C
Leukocyte telomere length
Novel & Emerging BiomarkersLab test / biomarkerprotectivepartially modifiable
16
evidence score
Also known as: Telomere length, leukocyte telomere length [LTL], telomere length
PREVENT status
Not a PREVENT input variable.
Causal support
observational only
Score components
lit volume: 10.8meta-analyses: 0trials: 4.8genetic: 0MR bonus:
References (11)
0 meta-analyses / systematic reviews- Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences. — Nature genetics 2024 · PMID 39192095
- Age at Menopause, Leukocyte Telomere Length, and Coronary Artery Disease in Postmenopausal Women. — Circulation research 2023 · PMID 37489536
- Influence of Chromosome 9p21.3 rs1333049 Variant on Telomere Length and Their Interactive Impact on the Prognosis of Coronary Artery Disease. — Journal of cardiovascular development and disease 2023 · PMID 37754816
- Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis. — Nature genetics 2022 · PMID 35835912
- Telomere length and the risk of cardiovascular diseases: A Mendelian randomization study — Frontiers in Cardiovascular Medicine 2022 · PMID 36352846
- Common and rare variant associations with clonal haematopoiesis phenotypes. — Nature 2022 · PMID 36450978
- Metformin for Cardiovascular Protection, Inflammatory Bowel Disease, Osteoporosis, Periodontitis, Polycystic Ovarian Syndrome, Neurodegeneration, Cancer, Inflammation and Senescence: What Is Next? — ACS Pharmacology & Translational Science 2021 · PMID 34927008
- Extra-telomeric impact of telomeres: Emerging molecular connections in pluripotency or stemness. — The Journal of biological chemistry 2020 · PMID 32444498
- DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions — Blood 2017 · PMID 28655780
- Is Post-Traumatic Stress Disorder Associated with Premature Senescence? A Review of the Literature. — The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2015 · PMID 25959921
- Depression and Leukocyte Telomere Length in Patients With Coronary Heart Disease — Psychosomatic Medicine 2011 · PMID 21597035
Clinical trials (2)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT02299245 | Different Doses Rosuvastatin Effect on Telomere-telomerase System in Acute Coronary Syndrome Patients After Percutaneous Coronary INtervention: RETAIN Study | UNKNOWN | INTERVENTIONAL | rosuvastatin |
| NCT03928769 | Role of Telomere Length in Arterial Smooth Muscle Cells and Circulating/Tissue Endothelial Progenitors in the Development of Atherosclerotic Lesions: Set up of the Experimental Model | SUSPENDED | OBSERVATIONAL |
Genetic associations (0)
None linked.