A
Non-HDL cholesterol
Lipids & LipoproteinsLab test / biomarkerriskmodifiable
38
evidence score
Also known as: Non-HDL-C (total cholesterol minus HDL-C), calculated non-HDL cholesterol, non-HDL-C, non-HDL-cholesterol, non-hdl-c, non-high density lipoprotein cholesterol, non-high-density lipoprotein cholesterol (non-HDL-C)
PREVENT status
Not a PREVENT input variable.
Causal support
trial evidence
Score components
lit volume: 18.2meta-analyses: 13.8trials: 6genetic: 0MR bonus:
References (65)
4 meta-analyses / systematic reviews- METAMeta-analysis of serum non-high-density lipoprotein cholesterol and risk of coronary heart disease in the general population. — Clinica chimica acta; international journal of clinical chemistry 2017 · PMID 28495387
- METAAssociation of LDL cholesterol, non-HDL cholesterol, and apolipoprotein B levels with risk of cardiovascular events among patients treated with statins: a meta-analysis. — JAMA 2012 · PMID 22453571
- METAMeta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk. — Journal of the American College of Cardiology 2009 · PMID 19161879
- METABlood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. — Lancet (London, England) 2007 · PMID 18061058
- Trial-level surrogacy of non-high-density and low-density lipoprotein cholesterol reduction on the clinical efficacy of statins. — European heart journal. Cardiovascular pharmacotherapy 2025 · PMID 39999862
- Discordance analyses comparing LDL cholesterol, Non-HDL cholesterol, and apolipoprotein B for cardiovascular risk estimation. — Atherosclerosis 2025 · PMID 40073776
- Safety and Efficacy of Obicetrapib in Patients at High Cardiovascular Risk. — The New England journal of medicine 2025 · PMID 40337982
- Concordance-discordance between apolipoprotein B and lipid biomarkers in predicting 20-year atherosclerotic cardiovascular disease risk: The ATTICA study (2002-2022). — European journal of clinical investigation 2025 · PMID 40386959
- Cardiovascular risk and lipid control in older adults: Compliance with LDL and non-HDL cholesterol and triglyceride goals in a national cross-sectional study. — Journal of clinical lipidology 2025 · PMID 40414747
- Lipoprotein(a), Cholesterol, Triglyceride Levels, and Vulnerable Coronary Plaques: A PROSPECT II Substudy. — Journal of the American College of Cardiology 2025 · PMID 40436465
- Cumulative exposures to glycaemia and lipids are associated with coronary artery disease in type 1 diabetes: a call for action. — Cardiovascular diabetology 2025 · PMID 40514649
- ApoB, LDL-C, and non-HDL-C as markers of cardiovascular risk. — Journal of clinical lipidology 2025 · PMID 40681368
- Impact of Obicetrapib on Major Adverse Cardiovascular Events in High-Risk Patients: A Pooled Analysis. — Journal of the American College of Cardiology 2025 · PMID 40888776
- Olezarsen for Hypertriglyceridemia in Patients at High Cardiovascular Risk. — The New England journal of medicine 2024 · PMID 38587249
- Non-High-Density Lipoprotein Cholesterol Levels From Childhood to Adulthood and Cardiovascular Disease Events. — JAMA 2024 · PMID 38607340
- Discordance among apoB, non-high-density lipoprotein cholesterol, and triglycerides: implications for cardiovascular prevention. — European heart journal 2024 · PMID 38700053
- Obicetrapib on top of maximally tolerated lipid-modifying therapies in participants with or at high risk for atherosclerotic cardiovascular disease: rationale and designs of BROADWAY and BROOKLYN. — American heart journal 2024 · PMID 38705341
- Intensive early and sustained lowering of non-high-density lipoprotein cholesterol after myocardial infarction and prognosis: the SWEDEHEART registry. — European heart journal 2024 · PMID 39217499
- Role of apolipoprotein B in the clinical management of cardiovascular risk in adults: An Expert Clinical Consensus from the National Lipid Association. — Journal of clinical lipidology 2024 · PMID 39256087
