CoronaryAtlas logo
CoronaryAtlas
ASCVD Risk Atlas
← Back to table
A

High-sensitivity C-reactive protein

Inflammatory & ImmuneLab test / biomarkerriskmodifiable
60
evidence score

Also known as: c-reactive protein, crp, high-sensitivity C-reactive protein (hs-CRP), high-sensitivity C-reactive protein (hsCRP), hs-CRP, hs-crp, hscrp

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 24.7meta-analyses: 20trials: 15genetic: 0MR bonus:

References (293)

23 meta-analyses / systematic reviews

Clinical trials (51)

NCTTitleStatusTypeInterventions
NCT06561971Evaluating the Effect of Smoking Amount on Determining Salivary High Sensitive C-Reactive Protein(Hs-CRP) Values by Centrifuging the Saliva of the Same Individuals at Different Rpm and Time.RECRUITINGINTERVENTIONALsaliva obtaining
NCT07693868An NNC6022-0004 Single and Multiple Ascending Dose Study Investigating Safety, Tolerability, Pharmacokinetics, Food Effect and Target Engagement in Healthy Adults Including a Single Cohort in Adults Living With ObesityNOT YET RECRUITINGINTERVENTIONALNNC6022-0004, Placebo
NCT07566325Effects of Avocado Consumption on Inflammation and Insulin Sensitivity in Adults With Elevated High Sensitivity-C-reactive Protein (Hs-CRP): A Randomized, Controlled Crossover TrialNOT YET RECRUITINGINTERVENTIONALAvocado, Control
NCT07477301Supportive Psychotherapy As An Adjunct To Risperidone Improves Cognitive Function And Reduces High-Sensitivity C-Reactive Protein (Hs-CRP) In Schizophrenia: A Randomized Controlled TrialCOMPLETEDINTERVENTIONALStructured Supportive Psychotherapy, Risperidone 2 mg
NCT06871358The Effect of Pre- and Post-Administration of 80 mg Atorvastatin on Hs-CRP/Albumin Ratio in Reducing Thrombus Burden in STEMI Patients Undergoing Primary PCICOMPLETEDINTERVENTIONALAtorvastatin 80mg, Placebo
NCT06912035EFFICACY OF DIACEREIN ADDITION ON INTERLEUKIN-1Β, HS-CRP, TNF-Α LEVELS AND GLYCEMIC CONTROL IN UNCONTROLLED TYPE 2 DIABETES MELLITUS PATIENTS AT DR. MOHAMMAD HOESIN GENERAL HOSPITAL PALEMBANGCOMPLETEDINTERVENTIONALDiacerein 50 mg Capsule, Placebo
NCT06952231Comparison of Effect of Sitagliptin and Empagliflozin in Combination With Metformin on High-Sensitivity C-Reactive Protein Levels in Patients With Type 2 Diabetes MellitusCOMPLETEDINTERVENTIONALSitagliptin + Metformin, Empagliflozin + Metformin
NCT06362759A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Quarterly and Monthly TOUR006 in Participants With Chronic Kidney Disease and Elevated High-Sensitivity C-Reactive ProteinCOMPLETEDINTERVENTIONALTOUR006 - 50 MG, TOUR006 - 25 MG, TOUR006 - 15 MG
NCT07230873The Impact of Stationary Combined Exercise on Adiponectin and High-Sensitivity C-Reactive Protein Levels in Overweight WomenCOMPLETEDINTERVENTIONALCombined Exercise Group, No Structured Exercise
NCT06078904The Effects of Different Doses of Colchicine on High-sensitivity C-reactive Protein in Patients After Percutaneous Coronary InterventionCOMPLETEDINTERVENTIONALColchicine 0.5 MG, Colchicine 0.375 MG, Colchicine 0.25 MG
NCT06029920The Effect of Overground Walking on the Increase of Brain-Derived Neurotrophic Factor Levels, IL-6, HS-CRP, Cognitive Function, and Quality of Life in the ElderlyCOMPLETEDINTERVENTIONALOverground Walking
NCT06025071Efficacy and Safety of Residual Inflammatory Risk-Guided Low-dose Colchicine Therapy in Elderly Patients With Multivessel Coronary Artery Disease: A Multicenter Randomized Controlled TrialUNKNOWNINTERVENTIONALcolchicine
NCT05130892Effect of Inflammasome Inhibitor on High-sensitivity C-reactive Protein in Patients After Percutaneous Coronary InterventionCOMPLETEDINTERVENTIONALColchicine, Tranilast, Oridonin
NCT04980768Association of Apical Periodontitis With Systemic Levels of Hs-CRP and Hemogram Indices: A Clinical Study.UNKNOWNINTERVENTIONALRoot canal treatment
NCT05614362The Effect of Channa Striatus Extract on Serum Albumin and High Sensitive C-Reactive Protein in End-Stage Renal Disease PatientsCOMPLETEDINTERVENTIONALChanna Striatus extract, Maltodextrin
