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Metabolic syndrome

Glycemic & MetabolicDisease / conditionriskmodifiable
61
evidence score
PREVENT status

Not a PREVENT input variable.

Causal support

trial evidence

Score components
lit volume: 25.6meta-analyses: 20trials: 15genetic: 0MR bonus:

References (358)

18 meta-analyses / systematic reviews

Clinical trials (85)

showing top 60
NCTTitleStatusTypeInterventions
NCT07027995Food and Fitness With MedicineRECRUITINGINTERVENTIONALExercise is Medicine (EIM), Culinary Education, Food is Medicine
NCT06966258Inspire HER: Inspiring the Heart and Emotions for Radical HealthRECRUITINGINTERVENTIONALInspire HER Intervention
NCT07361887Deciphering the Effect of Moderate Wine Consumption on Healthy Aging Through Postprandial Extracellular VesiclesRECRUITINGINTERVENTIONALWhite Wine, Red Wine, Water
NCT06271200Effects of Intensive Lifestyle Interventions (ILI) on Weight Loss and Cardiometabolic Risks in Obese Adults With Metabolic Syndrome: A Randomized Clinical TrialRECRUITINGINTERVENTIONALStrategic lifestyle and drug interventions, Control
NCT06112418A Randomized Comparison of Cleerly Coronary Artery Disease Stage-Based Care Versus Risk Factor-Based Care for Primary Prevention of Cardiovascular EventsRECRUITINGINTERVENTIONALThe Cleerly CAD Staging System
NCT06172335Effects of Ketolic Acid on Atherosclerosis Markers in High-risk Patients With Metabolic Syndrome (Effekt av Ketolinsyre på aterosklerosemarkører i høyrisikopasienter Med Metabolsk Syndrom)RECRUITINGINTERVENTIONALCetoleic acid, Control oil
NCT06055036Black Impact: The Mechanisms Underlying Psychosocial Stress Reduction in a Cardiovascular Health InterventionRECRUITINGINTERVENTIONALBlack Impact Intervention
NCT05845424Comparison of Efficacy and Safety of High-Intensity Statin and Ezetimibe Combination Versus StanDard carE in AsymptomatiC PatIentS wIth Presence of COroNary Artery CALCIUM (DECISION-CAL)RECRUITINGINTERVENTIONALGuideline directed statin therapy, High intensity statin plus ezetimibe therapy
NCT07551960Design, Development and Pilot Validation of an Interventional System of the STELA Center for Preventive Medicine to Reduce Modifiable Health Risk Factors in the Adult Population (CPM-STELA)ENROLLING BY INVITATIONINTERVENTIONALSTELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
NCT07209527Evaluation of Truway Health-Sourced Portable Diagnostic Devices for Early Detection of Chronic Conditions in Outpatient Primary Care Settings: A Prospective Interventional StudyENROLLING BY INVITATIONINTERVENTIONALTruway Portable Ultrasound Device, Truway Blood Glucose Monitor, Standard Oral Hypoglycemic Agent
NCT07065357Treating the Metabolic Syndrome With a Sodium-glucose Cotransporter-2 Inhibitor: a Randomised Controlled TrialENROLLING BY INVITATIONINTERVENTIONALEmpagliflozin (oral), Matching placebo
NCT07563647A Randomized, Allocation-concealed, Assessor-blinded, Parallel-group Trial Evaluating the Association Between Erectile Dysfunction and Left Ventricular Diastolic Dysfunction and Comparing the Effects of Tadalafil, SGLT2 Inhibitors, and Their Combination in Patients With Metabolic Syndrome.COMPLETEDINTERVENTIONALTadalafil 5 mg, SGLT-2 inhibitor, Tadalafil plus SGLT2 inhibitors
NCT06051461Deciphering the Role of Dietary Fatty Acids on Extracellular Vesicles-mediated Intercellular Communication and Their Implication in Atherosclerosis and Metabolic Syndrome: a Multi-omics Approach to Precision NutritionACTIVE NOT RECRUITINGINTERVENTIONALOral lipid emulsions
