B
N-terminal pro-B-type natriuretic peptide
Novel & Emerging BiomarkersLab test / biomarkerrisknon modifiable
39
evidence score
Also known as: N-terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration, NT-proBNP, bnp, elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels, n-terminal pro-b-type, natriuretic peptide, nt-probnp
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 19.8meta-analyses: 9.1trials: 10.4genetic: 0MR bonus:
References (95)
2 meta-analyses / systematic reviews- METAAssociation of NT-proBNP and BNP With Future Clinical Outcomes in Patients With ESKD: A Systematic Review and Meta-analysis. — American journal of kidney diseases : the official journal of the National Kidney Foundation 2020 · PMID 32387090
- METANatriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis. — The lancet. Diabetes & endocrinology 2016 · PMID 27599814
- Associations Between Lead and Cadmium Exposure and Subclinical Cardiovascular Disease in U.S. Adults. — Cardiovascular toxicology 2025 · PMID 39873882
- Exploring the impact of metabolic comorbidities on epicardial adipose tissue in heart failure with preserved ejection fraction. — Cardiovascular diabetology 2025 · PMID 40121452
- Sex-specific proteomic signatures improve cardiovascular risk prediction for the general population without cardiovascular disease or diabetes. — Journal of advanced research 2025 · PMID 40154735
- Interplay of Chronic Kidney Disease and the Effects of Tirzepatide in Patients With Heart Failure, Preserved Ejection Fraction, and Obesity: The SUMMIT Trial. — Journal of the American College of Cardiology 2025 · PMID 40162940
- Use of NT-proBNP for the screening, diagnosis and risk-stratification of left ventricular dysfunction. — Diabetes, obesity & metabolism 2025 · PMID 40205856
- Cardiovascular Biomarkers: Tools for Precision Diagnosis and Prognosis. — International journal of molecular sciences 2025 · PMID 40244022
- Factors associated with NT-proBNP concentration in US children and adolescents: National Health and Nutrition Examination Survey 1999-2004. — American heart journal 2025 · PMID 40268182
- Distribution characteristics and screening reference values of NT-proBNP in high cardiovascular risk population. — Nutrition, metabolism, and cardiovascular diseases : NMCD 2025 · PMID 40300965
- Epidemiological and Translational Study of Calprotectin and Atherosclerotic Cardiovascular Disease. — JAMA cardiology 2025 · PMID 40332890
- A validated multivariable machine learning model to predict cardio-kidney risk in diabetic kidney disease. — Cardiovascular diabetology 2025 · PMID 40375260
- Proteomic Signatures for Risk Prediction of Atrial Fibrillation. — Circulation 2025 · PMID 40401370
- Non-linear association of coagulation factor XI with mortality. — Med (New York, N.Y.) 2025 · PMID 41455467
- Galectin-3, Metabolic Risk, and Incident Heart Failure: The ARIC Study. — Journal of the American Heart Association 2024 · PMID 38471823
- Longitudinal NT-proBNP: Associations With Echocardiographic Changes and Outcomes in Heart Failure. — Journal of the American Heart Association 2024 · PMID 38639333
- Circulating galectin-3 level association with cardiovascular risk factors during peritoneal dialysis. — Clinical and experimental nephrology 2024 · PMID 38643287
- Individual and Joint Associations of High-Sensitivity Troponin I and High-Sensitivity Troponin T with Cardiac Phenotypes and Outcomes in the General Population: An Analysis From the Dallas Heart Study. — Journal of the American Heart Association 2024 · PMID 38842289
- Role of dietary inflammatory index in the association of NT-proBNP with all-cause and cardiovascular mortality in NHANES 1999-2004. — Scientific reports 2024 · PMID 39198638
- Heart Failure Risk Assessment Using Biomarkers in Patients With Atrial Fibrillation: Analysis From COMBINE-AF. — Journal of the American College of Cardiology 2024 · PMID 39230543
- NT-proBNP and Cardiac Troponin I, but Not Cardiac Troponin T, Are Associated With 7-Year Changes in Cardiac Structure and Function in Older Adults: The ARIC Study. — Circulation 2024 · PMID 39315431
- Plasma Protein Biomarkers and Long-Term Cardiovascular Mortality Risk in Patients With Chronic Coronary Heart Disease. — Journal of the American Heart Association 2024 · PMID 39450716
- Obesity Paradox and the Effect of NT-proBNP on All-Cause and Cause-Specific Mortality. — Clinical cardiology 2024 · PMID 39514242
- Large-Scale Plasma Proteomics Profiles for Predicting Ischemic Stroke Risk in the General Population. — Stroke 2024 · PMID 39704077
