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Homocysteine

Novel & Emerging BiomarkersLab test / biomarkerriskpartially modifiable
56
evidence score

Also known as: Homocysteine (Hcy), Homocysteine (elevated), elevated homocysteine / hyperhomocysteinemia, elevated levels of homocysteine, elevated plasma homocysteine concentrations, hyperhomocysteinaemia, hyperhomocysteinemia, increased plasma total homocysteine (tHcy) concentrations, plasma homocysteine, raised levels of homocysteine, total homocysteine

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 21.1meta-analyses: 20trials: 15genetic: 0MR bonus:

References (127)

8 meta-analyses / systematic reviews

Clinical trials (146)

showing top 60
NCTTitleStatusTypeInterventions
NCT07029698Efficacy and Safety of a Parenterally Administered Fixed Vitamin Combination (Vitamin B6, B12 and Folic Acid) On Vitamin B12 Status and Methylation Capacity in Cobalamin Deficiency Compared to Oral Vitamin B12 SupplementationRECRUITINGINTERVENTIONALVitamin B12, Vitamin B6, Folic acid, Vitamin B12 (Cyanocobalamin)
NCT04974151Comparative Efficacy of Amlodipine Folic Acid vs. Amlodipine on the Risk of First Ischemic Stroke Among Participants With Hypertension and MTHFR 677 TT Genotype: A Multi-center, Randomized, Double-blind, Triple-dummy, Controlled Clinical TrialRECRUITINGINTERVENTIONALAmlodipine besylate, Amlodipine besylate And Folic Acid, 5-methyltetrahydrofolate (5-MTHF)
NCT04974138Comparative Efficacy of Amlodipine Folic Acid vs. Amlodipine on the Risk of First Ischemic Stroke Among Participants With H-type Hypertension and MTHFR 677 CC/CT Genotype: A Multi-center, Randomized, Double-blind, Double-dummy, Controlled Clinical TrialRECRUITINGINTERVENTIONALAmlodipine besylate, Amlodipine besylate and folic acid, Amlodipine placebos
NCT06772220Pilot Study of Open Label Homocysteine Management Therapy in Levodopa-treated Parkinson's DiseaseRECRUITINGINTERVENTIONALFolic Acid 1 MG, Vitamin B6 25 MG, Vitamin B12
NCT06264570Evaluation of a Genetically Determined Personalized Approach in Prescribing Biologically Active Substances in Patients With Elevated Blood Homocysteine Levels, Prospective,Double-blind Randomised Trial.RECRUITINGINTERVENTIONALB-TMG supplementation, B-SAM supplementation, B-TMG placebo
NCT07648251Furosemide Oral Versus Placebo for Reduction of Hospital Length of Stay in Postpartum Women With Severe Preeclampsia: A Double-Blind, Randomized Controlled TrialNOT YET RECRUITINGINTERVENTIONALFurosemide, Folic Acid 5 MG
NCT07377071Impact of Folate Administration on One-Year Mortality in Patients With Infection-Associated Acute Kidney Injury: An Open-Label Randomised Controlled StudyNOT YET RECRUITINGINTERVENTIONALFolic Acid 5 MG
NCT07013136Efficacy and Safety of Folic Acid on Acute Kidney Injury in Adults: A Feasibility StudyNOT YET RECRUITINGINTERVENTIONALFolic Acid 5 MG
NCT07163364A Single-arm Phase III Clinical Study to Evaluate the Efficacy and Safety of Hydroxocobalamin Chloride Injection in Participants With Methylmalonic Acidemia (MMA) With Elevated Homocysteine (Cobalamin C Deficiency)NOT YET RECRUITINGINTERVENTIONALHydroxocobalamin Chloride Injection
NCT06114550Acute Effect of Resistance Training With Different Intensity on Circulating Levels of Neurotrophic Growth Factors and Homocysteine in Young AdultsUNKNOWNINTERVENTIONALHigh intensity resistance training, Low intensity resistance training
NCT05720702A Feasibility Trial of One-carbon Metabolism Cofactor Supplements for the Treatment of Nonalcoholic Fatty Liver Disease (NAFLD)COMPLETEDINTERVENTIONALhomocysteine (Hcy) lowering supplements
