B
History of preeclampsia
Comorbid ConditionsDisease / conditionrisknon modifiable
40
evidence score
Also known as: Preeclampsia history, hypertensive disorders of pregnancy, pre-eclampsia, preeclampsia
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 18.3meta-analyses: 9.1trials: 12.3genetic: 0MR bonus:
References (67)
2 meta-analyses / systematic reviews- METAPostpartum hemorrhage and long-term cardiovascular disease risk: a comprehensive systematic review and meta-analysis. — The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians 2025 · PMID 40555257
- METAPreeclampsia and Future Cardiovascular Health: A Systematic Review and Meta-Analysis. — Circulation. Cardiovascular quality and outcomes 2017 · PMID 28228456
- Gestational Hypertension, Preeclampsia, and Eclampsia and Future Neurological Disorders. — JAMA neurology 2025 · PMID 39714850
- Maternal shift work during pregnancy and cardiovascular health impacts on mother and offspring. — Journal of molecular and cellular cardiology 2025 · PMID 39753391
- Pregnancy Complications and Long-Term Atherosclerotic Cardiovascular Disease Risk. — Current atherosclerosis reports 2025 · PMID 39832115
- Advances in Our Understanding of Cardiovascular Diseases After Preeclampsia. — Circulation research 2025 · PMID 40080539
- Synergistic effects of cardiovascular health and social isolation on adverse pregnancy outcomes. — Scientific reports 2025 · PMID 40442264
- Preeclampsia, gestational hypertension, and cardiovascular disease risk: a genetic epidemiological study. — European heart journal 2025 · PMID 40900121
- Cardiovascular biomarkers and preeclampsia: A narrative review. — European journal of clinical investigation 2025 · PMID 41059676
- Impact of Preeclampsia Duration on Long-Term Cardiovascular Disease Risk. — Hypertension (Dallas, Tex. : 1979) 2025 · PMID 41250989
- Predicting cardiovascular disease after preeclampsia: Emerging tools and early detection approaches. — Journal of reproductive immunology 2025 · PMID 41456495
- Socioeconomic status and adverse pregnancy outcome increase the risk of long-term cardiovascular disease: an analysis using the UK Biobank. — Epidemiology and health 2025 · PMID 41468998
- Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study. — Heart (British Cardiac Society) 2024 · PMID 38148158
- Development and validation of a new algorithm for improved cardiovascular risk prediction. — Nature medicine 2024 · PMID 38637635
- Implications of pregnancy on cardiometabolic disease risk: preeclampsia and gestational diabetes. — American journal of physiology. Cell physiology 2024 · PMID 39010840
- Pregnancy complications and later life women's health. — Acta obstetricia et gynecologica Scandinavica 2023 · PMID 36799269
- Association between preeclampsia in daughters and risk of cardiovascular disease in parents. — European journal of epidemiology 2023 · PMID 36922414
- Literature Overview of Association Between Preeclampsia and Cardiovascular Risk. — Anatolian journal of cardiology 2023 · PMID 36995054
- Ambient air pollution and maternal cardiovascular health in pregnancy. — Heart (British Cardiac Society) 2023 · PMID 37217298
- Risk of Cardiovascular Disease in Women With a History of Hyperemesis Gravidarum, With and Without Preeclampsia. — Journal of the American Heart Association 2023 · PMID 37259983
- Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy. — JAMA cardiology 2023 · PMID 37285119
- Blood pressure, arterial stiffness, and cardiovascular risk profiles in 8-12-year-old children following preeclampsia (FINNCARE-study). — Journal of hypertension 2023 · PMID 37337860
- Long-Term Impacts of Preeclampsia on the Cardiovascular System of Mother and Offspring. — Hypertension (Dallas, Tex. : 1979) 2023 · PMID 37377011
- Women, lipids, and atherosclerotic cardiovascular disease: a call to action from the European Atherosclerosis Society. — European heart journal 2023 · PMID 37611089
- Cardiovascular and renal health: Preeclampsia as a risk marker. — Nefrologia 2023 · PMID 37635012
- Hypertensive disorders of pregnancy and cardiovascular disease risk: A Mendelian Randomisation study. — European heart journal 2023 · PMID 38304335
- Arterial Stiffness as a Cardiovascular Risk Factor for the Development of Preeclampsia and Pharmacopreventive Options. — Current vascular pharmacology 2022 · PMID 34615450
- Augmentation index and pulse wave velocity in normotensive versus preeclamptic pregnancies: a prospective case-control study using a new oscillometric method. — Annals of medicine 2022 · PMID 34935572
- Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review. — Journal of the American College of Cardiology 2022 · PMID 35210038
- Hyperlipidemia and risk for preclampsia. — Journal of clinical lipidology 2022 · PMID 35260347
- Preeclampsia Emerging as a Risk Factor of Cardiovascular Disease in Women. — High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension 2021 · PMID 33660234
- The placenta and preeclampsia: villain or victim? — American journal of obstetrics and gynecology 2021 · PMID 33771361
- 2021 Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in Adults. — The Canadian journal of cardiology 2021 · PMID 33781847
- Physical Activity and Cardiovascular Risk Factor Outcomes in Women with a History of Hypertensive Disorders of Pregnancy: Integrative Review. — Worldviews on evidence-based nursing 2021 · PMID 34482625
- ST2 and galectin-3 as novel biomarkers for the prediction of future cardiovascular disease risk in preeclampsia. — Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 2021 · PMID 34930081
- Preeclampsia Emerging as a Novel Risk Factor for Cardiovascular Disease in the Offspring. — Current pediatric reviews 2020 · PMID 31884930
- Obesity and cardiovascular disease in women. — International journal of obesity (2005) 2020 · PMID 32066824
- Mechanisms linking exposure to preeclampsiaand the risk for cardiovascular disease. — Journal of developmental origins of health and disease 2020 · PMID 32070456
- Multi-Fetal Pregnancy, Preeclampsia, and Long-Term Cardiovascular Disease. — Hypertension (Dallas, Tex. : 1979) 2020 · PMID 32475315
- Pregnancy Complications, Cardiovascular Risk Factors, and Future Heart Disease. — Obstetrics and gynecology clinics of North America 2020 · PMID 32762933
- Cardiovascular Disease in Women: From Pathophysiology to Novel and Emerging Risk Factors. — Heart, lung & circulation 2020 · PMID 32843293
- Preventing Premature Atherosclerotic Disease. — Current hypertension reports 2020 · PMID 32893318
- Hypertensive Disorders of Pregnancy. — Clinics in perinatology 2020 · PMID 33153664
- Gut Microbiota Dysbiosis and Increased Plasma LPS and TMAO Levels in Patients With Preeclampsia — Frontiers in Cellular and Infection Microbiology 2019 · PMID 31850241
- Preeclampsia and Related Cardiovascular Risk: Common Genetic Background. — Current hypertension reports 2018 · PMID 29971632
- Cardiovascular Sequels During and After Preeclampsia. — Advances in experimental medicine and biology 2018 · PMID 30051401
- The value of pregnancy complication history for 10-year cardiovascular disease risk prediction in middle-aged women — European Journal of Epidemiology 2018 · PMID 30062549
- Does pregnancy complication history improve cardiovascular disease risk prediction? Findings from the HUNT study in Norway — European Heart Journal 2018 · PMID 30596987
- Prevalence of periodontal disease, its association with systemic diseases and prevention. — PubMed 2017 · PMID 28539867
- Inflammatory Markers for Arterial Stiffness in Cardiovascular Diseases — Frontiers in Immunology 2017 · PMID 28912780
- Cardiovascular origins of preeclampsia. — Current opinion in obstetrics & gynecology 2017 · PMID 28961633
- [Gestational hypertension]. — Hipertension y riesgo vascular 2017 · PMID 29908662
- Long-term renal and cardiovascular risk after preeclampsia: towards screening and prevention. — Clinical science (London, England : 1979) 2016 · PMID 26769659
- Preeclampsia and Vascular Function: A Window to Future Cardiovascular Disease Risk. — Journal of women's health (2002) 2016 · PMID 26779584
- Pre-eclampsia and Cardiovascular Disease Risk Assessment in Women. — American journal of perinatology 2016 · PMID 27031056
- Preeclampsia and the Risk of Future Vascular Disease and Mortality: A Review. — Journal of midwifery & women's health 2016 · PMID 27155218
- Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review — Journal of Advanced Research 2016 · PMID 28748119
- Preeclampsia and future cardiovascular disease in women: How good are the data and how can we manage our patients? — Seminars in perinatology 2015 · PMID 26117165
- Preeclampsia and the risk of cardiovascular disease later in life--A review of the evidence. — Midwifery 2015 · PMID 26460274
- Pre-eclampsia and cardiovascular disease. — Cardiovascular research 2014 · PMID 24532051
- Maternal preeclampsia and risk for cardiovascular disease in offspring. — Current hypertension reports 2014 · PMID 25097112