NCT04477590Optimizing Exercise Training Effects on Metabolic Syndrome Factors by Altering the Timing of Medication and Meal IngestionUNKNOWNINTERVENTIONALEXERCISE TRAINING WITH OR WITHOUT MEDICATION
NCT05259475Ectopic Fat in Singaporean Women - the Culprit Leading to Gestational Diabetes, Metabolic Syndrome, and Type 2 DiabetesCOMPLETEDINTERVENTIONALLifestyle Advice, Diet Intervention, OCFA Meal-Based Diet-Intervention
NCT05565976Dapagliflozin Effect in Cognitive Impairment in Stroke TrialUNKNOWNINTERVENTIONALDapagliflozin 10mg Tab, Statins (Cardiovascular Agents), Platelet Antiaggregant
NCT04321018Effect of the Addition of Medium Chain Triglycerides to a Mixed Macronutritional Meal on the Oxidation of Postprandial MacronutrientsUNKNOWNINTERVENTIONALMixed meal with medium chain triglycerides, Mixed meal with the replacement of medium chain triglycerides with unsaturated tryglicerides
NCT04959318Precision Nutrition Impact on Health-Related Behavior Change in Active Duty Service MembersCOMPLETEDINTERVENTIONALProfessional nutrition counseling, No professional nutrition counseling
NCT03877003Plasma TMAO and Choline Levels in Individuals With Metabolic Syndrome - Comparison Between Eggs and Choline Supplement IntakeCOMPLETEDINTERVENTIONALEggs
NCT03420989Development of a Novel Healthy Snacks Including Seaweeds and Carob Which Improve Risk Factors Associated With Metabolic SyndromeCOMPLETEDINTERVENTIONALActive snack food, Control snack food
NCT03921853Preventing Metabolic Syndrome in Patients With Morbid Obesity by Resistance Training: Reporting Non-responder PrevalenceCOMPLETEDINTERVENTIONALBehavioral
NCT05423457Effectiveness of Vegan Diet and MyPlate Diet (Taiwanese Version) on Lipoproteins, Novel Markers of Cardiovascular Diseases, and Traditional Cardiometabolic Risk FactorsCOMPLETEDINTERVENTIONALVegan diet
NCT02858102Impact From Aerobic Exercise (a Program of Physical Activity) in the Metabolic Syndrome, Neurocognition and Empowerment in Individuals With Severe Mental Disorders Including Depression, Bipolar Disorder and Psychosis: a Longitudinal StudyUNKNOWNINTERVENTIONALPhysical activity program
NCT02660047Magnetic Resonance Assessment of Victoza Efficacy in the Regression of Cardiovascular Dysfunction In Type 2 Diabetes Mellitus and South Asian DescentCOMPLETEDINTERVENTIONALLiraglutide, Liraglutide - Placebo
NCT02404207The Effect of High-Oleic Soybean Oil on Biomarkers of Risk for Metabolic SyndromeCOMPLETEDINTERVENTIONALSoybean oil, High-oleic soybean oil, High-oleic soybean oil + fully hydrogenated soybean oil
NCT02117661ECoM Study: Effect of Carnitine Supplementation on Progression of Carotid Plaque in the Metabolic Syndrome.COMPLETEDINTERVENTIONALL-carnitine capsules, Cellulose capsules
NCT02091583Developing and Evaluating a Novel Food Supplement, Consisting of Canola Oil, Fibre and DHA, Aiming at the Management of CVD Risk in a Population With Metabolic SyndromeCOMPLETEDINTERVENTIONALButter, sunflower and safflower oil, High Oleic Canola Oil and DHA (HOCO-DHA), Barley beta-glucan
NCT02616471Effect of High Cheese Consumption on Metabolic Syndrome Risk Factors in a Metabolically Vulnerable PopulationCOMPLETEDINTERVENTIONALHigh-fat cheese, Low-fat cheese, No-cheese/carbohydrate
NCT02075307Highbush Blueberries, the DNA-damage of Obesity, Somatic Mutations and Metabolic SyndromeCOMPLETEDINTERVENTIONALBlueberry Powder, Placebo
