A
High-sensitivity cardiac troponin
Novel & Emerging BiomarkersLab test / biomarkerrisknon modifiable
43
evidence score
Also known as: High-sensitivity troponin, cardiac troponin, cardiac troponin (cTn), cardiac troponins, high sensitivity troponin, high-sensitivity cardiac troponin (hs-cTn), high-sensitivity troponin, hs-ctni, hs-ctnt, hs-troponin
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 18.4meta-analyses: 13.8trials: 11.1genetic: 0MR bonus:
References (68)
4 meta-analyses / systematic reviews- METAHigh-sensitivity Troponin (hs-Tn) for Cardiovascular Risk Prognostication: A Systematic Review and Meta-analysis. — Current medicinal chemistry 2024 · PMID 36924099
- METAPrognostic value of high-sensitivity cardiac troponin for major adverse cardiovascular events in patients with diabetes: a systematic review and meta-analysis. — PeerJ 2023 · PMID 38025710
- METAHigh-sensitivity troponin assays for early rule-out of acute myocardial infarction in people with acute chest pain: a systematic review and economic evaluation. — Health technology assessment (Winchester, England) 2021 · PMID 34061019
- METAMeta-analysis of preoperative high-sensitivity cardiac troponin measurement in non-cardiac surgical patients at risk of cardiovascular complications. — The British journal of surgery 2020 · PMID 31903596
- Associations Between Lead and Cadmium Exposure and Subclinical Cardiovascular Disease in U.S. Adults. — Cardiovascular toxicology 2025 · PMID 39873882
- Advancements and challenges in high-sensitivity cardiac troponin assays: diagnostic, pathophysiological, and clinical perspectives. — Clinical chemistry and laboratory medicine 2025 · PMID 39915924
- Interplay of Chronic Kidney Disease and the Effects of Tirzepatide in Patients With Heart Failure, Preserved Ejection Fraction, and Obesity: The SUMMIT Trial. — Journal of the American College of Cardiology 2025 · PMID 40162940
- Association Between High Sensitivity Cardiac Troponin and All-Cause and Cardiovascular Mortality in Adults at Risk of Non-Alcoholic Fatty Liver Disease: A Cohort Study. — Global heart 2025 · PMID 40322053
- Epidemiological and Translational Study of Calprotectin and Atherosclerotic Cardiovascular Disease. — JAMA cardiology 2025 · PMID 40332890
- A validated multivariable machine learning model to predict cardio-kidney risk in diabetic kidney disease. — Cardiovascular diabetology 2025 · PMID 40375260
- Safety of Using Risk Stratification Along With High-Sensitivity Cardiac Troponin in the Emergency Department: A Secondary Analysis. — Journal of the American College of Cardiology 2025 · PMID 41193094
- Lower Limits for Reporting High-Sensitivity Cardiac Troponin Assays and Impact of Analytical Performance on Patient Misclassification. — Clinical chemistry 2024 · PMID 38102065
- Galectin-3, Metabolic Risk, and Incident Heart Failure: The ARIC Study. — Journal of the American Heart Association 2024 · PMID 38471823
- Relationship between high sensitivity troponin I and clinical outcomes in non-acute coronary syndrome (non-ACS) acute heart failure patients - a one-year follow-up study. — Indian heart journal 2024 · PMID 38599282
- Markedly elevated high-sensitivity troponin and in-hospital mortality after cardiac surgery. — Cardiovascular revascularization medicine : including molecular interventions 2024 · PMID 38719633
- Individual and Joint Associations of High-Sensitivity Troponin I and High-Sensitivity Troponin T with Cardiac Phenotypes and Outcomes in the General Population: An Analysis From the Dallas Heart Study. — Journal of the American Heart Association 2024 · PMID 38842289
- Heart Failure Risk Assessment Using Biomarkers in Patients With Atrial Fibrillation: Analysis From COMBINE-AF. — Journal of the American College of Cardiology 2024 · PMID 39230543
- NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study. — Circulation 2024 · PMID 39315431
- High-sensitivity troponins and mortality in the general population. — European heart journal 2023 · PMID 37264651
- Improving 10-year cardiovascular risk prediction in apparently healthy people: flexible addition of risk modifiers on top of SCORE2. — European journal of preventive cardiology 2023 · PMID 37264679
- Association of interleukin-6 and interleukin-18 with cardiovascular disease in older adults: Atherosclerosis Risk in Communities study. — European journal of preventive cardiology 2023 · PMID 37306504
