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Insulin resistance

Glycemic & MetabolicLab test / biomarkerriskmodifiable
59
evidence score

Also known as: Impaired insulin signaling, homa-ir, hyperinsulinemia, impaired insulin signaling, inhibition of insulin signaling, insulin resistance (HOMA-IR), insulin resistance (IR), insulin resistance / impaired glucose metabolism, insulin signaling, insulin signaling impairment, insulin signalling, insulin-glucose homoeostasis

PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 24.2meta-analyses: 20trials: 15genetic: 0MR bonus:

References (263)

10 meta-analyses / systematic reviews

Clinical trials (42)

NCTTitleStatusTypeInterventions
NCT06609356Cardiometabolic Benefit of Reducing Iatrogenic Hyperinsulinemia Using Insulin Adjunctive Therapy in Type 1 DiabetesRECRUITINGINTERVENTIONALStudy Visit 1, Placebo, Study Visit 2
NCT06163768Effects of Insulin Resistance in Non-diabetic Acute Coronary Syndrome Patients by the Homeostasis Model Assessment Index (HOMA2-IR)RECRUITINGINTERVENTIONALInsulin resistance
NCT03875625Change of Adipose Tissues and Triglyceride in Obese Patients With Non-alcoholic Fatty Liver Disease After Bariatric Surgery or Life-style InterventionRECRUITINGINTERVENTIONALBariatric surgery, Dietitian led life style modification intervention, Conventional care (control)
NCT07551960Design, Development and Pilot Validation of an Interventional System of the STELA Center for Preventive Medicine to Reduce Modifiable Health Risk Factors in the Adult Population (CPM-STELA)ENROLLING BY INVITATIONINTERVENTIONALSTELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
NCT05560971The Effect of Palmitoleic Acid (POA) Supplementation on Insulin Sensitivity and Lipogenesis in Overweight and Obese IndividualsACTIVE NOT RECRUITINGINTERVENTIONALPalmitoleic acid, Placebo
NCT05193916A Multi-Center, Randomised, Double-blind, Placebo Controlled Phase II Clinical Study of Chiglitazar in Patients With Nonalcoholic Steatohepatitis Accompanied by Elevated Triglycerides and Insulin ResistanceCOMPLETEDINTERVENTIONALchiglitazar sodium tablets, Placebo
NCT05017571COLSIO Trial: Phase II Randomized, Controlled Trial of Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With ObesityCOMPLETEDINTERVENTIONALColchicine, Placebo
NCT04926415Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Obesity and Insulin ResistanceCOMPLETEDINTERVENTIONALtaVNS, Sham taVNS
NCT04314167Effect of Serum LDL Cholesterol Concentration on Pancreatic Insulin SecretionTERMINATEDINTERVENTIONALLowering cholesterol concentrations by PCSK-9 inhibitor
NCT04201938Probiotic With Omega-3 Fatty Acids on Obesity and Insulin Resistance Management in Patients With Type 2 DiabetesCOMPLETEDINTERVENTIONALSymbiter-Omega, Placebo
NCT03419767The Problem of Insulin Resistance in Patients After Carotid RevascularizationUNKNOWNINTERVENTIONALMelatonin, blank
NCT02706262Complex Effects of Dietary Manipulation on Metabolic Function, Inflammation and HealthACTIVE NOT RECRUITINGINTERVENTIONALMetabolically abnormal obese - Mediterranean diet, Metabolically abnormal obese - Low carbohydrate ketogenic diet, Metabolically abnormal obese - Plant-based, very-low-fat diet
NCT02577159Effects of Dapagliflozin on Hyperlipidemia, Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients (DAPHNIS Study)UNKNOWNINTERVENTIONALDapagliflozin
NCT02628301Is Microvascular Dysfunction an Early Phenomenon in the Development of Skeletal Muscle Insulin Resistance? A Dietary Intervention Study in Healthy MenCOMPLETEDINTERVENTIONALHypercaloric diet, Normocaloric diet
NCT02218931Effect of Simple, Targeted Diet in Pregnant Women With Metabolic Risk Factors on Pregnancy Outcomes (ESTEEM): A Randomised TrialCOMPLETEDINTERVENTIONALTargeted ESTEEM diet, Non-randomised cohort
NCT02582606Effects of the Constancy of Daily Meal Pattern on Energy Balance, Glucose Profiles and Plasma Lipoproteins in Obese WomenCOMPLETEDINTERVENTIONALRegular meal pattern, Irregular meal pattern
NCT02075307Highbush Blueberries, the DNA-damage of Obesity, Somatic Mutations and Metabolic SyndromeCOMPLETEDINTERVENTIONALBlueberry Powder, Placebo
NCT01860911Regulation of the Plasma Triglyceride Extraction in Muscle in Insulin ResistanceCOMPLETEDINTERVENTIONALInsulin, NG-monomethyl-L-arginine
NCT01889368Effect of a Grape Seed Extract (GSE) on Insulin ResistanceCOMPLETEDINTERVENTIONALGrape Seed Extract, Placebo
NCT03011775Effect of Pioglitazone on Insulin Resistance, Progression of Atherosclerosis and Clinical Course of Coronary Heart DiseaseCOMPLETEDINTERVENTIONALPioglitazone 15 mg Tablet, Isosorbide Dinitrate 10Mg Tablet, Acetylsalicylic Acid 75Mg Tablet