NCT04034160A Comparison of the Rise of Serum Lipids, Glucose, and Hs-CRP Levels After Consumption of a Beef Burger Versus a Vegetarian BurgerCOMPLETEDINTERVENTIONALvegetarian burger, beef burger
NCT04126330Effect of Omega-3 and Probiotic Dietary Supplements on Elevated High Sensitivity C-reactive Protein (Hs-CRP) as a Marker of Low-grade Inflammation: Targeting Inflammation and Intestinal Barrier Function in the Elderly and ObeseCOMPLETEDINTERVENTIONALProbiotic, Omega-3, Vitamin D supplement, Placebo
NCT04436445Effect of Neurogenic Acupoint Cupping on Hs-CRP and Pain Perception in Women With Chronic Pevic PainUNKNOWNINTERVENTIONALdry cupping, Life style modification
NCT03908606Prognostic Value of Serum Hs-CRP in Periodontitis Patients With or Without Type 2 Diabetes Following Non-surgical Periodontal TherapyCOMPLETEDINTERVENTIONALScaling and root planing
NCT03704766Alpha-Defensin and Synovial Proteins to Improve Detection of Pediatric Septic ArthritisUNKNOWNINTERVENTIONALSynovial Alpha-defensin assay, Synovial Neutrophil elastase assay, Synovial lactate assay
NCT02282098Targeting Inflammation in Atrial Fibrillation to Prevent Ischemic Stroke: A Feasibility Study Evaluating the Effect of Colchicine on D-dimer and Hs-CRP in Anticoagulated Patients With Atrial FibrillationCOMPLETEDINTERVENTIONALColchicine, Placebo
NCT01900600Substudy of the the CANTOS Trial (Interleukin-1 Blockade With Canakinumab to Improve Exercise Capacity in Patients With Chronic Systolic Heart Failure and Elevated Hs-CRP; CACZ885M2301)COMPLETEDINTERVENTIONALCardiopulmonary exercise test, Echocardiogram
NCT01755949Impact and Time Course of Colchicine Therapy on C-reactive Protein Elevation in Chronic Atrial Fibrillation (AF) and Post AF AblationCOMPLETEDINTERVENTIONALColchicine, 0.6 mg PO BID, Matching placebo
NCT02127177Long-term Effects of Continuous Positive Airway Pressure on Lipidemia and High-sensitivity C-reactive Protein Levels in Nonobese Patients With Coronary Heart Disease and Obstructive Sleep ApneaCOMPLETEDINTERVENTIONALContinuous Positive Airway Pressure Ventilator
NCT02165228A Stress Reduction Strategy for Decreasing CVD Risk Through C-reactive Protein ReductionCOMPLETEDINTERVENTIONALMindfulness-based stress reduction, Nutrition Enhancement
NCT00970918Prevalence of Atherosclerotic Disease in Asian Subjects Not on Lipid-lowering Agents, But With at Least Two CVD Risk FactorsCOMPLETEDINTERVENTIONALMeasurement of the Carotid Intima Media thickness, Blood sample testing for hs-CRP
NCT00655993Effect of Statin Therapy on C-reactive Protein Levels in Patients With COPDCOMPLETEDINTERVENTIONALsimvastatin
NCT00754819Colchicine Compared With Placebo to Reduce Hs-CRP in Patients With Acute Coronary Syndromes- Targeting Inflammation in Atherosclerosis TrialCOMPLETEDINTERVENTIONALColchicine, Placebo
NCT00719992Diagnostic Value of HS-CRP in Stable Angina Patients With Positive Exercise Test as Compared With Coronary Angiography.COMPLETEDINTERVENTIONALcoronary angiography
NCT00715169Phase 2 A, Double-Blind, Randomized, Placebo-Controlled Trial Measuring the Effects of MLN1202 on C-Reactive Protein Levels in Patients With Risk Factors for Cardiovascular DiseaseCOMPLETEDINTERVENTIONALMLN1202, Placebo
NCT00343876A Single Center, Double-Blind, Randomized Trial to Evaluate the Effects of Aspirin 325 mg + Clopidogrel 75 mg v. Aspirin 325 mg + Placebo on Plasma Concentration of C-Reactive Protein: The CATER Trial ProtocolCOMPLETEDINTERVENTIONALaspirin, clopidogrel
NCT07513922Correlation Between hs CRP TG Triglycerides Glucose Index in NAFLD and Liver FibrosisNOT YET RECRUITINGOBSERVATIONAL• Fasting triglycerides (TG) • Fasting plasma glucose • High-sensitivity C-reactive protein (hs-CRP) • Liver enzymes (ALT, AST, GGT) • Platelet count • HbA1c • Lipid profile (total cholesterol, HDL-C,
