C
Lipoprotein-associated phospholipase A2 (Lp-PLA2)
Inflammatory & ImmuneLab test / biomarkerriskpartially modifiable
21
evidence score
Also known as: Lipoprotein-associated phospholipase A2, Lp-PLA2, lipoprotein-associated phospholipase, lipoprotein-associated phospholipase A2
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 13meta-analyses: 0trials: 8.4genetic: 0MR bonus:
References (19)
0 meta-analyses / systematic reviews- Cardiovascular Biomarkers: Tools for Precision Diagnosis and Prognosis. — International journal of molecular sciences 2025 · PMID 40244022
- Novel Antiatherosclerotic Therapies. — Arteriosclerosis, thrombosis, and vascular biology 2019 · PMID 30816799
- Atherosclerosis assessment and rheumatoid arthritis. — Zeitschrift fur Rheumatologie 2018 · PMID 27913876
- Novel biomarkers of cardiovascular disease: Applications in clinical practice — Critical Reviews in Clinical Laboratory Sciences 2018 · PMID 30457415
- Novel biomarkers for cardiovascular risk prediction. — PubMed 2017 · PMID 28491088
- Biomarkers in stable coronary heart disease, their modulation and cardiovascular risk: The LIPID biomarker study. — International journal of cardiology 2015 · PMID 26318511
- Inflammation, oxidative stress and renin angiotensin system in atherosclerosis — World Journal of Biological Chemistry 2015 · PMID 26322175
- New and emerging risk factors for coronary heart disease. — The American journal of the medical sciences 2014 · PMID 23644407
- Lipoprotein-Associated Phospholipase A2 (Lp-PLA<sub>2</sub>): A Novel and Promising Biomarker for Cardiovascular Risks Assessment — Disease Markers 2013
- Inflammation, atherosclerosis, and psoriasis. — Clinical reviews in allergy & immunology 2013 · PMID 22359071
- Lipoprotein-associated phospholipase A2 (Lp-PLA(2)): a novel and promising biomarker for cardiovascular risks assessment. — PubMed 2013 · PMID 23478277
- Classical and Novel Biomarkers for Cardiovascular Risk Prediction in the United States — Journal of Epidemiology 2013 · PMID 23604062
- Oxidized Phospholipids on apoB-100-Containing Lipoproteins: a Biomarker Predicting Cardiovascular Disease and Cardiovascular Events — Biomarkers in Medicine 2011 · PMID 22003918
- Biomarkers and Cardiovascular Risk Assessment for Primary Prevention: An Update — Clinical Chemistry 2011 · PMID 22125305
- 2010 ACCF/AHA Guideline for Assessment of Cardiovascular Risk in Asymptomatic Adults — Circulation 2010 · PMID 21098428
- Novel and Conventional Biomarkers for Prediction of Incident Cardiovascular Events in the Community — JAMA 2009 · PMID 19567439
- Primary Prevention of Ischemic Stroke — Stroke 2006 · PMID 16675728
- Resistin Is an Inflammatory Marker of Atherosclerosis in Humans — Circulation 2005 · PMID 15710760
- Lipoprotein-Associated Phospholipase A<sub>2</sub>, a Novel Inflammatory Biomarker and Independent Risk Predictor for Cardiovascular Disease — The Journal of Clinical Endocrinology & Metabolism 2005 · PMID 15713711
Clinical trials (6)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT01895387 | Replacing With Whole Grains and Legumes Reduces Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Activities in Plasma and Peripheral Blood Mononuclear Cells in Patients With Prediabetes or Newly Diagnosed Type 2 Diabetes | COMPLETED | INTERVENTIONAL | Dietary intervention-whole grains and legumes, Dietary intervention-Refined rice |
| NCT01067339 | Lp-PLA2, Progenitor Cells and Coronary Atherosclerosis in Humans AIM III | COMPLETED | INTERVENTIONAL | darapladib, placebo |
| NCT00268996 | An International, Multicenter, Randomized, Placebo-controlled, Parallel-group, 1 Year Treatment, Integrated Biomarkers and Imaging Study in Subjects With Angiographically Documented Coronary Heart Disease (CHD) to Examine the Effects of the Novel Lipoprotein-associated Phospholipase A2 (Lp-PLA2) Inhibitor SB-480848 on Intermediate Cardiovascular Endpoints, Patient Safety and Tolerability | COMPLETED | INTERVENTIONAL | SB-480848, SB-480848 matching placebo |
| NCT04239352 | Levels of Inflammatory and Cardiovascular Risk Markers in Preeclamptic Patients; New Biomarkers: Pentraxin 3 & Lipoprotein-associated Phospholipase A2 | COMPLETED | OBSERVATIONAL | Pentraxin 3 ; new biomarker, Lipoprotein-associated phospholipase A2 ; new biomarker |
| NCT03041480 | The Association Between Periodontal Status, Serum Lipid Levels and Lipoprotein Associated Lipophosphase A2(Lp-PLA2) in Chronic Periodontitis Subjects and Healthy Controls: A Case Control Study | COMPLETED | OBSERVATIONAL | serum lipid levels and Lp-PLA2 |
| NCT01423201 | TIA Triage Trial and Evaluation of Vascular-Specific Inflammatory BiomarkerLp-PLA2 as a Stratification Tool for TIA Triage and Stroke Risk | COMPLETED | OBSERVATIONAL |
Genetic associations (0)
None linked.