A
HIV infection
Inflammatory & ImmuneDisease / conditionrisknon modifiable
44
evidence score
Also known as: hiv-positive, human immunodeficiency virus, people living with hiv
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 17.8meta-analyses: 11.6trials: 14.3genetic: 0MR bonus:
References (59)
3 meta-analyses / systematic reviews- METAPerformance of Cardiovascular Risk Prediction Models Among People Living With HIV: A Systematic Review and Meta-analysis. — JAMA cardiology 2023 · PMID 36576812
- METAAssociation between Immune Markers and Surrogate Markers of Cardiovascular Disease in HIV Positive Patients: A Systematic Review. — PloS one 2017 · PMID 28085961
- METAHIV/HCV coinfection and the risk of cardiovascular disease: A meta-analysis. — Journal of viral hepatitis 2017 · PMID 28502092
- Physical Activity, Sedentary Behavior, and Cardiometabolic Risk Factors in People Living with HIV. — Behavioral medicine (Washington, D.C.) 2025 · PMID 40785651
- Increased Pro-inflammatory Biomarkers and Cardiovascular Risk in Young Adults Living With Perinatal HIV in Thailand. — Journal of the Pediatric Infectious Diseases Society 2025 · PMID 41432991
- HIV-Associated Hypertension: Risks, Mechanisms, and Knowledge Gaps. — Circulation research 2024 · PMID 38781298
- Galectin-3, Galectin-9, and Interleukin-18 Are Associated with Monocyte/Macrophage Activation and Turnover More so than Simian Immunodeficiency Virus-Associated Cardiac Pathology or Encephalitis. — AIDS research and human retroviruses 2024 · PMID 38787309
- Menopausal Hormone Therapy and Subclinical Cardiovascular Disease in Women With and Without Human Immunodeficiency Virus. — Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2023 · PMID 35903868
- Cardiovascular disease and risk assessment in people living with HIV: Current practices and novel perspectives. — Hellenic journal of cardiology : HJC = Hellenike kardiologike epitheorese 2023 · PMID 36646212
- The Gut Microbiome, Microbial Metabolites, and Cardiovascular Disease in People Living with HIV. — Current HIV/AIDS reports 2023 · PMID 36708497
- Human Immunodeficiency Virus and Clonal Hematopoiesis. — Cells 2023 · PMID 36899822
- Selected inflammatory and coagulation biomarkers pre-viral suppression in people with human immunodeficiency virus (HIV) infection without overt cardiovascular disease: Is there a need to redefine reference indices? — Cytokine 2023 · PMID 36996538
- Perceptions of women enrolled in a cardiovascular disease screening and prevention in HIV study. — South African family practice : official journal of the South African Academy of Family Practice/Primary Care 2023 · PMID 37132568
- Human Immunodeficiency Virus as a Risk Factor for Cardiovascular Disease. — Cardiovascular toxicology 2023 · PMID 37982976
- CSI clinical practice guidelines for dyslipidemia management: Executive summary. — Indian heart journal 2023 · PMID 38052658
- HIV and Global Cardiovascular Health. — Current cardiology reports 2022 · PMID 35802233
- Cystatin C and Urine Albumin to Creatinine Ratio Predict 5-Year Mortality and Cardiovascular Events in People Living With HIV. — The Journal of infectious diseases 2021 · PMID 32691827
- Methotrexate and cardiovascular risk in rheumatic diseases:A comprehensive review. — Expert review of clinical pharmacology 2021 · PMID 34006152
- Coronary Artery Disease–Associated and Longevity-Associated Polygenic Risk Scores for Prediction of Coronary Artery Disease Events in Persons Living With Human Immunodeficiency Virus: The Swiss HIV Cohort Study — Clinical Infectious Diseases 2021 · PMID 34091660
