A
Leptin
Novel & Emerging BiomarkersLab test / biomarkerriskpartially modifiable
35
evidence score
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 15.2meta-analyses: 13.8trials: 6genetic: 0MR bonus:
References (32)
4 meta-analyses / systematic reviews- METAPhenotype-specific associations of circulating adipokine levels with carotid atherosclerosis: a systematic review and meta-analysis. — International journal of cardiology. Cardiovascular risk and prevention 2025 · PMID 41323746
- METACombined Aerobic and Resistance Training Improves Body Composition, Alters Cardiometabolic Risk, and Ameliorates Cancer-Related Indicators in Breast Cancer Patients and Survivors with Overweight/Obesity: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. — Journal of sports science & medicine 2024 · PMID 38841642
- METALeptin and coronary heart disease: a systematic review and meta-analysis. — Atherosclerosis 2013 · PMID 24529114
- METAIs Sleep Duration Associated With Childhood Obesity? A Systematic Review and Meta‐analysis — Obesity 2008 · PMID 18239632
- Exercised gut microbiota improves vascular and metabolic abnormalities in sedentary diabetic mice through gut‒vascular connection. — Journal of sport and health science 2025 · PMID 39827989
- GDF15: An emerging disease target and biomarker of metabolic diseases. — Journal of endocrinological investigation 2025 · PMID 40569532
- The adipose-neural axis is involved in epicardial adipose tissue-related cardiac arrhythmias. — Cell reports. Medicine 2024 · PMID 38744275
- Associations of Visceral Adipose Tissue, Circulating Protein Biomarkers, and Risk of Cardiovascular Diseases: A Mendelian Randomization Analysis — Frontiers in Cell and Developmental Biology 2022 · PMID 35186940
- Adipokines, adiposity, and atherosclerosis. — Cellular and molecular life sciences : CMLS 2022 · PMID 35503385
- Exercise modulation in inflammation and metabolic hormonal disorders of COVID-19 to decrease risk factors in coronary heart disease. — Hormone molecular biology and clinical investigation 2022 · PMID 36560914
- Obesity, kidney dysfunction, and inflammation: interactions in hypertension. — Cardiovascular research 2021 · PMID 33258945
- Shift working and cardiovascular health. — Chronobiology international 2021 · PMID 34100313
- GDF15: emerging biology and therapeutic applications for obesity and cardiometabolic disease. — Nature reviews. Endocrinology 2021 · PMID 34381196
- Behavioral, cardiovascular and endocrine alterations induced by chronic stress in rats fed a high-fat diet. — Physiology & behavior 2020 · PMID 32540332
- Protein Biomarkers of Cardiovascular Disease and Mortality in the Community — Journal of the American Heart Association 2018 · PMID 30006491
- [Psoriasis,Cardiovascular Disease,and Adipokines]. — Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 2018 · PMID 30193612
- The genetic basis of obesity complications. — Acta scientiarum polonorum. Technologia alimentaria 2017 · PMID 28362475
- Adipokines in Liver Cirrhosis. — International journal of molecular sciences 2017 · PMID 28661458
- A Comprehensive Review on Metabolic Syndrome — Cardiology Research and Practice 2014 · PMID 24711954
- High plasma uric acid concentration: causes and consequences — Diabetology & Metabolic Syndrome 2012 · PMID 22475652
- Improvement in coronary heart disease risk factors during an intermittent fasting/calorie restriction regimen: Relationship to adipokine modulations — Nutrition & Metabolism 2012 · PMID 23113919
- The levels of adiponectin and leptin and their relation to other markers of cardiovascular risk in patients with psoriasis — Journal of the European Academy of Dermatology and Venereology 2011 · PMID 21349112
- Leptin/adiponectin ratio in patients with coronary heart disease: comparing subjects with and without metabolic syndrome. — Annals of clinical biochemistry 2011 · PMID 21502199
- Cross-sectional associations between physical activity and selected coronary heart disease risk factors in young adults. The Cardiovascular Risk in Young Finns Study — Annals of Medicine 2011 · PMID 21721849
- Cystatin C, adipokines and cardiovascular risk in HIV infected patients. — Current HIV research 2010 · PMID 20426756
- Adipose tissue dysfunction in obesity, diabetes, and vascular diseases — European Heart Journal 2008 · PMID 18775919
- Cystatin C is associated with cardiovascular risk factors and metabolic syndrome in Aboriginal youth. — Pediatric nephrology (Berlin, Germany) 2007 · PMID 17394021
- Adiposity and cardiovascular disorders: disturbance of the regulatory system consisting of humoral and neuronal signals. — Circulation research 2007 · PMID 17615379
- The metabolic syndrome in children and adolescents ? an IDF consensus report — Pediatric Diabetes 2007 · PMID 17850473
- Obstructive sleep apnea. — Annals of internal medicine 2005 · PMID 15684207
- Adipokines: inflammation and the pleiotropic role of white adipose tissue — British Journal Of Nutrition 2004 · PMID 15469638
- Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index — PLoS Medicine 2004 · PMID 15602591
Clinical trials (3)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT07220772 | An Open-Label Study of Mibavademab (REGN4461), a Leptin Receptor Agonist, for the Treatment of Monogenic Obesity Due to Biallelic Loss of Function Variants of the LEP Gene | RECRUITING | INTERVENTIONAL | Mibavademab |
| NCT03377465 | Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis | COMPLETED | INTERVENTIONAL | ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin |
| NCT00659828 | Effects of Leptin Replacement in Children | COMPLETED | INTERVENTIONAL | Recombinant methionyl human leptin |
Genetic associations (0)
None linked.