NCT07551102Relationship Between Inflammatory (Hs-CRP, Neutrophil-to-Lymphocyte Ratio) and Cardiac (Troponin) Biomarkers, and Cardiac Dysfunction in Acute Coronary Syndrome.NOT YET RECRUITINGOBSERVATIONAL
NCT07363187Evaluation of Microvascular Changes by Nailfold Capillaroscopy and Serum ADMA, Von Willebrand Factor, Hs-CRP, and D-dimer Levels in Healthcare Workers Exposed to Chronic Low-Dose Ionizing RadiationNOT YET RECRUITINGOBSERVATIONAL
NCT07130721Assessment of Blood Biomarkers (D-dimer and C-Reactive Protein) in Predicting Cardiovascular Complications Among Hemodialysis Patients: A Cross-Sectional StudyNOT YET RECRUITINGOBSERVATIONALC-Reactive Protein (CRP) Test, D-dimer Test, Electrocardiogram (ECG)
NCT05845112Start Taking Action For TB Diagnosis (START4ALL)COMPLETEDOBSERVATIONALClass 1, Point of Care (POC) Quantitative C-Reactive Protein (CRP)., Class 2, POC Qualitative/Semiquantitative CRP, Class 3, Urine Lateral Flow Tests
NCT05164965C-reactive Protein and Homocysteine and Their Interaction Contribute to Postoperative DeliriumUNKNOWNOBSERVATIONAL
NCT06946667Pathogen Resistance Characteristics and Development of a Combined Diagnostic Model Using Hs-CRP, HBP, NGAL, and ADPN for Postoperative Urinary Tract Infections in Patients With Kidney StonesCOMPLETEDOBSERVATIONALthe UTI group, the Non-UTI group
NCT04952324MTHFR Gene Mutation C6777T and Concentration of Vitamin B12, Folic Acid, Homocysteine and High Sensitive CRP in the Blood of Pregnant Women With Gestational Diabetes Mellitus.COMPLETEDOBSERVATIONALBlood sampling and determination of MTHFR mutation,vitamin B12, folic acid, homocystein and HS CRP
NCT05479565The Association of Reduced Arterial Stiffness and Highly Sensitive C-reactive Protein With Gestational Diabetes Mellitus.COMPLETEDOBSERVATIONALvenous blood sample for determining the value of highly sensitive C-reactive C protein from serum
NCT03830060Clinical Usefulness of Cortisol, Antinuclear Antibodies and High-sensitivity C-reactive Protein in Diagnostic and Prognostic Evaluation of Acute PancreatitisUNKNOWNOBSERVATIONALMeasurement of cortisol
NCT03594695Hs-CRP and NLR as Markers of Perioperative Stress in Maternal And Fetal Blood in Different Anesthesia TechniquesCOMPLETEDOBSERVATIONALHSCRP and NLR
NCT04305171Effect of Non-surgical Periodontal Treatment on Plasma Fibrinogen, Plasminogen Activator Inhibitor 1 and C-reactive Protein Levels in Cardiovascular Disease Patients With PeriodontitisCOMPLETEDOBSERVATIONALnon-surgical periodontal treatment
NCT03342131Change of Serum Wnt2 or Wnt4 and the Relationship With Hs-CRP，cTnI and Prognosis in Patients With Acute Coronary SyndromeUNKNOWNOBSERVATIONALCirculating wnt 2 and wnt 4 concentration
NCT03335514Changes of GALNT4 and the Relationship With PSGL-1on Monocytes and Hs-CRP in Blood of Patients With Coronary Heart DiseaseCOMPLETEDOBSERVATIONALexpression of GALNT4
NCT03345745The Short-Term Effects of Non-Surgical Periodontal Therapy on The Saliva Levels of S100A12, High-Sensitivity C-Reactive Protein and Fetuin-A in Patients With Gingivitis and Chronic PeriodontitisCOMPLETEDOBSERVATIONALsalivary samples
NCT02767960Change of Serum Tenascin-C Concentration and the Relationship With Hs-CRP，cTnI and Prognosis in Patients With Acute Coronary SyndromeCOMPLETEDOBSERVATIONAL
NCT01645228Could Non-invasive Biochemical, Image or Physiological Index Predict Significant Coronary Arterial Stenosis in Symptomatic Adults?UNKNOWNOBSERVATIONALcoronary calcium score measurement, high sensitivity C reactive protein measurement, ankle brachial index measurement
NCT00819273Investigation Into the CorrelAtion of pLasma Hs-CRP Concentrations and cardiovascuLar rISk in Korean populaTiOnCOMPLETEDOBSERVATIONAL
NCT00169871Hs-CRP as Clinical Marker of Inflammatory Atherogenic DyslipidemiaCOMPLETEDOBSERVATIONAL
NCT00021918Serum Total Homocysteine and C-Reactive Protein - Ancillary to IDNTCOMPLETEDOBSERVATIONAL

Genetic associations (0)

None linked.