NCT06363565Study on the Effect of Compound Nutrients on Reducing Homocysteine -- A 3-month Double-blind Randomized Controlled TrialUNKNOWNINTERVENTIONALsupplementation of compound nutrients, placebo control
NCT05807711Efficacy of L-methylfolate and Methylcobalamine in Treating Resistant Hypertension Associated With Elevated Serum Homocysteine in Hemodialysis Patients.COMPLETEDINTERVENTIONALL-Methyl Folate and methylcobalamine
NCT05994794A Randomized, Single-Blind, Placebo-Controlled Trial for the Role of a Dietary Supplement in Lowering S-Adenosylhomocysteine (SAH) in Healthy Adults With Elevated Plasma SAH and Normal Homocysteine Levels and Identification of Participants With Elevated Plasma SAH in the General Population Using the MethylQ ScoreCOMPLETEDINTERVENTIONALAlpha-GPC, Creatine and Ashwagandha (Sensoril®), Placebo
NCT06163443Evaluating the Impact of B Vitamin Supplementation (Soloways™) on Homocysteine and LDL-C Levels in Patients With MTHFR, MTR, and MTRR Polymorphisms: A Randomized, Double-blind, Placebo-controlled TrialCOMPLETEDINTERVENTIONALVitamin B, Placebo
NCT05169021Folic Acid and Intensive Antihypertensive Therapy for Cerebrovascular and Cardiovascular Events Prevention Among Patients With Hypertension and Cerebral Small Vascular Diseases (FAITH)----A Multicenter, Randomized, Controlled, Open-label, 2x2 Factorial, Blinded End-point TrialNOT YET RECRUITINGINTERVENTIONALAmlodipine folic acid 5.8mg+intensive antihypertensive therapy, Amlodipine folic acid 5.8mg+standard antihypertensive therapy, Amlodipine+intensive antihypertensive therapy
NCT05011032Effects of Homocysteine in Myocardial Infarction Patients in a Tertiary Care Hospital of Twin Cities of PakistanWITHDRAWNINTERVENTIONALHomocysteine
NCT05529888Serum Homocysteine Level in Acne Patients Before and After Oral IsotretinoinCOMPLETEDINTERVENTIONALIsotretinoin
NCT04558268Low Dose Prednisone Therapy in Women With Recurrent Pregnancy LossUNKNOWNINTERVENTIONALPrednisone, Progesterone, vit D
NCT04301336Comparative Effectiveness of the Different Treatment Modalities for Management of Vaso-occlusive Painful Crisis in Pediatric Sickle Cell DiseaseCOMPLETEDINTERVENTIONALOmega 3, Vit D, Zinc sulfate
NCT03887169Oral or Enteral Administration of Methionine in Patients With Pulmonary Alveolar Proteinosis by Mutation of the MARS Gene.COMPLETEDINTERVENTIONALMethionine, Vitamin B12, B9, B6, C supplementation, Methionine/homocysteine Dosage
NCT03994731A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Efficacy and Safety Study of Methotrexate to Increase Response Rates in Patients With Uncontrolled Gout Receiving KRYSTEXXA® (Pegloticase) (MIRROR Randomized Controlled Trial [RCT])COMPLETEDINTERVENTIONALPegloticase, methotrexate, placebo
NCT03720249Supplementation of Compound Nutrients on Plasma Homocysteine in Chinese Adults With Hyperhomocysteinemia: a Randomized Double-blind Control TrialUNKNOWNINTERVENTIONALsupplementation of compound nutrients, placebo control
NCT03674333Effect of Adding Folic Acid on Lipid Parameters in Population With DyslipidemiasUNKNOWNINTERVENTIONALFolic Acid, Placebo
NCT03431597Effectiveness of a Micronutrient Supplement to Lower Plasma Homocysteine in Non-pregnant Women of Reproductive AgeCOMPLETEDINTERVENTIONALnovel micronutrient, existing micronutrient supplement, UNIMMAP
NCT03472508A Randomized, Double-Blind, Controlled Trial on the Homocysteine-Lowering Effects of Different Doses of Folic Acid Among Patients With Hypertension According to Methylenetetrahydrofolate Reductase C677T GenotypesUNKNOWNINTERVENTIONALFolic Acid, Enalapril Maleate and Folic Acid Tablets (Yiye), Enalapril