- Cardiovascular risk, lipids and pregnancy: preeclampsia and the risk of later life cardiovascular disease. — Heart, lung & circulation 2013 · PMID 24268601
- Linking preeclampsia and cardiovascular disease later in life. — Clinical chemistry and laboratory medicine 2012 · PMID 22107134
- Preeclampsia and hypertensive disease in pregnancy: their contributions to cardiovascular risk. — Clinical cardiology 2012 · PMID 22389120
- Preeclampsia and cardiovascular risk. — Minerva ginecologica 2012 · PMID 22728573
- Lack of Exercise Is a Major Cause of Chronic Diseases — Comprehensive physiology 2012 · PMID 23798298
- Preeclampsia and future cardiovascular risk. — Expert review of cardiovascular therapy 2007 · PMID 17338672
Clinical trials (16)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT05826925 | Optimizing Cardiovascular Preventive Care for Women Following Hypertensive Disorders of Pregnancy | RECRUITING | INTERVENTIONAL | Decision aid |
| NCT05999851 | Multiparametric Assessment of Maternal Vascular Function as a New Diagnostic and Prognostic Tool for Hypertensive Disorders of Pregnancy and Preeclampsia - EDIPE Study | RECRUITING | INTERVENTIONAL | Arterial applanation tonometry, In vivo endothelial glycocalyx measurement, Serum markers of angiogenesis and endothelial dysfunction |
| NCT07648251 | Furosemide Oral Versus Placebo for Reduction of Hospital Length of Stay in Postpartum Women With Severe Preeclampsia: A Double-Blind, Randomized Controlled Trial | NOT YET RECRUITING | INTERVENTIONAL | Furosemide, Folic Acid 5 MG |
| NCT07255677 | Effect of Stretching Exercises Versus Aerobic Exercises on Preeclampsia | NOT YET RECRUITING | INTERVENTIONAL | Stretching exercises program, Aerobic exercises program, Antihypertensive drugs |
| NCT06898567 | EFFECT OF BLOOD PRESSURE MEASUREMENT IN DIFFERENT POSITIONS ON BLOOD PRESSURE VALUES AND ANXIETY LEVELS IN PREGNANT WOMEN WITH PREECLAMPSIA | COMPLETED | INTERVENTIONAL | Right Lateral Position, Left Lateral Position, Semi Fowler Position (45° Fowler) |
| NCT02147626 | Heart Health 4 Moms: Engaging Women With a Recent History of Preeclampsia to Reduce Their Cardiovascular Disease Risk | COMPLETED | INTERVENTIONAL | Web-based educational and motivational modules, Information and Screening Group |
| NCT02531490 | Personalized Hemodynamically Guided Antihypertensive Treatment in Pregnant Women With Mild to Moderate Hypertension: a Randomized Controlled Trial | UNKNOWN | INTERVENTIONAL | Labetalol, Nifedipine, Methyldopa |
| NCT02218931 | Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes (ESTEEM): A Randomised Trial | COMPLETED | INTERVENTIONAL | Targeted ESTEEM diet, Non-randomised cohort |
| NCT07349277 | Evaluation of sFlt-1/PlGF Ratio, Osteoprotegerin (OPG) and Soluble Endoglin (sEng) as Predictive Biomarkers in the Diagnosis and Treatment Evaluation of Preeclampsia | RECRUITING | OBSERVATIONAL | |
| NCT07547046 | Assessment of the Association Between Predefined Factors and Response or Failure of Blood Pressure Control With Intravenous Labetalol Monotherapy in Severe Preeclampsia: a Multicenter Observational Study | NOT YET RECRUITING | OBSERVATIONAL | |
| NCT06413576 | The Clinical Utility of Homocysteine in Critically Ill Preeclampsia Patients | COMPLETED | OBSERVATIONAL | homocysteine measurement |
| NCT04239352 | Levels of Inflammatory and Cardiovascular Risk Markers in Preeclamptic Patients; New Biomarkers: Pentraxin 3 & Lipoprotein-associated Phospholipase A2 | COMPLETED | OBSERVATIONAL | Pentraxin 3 ; new biomarker, Lipoprotein-associated phospholipase A2 ; new biomarker |
| NCT04508582 | Linking the Maternal Immune System to Cardiac Function in Preeclampsia | COMPLETED | OBSERVATIONAL | Cardiovascular magnetic resonance, Echocardiography, Blood test |
| NCT04455204 | Implication of Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in the Pathogenesis of Preeclampsia and in Pregnancy Related Complications | COMPLETED | OBSERVATIONAL | Serum asymmetteric dimethyl arginine, serum lipid profiles, Serum vaspin |
| NCT02541110 | Second Trimester Maternal Serum Homocysteine Level & Uterine Artery Doppler for Prediction of Preeclampsia , Intra-Uterine Growth Retardation (IUGR) & Other Obstetric Complications | UNKNOWN | OBSERVATIONAL | |
| NCT02854501 | Second Trimester Maternal Serum Homocysteine Levels and Uterine Artery Doppler for Prediction of Preeclampsia and Poor Placentation Disorders | COMPLETED | OBSERVATIONAL |
Genetic associations (0)
None linked.