NCT02233088A Pilot Study of a Lifestyle Intervention on the Metabolic SyndromeCOMPLETEDINTERVENTIONALELM Group, ELM Classes, ELM Individual
NCT02288572Mechanisms of Action of Probiotic and Protective Bacteria PCS 20, PCS 26, and LGG in Prevention of the Metabolic SyndromeCOMPLETEDINTERVENTIONALLactobacillus plantarum PCS 26, Placebo
NCT01594333A Randomized, Double-blind, Placebo-controlled, Event-driven Trial of Weekly Low-dose Methotrexate (LDM) in the Prevention of Cardiovascular Events Among Stable Coronary Artery Disease Patients With Type 2 Diabetes or Metabolic SyndromeCOMPLETEDINTERVENTIONALMethotrexate, Placebo
NCT04208308Comparison of Effect of Animal and Plant Sources of Omega-3 PUFA in Prevention of Cardiovascular and Metabolic DiseasesUNKNOWNINTERVENTIONALChia seeds supplementation (25 g), Chia seeds supplementation (15 g), Combine supplementation: chia seeds (15g) and fish oil Maxi Cor 70+20
NCT01889368Effect of a Grape Seed Extract (GSE) on Insulin ResistanceCOMPLETEDINTERVENTIONALGrape Seed Extract, Placebo
NCT02137421Effects of Resveratrol on Crosstalk Between Canonical β-catenin/Wnt and FOXO Pathways in Coronary Artery Disease Patients With Metabolic Syndrome: A Case Control StudyCOMPLETEDINTERVENTIONALResveratrol (3, 4´, 5 trihydroxystilbene)
NCT02114892Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity and Insulin SecretionCOMPLETEDINTERVENTIONALResveratrol, Placebo
NCT02061267OLIVE OIL ON NAMPT AND ITS RELATION WITH POSTPRANDIAL INFLAMMATION AND ATHEROSCLEROSIS IN THE SETTING OF METABOLIC SYNDROME. The OLNAMS ProjectCOMPLETEDINTERVENTIONALNiacin, Saturated meal, Monounsaturated meal
NCT01094158A Phase II Placebo Controlled Randomised Study of Aramchol on Liver Triglyceride in Patients With Steatosis Due to NAFLD or NASHCOMPLETEDINTERVENTIONALAramchol, Aramchol, Placebo
NCT00817843Multicenter,Double Blind,Randomized, 2-period, Crossover Study to Compare Ezetimibe/Simvastatin (10mg/10 mg) Combination Tablet Versus Simvastatin 80mg Tablet on Postprandial Arterial Endothelial Function in Patients With Metabolic SyndromeCOMPLETEDINTERVENTIONALSimvastatin, Simvastatin/Ezetimibe
NCT01099306Pharmacist - Physician Collaborative Approach to the Management of Metabolic SyndromeCOMPLETEDINTERVENTIONALPharmaceutical care services
NCT00857298Effect of Diet-induced Weight Loss on HIV-associated Metabolic SyndromeCOMPLETEDINTERVENTIONALDietary Intervention
NCT01806506Randomized Clinical Trial Comparing Laparoscopic Sleeve Gastrectomy and Gastric Bypass for Morbid Obesity and Underlying Metabolic and Hormonal AbnormalitiesCOMPLETEDINTERVENTIONALLaparoscopic sleeve gastrectomy, Roux-en-Y Gastric Bypass
NCT00943254Metabolic Syndrome: Impact of Receiving the Diagnosis and Education Intervention on Cardiovascular Risk Factor Modification and Willingness to ChangeCOMPLETEDINTERVENTIONALHigh-Tech Education, Low-Tech Education
NCT00477191Effects of TNF-alpha Antagonism (Etanercept) in Patients With the Metabolic Syndrome and PsoriasisTERMINATEDINTERVENTIONALEtanercept
NCT00508937The Effects of Increased Dietary Protein Intake on Insulin Sensitivity in Stable Weight Individuals, Independent of Dietary Content of Carbohydrate and Saturated FatCOMPLETEDINTERVENTIONALDiet, Diet, Diet
NCT00314561The Effect of Pioglitazone and Rosiglitazone on Atherosclerotic and Inflammatory Markers in Patients With Metabolic Syndrome: A Prospective, Randomized, Open-label, Crossover TrialCOMPLETEDINTERVENTIONALPioglitazone, Rosiglitazone