NCT03595163Effects of Propofol and Sevoflurane on Blood Folic Acid and Homocysteine Concentrations in Children With Cochlear Implant SurgeryUNKNOWNINTERVENTIONALSevoflurane, Propofol
NCT03997032A Pilot Study to Assess the Effect of a 3-month Folate Supplementation on Systemic Homocysteine Plasma Concentration and Ocular Blood Flow in Patients With DiabetesCOMPLETEDINTERVENTIONALOcufolin
NCT03844958Effect of Consuming Red Furu On Serum Vitamin B12, Homocysteine And Other Cardio-Metabolic Risk Factors In Healthy Young Volunteers: A Randomized Controlled TrialCOMPLETEDINTERVENTIONALRed Furu, Tofu
NCT03495336A 4-week Consumption of Light or Dark Roast Unfiltered (Turkish) Coffee Affects Cardiovascular Risk Parameters of Homocysteine and Cholesterol Concentrations in Healthy Subjects: A Randomized Crossover Clinical TrialCOMPLETEDINTERVENTIONALcoffee abstention phase, LR Coffee consumption, DR Coffee consumption
NCT03186196Influence of Polymorphism C677T MTHFR and Folate Intake in Interleukins, Homocysteine and TNF-αCOMPLETEDINTERVENTIONALDiet containing Folate
NCT03310307Vitamin D3 Treatment Decreases Serum Total Homocysteine Concentrations of Overweight Reproductive Women: Randomized Placebo Controlled Clinical TrailCOMPLETEDINTERVENTIONALVit D, Placebo
NCT02773147Effect of Vitamin B Substitution on Plasma NFL and Neurocognitive Performance in HIV-infected Individuals With Increased Plasma HomocysteineUNKNOWNINTERVENTIONALCyanocobalamin, Folate, Pyridoxine
NCT02674022Screening for Metabolic Problems in Women, and Possible Treatment With Vitamin/Mineral SupplementCOMPLETEDINTERVENTIONALPrenatal supplement
NCT02575092Department of GeriatricsCOMPLETEDINTERVENTIONALEnalapril Maleate Tablets(as the program-based antihypertension), Enalapril Maleate and Folic Acid tablets(as the program-based antihypertension), Placebo
NCT02953522Polymorphism C677T MTHFR and Diet With Folate in Oxidative Stress, Lipid Profile and HomocysteineCOMPLETEDINTERVENTIONAL191 mcg/day of Folate, 90 mcg / day of Folate
NCT02318446Efficacy Study of Folic Acid Supplementation on Homocysteine Levels in Adolescent Epileptics Taking Antiepileptic Drugs: A Single Blind Randomized Controlled Clinical TrialUNKNOWNINTERVENTIONALFolic Acid, Saccharine
NCT02961972Effects of Oral Supplementation With Creatine on Plasma Homocysteine Levels and Systemic Microvascular Endothelial Function in Vegetarian IndividualsCOMPLETEDINTERVENTIONALmonohydrate and micronized creatine, placebo
NCT02321579The Effects of Vitamin B-6 and Glutathione on Inflammatory Responses, Homocysteine Metabolism, Oxidative Stress and Antioxidant Capacities in Patients With Liver Cirrhosis or Hepatocellular CarcinomaUNKNOWNINTERVENTIONALvitamin B-6, Glutathione, Dextrins
NCT01956786Efficacy of Amlodipine-Folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine in Patients With Mild to Moderate Hypertension, Hyperhomocysteinemia and Angiotension-Converting Enzyme Inhibitor IntoleranceUNKNOWNINTERVENTIONALAmlodipine-FA tablet,low dose group, Amlodipine-FA tablet,high dose group, Amlodipine
NCT02709668Clinical Response and Homocysteine Reduction Using Reduced B-Vitamin Therapy in MTHFR C677T/A1298C Patients With Major Depressive Disorder : an Analysis of FindingsCOMPLETEDINTERVENTIONALEnlyte, placebo
NCT01712165Micronutrient-supplemented Milk Study in Women of Childbearing AgeCOMPLETEDINTERVENTIONALANMUM Materna, Control (milk powder)