- A polygenic risk score predicts atrial fibrillation in cardiovascular disease. — European heart journal 2023 · PMID 35980763
- NT-proBNP and All-Cause and Cardiovascular Mortality in US Adults: A Prospective Cohort Study. — Journal of the American Heart Association 2023 · PMID 37232235
- Association of interleukin-6 and interleukin-18 with cardiovascular disease in older adults: Atherosclerosis Risk in Communities study. — European journal of preventive cardiology 2023 · PMID 37306504
- NT-proBNP level as a substitute for myocardial perfusion scan in preoperative cardiovascular risk assessment in noncardiac surgery. — BMC anesthesiology 2023 · PMID 37474913
- [Renal insufficiency and cardiovascular risk]. — Deutsche medizinische Wochenschrift (1946) 2023 · PMID 37541291
- Association of growth and differentiation factor-15 with coronary artery calcium score and ankle-brachial index in a middle-aged and elderly Caucasian population sample free of manifest cardiovascular disease. — GeroScience 2023 · PMID 37548881
- Practical algorithms for early diagnosis of heart failure and heart stress using NT-proBNP: A clinical consensus statement from the Heart Failure Association of the ESC. — European journal of heart failure 2023 · PMID 37712339
- NT-proBNP and cardiovascular event risk in individuals with prediabetes undergoing cardiovascular evaluation. — Diabetes research and clinical practice 2023 · PMID 37774978
- Cardiovascular risk evaluation in pregnancy: focus on cardiac specific biomarkers. — Clinical chemistry and laboratory medicine 2023 · PMID 37942796
- Deep learning-based NT-proBNP prediction from the ECG for risk assessment in the community. — Clinical chemistry and laboratory medicine 2023 · PMID 37982681
- Liver fibrosis, NT-ProBNP and mortality in patients with MASLD: A population-based cohort study. — Nutrition, metabolism, and cardiovascular diseases : NMCD 2023 · PMID 38161125
- Ceramides and Cardiovascular Risk Factors, Inflammatory Parameters and Left Ventricular Function in AMI Patients. — Biomedicines 2022 · PMID 35203637
- Epicardial fat and incident heart failure with preserved ejection fraction in patients with coronary artery disease. — International journal of cardiology 2022 · PMID 35395282
- Cardiac troponin T and NT-proBNP for detecting myocardial ischemia in suspected chronic coronary syndrome. — International journal of cardiology 2022 · PMID 35577165
- Elevated NT-ProBNP as a Cardiovascular Disease Risk Equivalent: Evidence from the Atherosclerosis Risk in Communities (ARIC) Study. — The American journal of medicine 2022 · PMID 36007589
- Reference Ranges for NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) and Risk Factors for Higher NT-proBNP Concentrations in a Large General Population Cohort. — Circulation. Heart failure 2022 · PMID 36098049
- Impact of socioeconomic and cardiovascular risk factors on the effect of genetic variants associated with NT-proBNP. — Scientific reports 2022 · PMID 36114409
- NT-ProBNP and mortality across the spectrum of glucose tolerance in the general US population. — Cardiovascular diabetology 2022 · PMID 36344968
- Clinical features, risk factors and survival in cardiac myxoma-related ischemic stroke: A multicenter case-control study. — Journal of the neurological sciences 2022 · PMID 36528975
- High-sensitivity cardiac troponin T and the risk of heart failure in postmenopausal women of the ARIC Study. — Menopause (New York, N.Y.) 2021 · PMID 33399316
- Performance of the recommended ESC/EASD cardiovascular risk stratification model in comparison to SCORE and NT-proBNP as a single biomarker for risk prediction in type 2 diabetes mellitus. — Cardiovascular diabetology 2021 · PMID 33530999
- Association of NT-ProBNP, Blood Pressure, and Cardiovascular Events: The ARIC Study. — Journal of the American College of Cardiology 2021 · PMID 33538254
- Growth Differentiation Factor (GDF)-15 and Cardiometabolic Outcomes among Older Adults: The Atherosclerosis Risk in Communities Study. — Clinical chemistry 2021 · PMID 33582779
- Prognostic value of cardiac biomarkers in COVID-19 infection. — Scientific reports 2021 · PMID 33654230
- Cardiovascular biomarkers in patients with COVID-19. — European heart journal. Acute cardiovascular care 2021 · PMID 33655301
- NT-proBNP versus routine clinical risk factors as a predictor of cardiovascular events or death in people with dysglycemia - A brief report from the ORIGIN trial. — Journal of diabetes and its complications 2021 · PMID 33906818