- High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease. — Journal of the American College of Cardiology 2023 · PMID 37532417
- High-sensitivity cardiac troponin I for cardiovascular risk stratification in apparently healthy individuals. — Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2023 · PMID 37743017
- Cardiovascular risk evaluation in pregnancy: focus on cardiac specific biomarkers. — Clinical chemistry and laboratory medicine 2023 · PMID 37942796
- Emergency Department Cardiac Risk Stratification With High-Sensitivity vs Conventional Troponin HEART Pathway. — JAMA network open 2023 · PMID 38113042
- Estimating the cost-effectiveness of screening a general population for cardiovascular risk with high-sensitivity troponin-I. — European heart journal. Quality of care & clinical outcomes 2022 · PMID 33502472
- Tobacco Consumption and High-Sensitivity Cardiac Troponin I in the General Population: The HUNT Study. — Journal of the American Heart Association 2022 · PMID 35001649
- Lipocalin-2, S100A8/A9, and cystatin C: Potential predictive biomarkers of cardiovascular complications in COVID-19. — Experimental biology and medicine (Maywood, N.J.) 2022 · PMID 35466734
- Cardiac troponin T and NT-proBNP for detecting myocardial ischemia in suspected chronic coronary syndrome. — International journal of cardiology 2022 · PMID 35577165
- Prognostic Value of High-Sensitivity Cardiac Troponin in Women. — Biomolecules 2022 · PMID 36291705
- High-sensitivity cardiac troponin T and the risk of heart failure in postmenopausal women of the ARIC Study. — Menopause (New York, N.Y.) 2021 · PMID 33399316
- Growth Differentiation Factor (GDF)-15 and Cardiometabolic Outcomes among Older Adults: The Atherosclerosis Risk in Communities Study. — Clinical chemistry 2021 · PMID 33582779
- Cardiovascular biomarkers in patients with COVID-19. — European heart journal. Acute cardiovascular care 2021 · PMID 33655301
- Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease — Frontiers in Cardiovascular Medicine 2021 · PMID 34660715
- Galectin-3 and Cardiovascular Biomarkers Reflect Adaptation Response to Scuba Diving. — International journal of sports medicine 2020 · PMID 31975358
- The heart remembers what the mind forgets. — Acta clinica Belgica 2020 · PMID 31996105
- High-sensitivity cardiac troponin assays for cardiovascular risk stratification in the general population. — European heart journal 2020 · PMID 32077940
- Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study — BMJ 2020 · PMID 32217556
- High-Sensitivity Troponins in Cardiovascular Disease. — Current cardiology reports 2020 · PMID 32232671
- COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options — Cardiovascular Research 2020 · PMID 32352535
- High-Sensitivity Troponin-T and Cardiovascular Outcomes in the Community: Differences Between Women and Men. — Mayo Clinic proceedings 2020 · PMID 32498772
- High-sensitivity troponin in chronic kidney disease: Considerations in myocardial infarction and beyond. — Reviews in cardiovascular medicine 2020 · PMID 32706208
- High-Sensitivity Cardiac Troponin I for Risk Stratification in Older Adults. — Journal of the American Geriatrics Society 2020 · PMID 33150614
- High-sensitivity troponin I for cardiovascular risk stratification in the general asymptomatic population: Perspectives from Asia-Pacific. — International journal of cardiology 2019 · PMID 30745254
- High-Sensitivity Cardiac Troponin I Improves Cardiovascular Risk Prediction in Older Men: HIMS (The Health in Men Study). — Journal of the American Heart Association 2019 · PMID 30819029
- Association of Unrecognized Obstructive Sleep Apnea With Postoperative Cardiovascular Events in Patients Undergoing Major Noncardiac Surgery — JAMA 2019 · PMID 31087023
- Family history of coronary artery disease is associated with acute coronary syndrome in 28,188 chest pain patients. — European heart journal. Acute cardiovascular care 2019 · PMID 31124704
- High-sensitivity troponin and the risk of atrial fibrillation in chronic kidney disease: Results from the Chronic Renal Insufficiency Cohort Study. — Heart rhythm 2019 · PMID 31421237
- The predictive value of NT-proBNP and hs-TnT for risk of death in cardiac surgical patients. — Clinical biochemistry 2018 · PMID 29371002
- Cardiovascular Risk Prediction in CKD. — Seminars in nephrology 2018 · PMID 29753398
