ASCVD Risk Atlas

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B

LPA gene variants

Genetic & Family HistoryGenetic / heritablerisknon modifiablegenetic-causal

40

evidence score

Also known as: LPA genetic variants, LPA locus variants (rs10455872, rs3798220), lpa gene, lpa locus

PREVENT status

Not a PREVENT input variable.

Causal support

genetic causal candidate

Score components

lit volume: 10.4meta-analyses: 0trials: 0genetic: 20MR bonus:

Associated genes

LPA

References (10)

0 meta-analyses / systematic reviews

Lipoprotein(a): from Causality to Treatment. — Current atherosclerosis reports 2024 · PMID 38252372
Lipoprotein (a) and cerebrovascular disease. — The Journal of international medical research 2024 · PMID 39082245
Lipoprotein(a). — Handbook of experimental pharmacology 2022 · PMID 34196811
Ancestry, Lipoprotein(a), and Cardiovascular Risk Thresholds: JACC Review Topic of the Week. — Journal of the American College of Cardiology 2022 · PMID 36007992
Lipoprotein(a): An independent, genetic, and causal factor for cardiovascular disease and acute myocardial infarction. — Indian heart journal 2019 · PMID 31280836
Effects of the coronary artery disease associated LPA and 9p21 loci on risk of aortic valve stenosis. — International journal of cardiology 2018 · PMID 30482443
Structure, function, and genetics of lipoprotein (a). — Journal of lipid research 2016 · PMID 27074913
Lipoprotein Apheresis in Patients With Maximally Tolerated Lipid-Lowering Therapy, Lipoprotein(a)-Hyperlipoproteinemia, and Progressive Cardiovascular Disease — Circulation 2013 · PMID 24056686
Emerging genomic applications in coronary artery disease. — JACC. Cardiovascular interventions 2011 · PMID 21596318
Genetic variants associated with Lp(a) lipoprotein level and coronary disease. — The New England journal of medicine 2009 · PMID 20032323

Clinical trials (0)

None linked.

Genetic associations (258)

showing top 80 by significance

Variant	Gene(s)	Trait	p	OR/β	Study
	LPA		1e-22136	1.7 ln nmol/L increase	GCST011087
	LPA		1e-19380	1.02095 nmol/l decrease	GCST012232
	LPA		1e-19215	1.4083 unit increase	GCST90019513
	LPA		1e-1032	0.26 mmol/L increase	GCST90501340
	LPA		1e-929	0.24 mmol/L increase	GCST90501336
	LPA		1e-891	0.24 % decrease	GCST90501331
	LPA		1e-814	0.23 % increase	GCST90501341
	LPA		1e-813	0.22 mmol/L increase	GCST90501337
	LPA		1e-808	0.22 mmol/L increase	GCST90501338
	LPA		1e-789	0.22 mmol/L increase	GCST90501334
	LPA		1e-750	0.22 % decrease	GCST90501335
	LPA		1e-722	0.22 % decrease	GCST90501333
	LPA		1e-710	0.21 mmol/L increase	GCST90501330
	LPA		1e-649	0.19 nm increase	GCST90501292
	LPA		1e-632	0.2 mmol/L increase	GCST90501332
	LPA		1e-586	0.19 % decrease	GCST90501309
	LPA		1e-578	0.19 mmol/L increase	GCST90501316
	LPA		1e-522	0.18 % decrease	GCST90501307
	LPA		1e-518	0.18 mmol/L increase	GCST90501293
	LPA		1e-505	0.17 % decrease	GCST90501161
	LPA		1e-499	0.18 mmol/L increase	GCST90501312
	LPA		1e-471	0.17 mmol/L increase	GCST90501314
	LPA		1e-470	0.17 mmol/L increase	GCST90501168
	LPA		1e-459	0.17 mmol/L increase	GCST90501313
	LPA		1e-439	0.17 % decrease	GCST90501159
	LPA		1e-436	0.16 mmol/L increase	GCST90501282
	LPA		1e-432	0.17 mmol/L increase	GCST90501310
	LPA		1e-420	0.16 mmol/L increase	GCST90501256
	LPA		1e-412	0.15 ratio increase	GCST90501273
	LPA		1e-396	32.43 mg/dL increase	GCST004398
	LPA		1e-369	0.15 % decrease	GCST90501251
	LPA		1e-367	—	GCST90239655
	LPA		1e-366	0.15 mmol/L increase	GCST90501164
	LPA		1e-364	0.15 mmol/L increase	GCST90501165
	LPA		1e-357	0.15 % increase	GCST90501317
	LPA		1e-337	0.14 mmol/L increase	GCST90501166
	LPA		1e-321	0.135534 unit decrease	GCST90002412
	LPA		1e-320	0.281537 unit increase	GCST90093050
	LPA		1e-312	0.14 mmol/L increase	GCST90501289
	LPA		1e-309	0.13 % decrease	GCST90501199
	LPA		1e-305	0.14 % decrease	GCST90501255
	LPA		1e-305	0.14 mmol/L increase	GCST90501306
	LPA		1e-304	0.14 mmol/L increase	GCST90501162
	LPA		1e-303	—	GCST90239673
	LPA		1e-295	0.14 mmol/L increase	GCST90501216
	LPA, LPAL2		1e-289	0.24159032 unit decrease	GCST90468081
	LPA		1e-284	0.14 mmol/L increase	GCST90501218
	LPA		1e-283	0.277545 unit decrease	GCST90093041
	LPA		1e-282	0.113763 unit increase	GCST90239658
	LPA		1e-281	0.14 % increase	GCST90501249
	LPA, PLG		1e-281	0.134443 % increase	GCST90500518
	LPA		1e-279	0.0500926 unit decrease	GCST90828065
	LPA		1e-279	0.14 % increase	GCST90501197
	LPA		1e-277	0.261294 unit increase	GCST90093046
	LPA		1e-274	0.13 % increase	GCST90501257
	LPA, PLG		1e-274	0.34183052 unit decrease	GCST90470257
	LPA		1e-265	0.266534 unit decrease	GCST90093045
	LPA		1e-262	0.397064 % increase	GCST90498146
	LPA		1e-261	1.43	GCST90837544
	LPA		1e-258	1.43	GCST90837546
	LPA		1e-256	0.265252 unit increase	GCST90093051
	LPA		1e-246	0.187148 mmol/L decrease	GCST90499740
	LPA		1e-243	0.12 mmol/L increase	GCST90501268
	LPA		1e-241	—	GCST90321120
	LPA		1e-240	0.101838 unit decrease	GCST90828061
	LPA		1e-239	0.242419 unit increase	GCST90093047
	LPA		1e-239	0.380979 % increase	GCST90498119
rs10455872	LPA	coronary atherosclerosis	1e-234	0.2816 unit decrease	GCST90475936
	LPA		1e-234	0.2816 unit decrease	GCST90475936
	LPA		1e-233	0.23877 unit increase	GCST90093048
	LPA		1e-233	0.12 mmol/L increase	GCST90501270
	LPA		1e-231	0.238256 unit increase	GCST90093044
	LPA		1e-225	0.234177 unit decrease	GCST90093019
	LPA		1e-221	0.100603 unit increase	GCST90239676
	LPA		1e-221	0.12 mmol/L increase	GCST90501304
	LPA		1e-220	—	GCST90239667
	LPA		1e-220	0.247126 unit decrease	GCST90093043
	LPA		1e-219	0.12 % decrease	GCST90501231
	LPA		1e-219	1.47245E-4 unit decrease	GCST90828062
	LPA		1e-219	0.12 mmol/L increase	GCST90501277