- Analysis of risk factors for different subtypes of acute coronary syndrome. — The Journal of international medical research 2021 · PMID 33969735
- Trastuzumab-induced cardiotoxicity: a review of clinical risk factors, pharmacologic prevention, and cardiotoxicity of other HER2-directed therapies. — Breast cancer research and treatment 2021 · PMID 34115243
- Circulating Biomarkers for Cardiovascular Disease Risk Prediction in Patients With Cardiovascular Disease — Frontiers in Cardiovascular Medicine 2021 · PMID 34660715
- Galectin-3 and Cardiovascular Biomarkers Reflect Adaptation Response to Scuba Diving. — International journal of sports medicine 2020 · PMID 31975358
- Plasma Ceramides and Sphingomyelins in Relation to Atrial Fibrillation Risk: The Cardiovascular Health Study. — Journal of the American Heart Association 2020 · PMID 32019406
- Combining Novel Biomarkers for Risk Stratification of Two-Year Cardiovascular Mortality in Patients with ST-Elevation Myocardial Infarction — Journal of Clinical Medicine 2020 · PMID 32085400
- Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study — BMJ 2020 · PMID 32217556
- Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19) — JAMA Cardiology 2020 · PMID 32219356
- COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options — Cardiovascular Research 2020 · PMID 32352535
- NT-proBNP and metabolic risk factors in a bi-ethnic cohort: the Ambulatory Blood Pressure in African prospective cohort study. — Cardiovascular journal of Africa 2020 · PMID 33180090
- Cardiovascular aspects of COVID-19. — Swiss medical weekly 2020 · PMID 33382450
- Heart Failure Association of the European Society of Cardiology practical guidance on the use of natriuretic peptide concentrations. — European journal of heart failure 2019 · PMID 31222929
- NT-proBNP and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study. — Journal of the American Heart Association 2019 · PMID 31446828
- GDF-15 in solid vs non-solid treatment-naïve malignancies. — European journal of clinical investigation 2019 · PMID 31463975
- Change in NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) Level and Risk of Dementia in Multi-Ethnic Study of Atherosclerosis (MESA). — Hypertension (Dallas, Tex. : 1979) 2019 · PMID 31865797
- The predictive value of NT-proBNP and hs-TnT for risk of death in cardiac surgical patients. — Clinical biochemistry 2018 · PMID 29371002
- Psoriasis as a cardiovascular risk factor: updates and algorithmic approach. — Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 2018 · PMID 29683293
- N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts the cardio-renal response to aliskiren in patients with type 2 diabetes at high renal and cardiovascular risk. — Diabetes, obesity & metabolism 2018 · PMID 29987919
- Protein Biomarkers of Cardiovascular Disease and Mortality in the Community — Journal of the American Heart Association 2018 · PMID 30006491
- High-Sensitivity Troponin T and Incident Heart Failure in Older Men: British Regional Heart Study. — Journal of cardiac failure 2018 · PMID 30103019
- Co-exposure subacute toxicity of silica nanoparticles and lead acetate on cardiovascular system. — International journal of nanomedicine 2018 · PMID 30538461
- Cardiac Impairment in Rheumatoid Arthritis and Influence of Anti-TNFα Treatment. — Clinical reviews in allergy & immunology 2017 · PMID 27342458
- NT-proBNP is increased in differentiated thyroid carcinoma patients and may predict cardiovascular risk. — Clinical biochemistry 2017 · PMID 28242284
- Coronary Artery Calcification and Risk of Cardiovascular Disease and Death Among Patients With Chronic Kidney Disease — JAMA Cardiology 2017 · PMID 28329057
- Heart Failure with Preserved and Reduced Ejection Fraction in Hemodialysis Patients: Prevalence, Disease Prediction and Prognosis — Kidney & Blood Pressure Research 2017 · PMID 28395286
- Cardiovascular Disease Risk Factors in Patients with Posttraumatic Stress Disorder (PTSD): A Narrative Review. — Psychiatria Danubina 2017 · PMID 29197198
- Role of Coronary Artery Calcium Score of Zero and Other Negative Risk Markers for Cardiovascular Disease — Circulation 2016 · PMID 26801055
- NT-proANP and NT-proBNP circulating levels as predictors of cardiovascular outcome following coronary stent implantation. — Cardiovascular revascularization medicine : including molecular interventions 2016 · PMID 26987266
- Novel Biomarkers to Improve the Prediction of Cardiovascular Event Risk in Type 2 Diabetes Mellitus — Journal of the American Heart Association 2016 · PMID 27247335
