023 · PMID 38115080
- Efficacy and safety of alogliptin versus acarbose in Chinese type 2 diabetes patients with high cardiovascular risk or coronary heart disease treated with aspirin and inadequately controlled with metformin monotherapy or drug-naive: A multicentre, randomized, open-label, prospective study (ACADEMIC). — Diabetes, obesity & metabolism 2022 · PMID 35112779
- Correlation Between Glycated Hemoglobin (HbA1c) and Post-Systolic Index Measured by Speckle-Tracking Echocardiography in Patients with Non-apparent Coronary Artery Disease. — Cardiovascular toxicology 2022 · PMID 35192134
- Association of HbA1c with carotid artery plaques in patients with coronary heart disease: a retrospective clinical study. — Acta cardiologica 2022 · PMID 35356852
- Impact of risk factor control on peripheral artery disease outcomes and health disparities. — Vascular medicine (London, England) 2022 · PMID 35387516
- Management of dyslipidemia and atherosclerotic cardiovascular risk in prediabetes. — Diabetes research and clinical practice 2022 · PMID 35787415
- Metabolic risk factors in first acute coronary syndrome (MERIFACS) Study. — Indian heart journal 2022 · PMID 35931204
- l-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study — BMC Medicine 2022 · PMID 36045366
- Relationship Between the Progression of Coronary Artery Disease and Pulse Pressure Index: A Cross-Sectional Work. — Angiology 2022 · PMID 36052894
- Glycemia Reduction in Type 2 Diabetes - Microvascular and Cardiovascular Outcomes. — The New England journal of medicine 2022 · PMID 36129997
- SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study. — Diabetes care 2022 · PMID 36161993
- Level of education is associated with coronary heart disease and chronic kidney disease in individuals with type 2 diabetes: a population-based study. — BMJ open diabetes research & care 2022 · PMID 36171015
- Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses — Circulation 2022 · PMID 36314129
- Clinical laboratory test-wide association scan of polygenic scores identifies biomarkers of complex disease — Genome Medicine 2021 · PMID 33441150
- Adherence to prescription guidelines and achievement of treatment goals among persons with coronary heart disease in Tromsø 7. — BMC cardiovascular disorders 2021 · PMID 33478404
- Psoriasis and Diabetes, a Dangerous Association: Evaluation of Insulin Resistance, Lipid Abnormalities, and Cardiovascular Risk Biomarkers — Frontiers in Medicine 2021 · PMID 33834030
- Race/Ethnic Differences in Atherosclerotic Cardiovascular Disease Risk Factors Among Patients With Hypertension: Analysis From 143 Primary Care Clinics — American Journal of Hypertension 2021 · PMID 33876823
- Cardiovascular and Kidney Outcomes Across the Glycemic Spectrum: Insights From the UK Biobank. — Journal of the American College of Cardiology 2021 · PMID 34015477
- Sodium glucose co-transporter-2 inhibitor, Empagliflozin, is associated with significant reduction in weight, body mass index, fasting glucose, and A1c levels in Type 2 diabetic patients with established coronary heart disease: the SUPER GATE study. — Irish journal of medical science 2021 · PMID 34476725
- Trends in Cardiovascular Risk Factors in US Adults by Race and Ethnicity and Socioeconomic Status, 1999-2018. — JAMA 2021 · PMID 34609450
- Association of Region-Specific Cardiac Adiposity With Dysglycemia and New-Onset Diabetes. — Journal of the American Heart Association 2021 · PMID 34889106
- Fibrinogen is associated with glucose metabolism and cardiovascular outcomes in patients with coronary artery disease. — Cardiovascular diabetology 2020 · PMID 32192491
- In patients with stable coronary heart disease, low-density lipoprotein-cholesterol levels < 70 mg/dL and glycosylated hemoglobin A1c < 7% are associated with lower major cardiovascular events. — American heart journal 2020 · PMID 32480059
- Effects of SGLT2 Inhibitors on Kidney and Cardiovascular Function. — Annual review of physiology 2020 · PMID 33197224
- Area-based socioeconomic status and mortality: the Ludwigshafen Risk and Cardiovascular Health study. — Clinical research in cardiology : official journal of the German Cardiac Society 2019 · PMID 31144063
- Aortic Pulse Pressure Does Not Adequately Index Cardiovascular Risk Factor-Related Changes in Aortic Stiffness and Forward Wave Pressure. — American journal of hypertension 2018 · PMID 29684105
- Prediabetes. — The Canadian journal of cardiology 2018 · PMID 29731022
- The Impact of Glycated Hemoglobin (HbA1c) on Cardiovascular Disease Risk: A Mendelian Randomization Study Using UK Biobank — Diabetes Care 2018 · PMID 29950300
- Regional Differences in the Prevalence of Coronary Heart Disease and Stroke in Patients With Type 2 Diabetes in China. — The Journal of clinical endocrinology and metabolism 2018 · PMID 29982638
- Risk Factors, Mortality, and Cardiovascular Outcomes in Patients with Type 2 Diabetes — New England Journal of Medicine 2018 · PMID 30110583
- Coronary Artery Calcification and Risk of Cardiovascular Disease and Death Among Patients With Chronic Kidney Disease — JAMA Cardiology 2017 · PMID 28329057
- Postprandial Blood Glucose Outweighs Fasting Blood Glucose and HbA1c in screening Coronary Heart Disease. — Scientific reports 2017 · PMID 29079813
- Normal LDL-Cholesterol Levels Are Associated With Subclinical Atherosclerosis in the Absence of Risk Factors — Journal of the American College of Cardiology 2017 · PMID 29241485
- Relationship between Diabetes Mellitus and Coronary Heart Disease. — Current diabetes reviews 2016 · PMID 26728362
- Life course SES and cardiovascular risk: Heterogeneity across race/ethnicity and gender. — Social science & medicine (1982) 2016 · PMID 26854625
- Cardiovascular Risk Factor Targets and Cardiovascular Disease Event Risk in Diabetes: A Pooling Project of the Atherosclerosis Risk in Communities Study, Multi-Ethnic Study of Atherosclerosis, and Jackson Heart Study — Diabetes Care 2016 · PMID 27208374
- Socioeconomic Status and Cardiovascular Risk Control in Adults With Diabetes. — The American journal of the medical sciences 2016 · PMID 27432033
- Associations between plasma fibulin-1, pulse wave velocity and diabetes in patients with coronary heart disease. — Journal of diabetes and its complications 2015 · PMID 25633574
- Health literacy and cardiovascular disease risk factors among the elderly: a study from a patient-centered medical home. — The American journal of managed care 2015 · PMID 25880363
- Endodontic medicine: connections between apical periodontitis and systemic diseases. — International endodontic journal 2015 · PMID 26174809
- The effect of empagliflozin on arterial stiffness and heart rate variability in subjects with uncomplicated type 1 diabetes mellitus — Cardiovascular Diabetology 2014 · PMID 24475922
Clinical trials (1)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT04695158 | Determination of Hemoglobin A1c, Lipid Profiles, Homocysteine, Oxidative Stress Parameters and Physical Activity Levels in Patients With Type II Diabetes and/or COVID-19 | UNKNOWN | OBSERVATIONAL | COVID-19 group (Group I), Type II Diabetes Mellitus and COVID-19 group (Group II) |
Genetic associations (0)
None linked.