- Viral Bad News Sent by EVAIL. — Viruses 2021 · PMID 34207152
- Patterns of Immune Activation in HIV and Non HIV Subjects and Its Relation to Cardiovascular Disease Risk. — Frontiers in immunology 2021 · PMID 34290695
- Subclinical Carotid Atherosclerosis and Reduced DAD Score for Cardiovascular Risk Stratification in HIV-Positive Patients. — Arquivos brasileiros de cardiologia 2020 · PMID 31664317
- Senotherapeutics for HIV and aging. — Current opinion in HIV and AIDS 2020 · PMID 31833962
- Epigenetics, HIV, and Cardiovascular Disease Risk. — Current problems in cardiology 2020 · PMID 32507271
- HIV Infection and Long-Term Residual Cardiovascular Risk After Acute Coronary Syndrome. — Journal of the American Heart Association 2020 · PMID 32844734
- Inflammatory Bowel Disease and Atherosclerotic Cardiovascular Disease: JACC Review Topic of the Week. — Journal of the American College of Cardiology 2020 · PMID 33303079
- Predictive Performance of Cardiovascular Disease Risk Prediction Algorithms in People Living With HIV — JAIDS Journal of Acquired Immune Deficiency Syndromes 2019 · PMID 31045648
- The role of HIV Tat protein in HIV-related cardiovascular diseases. — Journal of translational medicine 2018 · PMID 29739413
- HIV and Cardiovascular Disease: Update on Clinical Events, Special Populations, and Novel Biomarkers. — Current HIV/AIDS reports 2018 · PMID 29752699
- Global Burden of Atherosclerotic Cardiovascular Disease in People Living With HIV — Circulation 2018 · PMID 29967196
- Haemophilia and ageing. — British journal of haematology 2018 · PMID 30592034
- HIV and Ischemic Heart Disease. — Journal of the American College of Cardiology 2017 · PMID 28057253
- HIV and Nonischemic Heart Disease. — Journal of the American College of Cardiology 2017 · PMID 28057254
- Nanomedicines for dysfunctional macrophage-associated diseases. — Journal of controlled release : official journal of the Controlled Release Society 2017 · PMID 28057522
- Cardiovascular disease in women with HIV-1 infection. — International journal of cardiology 2017 · PMID 28285796
- Suboptimal primary and secondary cardiovascular disease prevention in HIV-positive individuals on antiretroviral therapy. — European journal of preventive cardiology 2017 · PMID 28578613
- HIV-1-Associated Atherosclerosis: Unraveling the Missing Link. — Journal of the American College of Cardiology 2017 · PMID 28641798
- HIV-1-Related Cardiovascular Disease Is Associated With Chronic Inflammation, Frequent Pericardial Effusions, and Probable Myocardial Edema. — Circulation. Cardiovascular imaging 2016 · PMID 26951605
- Cardiovascular Disease Risk Prediction in the HIV Outpatient Study — Clinical Infectious Diseases 2016 · PMID 27613562
- An updated prediction model of the global risk of cardiovascular disease in HIV-positive persons: The Data-collection on Adverse Effects of Anti-HIV Drugs (D:A:D) study — European Journal of Preventive Cardiology 2015 · PMID 25882821
- Risk of cardiovascular disease associated with HCV and HBV coinfection among antiretroviral-treated HIV-infected individuals. — Antiviral therapy 2014 · PMID 24429380
- Cardiovascular disease in human immunodeficiency virus. — Internal medicine journal 2014 · PMID 24754684
- Should we expand the concept of coronary heart disease equivalents? — Current opinion in cardiology 2014 · PMID 25029454
- HIV Infection, Cardiovascular Disease Risk Factor Profile, and Risk for Acute Myocardial Infarction — JAIDS Journal of Acquired Immune Deficiency Syndromes 2014 · PMID 25588033