- NT-proBNP and the risk of dementia: a prospective cohort study with 14 years of follow-up. — Journal of Alzheimer's disease : JAD 2015 · PMID 25408211
- Exercise and the heart--the harm of too little and too much. — Current sports medicine reports 2015 · PMID 25757005
- Novel methodologies for biomarker discovery in atherosclerosis — European Heart Journal 2015 · PMID 26049157
- High-Sensitivity Cardiac Troponin T and Risk of Hypertension. — Circulation 2015 · PMID 26152706
- Biomarkers in stable coronary heart disease, their modulation and cardiovascular risk: The LIPID biomarker study. — International journal of cardiology 2015 · PMID 26318511
- Biomarkers and heart disease. — European review for medical and pharmacological sciences 2014 · PMID 25339488
- GDF-15 for prognostication of cardiovascular and cancer morbidity and mortality in men. — PloS one 2013 · PMID 24312445
- Prognostic Utility of Novel Biomarkers of Cardiovascular Stress — Circulation 2012 · PMID 22907935
- Biomarkers and Cardiovascular Risk Assessment for Primary Prevention: An Update — Clinical Chemistry 2011 · PMID 22125305
- Contribution of 30 Biomarkers to 10-Year Cardiovascular Risk Estimation in 2 Population Cohorts — Circulation 2010 · PMID 20497981
- Novel and Conventional Biomarkers for Prediction of Incident Cardiovascular Events in the Community — JAMA 2009 · PMID 19567439
- Growth-differentiation factor-15 improves risk stratification in ST-segment elevation myocardial infarction — European Heart Journal 2007 · PMID 17977844
- Cardio-protection in acute stroke. — International journal of stroke : official journal of the International Stroke Society 2007 · PMID 18705931
- Rationale for testing the cardiovascular risk for patients with COX-2 inhibitors on the basis of biomarker NT-proBNP. — Clinical laboratory 2005 · PMID 15719708
- Asymmetric Dimethylarginine and the Risk of Cardiovascular Events and Death in Patients With Coronary Artery Disease — Circulation Research 2005 · PMID 16100045
- Arterial Stiffening as a Possible Risk Factor for Both Atherosclerosis and Diastolic Heart Failure — Hypertension Research 2004 · PMID 15750255
Clinical trials (10)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06593327 | Evaluation of a Pragmatic NT-ProBNP-based Heart Failure Screening Strategy Among Patients With Type 2 Diabetes: STRONG-DM Study (Screening and Treatment Using Risk-based apprOach With NT-ProBNP Guidance in Diabetes Mellitus | RECRUITING | INTERVENTIONAL | Intensive Prevention Strategy |
| NCT05705869 | Targeted Assessment in High-Risk paTients With dIAbetes to ideNtify Undiagnosed Heart Failure (TARTAN-HF) | ACTIVE NOT RECRUITING | INTERVENTIONAL | NT-proBNP |
| NCT04023227 | A Multicenter, Prospective, Randomized, Open-label, Blinded-endpoint, Phase 4 Study to Evaluate the Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With Chronic Chagas' Cardiomyopathy. The Study is Also Know as Prevention And Reduction of Adverse Outcomes in Chagasic Heart failUre Trial Evaluation (PARACHUTE-HF). | COMPLETED | INTERVENTIONAL | Sacubitril/valsartan, Enalapril |
| NCT03377465 | Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis | COMPLETED | INTERVENTIONAL | ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin |
| NCT05838547 | PET-MR Imaging of Natriuretic Peptide Receptor C (NPR-C) in Carotid Atherosclerosis With Cu[64]-25%-CANF-Comb-II | RECRUITING | OBSERVATIONAL | 64Cu-25%-CANF-Comb, 64Cu-25%-CANF-Comb |
| NCT05939089 | Cardiovascular Assessment of Pediatric Cancer Survivors: Understanding Long-Term Effects and Risks | COMPLETED | OBSERVATIONAL | ECG, Echocardiography, cTnI, NT-ProBNP |
| NCT04710745 | Atrial Fibrillation in Relationship to Plasma Biomarkers | UNKNOWN | OBSERVATIONAL | Peripheral blood samples for routine analysis including NT-proBNP and plasmatic biomarkers., Echocardiography, ECG Holter monitor |
| NCT03926104 | Evaluation of BNP Values in Major Vascular Surgery | UNKNOWN | OBSERVATIONAL | |
| NCT05214872 | Assessment of the Impact of Selected Factors on the Cardiovascular System in Patients With Different Chronic Kidney Disease Stages | COMPLETED | OBSERVATIONAL | laboratory parameters - complete blood count, body mass index (BMI) [kg/m^2] calculation, selected parameters of oxidative stress (1) |
| NCT00479518 | Prognostic Value of Cardiac and Renal Markers in the Acute Phase of Ischemic Stroke or Transient Ischemic Attack :Albuminuria-Brain Natriuretic Peptide-Cystatine C in Stroke | COMPLETED | OBSERVATIONAL |
Genetic associations (0)
None linked.