NCT01509482Insulin Resistance : a New Diagnosis of the Pathogenesis of Idiopathic Oligozoospermia and Non Obstructive AzoospermiaCOMPLETEDINTERVENTIONALblood samples, Blood samples
NCT03853590Mechanisms Underlying the Improvement of Insulin Resistance in Response to Bariatric SurgeryCOMPLETEDINTERVENTIONALRoux-en-Y gastric bypass, Laparoscopic adjustable gastric banding
NCT01025492Mechanisms of Atheroprotection by Fenofibric Acid (ABT 335) Added to a Statin in Subjects With Insulin Resistance (Hypertriglyceridemia and Low HDL-C)TERMINATEDINTERVENTIONALTrilipix, placebo
NCT00721617Free Fatty Acids-Induced Hypertension, Endothelial Dysfunction, Inflammation, Insulin Resistance, and Autonomic Dysfunction in Lean and Obese SubjectsCOMPLETEDINTERVENTIONALIntralipid 20%, Normal Saline, Oral fat load
NCT00546455Phase 2 Study of the Assessment of the Insulin Sensitizing Activity of Fenretinide in Subjects With Insulin Resistance With BMI >30Kg/m2, and Liver Inflammation Related to Non-alcoholic Fatty LiverSUSPENDEDINTERVENTIONALFenretinide, Placebo
NCT00508937The Effects of Increased Dietary Protein Intake on Insulin Sensitivity in Stable Weight Individuals, Independent of Dietary Content of Carbohydrate and Saturated FatCOMPLETEDINTERVENTIONALDiet, Diet, Diet
NCT00152945Determining the Responsiveness of Intestinal Lipoprotein Production to an Elevation of Plasma Free Fatty AcidsCOMPLETEDINTERVENTIONALIntravenous Intralipid, Intravenous leucine, glycerol
NCT00408577Prevention of Cardiovascular Relapses by L-Arginine Oral Administration in Patients With CAD and IGT and/or Insulin Resistance.COMPLETEDINTERVENTIONALL-arginine
NCT00153166The Contribution of Inflammation and Insulin Resistance to Intermittent ClaudicationCOMPLETEDINTERVENTIONALatorvastatin and pioglitazone, atorvastatin/placebo, pioglitazone/placebo
NCT00186537Comparison Fenofibrate, Rosiglitazone, or Weight Loss to Decrease Cardiovascular Risk in Insulin Resistant Dyslipidemic Individuals.COMPLETEDINTERVENTIONALRosiglitazone, Fenofibrate, Weight Loss
NCT00401089A Placebo-controlled Cross Study of Panax Ginseng in Augmentation of Antipsychotics in 60 Partially Treatment Responsive Patients With SchizophreniaCOMPLETEDINTERVENTIONALPanax Ginseng
NCT00006305Bypass Angioplasty Revascularization Investigation in Type 2 DiabetesCOMPLETEDINTERVENTIONALAngioplasty, Transluminal, Percutaneous Coronary, other catheter-based interventions, Coronary Artery Bypass, Biguanides, thiazolidinediones
NCT07468097THE IMPACT OF METABOLIC STATUS ON PAIN AND CENTRAL SENSITIZATION IN WOMEN WITH LIPEDEMA: A CROSS-SECTIONAL OBSERVATIONAL STUDYRECRUITINGOBSERVATIONAL
NCT07589374Correlation Between Carotid-Femoral Pulse Wave Velocity and Triglyceride-Glucose Index and Its Derived MetricsNOT YET RECRUITINGOBSERVATIONAL
NCT07567378Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts (CARTIZ): A Prospective Observational Multi-Institutional Registry of the VAT-Articular-Cardiac-Aging Axis in Adults Exposed to Tirzepatide in Mexico, With Quantitative Knee Cartilage T2 Mapping, Cardiac CT Epicardial Adipose Tissue Radiomic Phenotyping, HLA Stratification, Longitudinal Multi-Frequency Bioimpedance Body Composition, and a Prespecified Surgical Tissue Acquisition SubcohortNOT YET RECRUITINGOBSERVATIONALTirzepatide
NCT07467161Impact of Vitamin D Deficiency on Insulin Resistance Assessed by Triglyceride Glucose Index in Type 2 Diabetic PatientsNOT YET RECRUITINGOBSERVATIONAL
NCT07279922The Role of Triglyceride-glucose Index as a Predictive Marker for Insulin Resistance in Pre Diabetic Chronic Kidney Disease Patients.NOT YET RECRUITINGOBSERVATIONALTriglyceride-glucose index
NCT07260201Evaluating the Triglyceride-Glucose Index and TGI-BMI for Insulin Resistance Assessment: A Comparative Study With HOMA-IRCOMPLETEDOBSERVATIONAL
NCT06358989Association Between Triglycerides Glucose Ratio With HOMA -IR as Indicators of Insulin Resistance in Obese AdultsUNKNOWNOBSERVATIONALHOMA IR
NCT05695651Association of Triglyceride Glucose Index and HOMA IR as Predictors of Vascular Complications of Type 2 Diabetes MellitusUNKNOWNOBSERVATIONALtriglyceride glucose index and HOMA IR
NCT04455204Implication of Adipokines, Inflammation, Insulin Resistance and Endothelial Dysfunction in the Pathogenesis of Preeclampsia and in Pregnancy Related ComplicationsCOMPLETEDOBSERVATIONALSerum asymmetteric dimethyl arginine, serum lipid profiles, Serum vaspin
NCT02258698Insulin Sensitivity, Irisin and Adipokines as Outcome Parameters in Patients Undergoing Cardiac SurgeryCOMPLETEDOBSERVATIONALCardiac surgery

Genetic associations (0)

None linked.