- Quantifying Triglyceride-Rich Lipoprotein Atherogenicity, Associations With Inflammation, and Implications for Risk Assessment Using Non-HDL Cholesterol. — Journal of the American College of Cardiology 2024 · PMID 39322327
- Carotid Intima Media Thickness and Risk Factor for Atherosclerosis: Tohoku Medical Megabank Community-Based Cohort Study. — Journal of atherosclerosis and thrombosis 2023 · PMID 36775331
- Remnant cholesterol, vascular risk, and prevention of atherosclerosis. — Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2023 · PMID 36889989
- Association of non-HDL-C-to-HDL-C ratio with coronary lesions and its prognostic performance in first-onset NSTEMI. — Biomarkers in medicine 2023 · PMID 36994674
- Remnant cholesterol and risk of myocardial infarction in patients with coronary artery disease undergoing revascularization. — Journal of clinical lipidology 2023 · PMID 37005155
- Apolipoprotein Particle and Cardiovascular Risk Prediction (from a Prospective Cohort Study). — The American journal of cardiology 2023 · PMID 37352662
- Non-HDL cholesterol and long-term follow-up outcomes in patients with metabolic syndrome. — Lipids in health and disease 2023 · PMID 37794473
- Non-HDL-cholesterol in dyslipidemia: Review of the state-of-the-art literature and outlook. — Atherosclerosis 2023 · PMID 37826864
- Low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol and apolipoprotein B for cardiovascular care. — Current opinion in cardiology 2023 · PMID 37934698
- Childhood Non-HDL Cholesterol and LDL Cholesterol and Adult Atherosclerotic Cardiovascular Events. — Circulation 2023 · PMID 38014550
- CSI clinical practice guidelines for dyslipidemia management: Executive summary. — Indian heart journal 2023 · PMID 38052658
- Rationale and design of the effect of evolocumab in patients at high cardiovascular risk without prior myocardial infarction or stroke (VESALIUS-CV) trial. — American heart journal 2023 · PMID 38160917
- Association of Apolipoprotein B-Containing Lipoproteins and Risk of Myocardial Infarction in Individuals With and Without Atherosclerosis: Distinguishing Between Particle Concentration, Type, and Content. — JAMA cardiology 2022 · PMID 34773460
- Non-HDL cholesterol paradox and effect of underlying malnutrition in patients with coronary artery disease: A 41,182 cohort study. — Clinical nutrition (Edinburgh, Scotland) 2022 · PMID 35168005
- Eveningness is associated with sedentary behavior and increased 10-year risk of cardiovascular disease: the SCAPIS pilot cohort. — Scientific reports 2022 · PMID 35581309
- Correlation between the triglyceride-to-high-density lipoprotein cholesterol ratio and other unconventional lipid parameters with the risk of prediabetes and Type 2 diabetes in patients with coronary heart disease: a RCSCD-TCM study in China. — Cardiovascular diabetology 2022 · PMID 35659300
- Apolipoprotein B and Non-HDL Cholesterol Better Reflect Residual Risk Than LDL Cholesterol in Statin-Treated Patients. — Journal of the American College of Cardiology 2021 · PMID 33736827
- Genetics of hypertriglyceridemia and atherosclerosis. — Current opinion in cardiology 2021 · PMID 33818545
- Update on apolipoprotein B. — Current opinion in lipidology 2021 · PMID 33870931
- Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study. — European heart journal 2021 · PMID 34293083
- LDL-C, NON-HDL-C and APO-B for cardiovascular risk assessment: Looking for the ideal marker. — Indian heart journal 2021 · PMID 34627566
- Chronic cadmium exposure and cardiovascular disease in adults. — Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering 2020 · PMID 32149559
- Non-HDL Cholesterol Levels in Childhood and Carotid Intima-Media Thickness in Adulthood. — Pediatrics 2020 · PMID 32209701
- Quantifying Importance of Major Risk Factors for Coronary Heart Disease — Circulation 2019 · PMID 30586759
- Comparison of Conventional Lipoprotein Tests and Apolipoproteins in the Prediction of Cardiovascular Disease — Circulation 2019 · PMID 31216866
- Effects of betalains on atherogenic risk factors in patients with atherosclerotic cardiovascular disease — Food & Function 2019 · PMID 31723956