- HIV Infection and the Risk of Acute Myocardial Infarction — JAMA Internal Medicine 2013 · PMID 23459863
- Metabolic disease in HIV infection. — The Lancet. Infectious diseases 2013 · PMID 24156897
- HIV, inflammation, and calcium in atherosclerosis. — Arteriosclerosis, thrombosis, and vascular biology 2013 · PMID 24265418
- Approach to dyslipidemia, lipodystrophy, and cardiovascular risk in patients with HIV infection. — Current atherosclerosis reports 2011 · PMID 21181310
- Nutritional and metabolic correlates of cardiovascular and bone disease in HIV-infected patients. — The American journal of clinical nutrition 2011 · PMID 22089442
- Focus on the heart: alcohol consumption, HIV infection, and cardiovascular disease. — Alcohol research & health : the journal of the National Institute on Alcohol Abuse and Alcoholism 2010 · PMID 23584065
- Risk of premature atherosclerosis and ischemic heart disease associated with HIV infection and antiretroviral therapy. — The Journal of infection 2008 · PMID 18358535
- Low CD4+ T-cell count as a major atherosclerosis risk factor in HIV-infected women and men — AIDS 2008 · PMID 18670221
- Current update on HIV-associated vascular disease and endothelial dysfunction. — World journal of surgery 2007 · PMID 17372667
- Increased Acute Myocardial Infarction Rates and Cardiovascular Risk Factors among Patients with Human Immunodeficiency Virus Disease — The Journal of Clinical Endocrinology & Metabolism 2007 · PMID 17456578
- Class of Antiretroviral Drugs and the Risk of Myocardial Infarction — New England Journal of Medicine 2007 · PMID 17460226
- Metabolic syndrome, cardiovascular disease and type 2 diabetes mellitus after initiation of antiretroviral therapy in HIV infection — AIDS 2007 · PMID 18025881
- Risk of Cardiovascular Disease in a Cohort of HIV-Infected Adults: A Study Using Carotid Intima-Media Thickness and Coronary Artery Calcium Score — Clinical Infectious Diseases 2006 · PMID 17083026
- Atherosclerotic cardiovascular disease risk in the HAART-treated HIV-1 population. — HIV clinical trials 2005 · PMID 15765307
- Pathophysiology of dyslipidemia and increased cardiovascular risk in HIV lipodystrophy: a model of 'systemic steatosis'. — Current opinion in lipidology 2004 · PMID 15166810
Clinical trials (26)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT04725617 | Using Sleep Health to Optimize Smoking Cessation Treatment Response in HIV-Positive Adults | RECRUITING | INTERVENTIONAL | Varenicline, Smoking Cessation Counseling, Health Approach 1 to Reduce Smoking |
| NCT06739915 | TUTT-PT: Targeted Universal TB Testing With Simultaneous TPT Prescribing Among People Living With HIV in South Africa | COMPLETED | INTERVENTIONAL | TUTT-PT Intervention |
| NCT06403787 | Effect of Implementing an Aerobic Training Program and Administering Ginkgo Biloba Extract on Plasma Concentrations of LDL and HDL in HIV Positive Patients Undergoing Antiretroviral Treatment at the HIV Unit of Hospital Civil Fray Antonio Alcalde | COMPLETED | INTERVENTIONAL | Aerobic exercise + Ginkgo Biloba Extract, Aerobic exercise + Calcined magnesia (placebo), Aerobic exercise + Atorvastatin |
| NCT05168137 | Efficacy and Safety of Low-Dose Colchicine on Surrogate Markers of Cardiovascular Events in People Living With HIV Receiving Antiretroviral Therapy | UNKNOWN | INTERVENTIONAL | Low-dose colchicine, Placebo |
| NCT03500302 | Effect of Evolocumab on Coronary Endothelial Function | COMPLETED | INTERVENTIONAL | Evolocumab |
| NCT03207945 | Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study) | COMPLETED | INTERVENTIONAL | Alirocumab, Placebo |
