C
Nitric oxide bioavailability
Novel & Emerging BiomarkersLab test / biomarkerprotectivepartially modifiable
17
evidence score
Also known as: Nitric oxide production/bioavailability impairment, decreased nitric oxide (NO•) bioavailability, nitric oxide, nitric oxide production
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 7meta-analyses: 0trials: 9.5genetic: 0MR bonus:
References (4)
0 meta-analyses / systematic reviews- Oxidative Stress and Cardiovascular Dysfunction Associated with Cadmium Exposure: Beneficial Effects of Curcumin and Tetrahydrocurcumin. — The Tohoku journal of experimental medicine 2016 · PMID 27151191
- Alcohol consumption, cardiovascular health, and endothelial function markers. — Alcohol (Fayetteville, N.Y.) 2007 · PMID 17980786
- Endothelial dysfunction in diabetic erectile dysfunction. — International journal of impotence research 2006 · PMID 16775612
- Folate, homocysteine, endothelial function and cardiovascular disease. — The Journal of nutritional biochemistry 2004 · PMID 14972346
Clinical trials (8)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT06657976 | Response to Exercise and Nitric Oxide in Peripheral Artery Disease: The RESIST PAD Trial | RECRUITING | INTERVENTIONAL | Supervised Treadmill Exercise, Attention Control, Nitrate-Rich Beetroot Juice + supervised exercise therapy |
| NCT04800692 | The Effects of ATLAS (Arginine Tetrahydrobiopterin L-Ascorbate) Therapy on Nitric Oxide Bioavailability and Pain-free Walking in Patients With Intermittent Claudication | ACTIVE NOT RECRUITING | INTERVENTIONAL | Tetrahydrobiopterin 10 mg/kg, Tetrahydrobiopterin 20 mg/kg, L-Ascorbate |
| NCT03534661 | Role of a Nitric Oxide Synthase Inhibitor on GLP-2 Mediated Intestinal Lipoprotein Release | COMPLETED | INTERVENTIONAL | Teduglutide + Normal Saline, Teduglutide + L-NMMA, Placebo + L-NMMA |
| NCT04179942 | Fractional Exhaled Nitric Oxide and CRP Levels in Egyptian Patients With Obstructive Sleep Apnea Syndrome | COMPLETED | INTERVENTIONAL | Fractional exhaled nitric oxide and CRP levels |
| NCT01802619 | Prevention of Renal Failure by Nitric Oxide in Prolonged Cardiopulmonary Bypass: A Double Blind Randomized Controlled Trial. | COMPLETED | INTERVENTIONAL | inhaled nitric oxide, inhaled Nitrogen |
| NCT00981591 | A Randomized, Double Blind, Placebo-controlled Pilot Study of the Safety and Effective Dosing of Inhaled Iloprost in Pediatric Patients With Pulmonary Hypertension Treated With Inhaled Nitric Oxide | WITHDRAWN | INTERVENTIONAL | Iloprost, Placebo |
| NCT00782652 | The Effects of Nitric Oxide for Inhalation on Survival or the Need for Dialysis or a Right Ventricular Assistance Device (RVAD) in Right Ventricular Infarction Patients | TERMINATED | INTERVENTIONAL | inhaled nitric oxide, nitrogen gas |
| NCT00160745 | A Randomised, Double-blind, Placebo-controlled, Mono-centre, Explorative Phase II Trial to Study the Effects of Rosuvastatin on Basal Production and Release of Nitric Oxide From the Renal Vasculature in Patients With Hypercholesterolemia. | COMPLETED | INTERVENTIONAL | Rosuvastatin |
Genetic associations (0)
None linked.