NCT01848873Efficacy of Amlodipine-folic Acid Tablets on Reduction of Blood Pressure and Plasma Homocysteine in Patients With Mild to Moderate Hypertension and Hyperhomocysteinemia ：a Double-blind Randomized Controlled TrialUNKNOWNINTERVENTIONALAmlodipine, amlodipine-FA tablet, low dose group, amlodipine-FA tablet ,high dose group
NCT01762072Effect of Vitamin B12 and n-3 Polyunsaturated Fatty Acids on Plasma HomocysteineUNKNOWNINTERVENTIONALFish oil, vitaminB12
NCT01766310Effect of Folic Acid Supplementation on Plasma Homocysteine Level in Obese Children: a Randomized Double Blinded Placebo Controlled TrialCOMPLETEDINTERVENTIONALFolic Acid, placebo
NCT02810275Effect of Folic Acid on Homocysteine Levels and Flow-mediated Dilation in HIV and HIV-HCV Coinfected Patients: a Randomized Controlled TrialCOMPLETEDINTERVENTIONALFolinic Acid, Placebo
NCT01594086Effects of Green Tea Consumption on Homocysteine Metabolism and Cognitive Dysfunction in Elderly: An Exploratory Clinical StudyCOMPLETEDINTERVENTIONALgreen tea powder
NCT01661309To Critically Investigate and Evaluate Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians, Who May Have a Resultant Susceptibility to Hyperhomocysteinemia Related Diseases.COMPLETEDINTERVENTIONALInactive lozenge, Methylcobalamin
NCT01665378Impact of Pre-Pregnancy Micronutrient Supplementation on Maternal and Child OutcomesCOMPLETEDINTERVENTIONALMultiple Micronutrient, Iron and Folic Acid, Folic Acid
NCT01755650A Phase 0 Exploratory Microdosing Study of S-(3-18Ffluoropropyl)Homocysteine Hydrochloride; 18FFPM Using PET/CT in Patients With a Variety of Malignancies.TERMINATEDINTERVENTIONAL18F FPM
NCT01426490The Effects of Vitamin B-6 Status on Homocysteine, Oxidative Stress, One-carbon Metabolism and Methylation: Cross-section, Case-control, Intervention and Follow-up Studies in Colorectal CancerUNKNOWNINTERVENTIONALVitamin C, Vitamin B6, Folic acid
NCT01317849Folic Acid and B Vitamins for Secondary Prevention of Stroke : A Double-blinded Randomized Controlled TrialWITHDRAWNINTERVENTIONALFolic Acid, Vitamin B6, Vitamin B12
NCT01371357The Effects of 8-week Choline, Betaine, and Folic Acid Supplementation on Plasma Homocysteine Concentration During Guanidinoacetic Acid Loading in Young Healthy VolunteersCOMPLETEDINTERVENTIONALTEST 1, TEST 2, TEST 3
NCT01976676Comparison of the Effect of Folic Acid and 5-methyltetrahydrofolate (5MTHF) on Serum Folate and Homocysteine Levels, and Abortion Rates in Women Suffering From Recurrent AbortionCOMPLETEDINTERVENTIONAL5-methyltetrahydrofolate, folic Acid
NCT01105351Effect of Mild Increase in Folic Acid Intake on the Distribution of Folate Forms in Relation to a Common Polymorphism in One Folate Catabolising EnzymeCOMPLETEDINTERVENTIONALfolic acid plus B6 and B12, folic acid
NCT01091506A Placebo-Controlled Study of Physiologic Effects of L-methylfolate in Schizophrenia PatientsCOMPLETEDINTERVENTIONALPlacebo, L-methylfolate
NCT00717730Routine Administration of Folic Acid and Vitamin B12 to Prevent Childhood Infections in Young Indian ChildrenCOMPLETEDINTERVENTIONALFolic Acid, Vitamin B12, Placebo
NCT00473200Effect of Oral S-adenosylmethionine (SAMe) on Blood Levels of Homocysteine in Human SubjectsCOMPLETEDINTERVENTIONALS-adenosylmethionine
NCT00901394Influence of Preoperative Vitamin B12 and Folate Administration on Homocysteine Concentrations After Nitrous Oxide AnesthesiaCOMPLETEDINTERVENTIONALB12-Folic Acid, nitrous oxide, Nitrous oxide (NO) and placebo, Placebo
NCT00941837Effect of Dietary Fat Type in Combination With High Protein on Plasma Homocysteine Levels and Selected Markers of Cardiovascular Heart Disease Risk in Human VolunteersCOMPLETEDINTERVENTIONALOlive Oil, Palm Olein Oil, Coconut Oil

Genetic associations (0)

None linked.