| NCT02833844 | A Double Blind, Randomized, Placebo Controlled, Multicenter Study to Evaluate Safety, Tolerability, and Efficacy on LDL-C of Evolocumab (AMG 145) in Subjects With HIV and With Hyperlipidemia and/or Mixed Dyslipidemia | COMPLETED | INTERVENTIONAL | Evolocumab, Placebo |
| NCT02841774 | High Intensity Lipid Lowering Following Acute Coronary Syndromes for Persons Living With Human Immunodeficiency Virus (HILLCLIMBER) | COMPLETED | INTERVENTIONAL | Pravastatin, Rosuvastatin |
| NCT02624180 | Inflammatory Pathogenesis of Coronary Atherosclerosis in HIV | COMPLETED | INTERVENTIONAL | Colchicine, Placebo |
| NCT02810275 | Effect of Folic Acid on Homocysteine Levels and Flow-mediated Dilation in HIV and HIV-HCV Coinfected Patients: a Randomized Controlled Trial | COMPLETED | INTERVENTIONAL | Folinic Acid, Placebo |
| NCT01041521 | The Impact of Omega Three Fatty Acids on Vascular Function in HIV | COMPLETED | INTERVENTIONAL | Lovaza |
| NCT00857298 | Effect of Diet-induced Weight Loss on HIV-associated Metabolic Syndrome | COMPLETED | INTERVENTIONAL | Dietary Intervention |
| NCT00795717 | Human Immunodeficiency Virus (HIV), Arterial Dysfunction, Lipids, Lovaza (HALO) Trial | COMPLETED | INTERVENTIONAL | Lovaza, Placebo |
| NCT00665717 | The Influence of Raltegravir on Pravastatin Pharmacokinetics in Healthy Volunteers (GRAPPA) | COMPLETED | INTERVENTIONAL | Pravastatin, Raltegravir, Pravastatin and raltegravir |
| NCT00986986 | Prospective Randomized Pilot Study of the Effect of Niaspan on Endothelial Function in HIV-infected Subjects With Low HDL Cholesterol Levels | COMPLETED | INTERVENTIONAL | extended release niacin |
| NCT00264394 | Efficacy of a Computerised Physician Reminder System to Control Cardiovascular Risk Factors in HIV-infected Patients Receiving Antiretroviral Therapy: A Nested Randomised Controlled Cluster Trial Within the Swiss HIV Cohort Study | COMPLETED | INTERVENTIONAL | Updated CHD risk profiles, Guidelines |
| NCT00405171 | Efavirenz to Nevirapine Switch in HIV-1 Infected Patients With Severe Dyslipidemia: A Randomized Controlled Study | COMPLETED | INTERVENTIONAL | Nevirapine |
| NCT05881447 | Prevalence, Incidence and Risk Signature of Chronic Kidney Disease in a Primary Care Setting in Semirural Sub-Saharan Africa | RECRUITING | OBSERVATIONAL | |
| NCT07662161 | Coronary Artery Calcium Score in HIV Mexican Population (The CACsHIVMex Study) | NOT YET RECRUITING | OBSERVATIONAL | Simple coronary CT scan |
| NCT05563116 | Coronary Artery Calcium Score in People Living With HIV: the French HIV-CAC Cohort Study | COMPLETED | OBSERVATIONAL | Computed tomography coronary artery calcium (CAC) score (part of routine workup) |
| NCT00918073 | Evaluation of Cardiovascular Effects of Smoking Cessation in HIV Infected Patients | COMPLETED | OBSERVATIONAL | |
| NCT00381992 | Risk Assessment of Long-Haul Truck Drivers | COMPLETED | OBSERVATIONAL | |
| NCT03416257 | Gut Microbial-related Choline Metabolite Trimethylamine-N-oxide is Associated With Progression of Carotid Artery Atherosclerosis in HIV Infection | COMPLETED | OBSERVATIONAL | No intervention |
| NCT01519141 | Immunologic and Inflammatory Factors and Cardiovascular Risk in Patients With HIV Infection or Autoimmune Diseases | COMPLETED | OBSERVATIONAL | |
| NCT00253682 | Cardiac Status of HAART Exposed Infants of HIV-Infected Mothers (CHAART I) | COMPLETED | OBSERVATIONAL | |
| NCT00001102 | Metabolic Consequences of Highly Active Antiretroviral Therapy (HAART) in HIV-Positive Individuals | COMPLETED | OBSERVATIONAL |
Genetic associations (0)
None linked.