- Clinical implications of high-sensitivity cardiac troponins. — Journal of internal medicine 2018 · PMID 29804300
- High-Sensitivity Troponin T and Incident Heart Failure in Older Men: British Regional Heart Study. — Journal of cardiac failure 2018 · PMID 30103019
- Novel biomarkers for cardiovascular risk prediction. — PubMed 2017 · PMID 28491088
- High-Sensitivity Cardiac Troponin Concentration and Risk of First-Ever Cardiovascular Outcomes in 154,052 Participants. — Journal of the American College of Cardiology 2017 · PMID 28750699
- High-sensitivity cardiac troponin I and risk of cardiovascular disease in an Australianpopulation-based cohort. — Heart (British Cardiac Society) 2017 · PMID 29066610
- High-Sensitivity Cardiac Troponin, Statin Therapy, and Risk of Coronary Heart Disease. — Journal of the American College of Cardiology 2016 · PMID 28007133
- High-Sensitivity Cardiac Troponin T and Risk of Hypertension. — Circulation 2015 · PMID 26152706
- High-sensitivity cardiac troponin in acute conditions. — Current opinion in critical care 2014 · PMID 25159476
- High-sensitivity troponin: where are we now and where do we go from here? — Biomarkers in medicine 2014 · PMID 25343674
- Biomarkers of cardiovascular disease risk in women. — Metabolism: clinical and experimental 2014 · PMID 25487190
- High sensitivity troponin in cardiovascular disease. Is there more than a marker of myocardial death? — Current topics in medicinal chemistry 2013 · PMID 23470078
- Cardiovascular Disease Risk Prediction in Women: Is There a Role for Novel Biomarkers? — Clinical Chemistry 2013 · PMID 24100805
- GDF-15 for prognostication of cardiovascular and cancer morbidity and mortality in men. — PloS one 2013 · PMID 24312445
- Cardiac troponin and heart failure in the era of high-sensitivity assays. — Journal of cardiology 2012 · PMID 22867801
- Prognostic Utility of Novel Biomarkers of Cardiovascular Stress — Circulation 2012 · PMID 22907935
- Biomarkers and Cardiovascular Risk Assessment for Primary Prevention: An Update — Clinical Chemistry 2011 · PMID 22125305
- Acute coronary syndrome: emerging tools for diagnosis and risk assessment. — Journal of the American College of Cardiology 2010 · PMID 20359589
- Early Diagnosis of Myocardial Infarction with Sensitive Cardiac Troponin Assays — New England Journal of Medicine 2009 · PMID 19710484
Clinical trials (12)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06853626 | Improved Management of Acute Chest Pain in Emergency Primary Care. The OUT-POC Study (One-hoUr Troponin Using a High-sensitivity Point-Of-Care Assay in Emergency Primary Care) | ACTIVE NOT RECRUITING | INTERVENTIONAL | QuidelOrthos TriageTrue hs-cTnI whole-blood assay |
| NCT03968016 | Reference Interval Validation of High-Sensitivity Cardiac Troponin T Assay in Thai Population | COMPLETED | INTERVENTIONAL | SYSMEX HLSCL |
| NCT07315997 | The Coronary Artery Calcium and Troponins in Rheumatoid Arthritis (CAT-RA) Study | RECRUITING | OBSERVATIONAL | high sensitivity cardiac troponin |
| NCT05767619 | Development of a Decision Support System in the Assessment of Patients With Chest Pain in the Prehospital Setting | RECRUITING | OBSERVATIONAL | Troponin hs-cTnI, Plasma glucose |
| NCT05633290 | CharacterisatiON of carDiac funCTion in Intensive Care Unit Survivors of Sepsis (CONDUCT-ICU): A Pilot Study | UNKNOWN | OBSERVATIONAL | CMR, hs-troponin, NT-pro BNP |
| NCT05665127 | Point of Care Evaluation of High-sensitivity Cardiac Troponin | ACTIVE NOT RECRUITING | OBSERVATIONAL | |
| NCT04087538 | A Prospective Comparison of Cardiac Troponin T and Troponin I in the Diagnosis of Myocardial Infarction | UNKNOWN | OBSERVATIONAL | Troponin T and I |
| NCT04772157 | Evaluation of the Siemens POC HS CTn-I Test System | COMPLETED | OBSERVATIONAL | Cardiac Troponin Testing |
| NCT03581578 | VITROS Immunodiagnostic Products hs Troponin I | UNKNOWN | OBSERVATIONAL | |
| NCT03619733 | Does Modified Heart Score Incorporating Undetectable and 99th Percentile High Sensitivity Troponin T Limits Improve Early, Safe Discharge for Suspected Acute Coronary Syndromes | UNKNOWN | OBSERVATIONAL | no intervention |
| NCT03310450 | Predictors of Cardiac Troponin Release After Tour de Borobudur 2017 | COMPLETED | OBSERVATIONAL | 140kms cycling |
| NCT03634384 | Rapid Use of High-sensitive Cardiac Troponin I for ruling-in and Ruling-out of Acute Myocardial Infarction | UNKNOWN | OBSERVATIONAL |
Genetic associations (0)
None linked.