NCT00327002A Mechanistic Study of the Effects of LY518674 on HDL C MetabolismCOMPLETEDINTERVENTIONALLY518674
NCT00228176Randomized, Multicenter, Double-blind, Placebo-controlled, Two-arm Parallel Group Trial of Rimonabant 20-mg od, for Inhibition of Atherosclerosis Progression Assessed by Carotid Artery Intima-media Thickness (CIMT), in Overweight Patients With Additional Risk FactorsTERMINATEDINTERVENTIONALRimonabant, Placebo (for Rimonabant)
NCT00659828Effects of Leptin Replacement in ChildrenCOMPLETEDINTERVENTIONALRecombinant methionyl human leptin
NCT00204412Effectiveness of Flax Lignan and Exercise Training for Improving Lipid ProfilesCOMPLETEDINTERVENTIONALFlax lignan, Exercise (walking)
NCT00269646Effect of a Low-Carbohydrate and High-Carbohydrate, High-Fiber Diet on Insulin Sensitivity and Risk Markers for Cardiovascular Disease in Men and Women With the Metabolic SyndromeUNKNOWNINTERVENTIONALLow-carbohydrate and high-carbohydrate diets
NCT00175084Effect of Dietary Amino Acid Profile on Lipoprotein Metabolism, Vascular Reactivity and Inflammatory MarkersCOMPLETEDINTERVENTIONALComparison of dietary protein amino acid profile
NCT02503865Phase 1-2 Study of Development of Rational Ways of Medical and Non-medical Treatment Methods for Metabolic SyndromeCOMPLETEDINTERVENTIONALXenical, Pionorm, Diroton, Diltiazem, Atorvastatin, "Analimentary detoxication"
NCT00654485A 12 Week Randomized, Double-Blind, Force-Titration, Parallel Group, Multi Centre, Phase IIIb Study to Compare the Efficacy of Rosuvastatin With Atorvastatin and Placebo in the Treatment of Non-Diabetic, Non-Atheroscleric, Metabolic Syndrome Subjects With Raised LDL-C and a 10 Year Risk of CHD >10%COMPLETEDINTERVENTIONALRosuvastatin, Atorvastatin
NCT00356785Body Compositional and Endocrine-Metabolic Changes by Long-Term Lifestyle Intervention With Health Education, Diet (Almased®), Physical Activity or a Combination of Diet and Physical Activity in Overweight and Obese Persons.COMPLETEDINTERVENTIONALhealth education, food supplementation, food supplementation combined with physical activity program
NCT07431593Clinical Significance and Prognostic Value of Systemic Immune Inflammation Index and Systemic Inflammation Response Index in Obesity and Associated Metabolic ComplicationsRECRUITINGOBSERVATIONALNutritional counselling
NCT06889454The Effect of Different Treatment Options on Markers of Vascular, Myocardial and Endothelial Function in Women With Polycystic Ovary Syndrome and the Association With Metabolic and Hormonal Abnormalities of the SyndromeRECRUITINGOBSERVATIONALGLP-1 receptor agonist, Oral contraceptive, Metformin
NCT04040777Cardiometabolic Risk Factors RegistryRECRUITINGOBSERVATIONAL
NCT07567378Cartilage, Arthropathy and Imaging Under Tirzepatide in Zone-stratified Cohorts (CARTIZ): A Prospective Observational Multi-Institutional Registry of the VAT-Articular-Cardiac-Aging Axis in Adults Exposed to Tirzepatide in Mexico, With Quantitative Knee Cartilage T2 Mapping, Cardiac CT Epicardial Adipose Tissue Radiomic Phenotyping, HLA Stratification, Longitudinal Multi-Frequency Bioimpedance Body Composition, and a Prespecified Surgical Tissue Acquisition SubcohortNOT YET RECRUITINGOBSERVATIONALTirzepatide
NCT07357714Longitudinal Study on Urinary Function and Multimorbidity Risks Among Beijing Community-dwelling Elderly UFMR-BCE Longitudinal StudyNOT YET RECRUITINGOBSERVATIONAL

Genetic associations (0)

None linked.