- Non-HDL cholesterol as a therapeutic goal. — Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis 2019 · PMID 31806265
- Apolipoprotein B, Triglyceride-Rich Lipoproteins, and Risk of Cardiovascular Events in Persons with CKD. — Clinical journal of the American Society of Nephrology : CJASN 2019 · PMID 31831577
- Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. — BMJ open 2018 · PMID 29511019
- Long-Term Association of Low-Density Lipoprotein Cholesterol With Cardiovascular Mortality in Individuals at Low 10-Year Risk of Atherosclerotic Cardiovascular Disease — Circulation 2018 · PMID 30571575
- Association of Non-HDL Cholesterol, Homocysteine and Vitamin D in Acute Coronary Syndrome. — The Journal of the Association of Physicians of India 2018 · PMID 31324079
- Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease — New England Journal of Medicine 2017 · PMID 28847206
- Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points-a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine. — European heart journal 2016 · PMID 27122601
- Non-HDL Cholesterol and Triglycerides: Implications for Coronary Atheroma Progression and Clinical Events. — Arteriosclerosis, thrombosis, and vascular biology 2016 · PMID 27515380
- Update on pediatric hyperlipidemia. — Current opinion in pediatrics 2014 · PMID 24553633
- Cardiovascular disease risk factors in HIV-infected women after initiation of lopinavir/ritonavir- and nevirapine-based antiretroviral therapy in Sub-Saharan Africa: A5208 (OCTANE). — Journal of acquired immune deficiency syndromes (1999) 2014 · PMID 24562349
- Hypertriglyceridaemia, postprandial lipaemia and non-HDL cholesterol. — Current pharmaceutical design 2014 · PMID 24953399
- The relationship between carotid blood pressure reactivity to mental stress and carotid intima-media thickness. — Atherosclerosis 2014 · PMID 25099945
- LOX-1 in atherosclerotic disease. — Clinica chimica acta; international journal of clinical chemistry 2014 · PMID 25463747
- Comparison of a novel method vs the Friedewald equation for estimating low-density lipoprotein cholesterol levels from the standard lipid profile. — JAMA 2013 · PMID 24240933
- The role of non-HDL cholesterol in risk stratification for coronary artery disease. — Current atherosclerosis reports 2012 · PMID 22203405
- Lipoprotein Particle Profiles by Nuclear Magnetic Resonance Compared With Standard Lipids and Apolipoproteins in Predicting Incident Cardiovascular Disease in Women — Circulation 2009 · PMID 19204302
- Major lipids, apolipoproteins, and risk of vascular disease. — JAMA 2009 · PMID 19903920
- How Much of the Recent Decline in the Incidence of Myocardial Infarction in British Men Can Be Explained by Changes in Cardiovascular Risk Factors? — Circulation 2008 · PMID 18212284
- Ezetimibe: cholesterol lowering and beyond. — Expert review of cardiovascular therapy 2008 · PMID 18402536
- Non-HDL cholesterol as a measure of atherosclerotic risk. — Journal of atherosclerosis and thrombosis 2004 · PMID 15067193
Clinical trials (3)
| NCT | Title | Status | Type | Interventions |
|---|---|---|---|---|
| NCT02642159 | A Randomized, Open-Label, Parallel Group Study to Evaluate the Efficacy and Safety of Alirocumab Versus Usual Care in Patients With Type 2 Diabetes and Mixed Dyslipidemia at High Cardiovascular Risk With Non-HDL-C Not Adequately Controlled With Maximally Tolerated Statin Therapy | COMPLETED | INTERVENTIONAL | Alirocumab, Statins, Ezetimibe |
| NCT07476248 | The Non-high-density Lipoprotein Cholesterol (Non-HDL-C) to High-density Lipoprotein Cholesterol (HDL-C) Ratio (NHHR) and Its Association With Occurrence of Diabetic Nephropathy in Patients With Diabetes Mellitus | NOT YET RECRUITING | OBSERVATIONAL | |
| NCT01687686 | Differential Effects of Total Cholesterol, Non-HDL Cholesterol and Triglycerides on Initial Presentation of Specific Cardiovascular Diseases (a CALIBER Study) | UNKNOWN | OBSERVATIONAL |
Genetic associations (0)
None linked.