C
Hypothyroidism
Comorbid ConditionsDisease / conditionriskpartially modifiable
17
evidence score
Also known as: thyroid dysfunction
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 10.4meta-analyses: 0trials: 7genetic: 0MR bonus:
References (10)
0 meta-analyses / systematic reviews- Associations Between Subclinical Thyroid Dysfunction and Cardiovascular Risk Factors According to Age and Sex. — The Journal of clinical endocrinology and metabolism 2025 · PMID 39667018
- Metabolic Syndrome, Thyroid Dysfunction, and Cardiovascular Risk: The Triptych of Evil. — International journal of molecular sciences 2024 · PMID 39408957
- Thyroid Function, Cardiovascular Risk Factors, and Incident Atherosclerotic Cardiovascular Disease: The Atherosclerosis Risk in Communities (ARIC) Study — The Journal of Clinical Endocrinology & Metabolism 2017 · PMID 28605456
- The metabolism and significance of homocysteine in nutrition and health — Nutrition & Metabolism 2017 · PMID 29299040
- Hypothyroidism and Moderate Subclinical Hypothyroidism Are Associated with Increased All-Cause Mortality Independent of Coronary Heart Disease Risk Factors: A PreCIS Database Study — Thyroid 2011 · PMID 21745107
- Peripheral arterial disease and abdominal aortic aneurysm in elderly people. — Minerva medica 2011 · PMID 22193380
- Subclinical Hypothyroidism and the Risk of Coronary Heart Disease and Mortality — JAMA 2010 · PMID 20858880
- Migraine comorbidity constellations. — Headache 2007 · PMID 17578536
- Traditional and nontraditional cardiovascular risk factors are associated with atherosclerosis in rheumatoid arthritis. — PubMed 2005 · PMID 15742434
- Thyroid diseases and cerebrovascular disease. — Stroke 2005 · PMID 16179578
Clinical trials (4)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT03606824 | Thyroid Hormone Replacement for Subclinical Hypothyroidism and Dyslipidemia in Patients With Atherosclerotic Cardiovascular Diseases (ThyroHeart-Lipid Study) | UNKNOWN | INTERVENTIONAL | Pitavastatin and placebo, Pitavastatin and levothyroxine |
| NCT02512978 | Thyroid Hormone Replacement for Hypothyroidism and Acute Myocardial Infarction | UNKNOWN | INTERVENTIONAL | Levothyroxine |
| NCT01848171 | Effects of Long-term L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Patients With Hypothyroidism | UNKNOWN | INTERVENTIONAL | L-thyroxine |
| NCT03823859 | Metabolomics of Thyroid Hormones | COMPLETED | OBSERVATIONAL | Indirect calorimetry, Dual energy X-ray Absorptiometry (DXA), Blood sampling |
Genetic associations (0)
None linked.